KIDNEYS最新文献

{"title":"Clinical case of hydronephrotic form of multicystic dysplastic kidney complicated by pyelonephritis in adults","authors":"O. Chub, S.O. Reshetniak, Y. Dumanskiy, A. Maltsev","doi":"10.22141/2307-1257.11.2.2022.369","DOIUrl":"https://doi.org/10.22141/2307-1257.11.2.2022.369","url":null,"abstract":"Multicystic dysplastic kidney (MCDK) is a renal dysplasia characterized by the presence of multiple cysts that are non-communicating, varying in size, separated by dysplastic parenchyma that consume the renal cortex resulting in a non-functional kidney with the absence of a normal pelvocaliceal system. The incidence of MCDK is approximately 1 : 4300 of live births, with males being affected more often than females. Many concurrent urinary tract abnormalities have been described in patients with MCDK. The most common and potentially significant urologic defect seen is vesico-ureteral reflux to the contralateral kidney. In our clinical case, multicystic dysplastic kidney complicated by hydronephrotic transformation and septic obstructive pyelonephritis, which deve­loped on the base of undiagnosed vasorenal conflict.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76593068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of proteomic studies of the latest markers of kidney damage in the urine to assess the course, progression and complications in patients with CKD","authors":"Запрошені статті","doi":"10.22141/2307-1257.11.2.2022.363","DOIUrl":"https://doi.org/10.22141/2307-1257.11.2.2022.363","url":null,"abstract":"Сhronic kidney Disease (CKD) is the cause of both morbidity and mortality worldwide. In Ukraine, 12 % of the population is diagnosed with CKD. Significantly worsen the quality of life in patients with CKD progression of renal fibrosis and impaired mineral homeostasis. Early diagnosis and treatment are the main measures to prevent CKD progression and delay adverse effects. Deficiency of early, non-invasive biomarkers adversely affects the ability to rapidly detect and treat CKD. Proximal tubular lesions play an important role in the progression of CKD. There are new markers of kidney damage, such as uromodulin (UMOD), Klotho protein and post-translational modifications of fetuin A (FtA). Treatment of CKD in the early stages may improve renal function and/or slow the progression of CKD.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72968795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infusion reactions to rituximab administration: algorithm of management","authors":"D. Ivanov, I. Zavalna","doi":"10.22141/2307-1257.11.2.2022.364","DOIUrl":"https://doi.org/10.22141/2307-1257.11.2.2022.364","url":null,"abstract":"Background. Allergic reactions to rituximab, which have been used for the past 20 years, are common in 32–62 % of patients. The purpose of the study: to develop an algorithm for controlling adverse reactions that occur during the introduction of rituximab. Materials and methods. The personal experience of treatment of 46 patients with various kidney diseases who received rituximab according to the indications according to the established diagnosis was analyzed. Evaluation of infusion allergic reactions was performed according to P.М. Kasi et al. (2012) for 5 classes of side effects. Results. It was found that allergic reactions to ritu­ximab occurred in 46 % of patients in the range from 1 to 4 classes. The probability of their occurrence according to the class was almost the same, but somewhat less documented for the 4th grade. Re-administration of diphenhydramine, methylprednisolone 125 mg or hydrocortisone 125 mg, if necessary salbutamol, oxygen allowed to eliminate most of the reaction, and then resumed the introduction of rituximab, starting from 25 mg/h, gradually increasing to 300 mg/h. This administration, performed 1–2 times, was effective in 1–3 classes of allergic reactions. For fourth grade, one patient required omalizumab. Generalized experience allowed to give a graphical and descriptive algorithm of actions in case of infusion side effects for rituximab. Conclusions. Based on special data and literature analysis, an algorithm for controlling infusion allergic reactions with intravenous rituximab was formulated.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83287419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal dialysis in 2022: an accidental renaissance?","authors":"D. Ivanov","doi":"10.22141/2307-1257.11.2.2022.368","DOIUrl":"https://doi.org/10.22141/2307-1257.11.2.2022.368","url":null,"abstract":"The review focuses on peritoneal dialysis as a renal replacement therapy for stage 5 chronic kidney disease (CKD). About 10 % of the world’s population suffers from CKD, but its prevalence and incidence vary widely across the world due to social and economic conditions. The main areas of renal replacement therapy today are haemodialysis and peritoneal dialysis, the beginning of which is recommended for CKD stage 5. Both me­thods are effective and have similar survival and mortality rates. Both techniques are used successfully around the world, but peritoneal dialysis is less resource-intensive, making it the method of choice in many less affluent countries. The advantages of peritoneal dialysis can be: shorter sessions, limited patient movement, being in the family circle and better quality of life according to the patients themselves. Numerous studies are being conducted to improve the reliability and quality of peritoneal dialysis, including access and prevention of infections.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84251380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Kidney Day 2022 in Ukraine","authors":"No Authors","doi":"10.22141/2307-1257.11.1.2022.361","DOIUrl":"https://doi.org/10.22141/2307-1257.11.1.2022.361","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89722514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney replacement therapy and global issues: world experience and our challenges","authors":"D. Ivanov","doi":"10.22141/2307-1257.11.1.2022.358","DOIUrl":"https://doi.org/10.22141/2307-1257.11.1.2022.358","url":null,"abstract":"The problem of renal replacement therapy (RRT) is relevant in today’s world due to a large number of people with chronic kidney disease (CKD). According to current data, about 10–11 % of people suffer from CKD, of which up to 5 % need RRT. Unfortunately, the number of people with CKD in the world is increasing, which determines the growing need for RRT. There are three types of RRT, namely: hemodialysis, peritoneal dialysis, and kidney transplantation. Kidney transplantation is the most effective method of RRT, but its possibilities in the world are limited. Therefore, most people receive hemo- or peritoneal dialysis. But the long-term effects of choosing a dialysis method are not always predictable. The peritoneal dialysis and hemodialysis show similar effectiveness during the first two years. Subsequent studies compa­ring the efficacy of the two methods do not provide a clear picture due to differences in patient initial parameters and differences in treatment initiation time. It is clear that peritoneal dialysis can have significant advantages in low-income countries due to the resource costs of the latter. The known benefits of peritoneal dialysis, such as flexibility of use, high quality of life, and preservation of residual renal function, increase its attractiveness, especially for young people with stage 5 CKD. The main strategies today are timely detection and prevention of CKD, control of comorbidities, as well as the development of documents and recommendations for standardization and improving the quality of renal replacement therapy.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74411195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of plasmid-mediated resistance genes ESBLs and PMQR among uropathogens, isolated from non-dialysis CKD patients with pyelonephritis","authors":"O. Chub, S. Teslenko, O. Chub","doi":"10.22141/2307-1257.11.1.2022.354","DOIUrl":"https://doi.org/10.22141/2307-1257.11.1.2022.354","url":null,"abstract":"Urinary tract infections (UTIs) are thought to be the most common group of bacterial infections, worldwide. It is estimated that the proportion of UTIs remains at a high level reaching 150 million episodes per year worldwide and accounting for $6 billion in health care expenditures. In USA more than 100,000 hospital admissions per year are the UTIs patients, among them the patients with pyelonephritis are the most frequent. For the US outpatients, approximately 15 % of antibiotics used are prescribed for UTIs. However, recent studies in Europe and the United States have demonstrated a steady increase in the rate of uropathogen resistance to commonly prescribed antibiotics, and this obviously will lead to a reduction in therapeutic possibilities of UTI. CDC has estimated that more thаn 2 million infections and 23,000 deaths are due to antibiotic resistance each year. By 2050, it is estimated, that antibiotic resistance will cause 10 million deaths every year. Infection is an importаnt cause of mоrbidity and mоrtality amоng patients with kidney failurе and is the sеcond lеading causе of death following CVD. At the EU/EEA level, more than half (54 %) of the E.coli isolates reported to EARS-Net for 2020 were resistant to at least one of the antimicrobial groups under regular surveillance, i.e. aminopenicillins, fluoroquinolones, third-generation cephalosporins, aminoglycosides and carbapenems. A majority (87.4 %) of the third-generation cephalosporin-resistant E.coli isolates from 2020 were extended-spectrum beta-lactamase (ESBL) positive. Use of broad-spectrum antimicrobials is a known risk factor for colonization and spread of resistant Enterobacteriaceae, including E.coli. The high levels of ESBLs and increasing resistance to key antimicrobial groups might also lead to an increased consumption of carbapenems, which in turn can increase the selection pressure and facilitated the spread of carbapenem-resistant Enterobacteriaceae. The article presents data on the antibacterial susceptibility of isolated uropathogens, and their association with the presence or absence of plasmid-mediated resistance genes ESBLs and PMQR.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77810867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving medical standards of care to children of an early and preschool age with urinary tract infections at the primary care stage","authors":"V. Bezruk, D. Ivanov","doi":"10.22141/2307-1257.10.4.2021.247894","DOIUrl":"https://doi.org/10.22141/2307-1257.10.4.2021.247894","url":null,"abstract":"Timely diagnosis, prognostic value of clinical signs and further treatment of patients of an early age with urinary tract infections (UTI) during outpatient stage are important constituents of an integrated management of patients in childhood. The article deals with new approaches concerning clinical algorithm in diagnosis of urinary tract infections in children. The algorithm of diagnostic and therapeutic measures for providing care to children under 5 years of age with urinary tract infections, in particular at the stage of primary care, includes: diagnosis of urinary tract infection in young children using The Diagnosis of Urinary Tract infection in Young children, patient’s examination by Gorelick Scale and UTIcalc, imaging methods with mandatory ultrasound of the kidneys and bladder, micturating cystogram after the first episode of infection in boys and the second — in girls, the prescription of antibiotic therapy based on data from regional monitoring of antibiotic resistance of the main groups of uropathogens, monitoring antibiotic resistance using electronic means and the implementation in microbiological laboratories of the guidelines of the European Committee on Antimicrobial Susceptibility Testing, as well as introduction of the prescription sale of antibiotics.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77771540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uromodulin as a potential candidate marker for predicting the course of chronic kidney disease","authors":"L.D. Denova","doi":"10.22141/2307-1257.10.4.2021.247898","DOIUrl":"https://doi.org/10.22141/2307-1257.10.4.2021.247898","url":null,"abstract":"Uromodulin is a nephrospecific protein that is most common in normal urine. And although it has been known for more than 70 years, the function of uromodulin remains unclear. Uromodulin is involved in regulating the transport of salts, protects against urinary tract infections, namely, the mucous membrane of the bladder, and prevents the formation of kidney stones, as well as plays a role in kidney damage and innate immunity. Serum uromodulin and uromodulin of urine, daily excretion and excretion of uromodulin per 1 milliliter of creatinine clearance are actively studied. Complete genome studies of the association have established a correlation between uromodulin gene mutations and autosomal dominant tubulointerstitial kidney disease.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80462168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The opportunity of stem cells application in kidney transplantation: clinical studies (review)","authors":"A. Voroniak, R. Zograbyan","doi":"10.22141/2307-1257.10.4.2021.247897","DOIUrl":"https://doi.org/10.22141/2307-1257.10.4.2021.247897","url":null,"abstract":"Kidney transplantation remains the optimal method of end-stage renal disease treatment, but the result of such ope­rations depends on the immune response of the recipient to the transplanted organ. Side effects of modern immunosuppressive drugs, such as nephrotoxicity, opportunistic infection, and increased risk of cancer, negatively affect the long-term results of transplantation. In recent years, studies of the properties and uses of stem cells have aroused considerable interest and expectations. The biological characteristics of stem cells, inclu­ding multi-row differentiation, self-guidance, paracrine effects, immunomodulation, ability to suppress the immune response against graft, have opened new horizons for their use in kidney transplantation, but according to different studies, the safety and effectiveness of stem cells clinical use remain controversial. The use of stem cells in animal models with renal failure shows better results in the postoperative period and provides an opportunity for clinical research in the context of creating alternative induction therapy in kidney transplantation. The preclinical efficiency of stem cells in the chronic renal failure model and renal allotransplantation in laboratory animals showed their unique potential to improve function and repair the damaged kidney. They also demonstrate immunosuppressive effects that realize in the inhibition of T-cell proliferation and dendritic cells maturation, the induction of Т-regulatory cells, which can improve the long-term results of kidney allotransplantation. This review summarizes the results of previous studies and is aimed to provide an objective point of view based on a comprehensive analysis of currently known advantages and disadvantages of stem cell therapy in kidney transplantation and highlights aspects that require further research.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81032199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}