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The FLS mouse: a new inbred strain with spontaneous fatty liver. FLS小鼠:一种新的自发性脂肪肝近交系。
Laboratory animal science Pub Date : 1999-06-01
M Soga, Y Kishimoto, J kawaguchi, Y Nakai, Y Kawamura, S Inagaki, K Katoh, T Oohara, S Makino, I Oshima
{"title":"The FLS mouse: a new inbred strain with spontaneous fatty liver.","authors":"M Soga,&nbsp;Y Kishimoto,&nbsp;J kawaguchi,&nbsp;Y Nakai,&nbsp;Y Kawamura,&nbsp;S Inagaki,&nbsp;K Katoh,&nbsp;T Oohara,&nbsp;S Makino,&nbsp;I Oshima","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and purpose: </strong>A new strain of mouse, named FLS (fatty liver Shionogi), which develops spontaneous fatty liver without obesity, was established by inbreeding. Morphologic, physiologic, and genetic characterization of the strain was done.</p><p><strong>Methods: </strong>Characteristics of male FLS mice were compared with those of the sister strain, dd Shionogi (DS), which does not develop spontaneous fatty liver. A genetic cross experiment was performed by mating FLS with C3H/He/Shi mice.</p><p><strong>Results: </strong>The hepatocytes of neonatal FLS mice contained fine lipid droplets throughout the lobules, and large lipid droplets appeared as mice aged. Liver triglyceride concentrations of FLS mice were fivefold higher than those of DS mice, but serum lipid concentrations and the lipoprotein profile did not indicate abnormalities. Higher plasma aspartate transaminase and alanine transaminase activities in FLS, compared with DS mice, suggested hepatocellular lesions. The genetic cross experiment suggested that the fatty liver formation is a complex polygenic trait.</p><p><strong>Conclusion: </strong>The FLS mice develop a progressive hepatic steatosis without obesity and diabetes. The FLS mouse might be a good model for investigating hepatic disorders accompanied by fatty liver unrelated to alcoholism or obesity.</p>","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 3","pages":"269-75"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21270796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auditory brainstem responses in Golden Syrian hamsters (Mesocricetus auratus) affected with the Wh gene. 受Wh基因影响的金色叙利亚仓鼠(Mesocricetus auratus)听觉脑干反应。
Laboratory animal science Pub Date : 1999-04-01
G K Amedofu, K V Gopal, J H Asher, M Ahmadizadeh, E J Moore
{"title":"Auditory brainstem responses in Golden Syrian hamsters (Mesocricetus auratus) affected with the Wh gene.","authors":"G K Amedofu,&nbsp;K V Gopal,&nbsp;J H Asher,&nbsp;M Ahmadizadeh,&nbsp;E J Moore","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and purpose: </strong>The anophthalmic white (Wh) gene in Golden Syrian hamsters (Mesocricetus auratus) is autosomal semi-dominant and causes several developmental defects, including hearing loss. The Wh mutation is thought to be homologous to Waardenburg syndrome in humans, apparently affecting similar developmental processes. The purpose of this study was to assess the hearing of hamsters in the AN/As-Wh strain.</p><p><strong>Methods: </strong>Using auditory brainstem responses, electrophysiologic activity was determined in 20 hamsters of the AN/As-Wh strain, with the aim of elucidating hearing status. Hamsters were classified into five genotypes and were evaluated by use of click stimuli.</p><p><strong>Results and conclusion: </strong>Hamsters assigned to the genotypes differed in their hearing sensitivity and could be classified into categories of normal hearing, moderate hearing loss, and profound hearing loss.</p>","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"173-8"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21201198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influences of somatotropin on biomechanical properties of porcine skin. 生长激素对猪皮肤生物力学性能的影响。
Laboratory animal science Pub Date : 1999-04-01
T J Caperna, J Vossoughi
{"title":"Influences of somatotropin on biomechanical properties of porcine skin.","authors":"T J Caperna,&nbsp;J Vossoughi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"212-5"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21201204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corynebacterium bovis infection in waltzing mice. 华尔兹小鼠的牛棒状杆菌感染。
Laboratory animal science Pub Date : 1999-04-01
A Gobbi, L Crippa, E Scanziani
{"title":"Corynebacterium bovis infection in waltzing mice.","authors":"A Gobbi,&nbsp;L Crippa,&nbsp;E Scanziani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"132-3"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21200648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice. 三种表达人HER2/ new的小鼠细胞系在免疫功能小鼠体内的特性。
Laboratory animal science Pub Date : 1999-04-01
M L Penichet, P M Challita, S U Shin, S L Sampogna, J D Rosenblatt, S L Morrison
{"title":"In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice.","authors":"M L Penichet,&nbsp;P M Challita,&nbsp;S U Shin,&nbsp;S L Sampogna,&nbsp;J D Rosenblatt,&nbsp;S L Morrison","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and purpose: </strong>Expression of the HER2/neu proto-oncogene, a receptor-like transmembrane protein expressed at low levels on some normal cells, is markedly increased in a subset of human breast, colon, lung, and ovarian cancers. A humanized HER2/neu antibody has been tested as a therapeutic agent in several clinical trials, with promising results. We have developed a family of anti-HER2/neu fusion proteins. To evaluate the immunologic efficacy of these proteins, it is critical that tumors expressing the target antigen can grow in immunologically intact mice.</p><p><strong>Method: </strong>To produce murine tumors expressing human HER2/neu on the surface, CT26, MC38, and EL4 murine cell lines were transduced by use of a retroviral construct containing the cDNA encoding the human HER2/neu gene.</p><p><strong>Results: </strong>Histologic features and kinetics of tumor growth in subcutaneous space of the human HER2/neu-expressing cells were similar to those of the respective parental cell lines. Intravenous inoculation with these cells induced disseminated malignant disease. Flow cytometric and immmunohistochemical analyses of freshly isolated tumors revealed in vivo expression of human HER2/neu. Secretion of antigen was not detected by use of an ELISA.</p><p><strong>Conclusion: </strong>Although an antibody response against the human HER2/neu antigen was observed, this response does not affect the growth rate of the HER2/neu-expressing cells. These murine models may be useful tools for evaluation of anti-cancer therapeutic approaches that target human HER2/neu.</p>","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"179-88"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21201199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In response to the editorial on pathogen status (1998, 48:557-558) 对病原菌现状社论的回应(1998,48:557-558)
Laboratory animal science Pub Date : 1999-04-01
E Rose
{"title":"In response to the editorial on pathogen status (1998, 48:557-558)","authors":"E Rose","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"132"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21200647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engaging mouse genes in motion. 激活老鼠的基因。
Laboratory animal science Pub Date : 1999-04-01
R O Jacoby
{"title":"Engaging mouse genes in motion.","authors":"R O Jacoby","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"134"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21200649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2nd International Conference on Transgenic Animals (ICTA) in Beijing, China. 第二届转基因动物国际会议(ICTA)在北京召开。
Laboratory animal science Pub Date : 1999-04-01
M Baetscher
{"title":"2nd International Conference on Transgenic Animals (ICTA) in Beijing, China.","authors":"M Baetscher","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"135-6"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21200650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B-virus specific-pathogen-free breeding colonies of macaques (Macaca mulatta): retrospective study of seven years of testing. 猕猴(猕猴)无b病毒特异性病原体繁殖菌落:7年试验的回顾性研究。
Laboratory animal science Pub Date : 1999-04-01
J K Hilliard, J A Ward
{"title":"B-virus specific-pathogen-free breeding colonies of macaques (Macaca mulatta): retrospective study of seven years of testing.","authors":"J K Hilliard,&nbsp;J A Ward","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and purpose: </strong>National Institutes of Health's Division of Comparative Medicine has sponsored a multi-institutional program for the establishment of specific-pathogen-free (SPF) macaque colonies. B virus (Herpesvirus simiae, Cercopithecine herpesvirus type 1) has been targeted in this surveillance. Participating institutions have established individual timetables for frequency of testing and types of monitoring and husbandry techniques, all with the common goal of producing pathogen-free monkeys for research. The greatest biosecurity threat to the program comes from failure to detect seronegative latent infections, either in first-year macaques or macaques introduced in subsequent years, although these are supposed to operate as closed colonies.</p><p><strong>Methods: </strong>From January 1990 through December 1996, we screened macaques for B virus, using enzyme-linked immunoabsorbant assay (ELISA) and Western blot analysis.</p><p><strong>Results: </strong>During the first year, 1,097 macaques from six colonies were tested, and 88.4% tested negative for B virus. During the seventh year, 1,843 were tested, of which 99.7% tested negative. Seropositive macaques were detected as late as the seventh year.</p><p><strong>Conclusions: </strong>An aggressive program to establish an SPF colony of captive breeding macaques can be effective in reducing the risk of B-virus exposure.</p>","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"144-8"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21200652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New technique for superselective arterial (chemo-) embolization of the rat liver. 大鼠肝脏超选择性动脉(化疗)栓塞新技术。
Laboratory animal science Pub Date : 1999-04-01
E J Kamphorst, H Bödeker, S Koroma, U Linnemann, M R Berger
{"title":"New technique for superselective arterial (chemo-) embolization of the rat liver.","authors":"E J Kamphorst,&nbsp;H Bödeker,&nbsp;S Koroma,&nbsp;U Linnemann,&nbsp;M R Berger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 2","pages":"216-9"},"PeriodicalIF":0.0,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21201205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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