Kidney360最新文献

{"title":"Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis (MESA).","authors":"Armin Ahmadi, Hassan Gorji, Sanskrita Shashikant, Ronit Katz, Alfons J H M Houben, Robert N Weinreb, Matthew Allison, Stacy M Meuer, Barbara E Klein, Mary Frances Cotch, Orlando M Gutierrez, Mark J Sarnak, Michael Shlipak, Joachim H Ix, Rakesh Malhotra","doi":"10.34067/KID.0000000970","DOIUrl":"https://doi.org/10.34067/KID.0000000970","url":null,"abstract":"<p><strong>Background: </strong>CKD is strongly associated with cardiovascular disease (CVD), yet the etiology responsible for this link remains elusive. Novel blood and urine biomarkers reflecting kidney tubule dysfunction and injury may provide novel insights to mechanisms linking the kidney to CVD.</p><p><strong>Methods: </strong>In 470 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) without type 2 diabetes, CVD or CKD, we measured six plasma (kidney injury molecule-1 [KIM-1], monocyte chemoattractant protein-1 [MCP-1], soluble urokinase plasminogen activator receptor [suPAR], tumor necrosis factor receptor [TNFR] 1 and 2, and anti-chitinase-3-like protein 1 [YKL-40]) and six urinary (alpha 1 microglobulin [A-1M], epidermal growth factor [EGF], KIM-1, MCP-1, YKL-40 and uromodulin [UMOD]) kidney tubule health biomarkers. To assess microvascular health, we used retinal microvascular measurements assessed from fundus photography: central retinal arteriolar and venular equivalents (CRAE and CRVE, respectively). Multivariable linear regression evaluated associations of tubule biomarkers and kidney function with CRAE and CRVE.</p><p><strong>Results: </strong>The mean participant age was 60 ± 10 years with 52% female. The racial/ethnic distribution was 46% White, 24% African American, 18% Hispanic, and 11% Chinese. The mean eGFR was 92.1 ± 13.3 mL/min/1.73m2, and the median urine ACR was 4.7 mg/g (IQR 3.0, 9.4). Higher plasma KIM-1 (β -5.14, 95% confidence interval [95% CI], -9.84 to -0.45), and urine KIM-1 (β -5.68, 95% CI, -10.15 to -1.22) concentrations were individually associated with narrower CRAE, while plasma suPAR concentrations were individually associated with wider CRAE (β 9.15, 95% CI, 0.89 to 17.4) and CRVE (β 21.49, 95% CI, 9.39 to 33.59). There were no significant associations between the remaining tubule health biomarkers and CRAE or CRVE, nor were there associations between eGFR or urine ACR with CRAE and CRVE.</p><p><strong>Conclusions: </strong>In this study of community-living individuals without CKD, diabetes, or CVD, selected kidney tubule health markers are associated with retinal microvascular changes. These findings suggest that kidney tubules biomarkers may reflect or contribute to systemic microvascular dysfunction, above and beyond glomerular damage. Tubular biomarkers may help elucidate the shared microvascular mechanisms linking CKD and CVD.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrology in Nepal: How it Started and Where We Are.","authors":"Deepak Sharma, Taranath Sharma, Jie Tang","doi":"10.34067/KID.0000000991","DOIUrl":"10.34067/KID.0000000991","url":null,"abstract":"<p><p>Nepal has made significant strides in nephrology, progressing from no dialysis services to offering comprehensive kidney care, including dialysis and transplantation. The journey began in the 1980s with the establishment of the first nephrology unit at Bir Hospital and has since grown to encompass over 60 dialysis centers and multiple transplant facilities. Government initiatives, such as financial subsidies and health insurance schemes, have increased accessibility, yet disparities persist due to workforce shortages, uneven infrastructure distribution, and inconsistent quality control in dialysis services. Pre-dialysis care remains underdeveloped, and challenges in adopting peritoneal dialysis persist due to socioeconomic and logistical barriers. The kidney transplant program, primarily reliant on living donors, has shown steady growth. Critical care nephrology and interventional services are gradually emerging. To advance, addressing workforce shortages, improving care quality, and expanding equitable access through strategic investments and global partnerships are essential.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Sodium Correction Rates in Patients with Severe Hyponatremia Treated with Hypertonic Saline with and without Proactive Desmopressin.","authors":"Zain AlShanableh, Anna Woodall, Michelle Chisdak, Jonathan G Yabes, Richard H Sterns, Steven D Weisbord, Helbert Rondon-Berrios","doi":"10.34067/KID.0000000830","DOIUrl":"10.34067/KID.0000000830","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1462-1471"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience in Peritoneal Dialysis: Do Clinicians Accurately Perceive Patients' Perspectives?","authors":"Domenico Cozzo, Antonio Bellasi","doi":"10.34067/KID.0000000944","DOIUrl":"10.34067/KID.0000000944","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 9","pages":"1602-1604"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Kidney Injury in a Patient with Painless Jaundice.","authors":"Florian G Scurt, Carolin Herzog, Ben Hammoud","doi":"10.34067/KID.0000000806","DOIUrl":"10.34067/KID.0000000806","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 9","pages":"1634-1635"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rate of Procedures Required to Maintain Hemodialysis Vascular Access: A Data Linkage Analysis.","authors":"Katherine G Richards, Kevan R Polkinghorne, David O McGregor, Rachael C Walker, Curtis Walker, Jonathan A Williman, Suetonia C Green","doi":"10.34067/KID.0000000841","DOIUrl":"10.34067/KID.0000000841","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1549-1561"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving CKD Screening and Care in Diabetes Using Clinical Decision Support in a Large Health Care System.","authors":"Ken J Park, Michalah K Tandy, Shaun Flerchinger, Kathryn J Glassberg, Frank Y Chen, Eric S Albright, Lisa J Nakashimada","doi":"10.34067/KID.0000000829","DOIUrl":"10.34067/KID.0000000829","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1501-1509"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergistic Impact of Air Pollution and Residential Neighborhood Segregation on Post-Kidney Transplant Mortality.","authors":"Yiting Li, Gayathri Menon, Jane J Long, Malika Wilson, Byoungjun Kim, Babak J Orandi, Sunjae Bae, Wenbo Wu, George D Thurston, Dorry L Segev, Mara A McAdams-DeMarco","doi":"10.34067/KID.0000000915","DOIUrl":"10.34067/KID.0000000915","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1599-1601"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Cannabis Use with Access to Kidney Transplantation and Post-Transplant Outcomes.","authors":"Danielle S Kroll, Kyle J Woodward, Syed Ali Husain","doi":"10.34067/KID.0000000858","DOIUrl":"10.34067/KID.0000000858","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1596-1598"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Perspective of CKD: Chile.","authors":"Luis Toro, Eduardo Lorca, Tamara Bórquez","doi":"10.34067/KID.0000000898","DOIUrl":"10.34067/KID.0000000898","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1605-1608"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}