Korean Journal of Anesthesiology最新文献

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Current evidence on the use of sugammadex for neuromuscular blockade antagonism during electroconvulsive therapy: a narrative review. 在电休克治疗中使用苏加麦司拮抗神经肌肉阻滞的现有证据--叙述性综述。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-10-07 DOI: 10.4097/kja.24234
Vivek Arora, Laurence Henson, Sandeep Kataria
{"title":"Current evidence on the use of sugammadex for neuromuscular blockade antagonism during electroconvulsive therapy: a narrative review.","authors":"Vivek Arora, Laurence Henson, Sandeep Kataria","doi":"10.4097/kja.24234","DOIUrl":"10.4097/kja.24234","url":null,"abstract":"<p><p>Depression is a common mental health problem that is associated with significant disability and mortality. Electroconvulsive therapy (ECT) has been demonstrated to be effective at resolving expression of suicidal intent in patients with depression. In less acute situations, patients are usually referred for ECT after several medication trials. Neuromuscular blocking agents (NMBAs) are used to block tonic-clonic motor activity and associated physical harm during the delivery of ECT. Succinylcholine (Sch), with its rapid onset of muscle relaxation, short self-terminating duration of action, and rapid subsequent return of spontaneous ventilation, is the NMBA of choice for ECT. However, the use of Sch is problematic or contraindicated is some situations. Although non-depolarizing NMBAs can be used, the variable time to onset of adequate muscle relaxation and prolonged duration of action have limited their widespread acceptance as alternatives to Sch. Recently, however, with the widespread availability of sugammadex, a chemically modified γ-cyclodextrin that rapidly and predictably reverses the effect of non-depolarizing NMBAs, the muscle relaxation achieved by rocuronium can predictably and effectively be reversed. In situations where Sch is contraindicated or otherwise problematic, rocuronium, followed by pharmacological antagonism with sugammadex, can provide a safe and effective muscle relaxation approach comparable to that of Sch in terms of duration of action. This review provides a summary of the current state of evidence for the use of sugammadex during ECT, which should lend support to further acceptance and future studies of sugammadex in the context of ECT.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"3-15"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study". 关于 "经导管主动脉瓣置换术后在监测麻醉护理下瑞马唑仑与右美托咪定对恢复的影响:倾向得分匹配、非劣效性研究 "的评论
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.4097/kja.24716
Jo-Hsin Wu, Hui-Zen Hee, Cheng-Wei Lu
{"title":"Comment on \"Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study\".","authors":"Jo-Hsin Wu, Hui-Zen Hee, Cheng-Wei Lu","doi":"10.4097/kja.24716","DOIUrl":"10.4097/kja.24716","url":null,"abstract":"","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"86-87"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlled hypotension under rapid ventricular pacing technique in patients with cerebral arteriovenous malformation -a case report. 脑动静脉畸形患者在快速心室起搏技术下的可控性低血压:病例报告。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-10-28 DOI: 10.4097/kja.24508
Zijian Zhao, Hang Wang, Xinxu Min, Zheng Li, Feng Feng
{"title":"Controlled hypotension under rapid ventricular pacing technique in patients with cerebral arteriovenous malformation -a case report.","authors":"Zijian Zhao, Hang Wang, Xinxu Min, Zheng Li, Feng Feng","doi":"10.4097/kja.24508","DOIUrl":"10.4097/kja.24508","url":null,"abstract":"<p><strong>Background: </strong>The transvenous approach to the treatment of cerebral arteriovenous malformation (AVM) is difficult and requires strict blood pressure and blood flow control; however, the cure rate is very high. Appropriate blood pressure control techniques can greatly benefit these patients.</p><p><strong>Case: </strong>A 55-year-old male patient was found to have an aneurysm complicated with a cerebral AVM (length: 2.0 cm, width: 1.6 cm, height: 1.2 cm). Aneurysm embolization was considered for the first-stage surgery and transvenous AVM embolization for the second-stage surgery. Rapid ventricular pacing (RVP) provided a stable blood flow environment for the surgery, which was completed successfully.</p><p><strong>Conclusions: </strong>RVP can thus provide an ideal condition for the embolization of cerebral AVM through the transvenous approach and can be a viable surgical option.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"79-84"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of high-flow nasal oxygenation and standard low-flow nasal oxygenation during rigid bronchoscopy: a randomized controlled trial. 刚性支气管镜检查时高流量鼻氧合与标准低流量鼻氧合的比较:一项随机对照试验。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI: 10.4097/kja.24517
Hye Jin Kim, Chang Young Lee, Kyuho Lee, Namo Kim, Seungyeon Lee, Young Jun Oh
{"title":"Comparison of high-flow nasal oxygenation and standard low-flow nasal oxygenation during rigid bronchoscopy: a randomized controlled trial.","authors":"Hye Jin Kim, Chang Young Lee, Kyuho Lee, Namo Kim, Seungyeon Lee, Young Jun Oh","doi":"10.4097/kja.24517","DOIUrl":"10.4097/kja.24517","url":null,"abstract":"<p><strong>Background: </strong>The efficacy of high-flow nasal oxygenation (HFNO) in improving oxygenation is influenced by several factors, and its effectiveness is not always guaranteed. Therefore, we aimed to compare the effects of HFNO and standard low-flow nasal oxygenation during rigid bronchoscopy in the apneic patients.</p><p><strong>Methods: </strong>All patients were administered general anesthesia with full muscle relaxation and were randomly assigned to receive either HFNO (HFNO group) or standard low-flow oxygenation (Standard group). The study endpoints included the lowest peripheral oxygen saturation (SpO2), hypoxemia-related surgical interruptions (SpO2 ≤ 94%), and changes in arterial oxygen tension (PaO2) and carbon dioxide tension (PaCO2) during the apnea period for rigid bronchoscopy.</p><p><strong>Results: </strong>A total of 53 patients completed the study. No significant differences were found between the HFNO and the Standard groups in the lowest SpO2 levels (median [Q1, Q3]; 99 [98, 100]% vs. 98 [94, 100]%, P = 0.059) and in the increase rate of PaCO2 (mean ± standard deviation [SD]; 1.6 ± 0.7 mmHg/min vs. 2.0 ± 0.8 mmHg/min, P = 0.064). However, the HFNO group had fewer patients with hypoxemia-related surgical interruptions than the Standard group (1 [3.8%] vs. 8 [29.6%], P = 0.024) and exhibited an attenuated decline rate in PaO2 (median [Q1, Q3]: 4.6 [0.0, 7.9] mmHg/min vs. 10.5 [6.4, 12.9] mmHg/min, P = 0.005).</p><p><strong>Conclusions: </strong>While HFNO did not enhance the lowest SpO2 levels in comparison with standard low-flow oxygenation, it did reduce hypoxemia-related surgical interruptions with an attenuated decline in PaO2. Therefore, HFNO has considerable clinical efficacy for rigid bronchoscopy.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"39-47"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcatheter ventilation with a modified Rapid-O2 oxygen insufflation device. 使用改良的 Rapid-O2 氧气充气装置进行经导管通气。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-09-27 DOI: 10.4097/kja.24095
Jaewon Jang, Hye Jin Kim, Hyun Joo Kim, Wyun Kon Park
{"title":"Transcatheter ventilation with a modified Rapid-O2 oxygen insufflation device.","authors":"Jaewon Jang, Hye Jin Kim, Hyun Joo Kim, Wyun Kon Park","doi":"10.4097/kja.24095","DOIUrl":"10.4097/kja.24095","url":null,"abstract":"<p><strong>Background: </strong>The Rapid-O2 oxygen insufflation device® (Rapid-O2) was designed primarily for rescue oxygenation in cannot intubate, cannot oxygenate (CICO) events; thus, hypercapnia is inevitable. Rapid-O2 was modified to enhance ventilation using the Venturi effect during expiration.</p><p><strong>Methods: </strong>To determine the most effective combination of inner catheters (20 gauge [G], 18 G, 16 G, 14 G, and 2-mm inner diameter [ID] transtracheal catheter [TTC]) and insufflation catheters (16 G, 14 G, and 2-mm ID TTC) for achieving optimum ventilation, insufflating and expiratory flows were measured at an oxygen flow rate of 15 L/min. The insufflating and expiratory pressures were measured at 6-15 L/min. The flows and pressures were measured using a gas flow analyzer. The insufflating and expiratory times were measured using a trachea-lung model to obtain minute volumes. To assess the improvement by modifying the Rapid-O2, minute volumes were measured using the Rapid-O2.</p><p><strong>Results: </strong>The most appropriate inner catheter was 18 G. The insufflating pressures ranged from 97 (2-mm ID TTC) to 377 cmH2O (16 G) at 15 L/min. During expiration, similar negative pressures of 50 cmH2O were measured in the insufflation catheters at 15 L/min. At lung compliance of 100 ml/cmH2O, the minute volumes through a 2-mm ID and 14 G insufflation catheters were 7.0 and 5.37 L/min, respectively, at 15 L/min. The minute volumes were significantly greater in modified Rapid-O2.</p><p><strong>Conclusions: </strong>Modified Rapid-O2 provided sufficient minute volumes in adults using a 14 G or 2-mm ID insufflation catheter at 15 L/min, demonstrating its potential for ventilation in CICO events.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"61-72"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study". 评论"经导管主动脉瓣置换术后在监测麻醉护理下使用雷马唑仑与右美托咪定对恢复的影响:倾向得分匹配、非劣效性研究"。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.4097/kja.24684
Raghuraman M Sethuraman, Pranjali Kurhekar
{"title":"Comment on \"Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study\".","authors":"Raghuraman M Sethuraman, Pranjali Kurhekar","doi":"10.4097/kja.24684","DOIUrl":"10.4097/kja.24684","url":null,"abstract":"","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"85"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A discussion of anesthesiologically relevant aspects of Klinefelter syndrome -a case report. Klinefelter 综合征的麻醉学相关性--基于病例报告的讨论。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.4097/kja.24486
Christine Gaik, Katharina Politt
{"title":"A discussion of anesthesiologically relevant aspects of Klinefelter syndrome -a case report.","authors":"Christine Gaik, Katharina Politt","doi":"10.4097/kja.24486","DOIUrl":"10.4097/kja.24486","url":null,"abstract":"<p><strong>Background: </strong>Klinefelter syndrome (KS), usually the 47,XXY karyotype, is the most common sex chromosome anomaly in males. However, many cases remain undiagnosed because the clinical presentation is highly variable and physicians are not sufficiently trained to assess for this condition. To the best of our knowledge, only three detailed reports on anesthesia in patients with KS are currently available.</p><p><strong>Case: </strong>We report the case of a 74-year-old male with KS who underwent ureterorenoscopy under general anesthesia. Despite the characteristic clinical presentation of KS and its typical sequelae, the course of anesthesia was unremarkable.</p><p><strong>Conclusions: </strong>Despite the unremarkable anesthetic course in our case, anesthetists should be aware of the potential for a difficult airway and cardiovascular and other complications associated with this syndrome. During preoperative examination, attention should be paid to common secondary manifestations of KS to avoid perioperative complications.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"73-78"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to "Comment on Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study". 对 "关于经导管主动脉瓣置换术后在监测麻醉护理下使用雷马唑仑与右美托咪定对恢复的影响:倾向得分匹配、非劣效性研究 "的回复。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.4097/kja.24739
Ji-Hyeon Kim, Jae-Sik Nam
{"title":"Response to \"Comment on Effects of remimazolam versus dexmedetomidine on recovery after transcatheter aortic valve replacement under monitored anesthesia care: a propensity score-matched, non-inferiority study\".","authors":"Ji-Hyeon Kim, Jae-Sik Nam","doi":"10.4097/kja.24739","DOIUrl":"10.4097/kja.24739","url":null,"abstract":"","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"85-86"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Costoclavicular block as a diaphragm-sparing nerve block for shoulder surgery: a randomized controlled trial. 肩关节手术中肋锁骨阻滞作为膈保留神经阻滞:一项随机对照试验。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI: 10.4097/kja.24595
Youngin Lee, Seunguk Bang, Jihyun Chung, Min Suk Chae, Jungwon Shin
{"title":"Costoclavicular block as a diaphragm-sparing nerve block for shoulder surgery: a randomized controlled trial.","authors":"Youngin Lee, Seunguk Bang, Jihyun Chung, Min Suk Chae, Jungwon Shin","doi":"10.4097/kja.24595","DOIUrl":"10.4097/kja.24595","url":null,"abstract":"<p><strong>Background: </strong>Distal nerve block approaches have been explored to reduce hemidiaphragmatic paresis (HDP) more effectively than interscalene block (ISB). However, these approaches are associated with a high incidence of HDP. The costoclavicular block (CCB) provides effective analgesia while reducing HDP. Here, we hypothesized that CCB would decrease the incidence of HDP compared to ISB while still providing effective pain relief after surgery.</p><p><strong>Methods: </strong>Seventy patients who underwent arthroscopic rotator cuff repair were randomly allocated to receive either ultrasound-guided CCB (n = 35) or ISB (n = 35). Each group received 0.2% ropivacaine (20 ml CCB, 10 ml ISB). The primary outcome was the incidence of HDP, as measured using M-mode ultrasound. Diaphragmatic excursion, pulmonary function test results, opioid consumption, and pain scores were evaluated.</p><p><strong>Results: </strong>Sixty-six patients were included. CCB group had a significantly lower incidence of HDP than those in the ISB group (5.9% vs. 84.4%, P < 0.001). The diaphragmatic excursion reduction was significantly more in the ISB (3.87 cm) group than in the CCB (0.25 cm) group (P < 0.001). The decrease in forced vital capacity and forced expiratory volume in 1 s from baseline was significantly greater in the ISB. There was no significant difference in opioid consumption between the two groups during the entire postoperative period.</p><p><strong>Conclusions: </strong>Compared with ISB, CCB significantly reduced the incidence of HDP while maintaining effective analgesia and causing less pulmonary function impairment. CCB may be a viable option for diaphragmatic-sparing analgesia after shoulder surgery.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"30-38"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the safety and efficacy of remimazolam-based total intravenous anesthesia versus volatile agent-based anesthesia: a meta-analysis of randomized controlled trials. 比较雷马唑仑全静脉麻醉与挥发性药物麻醉的安全性和有效性:一项随机对照试验的荟萃分析。
IF 4.2 4区 医学
Korean Journal of Anesthesiology Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI: 10.4097/kja.24444
Ji-In Park, Hyo-Seok Na, Keum-O Lee, Jung-Hee Ryu, Hyun-Jung Shin
{"title":"Comparing the safety and efficacy of remimazolam-based total intravenous anesthesia versus volatile agent-based anesthesia: a meta-analysis of randomized controlled trials.","authors":"Ji-In Park, Hyo-Seok Na, Keum-O Lee, Jung-Hee Ryu, Hyun-Jung Shin","doi":"10.4097/kja.24444","DOIUrl":"10.4097/kja.24444","url":null,"abstract":"<p><strong>Background: </strong>Remimazolam is a novel short-acting benzodiazepine that has recently been used for general anesthesia. This study compared the safety and efficacy of remimazolam-based total intravenous anesthesia (TIVA) and volatile agent-based anesthesia in adults undergoing general anesthesia.</p><p><strong>Methods: </strong>We searched electronic databases including PubMed, Embase, CENTRAL, and Scopus for relevant studies. The primary outcome was the proportion of patients who experienced hypotension during surgery. Secondary outcomes included incidence of bradycardia, extubation time, duration in the post-anesthesia care unit hospital stay, and incidence of postoperative nausea and/or vomiting (PONV). We estimated the relative risk (RR) and mean difference with 95% CIs using a random-effects model.</p><p><strong>Results: </strong>A total of 969 patients from 12 randomized controlled trials were included. The incidence of hypotension was 14% and 34% in the remimazolam and volatile agent groups, respectively. Remimazolam significantly lowered the incidence of hypotension (RR: 0.43, 95% CI [0.29-0.63], P = 0.0000, I2 = 26%). The remimazolam group had a PONV incidence of 13%, compared to 28% in the volatile agent group, indicating a significant difference (RR: 0.51, 95% CI [0.37-0.72], P = 0.0001, I2 = 15%). No significant differences were observed in the other outcomes.</p><p><strong>Conclusions: </strong>Remimazolam-based TIVA demonstrated favorable hemodynamic effects, with a lower incidence of hypotension and similar bradycardia rates, compared to volatile agent-based anesthesia. Furthermore, the reduction in PONV supports the use of remimazolam-based TIVA as a valuable method for general anesthesia.</p>","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"48-60"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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