KONA Powder and Particle Journal最新文献_第4页

Advances in the Rheological Characterization of Slurries of Elongated Particles 细长颗粒浆料流变特性研究进展

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/KONA.2022009

Saif Shaikh, Scott Strednak, Jason E. Butler

{"title":"Advances in the Rheological Characterization of Slurries of Elongated Particles","authors":"Saif Shaikh, Scott Strednak, Jason E. Butler","doi":"10.14356/KONA.2022009","DOIUrl":"https://doi.org/10.14356/KONA.2022009","url":null,"abstract":"Inherent challenges regarding the rheological characterization of slurries of elongated particles have necessitated the development of alternatives to standardized rheometers. These methods of measurement, and the associated advances in the quantification of shear and normal stress measurements, are described. Also, recent advances in modeling and predictive capabilities are summarized. During shearing flows, confinement substantially influences the orientation distribution of the particles; this change in the microstructure impacts the rheology, even as the smallest confining dimension exceeds seven particle lengths. The slow development of the orientation distributions renders additional difficulties in evaluating the rheology. Achievements of the measurement methods include a universal shear viscosity as a function of concentration for a wide range of particle lengths to diameters (aspect ratios). The jamming limit (divergence of the viscosity with concentration) of the suspensions has been also shown to scale differently than for spheres. More general dynamics of the suspensions and the additional needs for measurement improvements are discussed.","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"4 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88923892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms 粒子设计研究对以病人为中心的剂型发展的贡献

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/kona.2022017

H. Takeuchi

{"title":"Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms","authors":"H. Takeuchi","doi":"10.14356/kona.2022017","DOIUrl":"https://doi.org/10.14356/kona.2022017","url":null,"abstract":"A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form, the tablet, are introduced. Research on oral dosage forms, including orally disintegrating tablets (ODTs) and films (ODFs), which have recently been developed with an aim toward more patient-centric drug therapy, is also introduced. Another trend in recent drug therapy is an increase in the number of large bioactive molecules among the newly developed active pharmaceutical ingredients (APIs). To design dosage forms for these APIs, novel dosage form design and administration routes are required. For this purpose, we have tried to effectively use the polymer-coated liposomes in oral, pulmonary and ophthalmic administration. For example, suitable polymers were introduced for the design of specific administration routes, such as mucoadhesive liposomes for oral administration. The key point in these researches is the particle design for the component particles of final dosage forms, both in the case of coarse powder particle design for formulating solid dosage forms and in the case of colloidal particle design, such as the design of liposomes for peptide drug delivery.","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"25 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80219202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

General Information 一般信息

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/kona.2022025

引用次数: 0

The Development of Thin-film Freezing and Its Application to Improve Delivery of Biologics as Dry Powder Aerosols 薄膜冷冻技术的发展及其在改善干粉气溶胶生物制剂输送中的应用

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/KONA.2022010

Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Z. Cui, R. Williams

{"title":"The Development of Thin-film Freezing and Its Application to Improve Delivery of Biologics as Dry Powder Aerosols","authors":"Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Z. Cui, R. Williams","doi":"10.14356/KONA.2022010","DOIUrl":"https://doi.org/10.14356/KONA.2022010","url":null,"abstract":"While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly critical for proteins, as they are expensive and complicated to manufacture. Powders also have improved aerosol properties for pulmonary delivery. Conventional techniques for formulating powders include spray-drying, shelf freeze-drying, spray freeze-drying, and spray freezing into liquid, but they produce powders with poor aerosol performance and/or activity due to suboptimal powder properties. Thin-film freezing (TFF) is a new cryogenic technique that can engineer highly porous, brittle, powder matrices with excellent aerosol performance properties and stability. Herein, we describe TFF in comparison to other cryogenic techniques. Physical properties of TFF powders such as morphology, moisture sorption, stability, solubility, and dissolution, as well as aerosol properties are discussed. In addition, factors that significantly affect the physical and aerosol properties of dry powders prepared by TFF, such as solids content, drug loading, solvent system, excipient, and dry powder delivery device, are analyzed. Finally, we provide evidence supporting the applicability of using TFF to prepare dry powder formulations of protein-based pharmaceuticals, enabling their cold chain-free storage as well as efficient pulmonary delivery.","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"11 1","pages":"2022010"},"PeriodicalIF":4.1,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75417937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

A Review of Distribution and Segregation Mechanisms of Dockage and Foreign Materials in On-Farm Grain Silos for Central Spout Loading 农业粮食仓中央喷口装填堆积物与外来物分布与分离机制研究进展

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/kona.2022014

F. Jian

引用次数: 4

The Sevilla Powder Tester: A Tool for Measuring the Flow Properties of Cohesive Powders at High Temperatures 塞维利亚粉末测试仪:在高温下测量粘性粉末流动特性的工具

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/KONA.2022008

R. Gannoun, J. Ebri, A. Pérez, J. Valverde

引用次数: 0

Numerical Modelling of Formation of Highly Ordered Structured Micro- and Nanoparticles – A Review 高度有序结构微粒子和纳米粒子形成的数值模拟研究综述

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/kona.2022019

J. Gac

{"title":"Numerical Modelling of Formation of Highly Ordered Structured Micro- and Nanoparticles – A Review","authors":"J. Gac","doi":"10.14356/kona.2022019","DOIUrl":"https://doi.org/10.14356/kona.2022019","url":null,"abstract":"The aerosol particles play a significant role in the environment and human health. They are also increasingly used in medicine (drug carriers), preparation (nanocatalysts) and many other fields. For these applications, the particles have to possess unique properties which arise directly from their structure and topology. Indeed, the functionality of the nanostructure particle is defined through its application, like chromatography, sensors, microelectronics, catalysis, and others. That is the reason why people are more and more interested in manufacturing structured particles. The structured particles are the particles with well-defined topological structure. Examples of such particles are porous particles, hollow particles (with the empty space inside), or multi-component particles with the segregation of components in the particle structure. Such particles usually have very interesting features, e.g. porous particles have a significantly larger surface area than the simple spherical particles with similar volume. The present paper contains a comprehensive review of the numerical simulation methods of the formation of highly ordered structured particles. The most important methods will be described in detail and their fields of application (with specific examples), advantages, limitations and information about their accuracy will be given.","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"23 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82632229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets 可生物降解聚乳酸微球在电喷涂液滴中的形成机制

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI: 10.14356/kona.2022018

Moe Tanaka, Ayaka Ochi, Aiko Sasai, Hiroyuki Tsujimoto, H. Kobara, Hiromitsu Yamamoto, A. Wakisaka

{"title":"Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets","authors":"Moe Tanaka, Ayaka Ochi, Aiko Sasai, Hiroyuki Tsujimoto, H. Kobara, Hiromitsu Yamamoto, A. Wakisaka","doi":"10.14356/kona.2022018","DOIUrl":"https://doi.org/10.14356/kona.2022018","url":null,"abstract":"Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique. The structure of the microspheres was controlled by changing the electric voltage of the electrospray. PLGA microspheres with porous structures and micro-sized nanocomposite particles comprising PLGA nanosphere aggregates were formed at 5.0–7.0 kV and 2.5–3.5 kV, respectively. The structural change was related to the extent of evaporation of the solvent from the droplets during their flight. When the evaporation was completed in the relatively small droplets, the microspheres with porous structures were formed in the droplets. To study the mechanism, we observed the effects of the electric voltage of the electrospray, PLGA concentration, flight distance of the droplets, and molecular weight of PLGA on the structure of the PLGA particles. The novelty of this study is the analysis of the size and structure of the PLGA microparticles, which were controlled by the electrospray technique. Therefore, this research has important implications for the structural design and preparation of nanocomposite particles.","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"43 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90212093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Computational Fluid Dynamic Modelling of Fully-Suspended Slurry Flows in Horizontal Pipes with Different Solids Concentrations 不同固体浓度水平管内全悬浮浆体流动的计算流体动力学模型

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-01 DOI: 10.14356/kona.2023008

G. Messa, Qi Yang, M. Rasteiro, P. Faia, V. Matoušek, Rui C. Silva, F. Garcia

引用次数: 0

Functionalized Graphitic Carbon Nitrides for Photocatalytic H2O2 Production: Desired Properties Leading to Rational Catalyst Design 用于光催化生产H2O2的功能化石墨氮化碳:理想的性能导致合理的催化剂设计

IF 4.1 4区材料科学

KONA Powder and Particle Journal Pub Date : 2022-01-01 DOI: 10.14356/kona.2023004

Zhengyuan Teng, Wenan Cai, T. Ohno

引用次数: 1