Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

IF 2.6 4区材料科学 Q3 ENGINEERING, CHEMICAL

KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI:10.14356/kona.2022018

Moe Tanaka, Ayaka Ochi, Aiko Sasai, Hiroyuki Tsujimoto, H. Kobara, Hiromitsu Yamamoto, A. Wakisaka

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引用次数: 2

Abstract

Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique. The structure of the microspheres was controlled by changing the electric voltage of the electrospray. PLGA microspheres with porous structures and micro-sized nanocomposite particles comprising PLGA nanosphere aggregates were formed at 5.0–7.0 kV and 2.5–3.5 kV, respectively. The structural change was related to the extent of evaporation of the solvent from the droplets during their flight. When the evaporation was completed in the relatively small droplets, the microspheres with porous structures were formed in the droplets. To study the mechanism, we observed the effects of the electric voltage of the electrospray, PLGA concentration, flight distance of the droplets, and molecular weight of PLGA on the structure of the PLGA particles. The novelty of this study is the analysis of the size and structure of the PLGA microparticles, which were controlled by the electrospray technique. Therefore, this research has important implications for the structural design and preparation of nanocomposite particles.

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可生物降解聚乳酸微球在电喷涂液滴中的形成机制

采用电喷雾技术在液滴中制备了聚乳酸-羟基乙酸(PLGA)微球。通过改变电喷雾的电压来控制微球的结构。在5.0 ~ 7.0 kV和2.5 ~ 3.5 kV下，分别形成具有多孔结构的PLGA微球和含有PLGA纳米球聚团的微尺寸纳米复合粒子。结构变化与液滴在飞行过程中溶剂的蒸发程度有关。当蒸发在相对较小的液滴内完成时，液滴内形成具有多孔结构的微球。为了研究其机理，我们观察了电喷雾电压、PLGA浓度、液滴飞行距离和PLGA分子量对PLGA颗粒结构的影响。本研究的新颖之处在于分析了由电喷雾技术控制的PLGA微粒的大小和结构。因此，本研究对纳米复合粒子的结构设计和制备具有重要意义。

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来源期刊

KONA Powder and Particle Journal 工程技术-材料科学：综合

CiteScore

8.40

自引率

4.90%

发文量

审稿时长

>12 weeks

期刊介绍： KONA publishes papers in the broad field of powder science and technology, ranging from fundamental principles to practical applications. Papers describing technological experience and critical reviews of existing knowledge in special areas are also welcome.