Immunological Reviews最新文献_第9页

Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation 器官移植中同种免疫的性别差异和其他免疫学考虑。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-30 DOI: 10.1111/imr.70104

Whitney A. Perry, Pritha Sen

{"title":"Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation","authors":"Whitney A. Perry, Pritha Sen","doi":"10.1111/imr.70104","DOIUrl":"10.1111/imr.70104","url":null,"abstract":"<div>\u0000 \u0000 <p>Sex-based differences in human immunity are well-described in the general population, cumulatively favoring a more hyperinflammatory immune response among females in different scenarios. It is imperative to understand how this applies in the setting of transplantation, where dynamic immune function determines key clinical outcomes, including graft rejection and responses to infection. Sex differences unique to transplant immunity begin at the chromosomal level and are influenced by steroid hormones and sex-specific factors ranging from pre-existing pregnancy-induced alloimmunization to differential metabolism of routine immunosuppressive medications. Given active efforts for greater sex and gender equity in transplantation, and with increasing transplantation of older candidates, the unique immunological considerations at the cross-roads of biological sex and age are also critical to consider. Age is an important modifier of the relationship between sex and immune-related outcomes as young females appear to have a greater risk for poor outcomes related to alloimmunity compared to similarly-aged male counterparts, particularly when receiving an organ from a male donor. However, this risk does not endure in post-menopausal age categories and there are some limited data to suggest, in fact, that post-menopausal women may have a greater risk for transplant-related infection. Greater efforts to incorporate sex as a biological variable into transplant research will lead to a more tailored strategy for immunosuppressive management, rejection surveillance, infection prophylaxis and other considerations for optimization of transplant outcomes.</p>\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"338 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti-Cancer Immunity Across the Lifespan 性别问题：一生中自身免疫和抗癌免疫的激素和染色体决定因素。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-24 DOI: 10.1111/imr.70096

Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su

引用次数: 0

Sex Differences in the Impact of Obesity on Immunity 肥胖对免疫力影响的性别差异。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-23 DOI: 10.1111/imr.70101

Saranya Vijayakumar, Saurav Pantha, Shristy Budha Magar, Santosh Dhakal

{"title":"Sex Differences in the Impact of Obesity on Immunity","authors":"Saranya Vijayakumar, Saurav Pantha, Shristy Budha Magar, Santosh Dhakal","doi":"10.1111/imr.70101","DOIUrl":"10.1111/imr.70101","url":null,"abstract":"<div>\u0000 \u0000 <p>The prevalence of obesity has increased significantly worldwide in the past few decades and is anticipated to rise further in the future. Obesity, characterized by excessive fat accumulation and chronic low-grade inflammation, dysregulates innate and adaptive immune responses, thereby increasing the risk of infectious diseases, cardiovascular diseases, and cancers. Males and females differ considerably in patterns of fat distribution, adipose tissue inflammation, and adipocytokine production, resulting in substantial sex-specific differences in metabolic health outcomes during obesity. Despite growing evidence of its importance, biological sex remains underprioritized in preclinical, clinical, and epidemiological obesity-related research. In this review, we explore the impact of biological sex on obesity-associated immune dysregulation and its consequences for a range of health outcomes, including infectious diseases, vaccine-induced immunity, autoimmune diseases, cancer, and cardiometabolic risk. We highlight recent findings from animal models and human studies to discuss the mechanistic roles of sex steroids and chromosome complements in shaping fat distribution, adipose inflammation, gut microbiota composition, and systemic inflammation, which collectively drive sex differences in obesity-associated immune responses. Greater consideration of biological sex in obesity research is essential to better understand disease risk, develop targeted interventions, and improve care.</p>\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"338 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome 免疫中的X因素：由X染色体形成的性别差异。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-23 DOI: 10.1111/imr.70107

Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera

{"title":"The X Factor in Immunity: Sex Differences Shaped by the X Chromosome","authors":"Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera","doi":"10.1111/imr.70107","DOIUrl":"10.1111/imr.70107","url":null,"abstract":"<p>There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function. Here, we present recent findings investigating sex differences with immune cells and responses, highlighting contributions from sex hormones or X-linked genes. We also review the epigenetic gene regulatory mechanisms that form the inactive X chromosome (Xi), known as X-Chromosome Inactivation (XCI), the heterochromatic nature of the Xi that allows for selective gene reactivation, and recent work investigating the mechanisms of XCI maintenance in female immune cells. We also highlight some dosage-sensitive X-linked genes involved in female-biased autoimmune disease, discuss sex differences with immune signaling pathways, and sex differences with viral infections and vaccine responses with the ultimate goal to leverage these insights for the development of sex-specific therapeutic interventions for immune-related diseases.</p>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"338 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis 动脉三级淋巴器官在动脉粥样硬化中形成神经免疫心血管界面。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-18 DOI: 10.1111/imr.70106

Sarajo K. Mohanta, Mingyang Hong, Xinyi Deng, Xinwen Dou, Xu Xu, Mohammad Monjezi, Yutao Li, Ting Sun, Zhihua Wang, Andreas J. R. Habenicht, Changjun Yin

{"title":"Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis","authors":"Sarajo K. Mohanta, Mingyang Hong, Xinyi Deng, Xinwen Dou, Xu Xu, Mohammad Monjezi, Yutao Li, Ting Sun, Zhihua Wang, Andreas J. R. Habenicht, Changjun Yin","doi":"10.1111/imr.70106","DOIUrl":"10.1111/imr.70106","url":null,"abstract":"<p>Arterial walls of large- and intermediate-sized arteries consist of three layers, that is, the intima, the media, and the adventitia. Under physiological conditions, the intima mainly comprises endothelial cells and a few monocyte/macrophages and dendritic cells; the media consists of smooth muscle cells and elastic fibers; and the adventitia is a complex connective tissue with structures as diverse as scattered immune cells, small blood vessels, lymph vessels, and multiple components of the nervous system. This review focuses on a subtype of tertiary lymphoid structures termed artery tertiary lymphoid organs (ATLOs), which develop specifically in atherosclerotic arterial segments in the adventitia but not in normal arteries. ATLOs have been characterized in aging hyperlipidemic mice and later have been identified in various diseased segments of the arterial tree, including the carotid arteries, the coronary arteries, and the aorta in humans. The effects of ATLOs on atherosclerosis remain largely unknown. Indeed, ATLOs host pro-inflammatory and anti-inflammatory immune cell subtypes. Stage-III ATLOs contain activated B cell follicles in which germinal centers develop in apparent antigen-dependent B cell maturation cycles. Recent research supports the idea that ATLOs create neuroimmune cardiovascular interfaces (NICIs), which may serve as key hubs in which three tissues interact: the nervous system, the immune system, and the cardiovascular system. Recent evidence indicates that NICIs are capable of impacting disease progression. These interfaces connect atherosclerotic plaques to the immune system, produce disease-related autoantibodies, participate in the development of autoreactive T cells, and transmit signals from arteries to the brain and receive signals from the brain in hardwired polysynaptic axonal connections.</p>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"337 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal-Fetal Impact of Respiratory Viral Infections: Immune Mechanisms and Clinical Outcomes 呼吸道病毒感染对母婴的影响：免疫机制和临床结果。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-16 DOI: 10.1111/imr.70099

Maclaine A. Parish, Sabra L. Klein

{"title":"Maternal-Fetal Impact of Respiratory Viral Infections: Immune Mechanisms and Clinical Outcomes","authors":"Maclaine A. Parish, Sabra L. Klein","doi":"10.1111/imr.70099","DOIUrl":"10.1111/imr.70099","url":null,"abstract":"<div>\u0000 \u0000 <p>Pregnancy is a unique immunological state characterized by physiological adaptations that support fetal growth and development. These immune changes, however, can leave pregnant women more vulnerable to severe outcomes from infections, including those caused by respiratory viruses. Respiratory viral infection during pregnancy can increase maternal morbidity and the likelihood of developing long-lasting neurodevelopmental consequences in the offspring, including autism spectrum disorder, schizophrenia, and other behavioral conditions, particularly in male offspring. Some respiratory viruses can infect reproductive tissues, placenta, and fetuses to cause detrimental pregnancy outcomes. Other respiratory viruses do not leave the respiratory tract but cause systemic maternal immune activation (MIA) that can also be detrimental to pregnancy and fetal outcomes. While antivirals may limit severe disease, they are not always effective at limiting MIA and adverse pregnancy outcomes, highlighting the need for a deeper understanding of the mechanisms that mediate these outcomes. Maternal vaccination offers protection against viral diseases for both mother and young. The effectiveness of these interventions is often limited by barriers such as concerns about vaccine and drug safety and restricted access to care and information. Addressing these challenges and advancing mechanistic understanding are essential for improving maternal and fetal outcomes in the face of respiratory viral infections.</p>\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"337 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship 性在免疫细胞和寄生虫疾病-一个复杂的关系。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-16 DOI: 10.1111/imr.70097

Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter

{"title":"Sex in Immune Cells and Parasitic Diseases — A Complex Relationship","authors":"Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter","doi":"10.1111/imr.70097","DOIUrl":"10.1111/imr.70097","url":null,"abstract":"<p>Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender-specific behaviors that influence exposure risk and health-seeking practices, especially in low- and middle-income countries. Increasing evidence also highlights that biological sex differences within the immune system significantly shape susceptibility to and control of parasitic infections. Recent advances combining classical immunology with single-cell transcriptomics have revealed hormonal and chromosomal factors driving sex-specific differences in innate and adaptive immune cells. These differences can critically influence the course and outcome of parasitic diseases. However, many studies on parasitic diseases still lack adequately sex-disaggregated data or fail to apply state-of-the-art immunological analyses needed to fully characterize biological sex effects. Studies in rodent models that mirror the sex bias observed in humans provide valuable tools to analyze immune mechanisms at the cellular level and dissect underlying biological differences. In this review, we summarize current knowledge on sex differences in key cellular components of innate and adaptive immunity and discuss their relevance for selected parasitic diseases of major global importance—leishmaniasis, Chagas disease, amebiasis, schistosomiasis, and malaria.</p>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"337 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Senescence, Inflammaging and Cardiovascular Disease 细胞衰老、炎症和心血管疾病。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-16 DOI: 10.1111/imr.70084

Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler

{"title":"Cellular Senescence, Inflammaging and Cardiovascular Disease","authors":"Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler","doi":"10.1111/imr.70084","DOIUrl":"10.1111/imr.70084","url":null,"abstract":"<p>Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long-term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes that modulate them. We highlight the roles of cellular senescence and the senescence-associated secretory phenotype (SASP), emphasizing their heterogeneous contributions to chronic low-grade inflammation and tissue remodeling—collectively termed inflammaging. Advances in biomarkers, animal models, and systems biology approaches have deepened our understanding of the interplay between senescence, inflammaging, and cardiovascular dysfunction, including the pivotal role of macrophages in senescent cell clearance. Therapeutic strategies are diverse, ranging from senolytic approaches designed to selectively eliminate senescent cells, to SASP modulation, and interventions targeting chronic inflammation and metabolic dysregulation. Of particular interest, drugs already in clinical use—such as metformin and other anti-diabetic agents—show beneficial effects on aging-related pathways, suggesting that their cardiovascular protection may in part reflect anti-aging properties. Despite these advances, therapies directly targeting senescence and inflammaging to reduce the global burden of CVD remain an urgent unmet need.</p>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"337 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12811516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Immunological Consequences of Clonal Hematopoiesis in Heart Failure 心力衰竭患者克隆造血的免疫学结果。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-16 DOI: 10.1111/imr.70094

Megan A. Evans, Kenneth Walsh

{"title":"The Immunological Consequences of Clonal Hematopoiesis in Heart Failure","authors":"Megan A. Evans, Kenneth Walsh","doi":"10.1111/imr.70094","DOIUrl":"10.1111/imr.70094","url":null,"abstract":"<p>Inflammation is increasingly recognized as a central driver of heart failure (HF), particularly in older adults, yet the underlying immune mechanisms remain diverse and incompletely understood. Clonal hematopoiesis (CH), defined by the expansion of somatically mutated hematopoietic clones, has emerged as a risk factor for the development of numerous age-related diseases including HF. Experimental and clinical evidence suggests that mutant clones carrying driver gene mutations promote a pro-inflammatory immune cell phenotype that contributes to cardiac injury, remodeling and adverse outcomes. Notably, CH has been implicated in HF across diverse etiologies, including both HFrEF and HFpEF, highlighting its broad impact on a vast array of HF syndromes. More recently, it has been discovered that hematopoietic loss of the Y chromosome (LOY) also contributes to HF. LOY appears to shift macrophages toward a fibrotic and away from a pro-inflammatory phenotype, contrasting with that observed for driver gene mutations and suggesting that different somatic alterations contribute to HF via divergent mechanisms. In this review, we examine the clinical and experimental associations between CH and HF. We also explore how CH may drive age-related immune heterogeneity in HF and highlight its potential to be leveraged for personalized interventions in patients with HF.</p>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"337 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction 代谢应激和免疫激活在心力衰竭与保留射血分数。

IF 8.3 2区医学

Immunological Reviews Pub Date : 2026-01-12 DOI: 10.1111/imr.70103

Ana Pereira, Santiago Alvarez-Argote, Isaac Meite, Hiroyasu Inui, Jacob K. Sterling, Evette J. Thorp, Matthew J. Feinstein, Mallory Filipp, Edward B. Thorp

引用次数: 0