{"title":"Formulation of Bacteriophage for Inhalation to Treat Multidrug-Resistant Pulmonary Infections.","authors":"Vaibhav Pathak, Hak-Kim Chan, Qi Tony Zhou","doi":"10.14356/kona.2025016","DOIUrl":"10.14356/kona.2025016","url":null,"abstract":"<p><p>Rapid development of antibiotic resistance in pathogenic bacteria and a decline in the pharmaceutical development of new antibiotics are pushing the research community to explore alternative antimicrobials that can replace or complement antibiotics. Bacteriophages (or, phages) are naturally occurring viruses that can kill bacteria with high specificity and can evolve to target resistant bacteria. Phages have been historically employed as antimicrobial agents, but they were overshadowed by the emergence of antibiotics. With a renewed focus on phages, it is important to study their clinical efficacy, safety, and formulation. Pulmonary infections have a large burden of global morbidity and frequently involve multidrug-resistant pathogens such as <i>Acinetobacter baumannii</i>, <i>Klebsiella pneumoniae</i>, <i>Mycobacterium tuberculosis</i>, and <i>Pseudomonas aeruginosa</i>. Therefore, this can be an important area of application of phages. Dry powder inhalers can be an effective strategy to deliver phages to the lungs because they are easy-to-use, portable, and capable of delivering a higher lung dose than oral or intravenous route. They also have longer shelf life and lower cold storage requirements than solutions. Therefore, the aim of the current review is to summarize recent findings on bacteriophage dry powder formulations, particularly focusing on the effect of various excipients and manufacturing factors on phage titer preservation.</p>","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"42 ","pages":"200-212"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 54th Symposium on Powder Technology and Special Lecture for the 30th Anniversary of the Establishment of HPTF","authors":"","doi":"10.14356/kona.2023018","DOIUrl":"https://doi.org/10.14356/kona.2023018","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77004184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The KONA Award 2021","authors":"","doi":"10.14356/kona.2023019","DOIUrl":"https://doi.org/10.14356/kona.2023019","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"41 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81721388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Thon, Marvin Röhl, Somayeh Hosseinhashemi, A. Kwade, C. Schilde
{"title":"Artificial Intelligence and Evolutionary Approaches in Particle Technology","authors":"C. Thon, Marvin Röhl, Somayeh Hosseinhashemi, A. Kwade, C. Schilde","doi":"10.14356/kona.2024011","DOIUrl":"https://doi.org/10.14356/kona.2024011","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"10 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81774459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applying Bubbling Fluidized-Bed Reactors for Strongly Exothermic Reactions: Focus on Methanation","authors":"Philipp Riechmann, T. Schildhauer","doi":"10.14356/kona.2024009","DOIUrl":"https://doi.org/10.14356/kona.2024009","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"11 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84655784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulation of the Classification of Manufactured Sands in the Throat Air Classifier","authors":"H. A. Petit, E. Irassar","doi":"10.14356/kona.2024006","DOIUrl":"https://doi.org/10.14356/kona.2024006","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"1 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88430648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Analytical Methods for Calculating Static Pressures in Bulk Solids Storage Structures","authors":"G. Dyck, Adam Rogers, J. Paliwal","doi":"10.14356/kona.2024013","DOIUrl":"https://doi.org/10.14356/kona.2024013","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"26 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80154129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Progress of Experimental and Simulation Work of Mixing Processes in Particulate Systems","authors":"Xin Jin, Yansong Shen","doi":"10.14356/kona.2024015","DOIUrl":"https://doi.org/10.14356/kona.2024015","url":null,"abstract":"","PeriodicalId":17828,"journal":{"name":"KONA Powder and Particle Journal","volume":"9 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78972337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}