Kidney360最新文献_第5页

Artificial Intelligence in Nephrology Practice: Practical Pathways to Improve Efficiency. 人工智能在肾脏病学实践中的应用：提高效率的实践途径。

IF 3.6

Kidney360 Pub Date : 2026-09-23 DOI: 10.34067/KID.0000001424

Noppawit Aiumtrakul, Charat Thongprayoon, Wisit Cheungpasitporn

引用次数: 0

Biopsy-Proven Versus Clinically-Suspected Acute Interstitial Nephritis: A Comparative Analysis. 活检证实与临床怀疑急性间质性肾炎：比较分析。

IF 3.6

Kidney360 Pub Date : 2026-09-22 DOI: 10.34067/KID.0000001413

Michael Kolland, Nikolaus Schreiber, Jascha A Amenitsch, Simon Aberger, Bernhard Tomek, Kathrin Eller, Alexander H Kirsch

引用次数: 0

Percutaneous Renal Biopsy of Native Kidneys in Adults: A Single Center 40-Year Experience. 成人原生肾脏经皮肾活检：单中心40年经验。

IF 3.6

Kidney360 Pub Date : 2026-09-22 DOI: 10.34067/KID.0000001362

Stephen M Korbet, Joni K Evans, William L Whittier

{"title":"Percutaneous Renal Biopsy of Native Kidneys in Adults: A Single Center 40-Year Experience.","authors":"Stephen M Korbet, Joni K Evans, William L Whittier","doi":"10.34067/KID.0000001362","DOIUrl":"https://doi.org/10.34067/KID.0000001362","url":null,"abstract":"Background: Percutaneous renal biopsy of native kidneys is essential in the diagnosis and management of renal disease. We report one of the largest single center experiences on the success and safety of the procedure.Methods: From 6/1983 to 12/2022, 1384 adults underwent percutaneous renal biopsy using real-time ultrasound guidance using predominantly automated 14- and 16-gauge needles. A complication was defined by the need for an intervention (transfusion, radiologic or surgical procedure) or death. Multivariate analysis using logistic regression was performed to determine which features were predictive of attaining >20 total glomeruli and a complication or need for a transfusion post renal biopsy.Results: Adequate tissue for diagnosis was obtained in 99% of biopsies. Significantly more glomeruli were obtained using the 14- vs 16-gauge automated needle (32±14 vs 27±12, P <0.001) with 81% vs 74% having >20 glomeruli (P 0.01). There was no difference in complication rate (7.0 vs 8.0%, P 0.6) or transfusion requirement (5.6 vs 5.7%, P 1.0) for the 14- vs 16-gauge automated needle. By multivariate analysis the features predictive of >20 total glomeruli per biopsy were the use of a 14- v. 16-gauge automated needle and obtaining >3 cores. By multivariate analysis, baseline features predictive of a complication were female gender (Adjusted Odds Ratio (OR) 2.1), systolic blood pressure >130 mmHg and >175 mmHg (OR 1.8 and 6.4, respectfully) and Hgb <10.5 g/dL OR 3.5).Conclusions: Percutaneous renal biopsy of native kidneys using real-time ultrasound remains a successful and safe procedure. The use of a 14-gauge automated needle not only provides a more glomeruli but is equally as safe as a 16-gauge automated needle.","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pkd1 Deficiency Causes Intrinsic Renal Circadian Clock Dysfunction. Pkd1缺乏导致肾脏内在生物钟功能障碍。

IF 3.6

Kidney360 Pub Date : 2026-09-22 DOI: 10.34067/KID.0000001347

Abeda Jamadar, Lauren G Douma, Robin L Maser, Michelle L Gumz, Reena Rao

{"title":"Pkd1 Deficiency Causes Intrinsic Renal Circadian Clock Dysfunction.","authors":"Abeda Jamadar, Lauren G Douma, Robin L Maser, Michelle L Gumz, Reena Rao","doi":"10.34067/KID.0000001347","DOIUrl":"10.34067/KID.0000001347","url":null,"abstract":"Background: Circadian rhythms are governed by cell-autonomous molecular clocks that regulate organ function and homeostasis. We previously showed that disruption of the renal circadian clock accelerates cyst growth in a mouse model of autosomal dominant polycystic kidney disease (ADPKD). Whether ADPKD is associated with intrinsic renal circadian clock dysfunction, and whether such dysfunction is directly attributable to loss of the PKD1 gene, remain unknown.Methods: We examined circadian regulation across organismal, organ and cellular levels using slow (Pkd1RC/RC) and rapidly (Pkd1-KO) progressing ADPKD mouse models, along with Pkd1 deficient proximal tubular and inner medullary collecting duct cells. Diurnal water intake and urine output were assessed longitudinally. Time-course analyses of core clock gene expression in mouse kidneys and synchronized renal epithelial cells, together with real-time Per2luciferase (PER2::LUC) bioluminescence imaging of kidney explants, were performed.Results: Pkd1RC/RC mice showed progressive disruption of diurnal rhythms in water intake and urine output, paralleling cystic burden. Cystic kidneys exhibited dampened, desynchronized oscillations of core circadian clock genes and PER2::LUC bioluminescence. These abnormalities were more pronounced in Pkd1-KO mice. Furthermore, Pkd1 loss blunted clock gene oscillations in synchronized renal epithelial cells in vitro, indicating cell-autonomous circadian clock dysfunction.Conclusions: Pkd1 deficiency contributes to intrinsic renal circadian clock dysfunction independent of systemic cues, although additional studies will be required to distinguish direct effects of Pkd1 loss from secondary consequences of cystic remodeling in vivo.","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CKD Progression to ESKD in Women. 女性CKD进展为ESKD。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001405

Joel Neugarten, Ladan Golestaneh

引用次数: 0

Female Reproductive Health in Kidney Disease. 肾脏疾病中的女性生殖健康。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001409

Mahua Bhaduri, Ippokratis Sarris, Kate Bramham

{"title":"Female Reproductive Health in Kidney Disease.","authors":"Mahua Bhaduri, Ippokratis Sarris, Kate Bramham","doi":"10.34067/KID.0000001409","DOIUrl":"https://doi.org/10.34067/KID.0000001409","url":null,"abstract":"Female reproductive health is an important yet frequently neglected component of care in women with CKD. As the global burden of CKD rises, increasing numbers of women of reproductive age are affected, with consequences across the reproductive lifespan, including fertility, menstruation, sexual function, contraception, pregnancy and menopause. CKD disrupts normal reproductive physiology through complex and multifactorial mechanisms. The hypothalamic-pituitary-ovarian axis is often affected in CKD. Loss of pulsatile gonadotrophin-releasing hormone (GnRH) secretion and hyperprolactinemia can lead to hormonal dysregulation and menstrual irregularities. Additional mechanisms contributing to reduced fertility include diminished ovarian reserve, altered endometrial receptivity and reproductive decision-making influenced by chronic illness. Chronic inflammation, a hallmark of CKD, may also negatively affect reproductive health. Together, these factors contribute to reduced fertility, menstrual abnormalities, premature menopause and sexual dysfunction; all of which can adversely affect quality of life and long-term health outcomes. Many nephrologists report feeling ill-equipped to counsel patients on reproductive decision-making, contraception and fertility preservation, highlighting an important gap in clinical care. The use of gonadotoxic therapies, such as cyclophosphamide, further complicates reproductive planning. Early counselling and consideration of fertility preservation strategies, including GnRH agonists and oocyte cryopreservation, are therefore important.","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women's Health Issues in Transplant. 移植中的妇女健康问题。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001406

Priyanka Jethwani, Arundati Rao

引用次数: 0

Kidney Consequences of Anti-Cancer Treatment for Female-Specific Cancers. 女性特异性癌症抗癌治疗对肾脏的影响。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001206

Emily M Moss, Mariya Rozenblit, Teresa Joseph

引用次数: 0

Cardiovascular-Kidney-Metabolic Syndrome in Women: Bridging Nephrology and the Female Cardiometabolic Disparity. 女性心血管-肾-代谢综合征：弥合肾脏病学和女性心脏代谢差异。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001404

Rebecca Kurian, Shiwani Mahajan, Menaka Sarav

{"title":"Cardiovascular-Kidney-Metabolic Syndrome in Women: Bridging Nephrology and the Female Cardiometabolic Disparity.","authors":"Rebecca Kurian, Shiwani Mahajan, Menaka Sarav","doi":"10.34067/KID.0000001404","DOIUrl":"https://doi.org/10.34067/KID.0000001404","url":null,"abstract":"The American Heart Association (AHA) introduced Cardiovascular-Kidney-Metabolic (CKM) syndrome to characterize a systemic disorder resulting from interconnected metabolic risks, CKD, and cardiovascular disease (CVD). The CKM Presidential Advisory outlines a five-stage framework (Stages 0-4) that categorizes individuals based on disease progression, risk, and opportunities for prevention or intervention. This framework is particularly significant for women, as sex-specific risk enhancers, including premature menopause and adverse pregnancy outcomes, influence CKM stage classification and long-term outcomes. The AHA PREVENT Scientific Statement presents PREVENT risk equations, which are sex-specific, race-neutral models designed to estimate absolute 10- and 30-year risk for total CVD, encompassing both atherosclerotic CVD and heart failure. These equations help clinical teams implement CVD prevention strategies and customize risk-reducing interventions. This review will focus on the impact of CKM syndrome in women, examine gaps in the current risk stratification and diagnostic strategy, and identify opportunities to improve prevention and management in this population.","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reframing Women's Health in Kidney Disease: Sex Differences, Gender Disparities, and Clinical Imperatives - Introduction to a Special Series. 重塑妇女健康肾脏疾病：性别差异，性别差异，和临床必要性-介绍一个特别系列。

IF 3.6

Kidney360 Pub Date : 2026-09-21 DOI: 10.34067/KID.0000001387

Menaka Sarav, Ladan Golestaneh, Ursula C Brewster

{"title":"Reframing Women's Health in Kidney Disease: Sex Differences, Gender Disparities, and Clinical Imperatives - Introduction to a Special Series.","authors":"Menaka Sarav, Ladan Golestaneh, Ursula C Brewster","doi":"10.34067/KID.0000001387","DOIUrl":"https://doi.org/10.34067/KID.0000001387","url":null,"abstract":"Kidney disease has often been approached as affecting women and men similarly, yet important differences in sex-specific biology and gender-related social experiences shape risk, recognition, and treatment for women with CKD. Women more commonly have early-stage CKD but progress more slowly to kidney failure, a pattern influenced by hormonal factors and complicated by diagnostic practices that may delay detection. Evidence also suggests women receive lower-quality CKD care than men, including fewer nephrology referrals and lower use of guideline-recommended therapies. Pregnancy-related exposures, particularly adverse pregnancy outcomes such as preeclampsia, are associated with substantially increased long-term risk of CKD and ESKD, yet structured postpartum kidney follow-up is uncommon. Menopause may represent a key inflection point for CKD progression and bone health. Additional disparities affect transplant access, and cancer survivorship introduces underrecognized renal risks. This special series examines these life stages and clinical domains and outlines practice-relevant, sex- and gender-informed approaches to improve equity and outcomes.","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0