Laboratory animal science最新文献_第10页

Lovelace Respiratory Research Institute annual symposium: validity of animal models of human respiratory diseases. 洛夫莱斯呼吸研究所年度研讨会:人类呼吸系统疾病动物模型的有效性。

Laboratory animal science Pub Date : 1999-02-01

J Seagrave, J L Mauderly

引用次数: 0

Transgenic mouse strain rescue by frozen ovaries. 冷冻卵巢挽救转基因小鼠品系。

Laboratory animal science Pub Date : 1999-02-01

J M Sztein, T E McGregor, H J Bedigian, L E Mobraaten

引用次数: 0

Surgical induction of cryptorchidism in rabbit pups. 兔幼犬隐睾的手术诱导。

Laboratory animal science Pub Date : 1999-02-01

S VandeWoude, J Palmer, D N Veeramachaneni

引用次数: 0

Detection of cilia-associated respiratory (CAR) bacillus in nasal-swab specimens from infected rats by use of polymerase chain reaction. 应用聚合酶链反应检测感染大鼠鼻拭子标本中纤毛相关呼吸(CAR)芽孢杆菌。

Laboratory animal science Pub Date : 1999-02-01

C L Franklin, J D Pletz, L K Riley, B A Livingston, R R Hook, C L Besch-Williford

引用次数: 0

The existence of differing monkey B virus genotypes with possible implications for degree of virulence in humans. 不同猴B型病毒基因型的存在可能对人类的毒力程度产生影响。

Laboratory animal science Pub Date : 1999-02-01

J K Hilliard, B J Weigler

引用次数: 0

Monoclonal antibody production in murine ascites. I. Clinical and pathologic features. 小鼠腹水单克隆抗体的产生。1 .临床病理特点。

Laboratory animal science Pub Date : 1999-02-01

L R Jackson, L J Trudel, J G Fox, N S Lipman

{"title":"Monoclonal antibody production in murine ascites. I. Clinical and pathologic features.","authors":"L R Jackson, L J Trudel, J G Fox, N S Lipman","doi":"","DOIUrl":"","url":null,"abstract":"Background and purpose: Murine ascites production has been associated with appreciable morbidity and mortality, thus raising animal-welfare concerns. To address these concerns, the clinicopathologic changes associated with in vivo production of monoclonal antibodies in mice were characterized, and results were compared among cell lines.Methods: Five hybridoma cell lines were grown in groups of 20 mice. Fourteen days prior to inoculation with 10(6) hybridoma cells, mice were primed with 0.5 ml of pristane given intraperitoneally; 12 mice were sham treated (controls). Ascites fluid was collected a maximum of three times by abdominal paracentesis. Clinical observations and pre- and postabdominal tap body weights were recorded. Necropsies were performed on all mice.Results: For all groups combined, overall survival to tap 1 was 98%, to tap 2 was 96%, and to tap 3 was 79%; survival among groups ranged from 90 to 100% for tap 1, 85 to 100% for tap 2, and 35 to 100% for tap 3. Disseminated intra-abdominal seeding with irregular soft tissue and/or solid tumor masses was observed at necropsy.Conclusions: Significant clinicopathologic changes were associated with monoclonal antibody production in mice, and differences between various hybridoma cell lines were apparent.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 1","pages":"70-80"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20962782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pelizaeus-Merzbacher disease. Pelizaeus-Merzbacher疾病。

Laboratory animal science Pub Date : 1999-02-01

T J Anderson, I R Griffiths

引用次数: 0

Virulence Enhancement Agents for Haemophilus influenzae type B infection in mice. B型流感嗜血杆菌小鼠感染的毒力增强剂。

Laboratory animal science Pub Date : 1999-02-01

S Sifontes Rodríguez, J F Infante Bourzac, O Marrero Chang, M Fariñas Medina, E Muñoz Carnago, Y López Hernández

引用次数: 0

Management of a measles outbreak among Old World nonhuman primates. 旧大陆非人类灵长类动物麻疹暴发的处理。

Laboratory animal science Pub Date : 1999-02-01

M E Willy, R A Woodward, V B Thornton, A V Wolff, B M Flynn, J L Heath, Y S Villamarzo, S Smith, W J Bellini, P A Rota

{"title":"Management of a measles outbreak among Old World nonhuman primates.","authors":"M E Willy, R A Woodward, V B Thornton, A V Wolff, B M Flynn, J L Heath, Y S Villamarzo, S Smith, W J Bellini, P A Rota","doi":"","DOIUrl":"","url":null,"abstract":"Background and purpose: A measles outbreak in a facility housing Old World nonhuman primates developed over a 2-month period in 1996, providing an opportunity to study the epidemiology of this highly infectious disease in an animal-handling setting.Methods: Serum and urine specimens were collected from monkeys housed in the room where the initial measles cases were identified, other monkeys with suspicious measles-like signs, and employees working in the affected areas. Serum specimens were tested for measles virus-specific IgG and IgM antibodies, and urine specimens were tested for measles virus by virus isolation or reverse transcriptase-polymerase chain reaction (RT-PCR).Results: A total of 94 monkeys in two separate facilities had evidence of an acute measles infection. The outbreak was caused by a wild-type virus that had been associated with recent human cases of acute measles in the United States; however, an investigation was unable to identify the original source of the outbreak. Quarantine and massive vaccination helped to control further spread of infection.Conclusions: Results emphasize the value of having a measles control plan in place that includes a preventive measles vaccination program involving human and nonhuman primates to decrease the likelihood of a facility outbreak.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 1","pages":"42-8"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20962777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial lipopolysaccharide induces a conduction block in the sciatic nerves of rats. 细菌脂多糖诱导大鼠坐骨神经传导阻滞。

Laboratory animal science Pub Date : 1999-02-01

R F Brown, G D Jackson, T Martin, R F Westbrook, J D Pollard, K W Westland

{"title":"Bacterial lipopolysaccharide induces a conduction block in the sciatic nerves of rats.","authors":"R F Brown, G D Jackson, T Martin, R F Westbrook, J D Pollard, K W Westland","doi":"","DOIUrl":"","url":null,"abstract":"A single injection of Escherichia coli lipopolysaccharide (LPS; intraperitoneally [i.p.] and intravenously [i.v.]) reliably induces peripheral nerve disturbances in the hindlimbs of inbred Australian albino Wistar (AaW) rats. In the series of experiments presented here, we aimed to characterize this syndrome by examining electrophysiologic, immunologic, and immunochemical features. The LPS-induced neurologic sequelae in AaW rats were transient, at least partly reversible by drug treatment, and were not associated with any detectable neuropathologic findings by light microscopy. Neurologic sequelae were prevented by administration of dexamethasone and by pretreatment with the macrophage inhibitor gadolinium chloride, suggesting that they were caused by LPS-induced activation of peripheral macrophages. Sequelae were associated with early decreases in compound muscle-action potential amplitudes, indicating impaired functioning of either proximal sciatic nerve axons and/or neuromuscular synapses. Spinal somatosensory-evoked potential latencies also were increased, indicating impaired somatosensory function at the sciatic nerve, dorsal roots, spinal cord, and/or postsynaptic interneurons, although the precise location of impairment could not be delineated. Similarities between this syndrome and immune-mediated polyneuropathies in humans are discussed.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 1","pages":"62-9"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20962781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0