Laboratory animal science最新文献

Nonhuman primate models of atherosclerosis. 非人类灵长类动物的动脉粥样硬化模型。

Laboratory animal science Pub Date : 2012-12-01 DOI: 10.1016/B978-0-12-381366-4.00008-0

T. B. Clarkson

引用次数: 54

Comparison of three treatments for control of ear mites in ferrets. 三种处理对雪貂耳螨的防治效果比较。

Laboratory animal science Pub Date : 1999-12-01

M M Patterson, S M Kirchain

引用次数: 0

Effects of histamine, carbachol, and methacholine on maximal expiratory lung mechanics in goats. 组胺、氨基酚和甲胆碱对山羊最大呼气肺力学的影响。

Laboratory animal science Pub Date : 1999-12-01

T G Mundie, G Hashiro

引用次数: 0

Depressive effects of anesthesia or sedation on exocrine pancreatic function in pigs. 麻醉或镇静对猪外分泌胰腺功能的抑制作用。

Laboratory animal science Pub Date : 1999-12-01

K Rådberg, J Botermans, B R Weström, S G Pierzynowski

引用次数: 0

Open-thorax guinea pig model for defibrillation. 开胸豚鼠除颤模型。

Laboratory animal science Pub Date : 1999-12-01

J N Eynard, R A Malkin

引用次数: 0

Experimental models of peripheral neuropathies. 周围神经病变的实验模型。

Laboratory animal science Pub Date : 1999-12-01

L Notterpek, R J Tolwani

引用次数: 0

Effect of weaning time and associated management practices on postweaning chronic diarrhea in captive rhesus monkeys (Macaca mulatta). 断奶时间和相关管理措施对圈养恒河猴断奶后慢性腹泻的影响。

Laboratory animal science Pub Date : 1999-12-01

C A Muñoz-Zanzi, M C Thurmond, D W Hird, N W Lerche

{"title":"Effect of weaning time and associated management practices on postweaning chronic diarrhea in captive rhesus monkeys (Macaca mulatta).","authors":"C A Muñoz-Zanzi, M C Thurmond, D W Hird, N W Lerche","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Our purpose was to assess the extent to which early weaning and other weaning-management factors affect development of postweaning chronic diarrhea in captive rhesus monkeys at the California Regional Primate Research Center between 1992 and 1995.Methods: Data for weaning, management, and onset of diarrhea were obtained from daily records. The Cox proportional hazard model was used to assess whether the risk of chronic diarrhea was related to early weaning.Results: Monkeys that were lighter at weaning had a threefold increase in risk of postweaning chronic diarrhea (P = 0.07), compared with that in heavier monkeys. An episode of preweaning diarrhea increased the risk of postweaning chronic diarrhea twofold (P = 0.08). Relocation of monkeys to outdoor facilities in the fall was associated with a fivefold decrease in risk (P < 0.001), compared with that of other seasons, and weaning in 1993 was associated with a twofold decrease in risk, compared with that of other years (P = 0.04).Conclusions: Multiple factors need to be considered for prevention of postweaning chronic diarrhea, including weaning weight, preweaning diarrhea, season weaned, and weaning conditions that change from year to year.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 6","pages":"617-21"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21494348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) monkeys as experimental models of acute Q fever after aerosol exposure to phase-I Coxiella burnetii. 对食蟹猴(Macaca fascicularis)和恒河猴(Macaca mulatta)作为气溶胶暴露于i期伯氏Coxiella后急性Q热实验模型的评价。

Laboratory animal science Pub Date : 1999-12-01

D M Waag, W R Byrne, J Estep, P Gibbs, M L Pitt, C M Banfield

{"title":"Evaluation of cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) monkeys as experimental models of acute Q fever after aerosol exposure to phase-I Coxiella burnetii.","authors":"D M Waag, W R Byrne, J Estep, P Gibbs, M L Pitt, C M Banfield","doi":"","DOIUrl":"","url":null,"abstract":"Background and purpose: Q fever is a disease of humans. Vaccines to prevent this disease have demonstrated efficacy in rodents and must also be evaluated for efficacy in a nonhuman primate model. Preliminary to vaccine efficacy experiments, cynomolgus and rhesus monkeys were evaluated as suitable experimental models of acute Q fever.Methods: Both species of monkeys were challenged with aerosolized 10(5) virulent phase-I Coxiella burnetii Henzerling strain, and clinical and serologic responses were determined.Results: Radiographic changes were observed in seven of eight monkeys of both species; however, changes in cynomolgus monkeys tended to be more significant. Between 7 and 10 days after challenge, all rhesus monkeys and 88% of cynomolgus monkeys were bacteremic. Sequential increases in antibody responses to C. burnetii phase-I and phase-II whole cells and phase-I lipopolysaccharide were observed in both species. Although the maximal rectal temperature increase was similar in both species, duration of fever was slightly longer in rhesus monkeys. Clinical features were similar to those described in human acute Q fever patients.Conclusions: On the basis of the more pronounced radiographic changes in cynomolgus monkeys, we favor use of this species for future studies of vaccine efficacy.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 6","pages":"634-8"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21494351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of two systems for tibial external fixation in rabbits. 家兔胫骨外固定架两种系统的比较。

Laboratory animal science Pub Date : 1999-12-01

R H Meffert, J E Tis, S Lounici, J S Rogers, N Inoue, E Y Chao

{"title":"Comparison of two systems for tibial external fixation in rabbits.","authors":"R H Meffert, J E Tis, S Lounici, J S Rogers, N Inoue, E Y Chao","doi":"","DOIUrl":"","url":null,"abstract":"Background and purpose: Use of rabbits in orthopedic investigations is common. In this study, focus is on factors that influence bone healing and on distraction osteogenesis. Biomechanical characteristics of two external fixator systems (Orthofix device and Hoffmann device) for long bones were tested.Methods: Twelve freshly dissected tibiae were obtained from six skeletally mature New Zealand White rabbits, and four-point bending stiffness in two planes (90 and 180 degrees to the fixator pins) and torsional stiffness and strength of the bone-fixator complex were evaluated by use of a material testing machine.Results: In four-point bending, Orthofix device had higher stiffness and strength, compared with Hoffmann device. When the load was applied 180 degrees to the pins, both devices had higher stiffness, compared with that at 90 degrees. In torsional testing, Orthofix device had significantly higher stiffness and strength.Conclusions: Significant differences in structural properties between the two systems were evident. Loading direction and gap conditions were important factors in determining properties of the systems. Therefore, type of external fixation system and fixation technique should be considered when designing experiments, using the rabbit long bone model.","PeriodicalId":17937,"journal":{"name":"Laboratory animal science","volume":"49 6","pages":"650-4"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21494278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major histocompatibility haplotype does not impact the course of experimentally induced murine vaginal candidiasis. 主要组织相容性单倍型不影响实验诱导的小鼠阴道念珠菌病的病程。

Laboratory animal science Pub Date : 1999-12-01

C A Black, F M Eyers, M L Dunkley, R L Clancy, K W Beagley

引用次数: 0