Korean Journal of SpinePub Date : 2016-06-01Epub Date: 2016-06-30DOI: 10.14245/kjs.2016.13.2.87
Dong-Hyun Lee, Kyoung-Tae Kim, Jeong-Ill Park, Ki-Su Park, Dae-Chul Cho, Joo-Kyung Sung
{"title":"Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty.","authors":"Dong-Hyun Lee, Kyoung-Tae Kim, Jeong-Ill Park, Ki-Su Park, Dae-Chul Cho, Joo-Kyung Sung","doi":"10.14245/kjs.2016.13.2.87","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.2.87","url":null,"abstract":"<p><p>We propose a double layered (intradural and epidural patch) duraplasty that utilizes Lyoplant and Duraseal. We examined a 47-year-old woman after decompression for thoracic ossification of posterior longitudinal ligament was performed in another hospital. On postoperative day 7, she complained of weakness in both legs. Postoperative magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) collection with cord compression. In the operative field, we found 2 large dural defects on the ventral dura mater. We performed a conventional fat graft with fibrin glue. However, the patient exhibited neurologic deterioration, and a postoperative MRI again showed CSF collection. We performed dorsal midline durotomy and inserted a intradural and epidural Lyoplant patch. She immediately experienced diminishing back pain postoperatively. Her visual analog scale and motor power improved markedly. Postoperative MRIs performed at 2 and 16 months showed no spinal cord compression or CSF leakage to the epidural space. We describe a new technique for double layered duraplasty. Although we do not recommend this technique for all dural repairs, double-layered duraplasty may be useful for repairing large inaccessible dural tears in cases of persistent CSF leakage refractory to conventional management. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 2","pages":"87-90"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/f4/kjs-13-87.PMC4949176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34746749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-06-01Epub Date: 2016-06-30DOI: 10.14245/kjs.2016.13.2.74
Jae Hoo Park, Hyeun Sung Kim, Seok Won Kim
{"title":"Cement Leakage into Adjacent Vertebral Body Following Percutaneous Vertebroplasty.","authors":"Jae Hoo Park, Hyeun Sung Kim, Seok Won Kim","doi":"10.14245/kjs.2016.13.2.74","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.2.74","url":null,"abstract":"<p><p>Percutaneous vertebroplasty (PV) is a minimally invasive procedure for osteoporotic vertebral compression fractures that fail to respond to conventional conservative treatment. It significantly improves intolerable back pain within hours, and has a low complication rate. Although rare, PV is not free of complications, most of which are directly related to cement leakage. Because of its association with new adjacent fracture, the importance of cement leakage into the adjacent disc space is paramount. Here, we report an interesting case of cement leakage into the adjacent upper vertebral body as well as disc space following PV. To the best of our knowledge, there has been no report of cement leakage into the adjacent vertebral body following PV. This rare case is presented along with a review of the literature. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 2","pages":"74-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/73/kjs-13-74.PMC4949172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34746745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effectiveness of Gelfoam Technique before Percutaneous Vertebroplasy: Is It Helpful for Prevention of Cement Leakage? A Prospective Randomized Control Study.","authors":"Jae-Sang Oh, Jae-Won Doh, Jai-Joon Shim, Kyeong-Seok Lee, Seok-Mann Yoon, Hack-Gun Bae","doi":"10.14245/kjs.2016.13.2.63","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.2.63","url":null,"abstract":"<p><strong>Objective: </strong>Preinjection gelfoam embolization during percutaneous vertebroplasty (PVP) has been thought alternative technique to prevent the leakage of bone cement. The goal of this study was to evaluate whether the gelfoam techniques are useful to reduce bone cement leakage.</p><p><strong>Methods: </strong>Total 100 PVPs of osteoporotic spine compression fractures were performed by 1 spine surgeon who experienced more than 500 PVP cases under prospective control study. Operation was done in T-L junction (T10-L2) fractures with bi-transpedicular approach. Preinjection gelfoam PVP was done in the 50 levels. As control group, PVP without gelfoam was done in the 50 levels. We did not perform preoperative venography. We inserted normal saline-mixed gelfoam to the anterior third of vertebral body via PVP needle, and then 3mL of polymethylmetacrylate (PMMA) was injected. We prospectively evaluated the incidence and leakage pattern of PMMA by postoperative computed tomography.</p><p><strong>Results: </strong>Between gelfoam and control groups, there were 11 leaks (22%) versus 12 leaks (26%). The mean operation time was 7.00 minutes versus 6.30 minutes. In gelfoam group, there were 6 spinal canal leaks, 4 paravertebral venous leaks, and 1 soft tissue leaks. In control group, there were 4 spinal canal leaks, 8 paravertebral venous leaks, and 1 disc space leak. In spite of cement leakage, there was no symptomatic case in both groups. Statistically, gelfoam technique was not related to decrease the incidence of leakage (p=0.64).</p><p><strong>Conclusion: </strong>Our prospective study showed that it did not significantly decrease cement leakage when vertebroplasty is performed by experienced spine surgeon.</p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 2","pages":"63-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/c5/kjs-13-63.PMC4949169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34587530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-06-01Epub Date: 2016-06-30DOI: 10.14245/kjs.2016.13.2.83
Sung Mo Ryu, Eun-Sang Kim, Seung-Kook Kim, Sun-Ho Lee, Whan Eoh
{"title":"Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report.","authors":"Sung Mo Ryu, Eun-Sang Kim, Seung-Kook Kim, Sun-Ho Lee, Whan Eoh","doi":"10.14245/kjs.2016.13.2.83","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.2.83","url":null,"abstract":"<p><p>Superficial siderosis of the central nervous system(SSCNS) is a rare disease characterized by hemosiderin deposition on the surface of the central nervous system. We report a case of SSCNS originating from the thoracic spine, presenting with neurological deficits including, sensorineuronal hearing loss, ataxia, and corticospinal and dorsal column tract signs. The patient underwent dural repair with an artificial dural patch. Clinical findings were elicited by neurological examination, imaging studies, and intraoperative findings, and these were addressed through literature review. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 2","pages":"83-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/36/kjs-13-83.PMC4949175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34746748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-06-01Epub Date: 2016-06-30DOI: 10.14245/kjs.2016.13.2.57
Do-Keun Kim, Hyunkeun Lim, Dae Cheol Rim, Chang Hyun Oh
{"title":"Clinical and Radiological Comparison of Semirigid (WavefleX) and Rigid System for the Lumbar Spine.","authors":"Do-Keun Kim, Hyunkeun Lim, Dae Cheol Rim, Chang Hyun Oh","doi":"10.14245/kjs.2016.13.2.57","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.2.57","url":null,"abstract":"<p><strong>Objective: </strong>Spinal fusion operation is an effective treatment in the spinal pathology, but it could change the physiological distribution of load at the instrumented and adjacent segments. This retrospective study compared the radiological and clinical outcomes of patients undergoing lumbar fusion with semirigid rods versus rigid rods system.</p><p><strong>Methods: </strong>Using transpedicular fixation and posterior lumbar interbody fusion at the level of L4/L5, 20 patients were treated with semirigid rods (WavefleX, SR group), and 20 patients with rigid rods (titanium, RR group). Clinical and radiological outcomes were evaluated, including visual analog score for lower back pain and leg pain, Prolo functional and economic scores, statues of implanted instruments, fusion rate, and complications during 24-month follow-up.</p><p><strong>Results: </strong>Clinical scores were significantly improved until postoperative 24-month follow-up as compared with preoperative scores in both groups (p<0.05), with similar levels of improvement observed at the same time points postoperatively between the 2 groups. Prolo economic scores were significantly improved in SR group compared to RR until 12 months, but this improvement became similar after 18 months. The overall fusion rate was 94.1% until the 24-month follow-up for both groups. No significant complication was observed in both groups.</p><p><strong>Conclusion: </strong>The results of the present study indicate that semirigid rods system with posterior lumbar interbody fusion showed similar clinical and radiological result with rigid rods system until 2 years after instrumentation. The WavefleX rods system, as a semirigid rods with unique characteristics, may be an effective alternative treatment for patients in lumbar fusion.</p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 2","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14245/kjs.2016.13.2.57","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34587529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-03-01Epub Date: 2016-03-31DOI: 10.14245/kjs.2016.13.1.37
Ali Fahir Ozer, Tuncer Suzer, Mehdi Sasani, Tunc Oktenoglu, Emrah Egemen
{"title":"Enlargement of Neural Foramina and Dynamic Stabilization in Spondylolisthesis without Restoring the Alignment: Technical Note.","authors":"Ali Fahir Ozer, Tuncer Suzer, Mehdi Sasani, Tunc Oktenoglu, Emrah Egemen","doi":"10.14245/kjs.2016.13.1.37","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.1.37","url":null,"abstract":"<p><p>It is well known that the cause of radiculopathy is the compression of the nerve root within the foramina which is narrowed secondary to sliding of the corpus and reduced disc height. In some patients, unroofing the foramen does not resolve this problem. We described a new decompression technique using pedicle removal and transpedicular dynamic instrumentation to stabilization the spine. We performed this operation in 2 patients and achieved very good results. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 1","pages":"37-9"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/d6/kjs-13-37.PMC4844660.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34498583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-03-01Epub Date: 2016-03-31DOI: 10.14245/kjs.2016.13.1.24
Young Il Won, Chi Heon Kim, Chun Kee Chung, Tae-Ahn Jahng, Sung Bae Park
{"title":"The Use Fibrin Sealant after Spinal Intradural Tumor Surgery: Is It Necessary?","authors":"Young Il Won, Chi Heon Kim, Chun Kee Chung, Tae-Ahn Jahng, Sung Bae Park","doi":"10.14245/kjs.2016.13.1.24","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.1.24","url":null,"abstract":"<p><strong>Objective: </strong>A fibrin sealant is commonly applied after closure of an incidental or intended durotomy to reduce the complications associated with the leakage of cerebrospinal fluid. Routine usage might not be essential after closure of an intended durotomy, which has clear cut-margins. We investigated the efficacy of fibrin sealants for primary intradural spinal cord tumor surgery.</p><p><strong>Methods: </strong>A retrospective review was performed for 231 consecutive surgically treated patients with primary intradural spinal cord tumors without extradural extension. Fibrin sealants were not used for 47 patients (group I: age, 51.57±16.75 years) and were applied to 184 patients (group II: age, 48.8±14.7 years). The surgical procedures were identical except for the use of a fibrin sealant after closure of the durotomy. The primary outcome was the occurrence of complications (wound problems, hematoma collection, infection, and neurological deterioration). The covariates were age, sex, body mass index, operation time, pre-/postoperative ambulation, number of laminectomies, and type of tumor.</p><p><strong>Results: </strong>Schwannoma was the most common pathology (n=134), followed by meningioma (n=35) and ependymoma (n=31). Complications occurred in 13 patients (3 in group I and 10 in group II, p=0.73). The postoperative ambulation status (p<0.01; odds ratio, 28.8; 95% confidence interval, 6.9-120.0) and operation time (p=0.04; cutoff, 229 minutes; sensitivity, 62%; specificity, 72%) were significant factors, whereas the use of a fibrin glue was not (p=0.47).</p><p><strong>Conclusion: </strong>The use of a fibrin sealant might not be essential to reduce complications after surgery for primary spinal intradural tumor.</p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 1","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14245/kjs.2016.13.1.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34498580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-03-01Epub Date: 2016-03-31DOI: 10.14245/kjs.2016.13.1.20
Ho Seok Choi, Sang Gu Lee, Woo Kyung Kim, Seong Son, Tae Seok Jeong
{"title":"Is Surgical Drain Useful for Lumbar Disc Surgery?","authors":"Ho Seok Choi, Sang Gu Lee, Woo Kyung Kim, Seong Son, Tae Seok Jeong","doi":"10.14245/kjs.2016.13.1.20","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.1.20","url":null,"abstract":"<p><strong>Objective: </strong>Surgical drains are commonly used after the spine surgeries for minimizing hematoma formation, which can delay wound healing and may become a source of fibrosis, infection, and pain. The drain, however, may provide a direct route for infection if it is contaminated. Our objective was to survey the relationship between surgical drains and infection.</p><p><strong>Methods: </strong>The 70 patients who had undergone single-level lumbar discectomy from April 2011 to March 2012 were retrospectively analyzed. Each patient's medical chart and magnetic resonance image were thoroughly reviewed after all the patients had been divided into the drainage and the nondrainage groups. The amounts and durations of the surgical drains in the drainage group were analyzed. Additionally, the levels of C-reactive protein, rates of infection, scores of preoperative and postoperative visual analog scale (VAS), and lengths of hospital stay after operation were compared between the 2 groups.</p><p><strong>Results: </strong>In this study, 70 patients were retrospectively analyzed; out of which, 42 and 28 patients were included in the drainage and the nondrainage groups, respectively. Two of the postoperative infection cases in the nondrainage group required to undergo repeated operations. The frequency of the postoperative infection cases was higher in the nondrainage group than in the drainage group; however, there was no significant statistical difference between the 2 groups (p=0.157).</p><p><strong>Conclusion: </strong>Surgical drains did not elevate postoperative infection. Furthermore, drain tip cultures allowed us to detect postoperative infection at an early stage, and it led to faster initiation of antibiotics treatment.</p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 1","pages":"20-3"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/b0/kjs-13-20.PMC4844656.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34498579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-03-01Epub Date: 2016-03-31DOI: 10.14245/kjs.2016.13.1.33
Ulaş Yener, Mustafa Güdük, Murat Şakir Ekşi, Murat Hamit Aytar, Aydın Sav, Serdar Özgen
{"title":"Concomitant Double Tumors of Myxopapillary Ependymoma Presented at Cauda Equina-Filum Terminale in Adult Patient.","authors":"Ulaş Yener, Mustafa Güdük, Murat Şakir Ekşi, Murat Hamit Aytar, Aydın Sav, Serdar Özgen","doi":"10.14245/kjs.2016.13.1.33","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.1.33","url":null,"abstract":"<p><p>A 32-year-old man presented with gradually increasing bilateral buttock pain. He had intermittent claudication. Multiple, homogenously enhanced intradural extramedullary lesions at L2-L3 and L5-S1 levels were observed on magnetic resonance imaging. The tumors were debulked and were removed in piecemeal pattern until they had completely been resected. Histopathological examination of the surgical specimens confirmed that both tumors were myxopapillary ependymomas (MPE). MPE presenting as concomitant double tumor at conus-cauda-filum level are very rare. This kind of presentation could not be directly considered as dissemination, since both tumors were in the site of classical origin of MPE. Ten cases of double spinal MPEs have been reported to date. Including the present case, analysis of the 11 patients revealed some facts. There is a male predominance, which is opposite to the ependymomas that are commonly observed in females. Median age at presentation is 15 years. Most pronounced symptom is low back pain that sometimes radiates to lower extremities. Surgical approach was aimed in all tumors, which could be succeeded in all tumors except one. Adjuvant radiation therapy was applied in 5 patients. No recurrences have been reported after surgery or surgery + radiotherapy regimens. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 1","pages":"33-6"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/68/kjs-13-33.PMC4844659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34498582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korean Journal of SpinePub Date : 2016-03-01Epub Date: 2016-03-31DOI: 10.14245/kjs.2016.13.1.30
Young-Seop Park, Seung-Jae Hyun, Ki-Jeong Kim, Tae-Ahn Jahng
{"title":"Multiple Intradural Disc Herniations Masquerading as Intradural Extramedullary Tumors: A Case Report and Review of the Literature.","authors":"Young-Seop Park, Seung-Jae Hyun, Ki-Jeong Kim, Tae-Ahn Jahng","doi":"10.14245/kjs.2016.13.1.30","DOIUrl":"https://doi.org/10.14245/kjs.2016.13.1.30","url":null,"abstract":"<p><p>Intradural disc herniation is a very rare condition, and multiple intradural disc herniations have not been reported to date. The latter may be confused with intradural extramedullary (IDEM) spinal tumors. Here, we report a case of multiple intradural disc herniations masquerading as multiple IDEM tumors and review the relevant literature. We retrospectively reviewed the patient's medical chart, reviewed the intraoperative microscopic findings, and reviewed of PubMed articles on intradural disc herniation. The masses considered to be IDEM tumors were confirmed to be multiple intradural disc herniations. A nonenhancing mass was found to have migrated along the intra-arachnoid space. Two enhancing masses could not migrate because of adhesion and showed peripheral neovascularization. We report an extremely rare case of multiple intradural lumbar disc herniations showing diverse enhancing patterns and masquerading as multiple IDEM tumors. In case of multiple enhancing IDEM masses suspected preoperatively, surgeons should consider the possibility of intradural disc herniation. </p>","PeriodicalId":17867,"journal":{"name":"Korean Journal of Spine","volume":"13 1","pages":"30-2"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/f0/kjs-13-30.PMC4844658.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34498581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}