ILD/DPLD of known origin最新文献_第4页

Transbronchial Cryobiopsy Validity in Diagnosing Indefinite Usual Interstitial Pneumonia in High Resolution Computed Tomography in Egyptian Population 埃及人群高分辨率计算机断层扫描经支气管冷冻活检诊断不确定间质性肺炎的有效性

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4729

H. Shafiek, S. Elbialy, Samar Elachy, A. Gad

{"title":"Transbronchial Cryobiopsy Validity in Diagnosing Indefinite Usual Interstitial Pneumonia in High Resolution Computed Tomography in Egyptian Population","authors":"H. Shafiek, S. Elbialy, Samar Elachy, A. Gad","doi":"10.1183/13993003.congress-2019.pa4729","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4729","url":null,"abstract":"Background and Objectives: Histopathology is a key element for the multidisciplinary diagnosis of diffuse parenchymal lung diseases (DPLD). We aimed to evaluate the efficacy, safety and diagnostic utility of bronchoscopic transbronchial cryobiopsy in diagnosing DPLD in Egyptian population and to identify the common DPLD pathologies in them. Methods: A prospective interventional study that enrolled 25 Egyptian patients presented to Main Alexandria University Hospital (Egypt) who had clinical and radiologic features of DPLD, but insufficient elements to achieve definite features of usual interstitial pneumonia (UIP/IPF) in chest high resolution computed tomography (HRCT). Twelve patients were subjected to transbronchial cryobiopsy and 13 patients to TBLB. Results: The diagnostic yield was significantly higher among transbronchial cryobiopsy group (83.3%) that increased to 100% with clinic-pathological correlation vs. TBLB group (38.5%,p= 0.041). Granulomatous diseases (24%; either sarcoidosis or hypersensitivity pneumonitis) were the common pathology followed by malignancy (12%) in both groups. The size of the TBLB was ranging from 1-3 mm vs. 2.5-5 mm in transbronchial cryobiopsy (p Conclusion: Transbronchial cryobiopsy is a safe tolerable procedure with high diagnostic yield for evaluating DPLD with indefinite UIP/IPF in HRCT.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133448338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Combined Rheumatology/ILD Service. The Wolverhampton Experience 风湿病/ILD联合服务。伍尔弗汉普顿体验

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4738

A. Zahid, P. Chohan, T. Sheeran, A. Fahim

{"title":"A Combined Rheumatology/ILD Service. The Wolverhampton Experience","authors":"A. Zahid, P. Chohan, T. Sheeran, A. Fahim","doi":"10.1183/13993003.congress-2019.pa4738","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4738","url":null,"abstract":"Introduction: Interstitial lung diseases (ILD), in the context of rheumatological disorders, present difficult diagnostic and management challenges.A combined rheumatology-ILD service has a potential to improve clinical outcomes in CTD-ILD. New Cross Hospital, a large district general hospital commenced providing this service in 2014 and we present an audit data over a 2 year period. Aims: To assess the effectiveness of combine rheumatology/ILD service at New Cross Hospital. Methods: A retrospective analysis of CTD-ILD clinic data over 2 years (January 2014- December 2015) was carried out. 78 patients, with known CTD, seen by both rheumatology and respiratory consultants in a combined clinical setting. All patients had proven pulmonary fibrosis on HRCT Chest. Results: Of the 78 patients, 10 patients (12%) had change in the diagnosis after clinic review. All patients (100%) had full lung functions after their first combined clinic review. Twenty five patients (32%) had a change in their management, (5 were treated with IV cyclophosphamide, 19 had an increase in prednisolone dosage while one patient received rituximab). No patient was felt to be a suitable candidate for lung transplantation. All patients had a transthoracic echocardiogram requested at their first clinic appointment to screen for pulmonary hypertension. Conclusions: Combined Rheumatology/ILD service reduces number of outpatient clinic appointments for patients with CTD-ILD. Moreover, it alters clinical management in a significant proportion of patients, improving diagnostic accuracy and clinical therapeutics.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121825168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health-related quality of life in children interstitial lung disease 儿童间质性肺病的健康相关生活质量

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5184

N. Nathan, Clara Lauby, R. A. Taam, K. Bessaci, J. Brouard, M. Dalphin, C. Delacourt, C. Delestrain, A. Deschildre, J. Dubus, M. Fayon, L. Giovannini-Chami, V. Houdouin, A. Houzel, C. Marguet, I. Pin, P. Reix, M. Renoux, C. Schweitzer, A. Tatopoulos, C. Thumerelle, F. Troussier, S. Wanin, L. Weiss, A. Clément, P. Böelle, R. Epaud

{"title":"Health-related quality of life in children interstitial lung disease","authors":"N. Nathan, Clara Lauby, R. A. Taam, K. Bessaci, J. Brouard, M. Dalphin, C. Delacourt, C. Delestrain, A. Deschildre, J. Dubus, M. Fayon, L. Giovannini-Chami, V. Houdouin, A. Houzel, C. Marguet, I. Pin, P. Reix, M. Renoux, C. Schweitzer, A. Tatopoulos, C. Thumerelle, F. Troussier, S. Wanin, L. Weiss, A. Clément, P. Böelle, R. Epaud","doi":"10.1183/13993003.congress-2019.pa5184","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5184","url":null,"abstract":"Introduction: Health-related quality of life (HR-QoL) is an understudied area in rare diseases. Interstitial lung diseases in children (chILD) are heterogeneous disorders that are associated with a high morbidity and mortality. The impaired lung function, the nutritional impact and the burden of the treatments can impair the HR-QoL of these children. The aim of this study was to compare the HR-QoL in chILD to an aged-matched healthy population and to identify the factors that were associated to an altered QoL. Methods: Patients were recruited in the French RespiRare network. Patients with chILD of all causes, aged 1 month to 18 years were prospectively included. The children over 8 years old and the 2 parents of all children were asked to complete the PedsQLTM 4.0 Generic Core Scale (0 to 100 points). Results: A total of 78 children were included in the RespiRare centres. Total mean scores appeared to be significantly reduced in child self-report and in parent proxy-report (11.94 points (p=0.0003) and 14.08 points (p Conclusion: The study shows that HR-QoL is significantly impaired in chILD compared to a healthy population, using a validated generic QoL scale. Factors altering QoL score are easy to recognize and could help identify children at a heightened risk of low QoL. A longitudinal follow-up of HR-QoL in chILD is necessary to follow the impact of the disease and the treatments. To better appreciate chILD QoL, a specific scale is currently under study by the chILD-EU group.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121421695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease course and outcome of progressive interstitial lung disease in systemic sclerosis 系统性硬化症患者进行性间质性肺病的病程和预后

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa3598

A. Hoffmann-Vold, Y. Allanore, M. Alves, N. Graf, P. Airó, L. Ananyeva, L. Czirják, S. Guiducci, E. Hachulla, Mengtao Li, C. Mihai, G. Riemekasten, P. Sfikakis, G. Valentini, O. Kowal-Bielecka, O. Distler

引用次数: 3

Prognostic factors in patients with EAA EAA患者预后因素分析

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5190

P. Sojka, M. Sterclova, N. Kaspříková, M. Vašáková

引用次数: 0

Lung involvement in autoimmune liver diseases 自身免疫性肝病的肺部病变

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1374

M. Brovko, M. Kalashnikov, L. Akulkina, V. Sholomova, Alisa Yanakaewa, D. Konovalov, M. Lebedeva, T. Rosina, S. Moiseev

引用次数: 0

Diagnosing Sjogrën’ syndrome in patients with Interstitial Lung Disease by minor salivary gland biopsy 小涎腺活检诊断间质性肺病患者Sjogrën综合征

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1368

Paloma Millán Billi, I. Castellví, Silvia Barril Farre, H. Park, Laura Martinez Martinez, L. Vilaro, Tomás Fraquet Casas, Francisco Aparicio, O. S. Vidal, H. Corominas, D. C. Villegas

引用次数: 0

Introduction of a new approach to interpret pulmonary function tests (PFT) based on Machine learning and Game theory 介绍一种基于机器学习和博弈论的新方法来解释肺功能测试(PFT)

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4726

N. Le-Dong, T. Hua-Huy, M. Topalovic, A. Dinh-Xuan

{"title":"Introduction of a new approach to interpret pulmonary function tests (PFT) based on Machine learning and Game theory","authors":"N. Le-Dong, T. Hua-Huy, M. Topalovic, A. Dinh-Xuan","doi":"10.1183/13993003.congress-2019.pa4726","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4726","url":null,"abstract":"Objective: We introduce a new interpretation method for PFT data. Methods: Our new method consists of 3 steps:\u0000 To build a diagnostic rule for a specific target from multi-PFT parameters. To estimate the Shapley-score, a game-theory based metric which measures the importance of each PFT index by comparing the model’s predictions with and without that index. To generate the interpretation, indicating the contribution level of each parameter to the positive/negative diagnosis. We applied this method to detect interstitial lung disease (ILD) in patients with systemic sclerosis. A machine learning diagnostic rule was developed from data of 300 patients undergoing 5 PFT techniques. Results: Validated on unseen data (n=100), the rule showed a good clinical performance (Sensitivity=0.86, Specificity=0.89, Positive and negative Likelihood-ratios of 7.86 and 0.16 respectively). At population level, the interpretation revealed that AV, TLCO-NO and FEV1 were the most important contributors to positive diagnosis. Personalized interpretations (Fig. 1) allow to verify the model’s plausibility in difficult cases with false negative/positive diagnosis and identify individual patterns of lung function impairments. Conclusion: Compared to the conventional approaches, our new method offers more advantages including ability of multivariate interpretation and valuable information for personalized treatment plan.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121311815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of endomicroscopic and high-resolution computer tomography patterns in patients with interstitial lung diseases 肺间质性疾病患者的显微内镜和高分辨率计算机断层扫描模式的相关性

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1364

O. Danilevskaya, A. Averyanov, V. Lesnyak

引用次数: 0

Induced sputum in systemic sclerosis: A new potential for biomarkers in SSc 系统性硬化症诱导痰:SSc生物标志物的新潜力

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1369

P. Jacquerie, B. André, M. Henquet, C. Moermans, D. Seny, F. Gester, R. Louis, M. Malaise, J. Guiot

引用次数: 1