The Journal of Pharmaceutical Sciences and Medicinal Research最新文献

{"title":"A Comprehensive Review On Pelletization Technology: A Novel Strategy For Formulation Development","authors":"A. Parihar, B. Prajapati, Himanshu Paliwal","doi":"10.53049/tjopam.2021.v001i03.013","DOIUrl":"https://doi.org/10.53049/tjopam.2021.v001i03.013","url":null,"abstract":"Pelletization technology is gaining very much attention in present times as it has provided a competent pathway for the oral drug delivery system manufacturing. Pellets offers many biopharmaceuticals as well as technological recompenses over the conventional dosage forms. Pellets offer required strength for dose which can be blended for the delivery of incompatible bioactive agents and helps in providing different release profiles. In this review we will be discussing the extensively used techniques of pelletization, extrusion and spheronization in detail with their methods and applications in the field of pharmacy as a competent pathway for the novel drug delivery systems.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132265248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies","authors":"J. Patel, Shalin Parikh, S. Patel, Ronak Patel, P. Patel, B. Bhavsar","doi":"10.53049/tjopam.2021.v001i03.010","DOIUrl":"https://doi.org/10.53049/tjopam.2021.v001i03.010","url":null,"abstract":"Because of the limitations of the oral drug delivery system, as well as the discomfort associated with the usage of needles in the case of injections, drug delivery research has shifted significantly toward the transdermal route of administration. Topical creams, gels, and transdermal patches are the most often utilised means of transdermal administration of drugs. Since the stratum corneum layer of the skin acts as a barrier to a drug molecule, the effect of the majority of therapeutic agents is limited. As a result, only a small number of molecules are able to reach the site of action. A new type of delivery method, known as microneedles, is being developed to improve the distribution of drugs through this route while also overcoming the various issues associated with existing formulations. Non-invasive and painless feature of microneedles have making them ideal for self-administration. This review describes various type of microneedles and their design, fabrication methodology, various materials used in fabrication of microneedles, drug release mechanism from the microneedles, evaluation parameters, it’s biological application, update about recent clinical studies and in last, challenges and future perspective of microneedles as drug delivery system.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127089363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Inserts – A Potential Ocular Controlled Drug Delivery Systems","authors":"J. Patel, B. Bhavsar, Shalin Parikh, S. Patel","doi":"10.53049/tjopam.2021.v001i02.010","DOIUrl":"https://doi.org/10.53049/tjopam.2021.v001i02.010","url":null,"abstract":"Ophthalmic drug delivery is one of the most exciting and difficult areas of research for pharmaceutical scientists. The eye's anatomy, physiology, and biochemistry render it impenetrable to outside chemicals. The capacity to maintain a therapeutic level of the drug at the site of action for an extended period of time is a significant hurdle in ocular therapy. The ocular insert represents a substantial development in the treatment of eye illness by extending the duration of the therapeutic level of the medicine at the site of action. They are constructed of a polymeric matrix that may or may not contain a pharmaceutical agent. The medicine can then be introduced into the polymeric support as a dispersion or solution. They have a number of advantages, including increased ocular residence and prolonged pharmaceutical release into the eye. The insert is composed of a body component that is tailored to fit within the eyelid's lachrymal canaliculus. The inserts are classed as insoluble, soluble, or bioerodible based on their solubility. The drug is released from the insert by diffusion, osmosis, and bioerosion. This review aimed to provide a brief overview of Ocular Inserts – A Potential Ocular Controlled Drug Delivery Systems.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130956975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon Nanotube (CNTs): Structure, Synthesis, Purification, Functionalisation, Pharmacology, Toxicology, Biodegradation and Application as Nanomedicine and Biosensor","authors":"J. Patel, Shalin Parikh, S. Patel, Ronak Patel, Payalben Patel","doi":"10.53049/tjopam.2021.v001i02.008","DOIUrl":"https://doi.org/10.53049/tjopam.2021.v001i02.008","url":null,"abstract":"It is well acknowledged that carbon nanotubes (CNTs) are a potential new class of nanomaterials for technological advancement. The recent discovery of diverse kinds of carbon nanostructures has sparked interest in the potential applications of these materials in a variety of disciplines. Numerous distinct carbon nanotube (CNT) production methods have been developed, and their characterisation, separation, and manipulation of individual CNTs are now possible. Structure, surface area, surface charge, size distribution, surface chemistry, aggregation state, and purity of the samples all have a significant impact on the reactivity of carbon nanotubes, as does the purity of the samples. Currently, carbon nanotubes (CNTs) are being successfully used in the medicinal, pharmaceutical, and biomedical fields because of their large surface area, which makes them capable of adsorbing or conjugating with a wide range of therapeutic and diagnostic substances (drugs, genes, vaccines, antibodies, biosensors, etc.). They were the first to demonstrate that they are a great vehicle for drug delivery straight into cells without the need for metabolic processing by the body. This paper discusses the different types, structures, and properties of CNTs, as well as CNT synthesis and purification methods, how to functionalize CNTs, and their application in medicinal, pharmaceutical, and biomedical fields, toxicological properties and their assessment, as well as in-vivo pharmacology and biodegradation pathways.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115654600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability Indicating RP-HPLC Method For Determination Of Ketoconazole In Bulk Drug And In Tablet Dosage Form","authors":"Shalin Parikh, J. Dave, Jayendrakumar Patel","doi":"10.53049/tjopam.2021.v001i02.006","DOIUrl":"https://doi.org/10.53049/tjopam.2021.v001i02.006","url":null,"abstract":"A simple, precise, accurate and sensitive isocratic stability indicating RP-HPLC method has been developed and validated for determination of Ketoconazole in bulk drug and pharmaceutical dosage form. Isocratic RP-HPLC separation was achieved on Agilent C8 (150 mm ?4.6 mm, 5 µm particle size) with the mobile phase 0.3 % Triaethylamine in 20 mM potassium dihydrogen phosphate buffer pH adjusted to 4.0: Acetonitrile (68:32 % v/v) at a flow rate 1.0 ml/min. The retention time of Ketoconazole was 8.97 ± 0.50 min. The method was validated for specificity, linearity, precision, accuracy and robustness. The linear regression analysis data of calibration curve showed good linearity in concentration range 10-60 ?g/ml. The Intraday and Interday precision were 0.59-1.11 % and 0.26-1.73 % RSD respectively. The accuracy was found to be 98.11-99.26 %. The drug was subjected to the stress conditions like hydrolysis, oxidation, photolysis and dry heat. The proposed method is found to be specific with respect to degradation product formed after Acidic hydrolysis, Oxidation, Thermal and Photolytic degradation. The Ketoconazole was found to be stable under neutral hydrolytic, thermal and photolytic stress conditions. Acidic, thermal, photolytic stress conditions showed degradation. The proposed chromatographic method can be used for estimation of drug during stress testing & formal stability studies.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122006326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Potential To Infect 4.44% Indian Population","authors":"Jayendrakumar Patel, Shalin Parikh, Rakesh Patel, S. Patel, Ronak Patel, P. Patel, Ankita Patel","doi":"10.21203/rs.3.rs-636515/v2","DOIUrl":"https://doi.org/10.21203/rs.3.rs-636515/v2","url":null,"abstract":"\u0000 Background: Quantitative characterisation of any contagious diseases could help in making effective strategy to prevent further spreading of the disease. Despite the rapid research in prevention of spreading COVID-19, yet there is no quantitatively information about spatiotemporal epidemiology and epidemic intensity of COVID-19. Therefore, we aimed to quantitatively characterize spatiotemporal epidemiology and epidemic intensity of COVID-19 in Indian geography by determine it’s infectability rate, efficacy rate, transmission rate and likelihood of total populations to be infected with COVID-19 in India.Method: Novel statistical model was designed to quantitatively characterize spatiotemporal epidemiology and epidemic intensity of COVID-19. A Retrospective Cohort study was carried out online and offline in Indian geography using a COVID-19 transmission questionnaires sheet that comprises five mandatory questions. The collected offline as well as online data was then entered into a Microsoft excel sheet to obtain primary data and secondary data required for the mathematical model to calculate quantitative data of spatiotemporal epidemiology and epidemic intensity of COVID-19 in India geography.Result and Discussion: Total 539 responses were analysed in the current study out of 557 received responses between April-2021 to May-2021. Average reproductive number of secondary cases was found 0.77. Infectability rate of COIVD-19 patient was found 38.11% while healthy person has 21.08% risk of becoming infected if they expose to the Primary case. J-Index and H-Index were found 55.32% and 4.44%, respectively, indicating that COVID-19 disease outbreaks as severe epidemic disease in India and has potential to infect ~4.44% Indian population.Conclusion: Higher infectability rate (38.11%) of COIVD-19 patient and higher efficacy rate (21.08%) of healthy individual to be infected with COVID-19 outbreak it a severe epidemic in India. COVID-19 potential to infect about 4.44% Indian population, at present, COVID-19 already infected ~2.13% Indian population, which is about 50% of the anticipated population to be infected i.e., 4.44%.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130869343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Overview On The Most Recent Trends In Covid-19 Diagnosis, Treatment Options And Vaccine Development Status","authors":"Jayendrakumar Patel, S. Parikh, S. Patel","doi":"10.53049/TJOPAM.2021.V001I01.001","DOIUrl":"https://doi.org/10.53049/TJOPAM.2021.V001I01.001","url":null,"abstract":"The global pandemic produced by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first appeared in Wuhan, China, in December 2019 and which then spread rapidly, made it difficult to find or develop effective medications for its prevention and treatment. Therefore, the first stage is necessitating the use of a precise and quick diagnostic method to detect SARS-CoV-2 infected patient followed by effective patient isolation and the commencement of early treatment, which can range from supportive therapy to specialised medications such corticosteroids, antiviral medications, antibiotics, and the recently introduced convalescent plasma. Despite the extraordinary developments in advanced medicinal system, no confirmed viable medicines exist at this time. Rapid research on SARS CoV-2 epidemiology has led to the discovery of certain new targets for prospective therapeutic treatments. Many therapeutic options have been evaluated, and clinical studies are proceeding at a breakneck speed. However, there is a lot of room for more study into finding cost-effective and safer medicines, vaccinations, and measures to ensuring that COVID-19 preventive and treatment programmes are available to everyone. The goal of this study is to compile all of the current advancements in the worldwide medical system in the fight against COVID-19.","PeriodicalId":179224,"journal":{"name":"The Journal of Pharmaceutical Sciences and Medicinal Research","volume":"212 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129511691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}