Korean Journal of Anesthesiology最新文献

Can painkillers quiet the bladder? Acetaminophen/ibuprofen and catheter-related bladder discomfort. 止痛药能使膀胱平静吗？对乙酰氨基酚/布洛芬和导尿管相关性膀胱不适。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-16 DOI: 10.4097/kja.261191

Ki Tae Jung

引用次数: 0

Anticholinergic rescue and quality-of-recovery data consistency in a trial of lidocaine-dexmedetomidine co-administration. 利多卡因-右美托咪定联合给药的抗胆碱能抢救和恢复质量数据一致性试验。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-14 DOI: 10.4097/kja.261120

Mo-Han Lin, Ming-Hui Hung

引用次数: 0

Easy DAO2 index: a novel hemodynamic risk factor for predicting mortality in surgical and critically ill patients. 简易DAO2指数：预测外科和危重病人死亡率的一种新的血流动力学危险因素。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-06-24 DOI: 10.4097/kja.251034

Da-In Eun, Hyeonhoon Lee, Hyung-Chul Lee

{"title":"Easy DAO2 index: a novel hemodynamic risk factor for predicting mortality in surgical and critically ill patients.","authors":"Da-In Eun, Hyeonhoon Lee, Hyung-Chul Lee","doi":"10.4097/kja.251034","DOIUrl":"10.4097/kja.251034","url":null,"abstract":"Background: Measurement of the arterial oxygen delivery index (DAO2I) requires substantial medical resources and invasive procedures. We proposed a novel hemodynamic parameter reflecting DAO2I, the Easy DAO2 index (EDI), and examined its association with mortality in non-cardiac surgical and critically ill patients.Methods: We retrospectively analyzed the data of 95,115 surgical cases from an Asian hospital and 90,420 intensive care unit (ICU) admissions from multicenter hospitals in the United States. EDI was the product of pulse pressure, heart rate, hemoglobin, and peripheral oxygen saturation, divided by body surface area, measured every 5 minutes during anesthesia and hourly for 24 hours post-ICU admission. We assessed the association between 7-day in-hospital mortality and duration of exposure to EDI values below the fifth percentile levels.Results: In non-cardiac surgical patients, mortality risk increased with duration of exposure below the low EDI threshold (adjusted odds ratio [aOR] 1.003 per minute; 95% CI [1.000-1.005]). In critically ill patients, mortality risk increased with duration of exposure below the low EDI threshold (aOR 1.014 per hour; 95% CI [1.004-1.023]).Conclusions: Low EDI values were independently associated with mortality in non-cardiac surgical and critically ill patients, suggesting that EDI may be a useful hemodynamic parameter for risk assessment.","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"525-533"},"PeriodicalIF":4.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between preoperative serum amyloid A levels and postoperative delirium in older adults undergoing hip surgery: a retrospective study. 老年髋关节手术患者术前血清淀粉样蛋白A水平与术后谵妄的关系：一项回顾性研究。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2025-09-23 DOI: 10.4097/kja.25523

Hyun-Jung Shin, Bon-Wook Koo, Hyo-Seok Na

{"title":"Association between preoperative serum amyloid A levels and postoperative delirium in older adults undergoing hip surgery: a retrospective study.","authors":"Hyun-Jung Shin, Bon-Wook Koo, Hyo-Seok Na","doi":"10.4097/kja.25523","DOIUrl":"10.4097/kja.25523","url":null,"abstract":"Background: Postoperative delirium (POD) is a common and serious complication in older adults. Prior studies have validated serum amyloid A (SAA) as a potential biomarker for various inflammatory conditions; however, its role in POD is poorly characterized. This study aimed to examine the association between preoperative SAA levels and the occurrence of POD.Methods: This study comprised a retrospective review of the electronic medical records of patients aged 60 and older who underwent hip surgery between April 2022 and January 2024. Cognitive function was assessed using the Nursing Delirium Screening Scale, while diagnosis was confirmed by psychiatrists using the Confusion Assessment Method. The associations between POD occurrence and preoperative SAA levels and other patient, anesthesia, and surgical factors were analyzed using logistic regression models.Results: Of 731 patients, delirium occurred in 121 patients (16.6%) within the first five postoperative days (five-day POD). Preoperative SAA levels were significantly higher in the POD group (96.6 mg/L) than the non-POD group (6.6 mg/L) (P < 0.001). Logistic regression showed that preoperative SAA levels were independently associated with POD occurrence (odds ratio [OR] = 1.004, 95% CI [1.002‒1.007], P < 0.001). Age (P < 0.001) and preoperative albumin levels (P = 0.008) were also identified as significant factors influencing POD risk.Conclusions: Elevated preoperative SAA levels were associated with an increased risk of five-day POD in older adults undergoing hip surgery. Further research is required to explore the clinical utility of SAA as a biomarker for identifying patients at risk of POD.","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"534-541"},"PeriodicalIF":4.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "The effect of perioperative ketamine and esketamine administration on postoperative nausea and vomiting in patients undergoing general anesthesia: a systematic review and meta-analysis". 《围手术期氯胺酮和艾氯胺酮对全身麻醉患者术后恶心呕吐的影响：一项系统综述和荟萃分析》评论。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-07-30 DOI: 10.4097/kja.26379

Abhijit Sukumaran Nair, Tuhin Mistry

引用次数: 0

Preoperative serum amyloid A: a practical window into neuroinflammatory vulnerability for postoperative delirium. 术前血清淀粉样蛋白A：术后谵妄神经炎症易感性的实用窗口。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-09-02 DOI: 10.4097/kja.26744

Jae Hoon Lee

引用次数: 0

Blamed but not at fault: anti-obesity medication adverse effects misidentified as perioperative complications - a comprehensive review and medicolegal warning for anesthesiologists. 被指责但没有过错：抗肥胖药物的副作用被误认为是围手术期并发症——对麻醉师的全面审查和医学法律警告。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-09-30 DOI: 10.4097/kja.26375.e1

Hyun Jeong Kwak, Jung Ju Choi, Dongchul Lee, Youn Yi Jo

引用次数: 0

From association to causation: interpreting PS-based analyses in real-world evidence. 从关联到因果关系：在现实世界证据中解释基于倾向得分的分析。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.4097/kja.26332

Eunjin Ahn, Sang Gyu Kwak

{"title":"From association to causation: interpreting PS-based analyses in real-world evidence.","authors":"Eunjin Ahn, Sang Gyu Kwak","doi":"10.4097/kja.26332","DOIUrl":"10.4097/kja.26332","url":null,"abstract":"Propensity score (PS) methods are widely used in real-world evidence studies to reduce confounding and to approximate randomized comparisons. However, statistical adjustment is often misinterpreted as evidence of causality, leading to overgeneralization and inappropriate clinical conclusions. In this statistical round, we present a clinically oriented framework for interpreting PS-based analyses, focusing on key principles of causal inference, including the definition of the estimand (average treatment effect [ATE] vs. average treatment effect on the treated [ATT]), covariate selection based on causal structure, assessment of positivity and overlap, and evaluation of robustness to unmeasured confounders. Using recent anesthesiology studies, we demonstrate that discrepancies between the analytical methods and interpretations are common. PS matching typically estimates the ATT and may not be generalizable to the entire population, whereas inverse probability of treatment weighting aims to estimate the ATE but may yield unstable estimates in the presence of limited overlap. Even with well-balanced covariates, unmeasured confounders remain a critical limitation. Failure to account for these issues may lead to biased estimates and overinterpretation of observational associations as causal effects. Causal interpretations of PS-based analyses require an alignment among the target estimand, underlying assumptions, and analytical methods. Rather than relying solely on statistical adjustment, researchers and clinicians should critically evaluate overlap, confounders, and generalizability. Transitioning from association to causation requires both advanced statistical methods and rigorous and transparent interpretations grounded in causal reasoning.","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"516-524"},"PeriodicalIF":4.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino acids for renal protection: time to implement in clinical practice. 氨基酸对肾脏的保护：临床应用的时机。

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-06-24 DOI: 10.4097/kja.26273

Giovanni Landoni, Rosario Losiggio, Alessandro Belletti, Alberto Zangrillo

{"title":"Amino acids for renal protection: time to implement in clinical practice.","authors":"Giovanni Landoni, Rosario Losiggio, Alessandro Belletti, Alberto Zangrillo","doi":"10.4097/kja.26273","DOIUrl":"10.4097/kja.26273","url":null,"abstract":"Acute kidney injury (AKI) is a common complication observed in both surgical and critical care settings. The PROTECTION trial, published in the New England Journal of Medicine, showed that short-term low-dose infusions of amino acids (AA) reduced the rate of both any-stage and severe AKI in more than 3,500 cardiac surgery patients. Its publication resulted in the inclusion of AA in the European guidelines for the management of adult cardiac surgery with cardiopulmonary bypass and changes in clinical practice worldwide. This rapid dissemination has raised practical questions regarding patient selection, formulation choice, dosages, and duration of infusion. In this narrative review, we used the \"Wh-questions\" framework to provide a clear and structured overview on perioperative AA administration. We outline the historical background of AA-mediated renal protection, the pathophysiological context, and the available AA formulations most commonly used in clinical studies. In addition to the conclusive evidence in cardiac surgery, data supporting potential benefits in other high-risk populations, including urological surgery patients and those receiving temporary mechanical circulatory support, are growing. Importantly, recent insights suggest that clinicians must not exceed a 48-hour infusion. Finally, a reduction in hospitalization costs associated with AA infusions has been demonstrated by a recent health economic analysis. Overall, AA infusions represent a simple, safe, and inexpensive intervention that is effective at reducing AKI. These data further support their immediate adoption in routine clinical practice.","PeriodicalId":17855,"journal":{"name":"Korean Journal of Anesthesiology","volume":" ","pages":"488-496"},"PeriodicalIF":4.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond blood pressure: can the Easy DAO2 index bring oxygen delivery to the bedside? 超越血压：简易DAO2指数能将氧气输送到床边吗？

IF 4 4区医学

Korean Journal of Anesthesiology Pub Date : 2026-10-01 Epub Date: 2026-09-09 DOI: 10.4097/kja.261029

Jong Wook Song

引用次数: 0