Chi-Fai Ng, Sylvia Luke, Peter K F Chiu, Jeremy Y C Teoh, Ka-Tak Wong, Simon S M Hou
{"title":"The effect of renal cortical thickness on the treatment outcomes of kidney stones treated with shockwave lithotripsy.","authors":"Chi-Fai Ng, Sylvia Luke, Peter K F Chiu, Jeremy Y C Teoh, Ka-Tak Wong, Simon S M Hou","doi":"10.4111/kju.2015.56.5.379","DOIUrl":"https://doi.org/10.4111/kju.2015.56.5.379","url":null,"abstract":"Purpose Because the shock wave passes through various body tissues before reaching the stone, stone composition may affect the treatment efficacy of shock wave lithotripsy (SWL). We investigated the effect of various tissue components along the shock wave path on the success of SWL. Materials and Methods From October 2008 to August 2010, a total of 206 patients with kidney stones sized 5 to 20 mm were prospectively recruited for a study of the factors that affect the outcome of treatment with a Sonolith Vision lithotripter. Successful SWL was defined as either stone-free status or residual fragments <4 mm at 12 weeks. Logistic regression analysis was performed to assess the factors that predicted treatment outcomes. Potential predictors included the patient's age, shock wave delivery rate, stone volume (SV), mean stone density (MSD), skin-to-stone distance (SSD), and the mean thickness of the three main components along the shock wave path: renal cortical thickness (KT), muscle thickness (MT), and soft-tissue thickness (ST). Results The mean age of the patients was 53.8 years (range, 25-82 years). The overall treatment success rate after one session of SWL was 43.2%. The mean KT, MT, and ST were 26.9, 16.6, and 40.8 mm, respectively. The logistic regression results showed that a slower shock wave delivery rate, smaller SV, a lower MSD, and a thicker KT were found to be significant predictors for successful SWL. SSD, MT, and ST were not predictors of successful treatment. Conclusions Among the main tissue components along the shock wave path, a thicker KT was a favorable factor for successful SWL after adjustment for SV, MSD, and the shock wave delivery rate.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 5","pages":"379-85"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.5.379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33294479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infection after transrectal ultrasound-guided prostate biopsy.","authors":"Seung-Ju Lee","doi":"10.4111/kju.2015.56.5.346","DOIUrl":"https://doi.org/10.4111/kju.2015.56.5.346","url":null,"abstract":"<p><p>Infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS-Bx) appear to be increasing, which reflects the high prevalence of antibiotic-resistant strains of Enterobacteriaceae. Identifying patients at high risk for antibiotic resistance with history taking is an important initial step. Targeted prophylaxis with a prebiopsy rectal swab culture or augmented antibiotic prophylaxis can be considered for patients at high risk of antibiotic resistance. If infectious complications are suspected, the presence of urosepsis should be evaluated and adequate antibiotic treatment should be started immediately. </p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 5","pages":"346-50"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.5.346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33174831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does skip metastasis or other lymph node parameters have additional effects on survival of patients undergoing radical cystectomy for bladder cancer?","authors":"Ozgur Ugurlu, Sumer Baltaci, Guven Aslan, Cavit Can, Cag Cal, Atilla Elhan, Levent Turkeri, Aydin Mungan","doi":"10.4111/kju.2015.56.5.357","DOIUrl":"https://doi.org/10.4111/kju.2015.56.5.357","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of lymph node metastasis, skip metastasis, and other factors related to lymph node status on survival in patients who underwent radical cystectomy (RC) and extended lymph node dissection (eLND).</p><p><strong>Materials and methods: </strong>RC and eLND were performed in 85 patients with a diagnosis of bladder cancer. Disease-free survival (DFS) and overall survival (OS) were determined by using a Cox proportional hazards model that included the number of excised lymph nodes, the presence of pathological lymph node metastasis, the anatomical level of positive nodes, the number of positive lymph nodes, lymph node density, and the presence of skip metastasis.</p><p><strong>Results: </strong>The mean number of lymph nodes removed per patient was 29.4±9.3. Lymph node positivity was detected in 85 patients (34.1%). The mean follow-up duration was 44.9±27.4 months (2-93 months). Five-year estimated OS and DFS for the 85 patients were 62.6% and 57%, respectively. Three of 29 lymph node-positive patients (10.3%) had skip metastasis. Only lymph node positivity had a significant effect on 5-year OS and DFS (p<0.001). No difference in OS and DFS was found between the three patients with skip metastasis and other lymph node-positive patients. Other factors related to lymph node status had no significant effect on 5-year OS and DFS.</p><p><strong>Conclusions: </strong>No factors related to lymph node status predict DFS and OS, except for lymph node positivity. OS and DFS were comparable between patients with skip metastasis and other lymph node-positive patients.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 5","pages":"357-64"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.5.357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33174833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikolas Christopher Katelaris, Damien Michael Bolton, Mahesha Weerakoon, Liam Toner, Phillip Mark Katelaris, Nathan Lawrentschuk
{"title":"Current role of multiparametric magnetic resonance imaging in the management of prostate cancer.","authors":"Nikolas Christopher Katelaris, Damien Michael Bolton, Mahesha Weerakoon, Liam Toner, Phillip Mark Katelaris, Nathan Lawrentschuk","doi":"10.4111/kju.2015.56.5.337","DOIUrl":"https://doi.org/10.4111/kju.2015.56.5.337","url":null,"abstract":"<p><p>The purpose of this review was to evaluate the current role of multiparametric magnetic resonance imaging (mp-MRI) in the management of prostate cancer (PC). The diagnosis of PC remains controversial owing to overdetection of indolent disease, which leads to overtreatment and subsequent patient harm. mp-MRI has the potential to equilibrate the imbalance between detection and treatment. The limitation of the data for analysis with this new technology is problematic, however. This issue has been compounded by a paradigm shift in clinical practice aimed at utilizing this modality, which has been rolled out in an ad hoc fashion often with commercial motivation. Despite a growing body of literature, pertinent clinical questions remain. For example, can mp-MRI be calibrated to reliably detect biologically significant disease? As with any new technology, objective evaluation of the clinical applications of mp-MRI is essential. The focus of this review was on the evaluation of mp-MRI of the prostate with respect to clinical utility. </p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 5","pages":"337-45"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.5.337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33174830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joong Sub Lee, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
{"title":"The prognostic impact of perioperative blood transfusion on survival in patients with bladder urothelial carcinoma treated with radical cystectomy.","authors":"Joong Sub Lee, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku","doi":"10.4111/kju.2015.56.4.295","DOIUrl":"https://doi.org/10.4111/kju.2015.56.4.295","url":null,"abstract":"PURPOSE\u0000The aim of our study was to assess the influence of perioperative blood transfusion (PBT) on survival outcomes following radical cystectomy (RC) and pelvic lymph node dissection (PLND).\u0000\u0000\u0000MATERIALS AND METHODS\u0000We reviewed and analyzed the clinical data of 432 patients who underwent RC for bladder cancer from 1991 to 2012. PBT was defined as the transfusion of allogeneic red blood cells during RC or postoperative hospitalization.\u0000\u0000\u0000RESULTS\u0000Of all patients, 315 patients (72.9%) received PBT. On multivariate logistic regression analysis, female gender (p=0.015), a lower preoperative hemoglobin level (p=0.003), estimated blood loss>800 mL (p<0.001), and performance of neoadjuvant chemotherapy (p<0.001) were independent risk factors related to requiring perioperative transfusions. The receipt of PBT was associated with increased overall mortality (hazard ratio, 1.91; 95% confidence interval, 1.25-2.94; p=0.003) on univariate analysis, but its association was not confirmed by multivariate analysis (p=0.058). In transfused patients, a transfusion of >4 packed red blood cell units was an independent predictor of overall survival (p=0.007), but not in cancer specific survival.\u0000\u0000\u0000CONCLUSIONS\u0000Our study was not conclusive to detect a clear association between PBT and survival after RC. However, the efforts should be made to continue limiting the overuse of transfusion especially in patients who are expected to have a high probability of PBT, such as females and those with a low preoperative hemoglobin level and history of neoadjuvant chemotherapy.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"295-304"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.4.295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33097682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taekmin Kwon, In Gab Jeong, Dalsan You, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
{"title":"Prevalence and clinical significance of incidental (18)F-fluoro-2-deoxyglucose uptake in prostate.","authors":"Taekmin Kwon, In Gab Jeong, Dalsan You, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim","doi":"10.4111/kju.2015.56.4.288","DOIUrl":"https://doi.org/10.4111/kju.2015.56.4.288","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence and clinical significance of incidental prostate fluoro-2-deoxyglucose (FDG) uptake and to evaluate its impact on patient management.</p><p><strong>Materials and methods: </strong>Of 47,109 men who underwent FDG positron emission tomography between 2004 and 2014, 1,335 (2.83%) demonstrated incidental FDG uptake in the prostate, with 99 of the latter undergoing prostate biopsy. The primary end point was the histological presence of prostate adenocarcinoma in the biopsy specimen. Outcomes, including treatment methods, survival, and causes of death, were also assessed. Factors associated with the diagnosis of prostate cancer were evaluated by using logistic regression analysis.</p><p><strong>Results: </strong>Patients with prostate cancer were more likely to have higher serum prostate-specific antigen (PSA) (p=0.001) and focal FDG uptake (p=0.036) than were those without. Prostate cancer occurred in 1 of 26 patients (3.8%) with serum PSA<2.5 ng/mL, compared with 40 of 67 patients (59.7%) with serum PSA≥2.5 ng/mL. Multivariable analysis showed that focal lesions (odds ratio [OR], 5.50; p=0.038), age (OR, 1.06; p=0.031), and serum PSA (OR, 1.28; p=0.001) were independent predictors of prostate cancer diagnosis. Most patients with prostate cancer had organ-confined tumors. Of these, 12 (29.3%) underwent radical prostatectomy and 25 (60.9%) received hormone therapy. Of the 11 patients who died, 9 died of primary cancer progression, with only 1 patient dying from prostate cancer.</p><p><strong>Conclusions: </strong>The prevalence of incidental FDG uptake in the prostate was not high, although patients with elevated serum PSA had a higher incidence of prostate cancer. Patients with FDG uptake in the prostate should be secondarily evaluated by measuring serum PSA, with those having high serum PSA undergoing prostate biopsy.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"288-94"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.4.288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33097681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Güneş, Mehmet Umul, Muammer Altok, Mehmet Akyuz, Cemal Selcuk İşoğlu, Fatih Uruc, Bekir Aras, Alpaslan Akbaş, Ercan Baş
{"title":"Predictive role of hematologic parameters in testicular torsion.","authors":"Mustafa Güneş, Mehmet Umul, Muammer Altok, Mehmet Akyuz, Cemal Selcuk İşoğlu, Fatih Uruc, Bekir Aras, Alpaslan Akbaş, Ercan Baş","doi":"10.4111/kju.2015.56.4.324","DOIUrl":"https://doi.org/10.4111/kju.2015.56.4.324","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the predictive role of the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet count (PLT) in the diagnosis of testicular torsion (TT) and testicular viability following TT.</p><p><strong>Materials and methods: </strong>We analyzed two study groups in this retrospective study: 75 patients with a diagnosis of TT (group 1) and 56 age-matched healthy subjects (group 2). We performed a complete blood count as a part of the diagnostic procedure, and NLR, PLR, MPV, and PLT values were recorded. We compared the patient and control groups in terms of these parameters. Then, TT patients were divided into two subgroups according to the time elapsed since the onset of symptoms. Subsequently, we evaluated the relationship between the duration of symptoms and these parameters.</p><p><strong>Results: </strong>There were significant differences between groups 1 and 2 in NLR, PLR, and PLT (p<0.001 for all). There was no predictive role of MPV in the diagnosis of TT (p=0.328). We determined significantly high sensitivity and specificity levels for NLR in the prediction of TT diagnosis (84% and 92%, respectively). Furthermore, NLR was significantly related to the duration of symptoms in TT patients (p=0.01).</p><p><strong>Conclusions: </strong>NLR may be a useful parameter in the diagnosis of TT. Furthermore, NLR may be used as a predictive factor for testicular viability following TT.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"324-9"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.4.324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33097686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amjad Alwaal, Ahmed A Hussein, Ching-Shwun Lin, Tom F Lue
{"title":"Prospects of stem cell treatment in benign urological diseases.","authors":"Amjad Alwaal, Ahmed A Hussein, Ching-Shwun Lin, Tom F Lue","doi":"10.4111/kju.2015.56.4.257","DOIUrl":"10.4111/kju.2015.56.4.257","url":null,"abstract":"<p><p>Stem cells (SCs) are undifferentiated cells that are capable of self-renewal and differentiation and that therefore contribute to the renewal and repair of tissues. Their capacity for division, differentiation, and tissue regeneration is highly dependent on the surrounding environment. Several preclinical and clinical studies have utilized SCs in urological disorders. In this article, we review the current status of SC use in benign urological diseases (erectile dysfunction, Peyronie disease, infertility, and urinary incontinence), and we summarize the results of the preclinical and clinical trials that have been conducted. </p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"257-65"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/fe/kju-56-257.PMC4392024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33092649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How much progress has been made in journal metrics two years after the citation analysis of the Korean Journal of Urology?","authors":"Sun Huh","doi":"10.4111/kju.2015.56.4.276","DOIUrl":"https://doi.org/10.4111/kju.2015.56.4.276","url":null,"abstract":"<p><strong>Purpose: </strong>In April 2013, the journal metrics of the Korean Journal of Urology (KJU) were reported. That report showed tremendous improvement from the point of view of journal metrics. Two years later, the same metrics were reanalyzed to determine the present position of the KJU among the international journals in the Web of Science.</p><p><strong>Materials and methods: </strong>I analyzed journal metrics of the KJU such as impact factor, total citations, and h-index by use of the same methods as in the previous report.</p><p><strong>Results: </strong>Total citations in the Web of Science were 332 in 2012, 439 in 2013, and 578 in 2014. Manually calculated impact factors from 2012 to 2014 were 0.770, 0.824, and 0.751, respectively. There was an increase in the h-index from 8 in 2012 to 11 in February 2015. Editorial board members were from 15 countries in 2014. Authors of KJU articles were from 21 countries in 2014.</p><p><strong>Conclusions: </strong>During 2 years, remarkable progress was made in KJU's citation indicators and in the diversity of the authors' and editorial board members' countries.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"276-9"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.4.276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33092650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A current perspective on geriatric lower urinary tract dysfunction.","authors":"Ha Bum Jung, Hyung Jee Kim, Sung Tae Cho","doi":"10.4111/kju.2015.56.4.266","DOIUrl":"https://doi.org/10.4111/kju.2015.56.4.266","url":null,"abstract":"<p><p>Lower urinary tract dysfunction-such as urinary incontinence (UI), detrusor overactivity, and benign prostatic hyperplasia-is prevalent in elderly persons. These conditions can interfere with daily life and normal functioning and lead to negative effects on health-related quality of life. UI is one of the most common urologic conditions but is poorly understood elderly persons. The overall prevalence of UI increases with age in both men and women. Elderly persons often neglect UI or dismiss it as part of the normal aging process. However, UI can have significant negative effects on self-esteem and has been associated with increased rates of depression. UI also affects quality of life and activities of daily living. Although UI is more common in elderly than in younger persons, it should not be considered a normal part of aging. UI is abnormal at any age. The goal of this review is to provide an overview of the cause, classification, evaluation, and management of geriatric lower urinary tract dysfunction. </p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 4","pages":"266-75"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.4.266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33092651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}