ILD/DPLD of known origin最新文献_第5页

Minor salivary gland biopsy and dry ocular tests to detect occult Sjögren Syndrome in patients with interstitial pneumonia with autoimmune features 伴有自身免疫特征的间质性肺炎患者的小涎腺活检和眼干试验检测隐匿性Sjögren综合征

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa3596

S. Auteri, C. Garbarino, M. G. Blanco, M. L. Alberti, F. Paulin, M. Fernández, G. Carballo, M. Rayá, G. Guman, F. Caro

引用次数: 0

Identification of an IL-6-dependent macrophage population required for driving fibrotic disease 鉴定驱动纤维化疾病所需的il -6依赖性巨噬细胞群

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa1610

E. Doran, Darren Ruane, Alexander R. Abbas, D. DePianto, P. Caplazi, C. Emson, J. Arron

引用次数: 0

Follistatin-like 1 promotes intermittent hypoxia-induced lung fibroblast activation in vitro and in vivo 卵泡抑素样1在体外和体内促进间歇性缺氧诱导的肺成纤维细胞活化

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1357

Leiqian Xu, Jie Cao

引用次数: 0

Peptide ToAP3 from T. obscurus interferes with idiopathic pulmonary fibrosis progression in murine model 暗尾霉肽ToAP3干扰小鼠特发性肺纤维化模型的进展

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1372

Karina Smidt Simon, C. Melo-Silva, P. Veloso, L. Coelho, J. P. Longo, L. Vianna, V. Amado, A. Bocca

引用次数: 0

Effect of photobiomodulation on inflammation and production of TGF-ß in experimental model of pulmonary fibrosis 光生物调节对肺纤维化实验模型炎症及TGF-ß产生的影响

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5199

Auriléia Aparecida De Brito Léia, K. Herculano, T. G. Santos, N. C. Rigonato-Oliveira, Cintia Estefano Alves, R. Palma, Cristiano Rodrigo Alvarenga-Nascimento, A. P. Ligeiro-Oliveira

{"title":"Effect of photobiomodulation on inflammation and production of TGF-ß in experimental model of pulmonary fibrosis","authors":"Auriléia Aparecida De Brito Léia, K. Herculano, T. G. Santos, N. C. Rigonato-Oliveira, Cintia Estefano Alves, R. Palma, Cristiano Rodrigo Alvarenga-Nascimento, A. P. Ligeiro-Oliveira","doi":"10.1183/13993003.congress-2019.pa5199","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5199","url":null,"abstract":"Pulmonary fibrosis is one of the most common interstitial diseases, which causes a great impact on the health of the affected population, has environmental and genetic risk factors, a poor prognosis and no effective treatment available. It is a normal consequence of tissue injury and chronic inflammation, characterized by accumulation and activation of excessive numbers of fibroblasts, deposition of extracellular matrix proteins (ECM), such as collagen, and distortion of normal tissue architecture. Photobiomodulation - PBM is a relatively new and effective therapy, low cost, with no side effects and possible use in the treatment of lung diseases. In this sense, the objective was to evaluate the inflammation and the level of TGF-b in the lung after PBM in an experimental model of fibrosis. We studied some parameters in C57BL/6 with fibrosis submitted to diode laser therapy (808nm, 30mW, 180s) for 15 days. The protocol used for the induction of fibrosis consisted of the application of bleomycin sulphate (1.5U/kg - orotracheal - 1x/day 0). Bronchoalveolar lavage (BAL) and lungs were collected for analysis. Data were submitted to the one-way ANOVA test followed by the Newman-Keuls test. Significance levels adjusted to 5% (p","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122375143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nintedanib mediates effective modulation of relevant pro-fibrotic biomarkers ex vivo 尼达尼布在体外介导相关促纤维化生物标志物的有效调节

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa1609

C. Hesse, S. Wollin, Sebastian Konzok, M. Niehof, D. Leeming, S. Rønnow, J. Sand, P. Braubach, D. Jonigk, M. Kühnel, G. Warnecke, H. Fieguth, O. Pfennig, K. Sewald, A. Braun

引用次数: 0

Tomographic pattern and disease progress or mortality in familial pulmonary fibrosis 家族性肺纤维化的层析模式与疾病进展或死亡率

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1375

E. Mancuzo, Deborah Strela, Luiz Fernando Ferreira Pereira, R. A. Corrêa

{"title":"Tomographic pattern and disease progress or mortality in familial pulmonary fibrosis","authors":"E. Mancuzo, Deborah Strela, Luiz Fernando Ferreira Pereira, R. A. Corrêa","doi":"10.1183/13993003.congress-2019.pa1375","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1375","url":null,"abstract":"Background: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. Aim: to evaluete if the pattern of fibrosis on HRCT has a significant impact on disease progression or mortality in patients with FPF. Methods: Baseline clinical, functional and radiological data of a FPF population were retrospectively collected and analysed according to the 2018 IPF guidelines High Resolution Computerized Tomography (HRCT) classification. There was considered disease progress, decline in CVF more then 10% in a year. Results: 49 patients were included, 29 male and 20 female patients (age at diagnosis 53 ± 8.5 years-old), with a predominance of former smokers (51%), belonging to 31 families. Radiological analysis demonstrated the presence of a “UIP“ pattern at HRCT was 15 (29 %) of patients, “Probable-UIP” in 10 (19.5 %), “Indeterminate-UIP” in 7(13,5%) and “CT features most consistent with non-IPF diagnosis” in 17 (33%) . The main diagnostic was idiopathic pulmonary fibrosis (IPF), 21(41%). Initial forced vital capacity (FVC) was 75,07 ± 17,01 % of predicted and Rest SpO2 was 92 ± 5.8%. After analysis, the survival time 28.3 ± 17 months. No difference was observed in the survival or progression of the disease when we compared the “UIP“ pattern and “Probable-UIP” with “Indeterminate-UIP” and “CT features most consistent with non-IPF diagnosis”(p = 0,81) Reference: 1-Bennett D et al. Respiratory Medicine. 2017: 126: 75-83.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131096578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of bronchitis and associations with spirometry in patients with interstitial lungdisease in a Canadian tertiary care centre 加拿大三级保健中心间质性肺疾病患者支气管炎患病率及其与肺活量测定的关系

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1363

T. Ho, C. Scallan, N. Hambly, G. Cox, M. Kolb, Parameswaran Nair

引用次数: 0

Biomarkers in peripheral blood from patients with chronic silicosis caused by artificial quartz agglomerates 人工石英凝聚引起的慢性矽肺患者外周血生物标志物

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5192

A. Jiménez, Gema Jiménez Gómez, A. H. Molina, Antonio Córdoba Doña, Antonio Campos Caro

{"title":"Biomarkers in peripheral blood from patients with chronic silicosis caused by artificial quartz agglomerates","authors":"A. Jiménez, Gema Jiménez Gómez, A. H. Molina, Antonio Córdoba Doña, Antonio Campos Caro","doi":"10.1183/13993003.congress-2019.pa5192","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5192","url":null,"abstract":"Background: Silicosis produced by Artificial Quartz Agglomerates (AQA) evolves more aggressively than the classical form in miners. This entity is emerging worldwide and a significant group of cases has been detected in the province of Cadiz (Spain) in recent years. Biomarkers in the blood of silicotic patients are needed as tools for diagnosis, prognosis of the disease and response to treatment. Objective: To evaluate the plasma levels of some biomarkers (MP-1, MMP-2, MMP-7, MMP-9 and MMP-10, TGFβ, IL-1β, TNFα, IL-18 and MIP-1α), in healthy subjects compared with patients with simple (SS) or complicated (CS) silicosis, in order to use them as biomarkers of the disease. Methods: Fifty-seven patients diagnosed with silicosis by AQA and 18 healthy controls were studied. The blood biomarkers were quantified by single or multiplex ELISA. Results: MMP-2 and MMP-7 were increased in patients with silicosis compared to healthy volunteers, but only MMP-7 (not MMP-2) was found significantly augmented when silicotic patients were split in SS and CS according to the ILO classification. No differences were found for MMP-1, MMP-9, MMP-10, IL-18 and TGFβ. However, IL-1β and TNFα were significantly increased in CS group compared to healthy patients, but not compared to SS group. MIP-1α, showed an increasing gradient when healthy, SS and CS groups were compared. Conclusions: Combining the results of some of the biomarkers studied may be useful in the diagnosis of silicosis. Moreover, several biomarkers, such as MIP-1α, should be helpful to improve predictions of the evolution of the disease","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133382360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute exacerbation admissions of fibrosing interstitial lung diseases – 3 years study 纤维化间质性肺疾病急性加重入院- 3年研究

ILD/DPLD of known origin Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4739

S. Guerra, M. Conceição, Â. Cunha, J. Correia, J. Vale, C. António, A. Torres

{"title":"Acute exacerbation admissions of fibrosing interstitial lung diseases – 3 years study","authors":"S. Guerra, M. Conceição, Â. Cunha, J. Correia, J. Vale, C. António, A. Torres","doi":"10.1183/13993003.congress-2019.pa4739","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4739","url":null,"abstract":"Introduction: Acute exacerbations (AE) are frequent in patients with fibrosing interstitial lung diseases (F-ILD) with usual interstitial pneumonia (UIP) pattern. AE are defined as a significant respiratory deterioration, less than 1-month duration, with new radiological abnormalities and associated with worse outcome. Aims: To study the etiology and outcomes of patients admitted with AE of F-ILD. Methods: Retrospective study of patients admitted with AE of F-ILD from January 2015 to August 2018. F-ILD due to pneumoconiosis and tuberculosis were excluded. Results: 115 admissions were identified, corresponding to 47 patients, median age 77±8 years and 61.7% males. Main diagnoses were F-ILD secondary to chronic hypersensitivity pneumonitis (CHP, 68.7%), connective tissue diseases (CTD, 11.3%), idiopathic pulmonary fibrosis (IPF, 9.6%) and drugs (3.5%). 8 inpatients had other F-ILD with UIP pattern. AE main cause was infection (75.7%). Hospitalization median duration was 9±6 days. 48.7% of cases occurred in Winter. Median time to new admission was 45±145 days. Each patient had a median of 2 admissions, statistically related with previous respiratory failure (RF) (p Conclusion: F-ILD implies high risk of respiratory acute event, mostly by infections. Previous RF were largely present, indicative of advanced disease and probability of more AE. Need for NIV meant poor prognosis. As in international studies, mortality was high among F-ILD due to IPF.","PeriodicalId":178396,"journal":{"name":"ILD/DPLD of known origin","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123055856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0