Journal of VitreoRetinal Diseases最新文献

{"title":"En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography for the Diagnosis and Monitoring of Syphilitic Posterior Placoid Chorioretinopathy.","authors":"Michael Wolek, Samantha Paul, Mark Seraly, Ankur Mehra, Warren Sobol","doi":"10.1177/24741264251358634","DOIUrl":"10.1177/24741264251358634","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a case of syphilitic posterior placoid chorioretinopathy, a rare ocular manifestation of syphilis requiring prompt diagnosis and treatment. <b>Methods:</b> A single case was evaluated. <b>Results:</b> Multimodality imaging including spectral-domain optical coherence tomography (SD-OCT), en face OCT, and OCT angiography (OCTA) were used to confirm a diagnosis in a patient presenting with symptoms of syphilitic posterior placoid chorioretinopathy. SD-OCT showed nodular hyperreflective thickening of the retinal pigment epithelium (RPE), an attenuated ellipsoid zone, loss of the outer segment/RPE junction, and trace hyperreflective vitreous material. En face OCT showed hyperreflective lesions at the avascular complex layer, and flow voids suggestive of nonperfusion within the choriocapillaris were seen on OCTA. SD-OCT showed resolution of disease after 1 week of treatment with penicillin, but en face OCT and OCTA findings persisted for 1 month before finally resolving. <b>Conclusions:</b> En face OCT and OCTA enable the early detection of placoid lesions and microvascular changes commonly seen in syphilitic posterior placoid chorioretinopathy, allowing for the development of an appropriate treatment plan.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251358634"},"PeriodicalIF":0.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faricimab as Treatment for Sarcoid Uveitis With Refractory Cystoid Macular Edema.","authors":"Ting-Han Lin, Hung-Yi Lin, Yu-Hsun Chuang, Po-Chen Tseng","doi":"10.1177/24741264251358628","DOIUrl":"10.1177/24741264251358628","url":null,"abstract":"<p><p><b>Purpose:</b> To describe the first use of the bispecific monoclonal antibody faricimab for sarcoid uveitis with refractory cystoid macular edema (CME). <b>Methods:</b> A single case was evaluated. <b>Results:</b> An 82-year-old woman presented with blurred vision and signs of sarcoid uveitis bilaterally, including swollen optic discs with disc nodules, CME with chorioretinal peripheral lesions in the right eye and segmental periphlebitis in the left eye. Treatment with intravitreal faricimab was initiated after systemic and topical prednisolone and oral ibuprofen failed. Significant improvement in the patient's best-corrected visual acuity and central subfield thickness was seen after 2 faricimab injections. Optical coherence tomography showed resolution of the intraretinal cyst and CME. Color fundus photography also showed improvement in the optic disc swelling and resolution of the retinal macroaneurysm. <b>Conclusions:</b> Faricimab can be a promising treatment for refractory CME in patients with sarcoid uveitis.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251358628"},"PeriodicalIF":0.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Ultra-Wide field Fluorescein Angiography on the Diagnosis and Management of Diabetic Retinopathy.","authors":"Nicole K Scripsema, Tala Al-Khaled, Amy Song, Joelle A Hallak, Rawan Allozi, Aziz A Khanifar, Thanos D Papakostas, Christina Y Weng, Ronald C Gentile, J Peter Campbell, Jessica G Lee, Gennady Landa, Felix Y Chau, William F Mieler, Meenakashi Gupta, Amani A Fawzi, Judy E Kim, Jennifer I Lim, Robison Vernon Paul Chan","doi":"10.1177/24741264251359907","DOIUrl":"10.1177/24741264251359907","url":null,"abstract":"<p><p><b>Purpose:</b> To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR). <b>Methods:</b> Ten experts in DR completed an online survey in which they were asked to diagnose and manage DR cases using different imaging modalities. Experts independently reviewed 20 cases of DR and provided a diagnosis and management plan for each case, first based on ultra-widefield color-free and red-free images alone and again with the corresponding ultra-widefield FA images. Experts were polled on their diagnostic confidence, use of FA in clinical practice, and opinions on the value of ultra-widefield FA. Based on the reference standard diagnosis, primary outcomes included diagnostic sensitivity and specificity with and without ultra-widefield FA. Secondary outcomes included intergrader agreement, expert confidence, management outcomes, and an analysis of experts' opinions on the clinical use of ultra-widefield FA. <b>Results:</b> Diagnostic sensitivity (95% CI) increased from 36% (29%-43%) to 69% (62%-75%) (<i>P</i> < .05) with ultra-widefield FA. Intergrader agreement (Fleiss kappa statistic, 0.29 [95% CI, 0.21-0.27] vs 0.44 [95% CI, 0.40-0.47]; <i>P</i> < .05) and expert confidence (38% vs 65%) also improved. In 39% of responses, management was changed from observation to treatment. Although 40% of experts did not request FA with the initial ultra-widefield color-free/red-free images, 80% found ultra-widefield FA clinically useful when provided. <b>Conclusions:</b> Diagnosis, treatment, and expert opinions on the use of FA all changed when a corresponding ultra-widefield FA was available. Incorporating FA into routine clinical practice may facilitate more accurate clinical decision-making.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251359907"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Amniotic Membrane Patch for Optic Disc Pit Maculopathy Remains Integrated at 2 Years.","authors":"Maram Alenazi, Marco Mura, Adel G Alakeely, Faisal S Al-Qahtani","doi":"10.1177/24741264251351662","DOIUrl":"10.1177/24741264251351662","url":null,"abstract":"<p><p><b>Purpose:</b> To evaluate the efficacy of a human amniotic membrane patch to treat optic disc pit maculopathy. <b>Methods:</b> Three cases are presented. <b>Results:</b> Three patients with optic disc pit maculopathy were treated with pars plana vitrectomy and a human amniotic membrane patch of the optic disc pit. The primary outcomes were resolution of subretinal fluid (SRF) and intraretinal fluid, changes in best-corrected visual acuity, and any postoperative complications. Complete resorption of SRF and substantial decreases in central retinal thickness were seen at follow-up. Significant improvements in VA and microperimetry correspond with a decline in retinal responsiveness related to the chronicity of maculopathy. No patient reported complications or recurrences, and the patch remained visible on optical coherence tomography for up to 26 months of follow-up. <b>Conclusion:</b> Anatomic and visual improvement was seen in all 3 patients. The human amniotic membrane patch is a safe and effective treatment for optic disc pit maculopathy.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251351662"},"PeriodicalIF":0.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Vitreous to Ventricles: Serial Imaging of Intracranial Silicone Oil Migration.","authors":"Christian P Pappas, Anna M Waldie, Parth R Shah","doi":"10.1177/24741264251358618","DOIUrl":"10.1177/24741264251358618","url":null,"abstract":"<p><p><b>Purpose:</b> To review a case of intracranial silicone oil (SO) migration with mobile intraventricular deposits and analyze serial imaging features over 53 postoperative months. <b>Methods:</b> A single case report and literature review were presented. <b>Results:</b> A 52-year-old man with advanced bilateral proliferative diabetic retinopathy who had placement of 1000 mPa.s viscosity Oxane 1300 SO (Bausch + Lomb) in the right eye presented with sudden loss of consciousness 31 and 53 months postoperatively. Serial computed tomography and magnetic resonance imaging showed progressive intracranial migration of SO with unilateral optic nerve, optic chiasm, bilateral mobile intraventricular deposits, and progressive parenchymal atrophy. <b>Conclusions:</b> Intracranial migration of intravitreal SO is an exceedingly rare complication thought to be associated with suboptimal postoperative intraocular pressure control and anatomic optic disc abnormalities, with variable symptomatology and uncertain clinical significance. Early and complete removal of SO is generally advised, while also maintaining adequate postoperative pressure control in susceptible eyes.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251358618"},"PeriodicalIF":0.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year Outcomes of Intravitreal Faricimab Injection in Treatment-Naïve Patients With Neovascular Age-Related Macular Degeneration.","authors":"Kazuyoshi Okawa, Maiko Maruyama-Inoue, Jacob Yuhang Chin, Tatsuya Inoue, Yasuo Yanagi, Kazuaki Kadonosono","doi":"10.1177/24741264251352888","DOIUrl":"10.1177/24741264251352888","url":null,"abstract":"<p><p><b>Purpose:</b> To investigate the 1-year functional and morphologic outcomes of intravitreal (IVT) faricimab in treatment-naïve Japanese patients with neovascular age-related macular degeneration (nAMD). <b>Methods:</b> A retrospective study was performed to examine the outcomes of patients with nAMD who received IVT faricimab using a treat-and-extend regimen. The best-corrected visual acuity (BCVA), central foveal thickness (CFT), central choroidal thickness, dry macular achievement, and treatment intervals at 48 weeks were evaluated. Furthermore, the presence of polypoidal lesions at 48 weeks, as indicated by indocyanine green angiography, was investigated in patients with polypoidal choroidal vasculopathy (PCV). <b>Results:</b> This study included 48 Japanese treatment-naïve patients with nAMD assessed at 1 year of follow-up. The BCVA was significantly improved 1 year after initial treatment (<i>P</i> < .001). CFT and central choroidal thickness were also significantly decreased after 1 year (<i>P</i> < .001 and <i>P</i> < .001, respectively). Dry macula was achieved in 42 eyes (87.5%), and the mean (±SD) treatment interval at 12 months was 14.5 ± 4.4 weeks. The 1-year polyp regression rate was 76.9% (10/13 eyes). <b>Conclusions:</b> IVT faricimab was well tolerated and appeared to improve both functional and anatomic outcomes in Japanese patients with nAMD. In addition, a high rate of polyp regression was seen in patients with PCV.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251352888"},"PeriodicalIF":0.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Adult and Pediatric Eyes With Coats Disease Using Multimodal Imaging.","authors":"Sandra Hoyek, Nimesh A Patel, Ayush Ashit Parikh, Antonio Yaghy, Shizuo Mukai, Caroline R Baumal","doi":"10.1177/24741264251355635","DOIUrl":"10.1177/24741264251355635","url":null,"abstract":"<p><p><b>Purpose:</b> To compare the clinical features, imaging findings, and treatment outcomes between adults and children with Coats disease. <b>Methods:</b> This retrospective, multicenter, observational case series comprised adult and pediatric patients with Coats disease treated between 2016 and 2022. <b>Results:</b> The study included 19 eyes from 10 children and 8 adults. The median age at presentation in children was 6 years (range, 2-17) and in adults was 29 years (range, 24-61). Children presented at later stages of disease compared with adults. The median total clock hours of exudation were greater (2.5 vs 1, <i>P</i> = .01) in children, and macular optical coherence tomography (OCT) findings, including subretinal and intraretinal fluid, were more common (60% vs 11%, <i>P</i> = .03) compared with adults. Children were more likely to present with vessels traversing the foveal avascular zone on OCT angiography (OCTA) (75% vs 29%). At presentation and final follow-up, the visual acuity (VA) was lower in children compared with adults (<i>P</i> ≤ .01). <b>Conclusions:</b> Upon diagnosis with Coats disease, children present at later stages and are more likely to have macular involvement and lower VA compared with their adult counterparts. OCTA showed more qualitative abnormalities in children, while the affected eyes of adults had a lower vessel density of the superficial and deep capillary plexuses compared with their fellow eyes.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251355635"},"PeriodicalIF":0.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occam Versus Hickam: Irreversible Vision Loss From Paclitaxel-Induced Cystoid Macular Edema.","authors":"Kevin C Allan, Alexie E Kindy, Alex Yuan","doi":"10.1177/24741264251356289","DOIUrl":"10.1177/24741264251356289","url":null,"abstract":"<p><p><b>Purpose:</b> To describe a case of cystoid macular edema (CME) caused by paclitaxel, a first-line chemotherapeutic for invasive breast cancer. <b>Methods:</b> A single case was presented. <b>Results:</b> CME developed shortly after initiation of paclitaxel; 7 months after discontinuation, improvement was seen. However, the patient's visual acuity never recovered. Changes consistent with macular telangiectasia, which may have been potentiated by paclitaxel toxicity, were seen on multimodal imaging. <b>Conclusions:</b> This is the first reported case of irreversible vision loss after paclitaxel treatment without evidence of phototoxicity. Paclitaxel may exacerbate underlying macular telangiectasia, resulting in ellipsoid zone loss after recovery from CME.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251356289"},"PeriodicalIF":0.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coring of Intravitreal Medication Vial Stoppers: A Report From the Research in Safety and Therapeutics Committee of the American Society of Retina Specialists.","authors":"Ferhina S Ali, Eric W Schneider, Sruthi Arepalli, Durga Borkar, Jordan D Deaner, Nieraj Jain, Nikolas J S London, Ivan J Suner, Akshay S Thomas, Lejla Vajzovic, Robin A Vora, Andre J Witkin","doi":"10.1177/24741264251356296","DOIUrl":"10.1177/24741264251356296","url":null,"abstract":"<p><p>In 2024, the American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee became aware of reports of coring of vial stoppers in relation to preparation of intravitreal injections. A literature review was performed to further understand and characterize this occurrence within the context of retina practice and the broader medical community. Relevant articles were identified through a systematic search of PubMed using predefined criteria. Coring can be observed when a needle punctures the rubber stopper of a medication vial, pushing a small piece or pieces of the stopper material into the container and introducing extrinsic particles into the drug product. Factors associated with coring include larger gauge needles, perpendicular needle entry, multiple-use vials, and thicker rubber stoppers. Rubber stopper thickness and composition also influence the likelihood of coring. To prevent patient safety issues from coring, filter needles are commonly used to draw up medications from vials because they are effective in mitigating particulate matter from entering syringes. No documented cases of clinical complications related to coring in ophthalmology have been identified. Coring represents an unreported phenomenon in the preparation of intraocular medications. Although there have been no safety implications in retina practice related to coring and intravitreal drug vials, these reports underscore the importance of careful medication preparation, inspection of vials, the use of appropriate needles, and adherence to best clinical practices.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251356296"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Secondary Vitreoretinal Lymphoma With Neurosurgical Stereotactic Biopsy: A Multimodal Diagnostic and Imaging Approach.","authors":"Neil Sheth, Margarita De Alba, Nayanika Challa, Michael T Massengill, William F Mieler","doi":"10.1177/24741264251356295","DOIUrl":"10.1177/24741264251356295","url":null,"abstract":"<p><p><b>Purpose:</b> To describe an atypical diagnostic approach with multimodal imaging analysis in a patient with primary testicular lymphoma who experienced secondary vitreoretinal recurrence. <b>Methods:</b> A single case was evaluated. <b>Results:</b> A complete ophthalmologic examination, including optical coherence tomography (OCT), fluorescein angiography (FA), fundus autofluorescence (FAF), neuroimaging, and stereotactic biopsy, was performed. A dilated fundus examination showed bilateral white subretinal lesions with pinpoint hyperfluorescence on FA and central hypoautofluorescence with peripheral hyperautofluorescence on FAF. OCT revealed bilateral subretinal hyperreflective material. Magnetic resonance imaging of the brain revealed a 7 mm contrast-enhancing lesion of the right thalamus. Following a negative diagnostic vitrectomy, subsequent stereotactic biopsy of the lesion confirmed recurrent lymphoma. <b>Conclusions:</b> This case emphasized the importance of using multidisciplinary methods to confirm a diagnosis of secondary vitreoretinal lymphoma and allowed an appropriate treatment plan to be made.</p>","PeriodicalId":17919,"journal":{"name":"Journal of VitreoRetinal Diseases","volume":" ","pages":"24741264251356295"},"PeriodicalIF":0.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}