碳纳米管(CNTs):结构、合成、纯化、功能化、药理学、毒理学、生物降解及其作为纳米医学和生物传感器的应用

J. Patel, Shalin Parikh, S. Patel, Ronak Patel, Payalben Patel
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引用次数: 4

摘要

碳纳米管(carbon nanotubes, CNTs)是一种极具发展潜力的新型纳米材料。最近各种碳纳米结构的发现引起了人们对这些材料在各种学科中的潜在应用的兴趣。许多不同的碳纳米管(CNT)生产方法已经开发出来,它们的表征、分离和单个碳纳米管的操作现在是可能的。样品的结构、表面积、表面电荷、尺寸分布、表面化学、聚集状态和纯度对碳纳米管的反应性有显著影响,样品的纯度也有显著影响。目前,碳纳米管(carbon nanotubes, CNTs)由于具有较大的表面积,能够吸附或偶联多种治疗和诊断物质(药物、基因、疫苗、抗体、生物传感器等),正成功地应用于医药、制药和生物医学领域。他们是第一个证明它们是一种很好的载体,可以直接将药物输送到细胞中,而不需要身体的代谢过程。本文讨论了碳纳米管的不同类型、结构和性质,碳纳米管的合成和纯化方法,如何功能化碳纳米管及其在医药、制药和生物医学领域的应用,毒理学性质及其评价,以及体内药理学和生物降解途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carbon Nanotube (CNTs): Structure, Synthesis, Purification, Functionalisation, Pharmacology, Toxicology, Biodegradation and Application as Nanomedicine and Biosensor
It is well acknowledged that carbon nanotubes (CNTs) are a potential new class of nanomaterials for technological advancement. The recent discovery of diverse kinds of carbon nanostructures has sparked interest in the potential applications of these materials in a variety of disciplines. Numerous distinct carbon nanotube (CNT) production methods have been developed, and their characterisation, separation, and manipulation of individual CNTs are now possible. Structure, surface area, surface charge, size distribution, surface chemistry, aggregation state, and purity of the samples all have a significant impact on the reactivity of carbon nanotubes, as does the purity of the samples. Currently, carbon nanotubes (CNTs) are being successfully used in the medicinal, pharmaceutical, and biomedical fields because of their large surface area, which makes them capable of adsorbing or conjugating with a wide range of therapeutic and diagnostic substances (drugs, genes, vaccines, antibodies, biosensors, etc.). They were the first to demonstrate that they are a great vehicle for drug delivery straight into cells without the need for metabolic processing by the body. This paper discusses the different types, structures, and properties of CNTs, as well as CNT synthesis and purification methods, how to functionalize CNTs, and their application in medicinal, pharmaceutical, and biomedical fields, toxicological properties and their assessment, as well as in-vivo pharmacology and biodegradation pathways.
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