{"title":"Can a dual-energy computed tomography predict unsuitable stone components for extracorporeal shock wave lithotripsy?","authors":"Sung Hoon Ahn, Tae Hoon Oh, Ill Young Seo","doi":"10.4111/kju.2015.56.9.644","DOIUrl":"https://doi.org/10.4111/kju.2015.56.9.644","url":null,"abstract":"Purpose To assess the potential of dual-energy computed tomography (DECT) to identify urinary stone components, particularly uric acid and calcium oxalate monohydrate, which are unsuitable for extracorporeal shock wave lithotripsy (ESWL). Materials and Methods This clinical study included 246 patients who underwent removal of urinary stones and an analysis of stone components between November 2009 and August 2013. All patients received preoperative DECT using two energy values (80 kVp and 140 kVp). Hounsfield units (HU) were measured and matched to the stone component. Results Significant differences in HU values were observed between uric acid and nonuric acid stones at the 80 and 140 kVp energy values (p<0.001). All uric acid stones were red on color-coded DECT images, whereas 96.3% of the nonuric acid stones were blue. Patients with calcium oxalate stones were divided into two groups according to the amount of monohydrate (calcium oxalate monohydrate group: monohydrate≥90%, calcium oxalate dihydrate group: monohydrate<90%). Significant differences in HU values were detected between the two groups at both energy values (p<0.001). Conclusions DECT improved the characterization of urinary stone components and was a useful method for identifying uric acid and calcium oxalate monohydrate stones, which are unsuitable for ESWL.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 9","pages":"644-9"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.9.644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34068458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of low-dose dual energy computed tomography for in vivo assessment of renal/ureteric calculus composition.","authors":"Harshavardhan Mahalingam, Anupam Lal, Arup K Mandal, Shrawan Kumar Singh, Shalmoli Bhattacharyya, Niranjan Khandelwal","doi":"10.4111/kju.2015.56.8.587","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.587","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the accuracy of low-dose dual-energy computed tomography (DECT) in predicting the composition of urinary calculi.</p><p><strong>Materials and methods: </strong>A total of 52 patients with urinary calculi were scanned with a 128-slice dual-source DECT scanner by use of a low-dose protocol. Dual-energy (DE) ratio, weighted average Hounsfield unit (HU) of calculi, radiation dose, and image noise levels were recorded. Two radiologists independently rated study quality. Stone composition was assessed after extraction by Fourier transform infrared spectroscopy (FTIRS). Analysis of variance was used to determine if the differences in HU values and DE ratios between the various calculus groups were significant. Threshold cutoff values to classify the calculi into separate groups were identified by receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>A total of 137 calculi were detected. FTIRS analysis differentiated the calculi into five groups: uric acid (n=17), struvite (n=3), calcium oxalate monohydrate and dihydrate (COM-COD, n=84), calcium oxalate monohydrate (COM, n=28), and carbonate apatite (n=5). The HU value could differentiate only uric acid calculi from calcified calculi (p<0.001). The DE ratio could confidently differentiate uric acid, struvite, calcium oxalate, and carbonate apatite calculi (p<0.001) with cutoff values of 1.12, 1.34, and 1.66, respectively, giving >80% sensitivity and specificity to differentiate them. The DE ratio could not differentiate COM from COM-COD calculi. No study was rated poor in quality by either of the observers. The mean radiation dose was 1.8 mSv.</p><p><strong>Conclusions: </strong>Low-dose DECT accurately predicts urinary calculus composition in vivo while simultaneously reducing radiation exposure without compromising study quality.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"587-93"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Meyer, Shyam Sukumar, Akshay Sood, Julian Hanske, Malte Vetterlein, Jack S Elder, Margit Fisch, Quoc-Dien Trinh, Ariella A Friedman
{"title":"Inpatients hypospadias care: trends and outcomes from the American nationwide inpatient sample.","authors":"Christian Meyer, Shyam Sukumar, Akshay Sood, Julian Hanske, Malte Vetterlein, Jack S Elder, Margit Fisch, Quoc-Dien Trinh, Ariella A Friedman","doi":"10.4111/kju.2015.56.8.594","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.594","url":null,"abstract":"<p><strong>Purpose: </strong>Hypospadias is the most common congenital penile anomaly. Information about current utilization patterns of inpatient hypospadias repair as well as complication rates remain poorly evaluated.</p><p><strong>Materials and methods: </strong>The Nationwide Inpatient Sample was used to identify all patients undergoing inpatient hypospadias repair between 1998 and 2010. Patient and hospital characteristics were attained and outcomes of interest included intra- and immediate postoperative complications. Utilization was evaluated temporally and also according to patient and hospital characteristics. Predictors of complications and excess length of stay were evaluated by logistic regression models.</p><p><strong>Results: </strong>A weighted 10,201 patients underwent inpatient hypospadias repair between 1998 and 2010. Half were infants (52.2%), and were operated in urban and teaching hospitals. Trend analyses demonstrated a decline in incidence of inpatient hypospadias repair (estimated annual percentage change, -6.80%; range, -0.51% to -12.69%; p=0.037). Postoperative complication rate was 4.9% and most commonly wound-related. Hospital volume was inversely related to complication rates. Specifically, higher hospital volume (>31 cases annually) was the only variable associated with decreased postoperative complications.</p><p><strong>Conclusions: </strong>Inpatient hypospadias repair have substantially decreased since the late 1990's. Older age groups and presumably more complex procedures constitute most of the inpatient procedures nowadays.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"594-600"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donghyun Lee, Seung-Kwon Choi, Jinsung Park, Myungsun Shim, Aram Kim, Sangmi Lee, Cheryn Song, Hanjong Ahn
{"title":"Comparative analysis of oncologic outcomes for open vs. robot-assisted radical prostatectomy in high-risk prostate cancer.","authors":"Donghyun Lee, Seung-Kwon Choi, Jinsung Park, Myungsun Shim, Aram Kim, Sangmi Lee, Cheryn Song, Hanjong Ahn","doi":"10.4111/kju.2015.56.8.572","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.572","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the oncologic outcomes of robot-assisted radical prostatectomy (RARP) in high-risk prostate cancer (PCa), we compared the surgical margin status and biochemical recurrence-free survival (BCRFS) rates between retropubic radical prostatectomy (RRP) and RARP.</p><p><strong>Materials and methods: </strong>A comparative analysis was conducted of high-risk PCa patients who underwent RRP or RARP by a single surgeon from 2007 to 2013. High-risk PCa was defined as clinical stage≥T3a, biopsy Gleason score 8-10, or prostate-specific antigen>20 ng/mL. Propensity score matching was performed to minimize selection bias, and all possible preoperative and postoperative confounders were matched. A Kaplan-Meier analysis was performed to assess the 5-year BCRFS, and Cox regression models were used to evaluate the effect of the surgical approach on biochemical recurrence.</p><p><strong>Results: </strong>A total of 356 high-risk PCa patients (106 [29.8%] RRP and 250 [70.2%] RARP) were included in the final cohort analyzed. Before adjustment, the mean percentage of positive cores on biopsy and pathologic stage were poorer for RRP versus RARP (p=0.036 vs. p=0.054, respectively). The unadjusted 5-year BCRFS rates were better for RARP than for RRP (RRP vs. RARP: 48.1% vs. 64.4%, p=0.021). After adjustment for preoperative variables, the 5-year BCRFS rates were similar between RRP and RARP patients (48.5% vs. 59.6%, p=0.131). The surgical approach did not predict biochemical recurrence in multivariate analysis.</p><p><strong>Conclusions: </strong>Five-year BCRFS rates of RARP are comparable to RRP in high-risk PCa. RARP is a feasible treatment option for high-risk PCa.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"572-9"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urologic robotic surgery in Korea: past and present.","authors":"Ill Young Seo","doi":"10.4111/kju.2015.56.8.546","DOIUrl":"10.4111/kju.2015.56.8.546","url":null,"abstract":"<p><p>Since 2005 when the da Vinci surgical system was approved as a medical device by the Korean Ministry of Health and Welfare, 51 systems have been installed in 40 institutions as of May 2015. Although robotic surgery is not covered by the national health insurance service in Korea, it has been used in several urologic fields as a less invasive surgery. Since the first robotic-assisted laparoscopic radical prostatectomy in 2005, partial nephrectomy, radical cystectomy, pyeloplasty, and other urologic surgeries have been performed. The following should be considered to extend the indications for robotic surgery: training systems including accreditation, operative outcomes from follow-up results, and cost-effectiveness. In this review, the history and current status of robotic surgeries in Korea are presented.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"546-52"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/45/kju-56-546.PMC4534428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New and contemporary markers of prognosis in nonmuscle invasive urothelial cancer.","authors":"M Hammad Ather, Syed M Nazim","doi":"10.4111/kju.2015.56.8.553","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.553","url":null,"abstract":"<p><p>Nonmuscle invasive (NMI) urothelial cancer (UC) is associated with varied biological potential. It is characterized by frequent recurrence and progression, which thus worsens the oncological outcome. Nearly three-quarters of NMI UCs recur within 5 years, whereas half can progress during follow-up. Progression is particularly seen in T1 and carcinoma in situ (CIS). Undoubtedly, NMI UC is one of the most expensive cancers to manage. The European Organisation for Research and Treatment of Cancer (EORTC) risk calculator is a commonly used tool for assessing the recurrence and progression potential of a newly diagnosed cancer. The parameters used in the assessment are tumor size and number, pathological stage and grade of the cancer, presence of CIS, and prior recurrence rate. The main advantages of the EORTC tool are its ease of use and the lack of need to run expensive molecular tests. However, reproducibility of pathologic stage and grade is modest, which is a concern to clinicians. Molecular markers have potential for predicting the clinical outcome of NMI UC, given that clinico-pathologic variables are not sufficient for prediction of prognosis in an individual. Significant work has been done in the past 2 decades in understanding the molecular biology of bladder cancer; however, the translational value of this knowledge remains poor. The role for molecular markers in predicting recurrence seems limited because multifocal disease and incomplete treatment are probably more important for recurrence than the molecular features of a resected tumor. Urinary markers have very limited value in prognostication of bladder cancer and are used (mainly as an adjunct to cytology) for detection and surveillance of urothelial cell cancer recurrence. Prediction of progression with molecular markers holds considerable promise. Nevertheless, the contemporary value of molecular markers over clinico-pathologic indexes is limited.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"553-64"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donghyun Lee, Chunwoo Lee, Taekmin Kwon, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
{"title":"Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia.","authors":"Donghyun Lee, Chunwoo Lee, Taekmin Kwon, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim","doi":"10.4111/kju.2015.56.8.565","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.565","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR.</p><p><strong>Results: </strong>In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR.</p><p><strong>Conclusions: </strong>PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"565-71"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ki Bom Kim, Jung Ki Jo, Soyeon Ahn, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee
{"title":"Clinical effect of abiraterone acetate in Korean patients with metastatic castration-resistant prostate cancer according to duration of androgen deprivation therapy.","authors":"Ki Bom Kim, Jung Ki Jo, Soyeon Ahn, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee","doi":"10.4111/kju.2015.56.8.580","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.580","url":null,"abstract":"<p><strong>Purpose: </strong>Few data are available concerning the clinical outcome of abiraterone acetate treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) in terms of the duration of androgen deprivation therapy (ADT) before diagnosis of CRPC. We investigated the clinical efficacy of abiraterone acetate according to the duration of ADT.</p><p><strong>Materials and methods: </strong>We reviewed the medical records of 20 patients with mCRPC who received abiraterone acetate after failure of docetaxel chemotherapy from May 2012 to March 2014 at Seoul National University Bundang Hospital. Clinical factors including prostate-specific antigen (PSA) nadir level, time to PSA nadir, PSA doubling time, PSA response, and modes of progression (PSA, radiologic, clinical) were analyzed. Disease progression was classified according to the Prostate Cancer Working Group 2 criteria.</p><p><strong>Results: </strong>The mean age and PSA value of the entire cohort were 76.0±7.2 years and 158.8±237.9 ng/mL, respectively. The median follow-up duration was 13.4±6.7 months. There were no statistically significant differences in clinical characteristics between patients who received abiraterone acetate with ADT duration<35 months and those who received abiraterone acetate with ADT duration≥35 months. There were also no significant differences in terms of PSA progression-free survival, radiologic progression-free survival, and clinical progression-free survival between patients with ADT duration<35 months and those with ADT duration ≥35 months.</p><p><strong>Conclusions: </strong>Although this was a retrospective study with a small sample size, we did not observe any statistically significant differences in the clinical response to abiraterone acetate between mCRPC patients with long ADT duration and those with short ADT duration in terms of disease progression-free survival.</p>","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"580-6"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of neurogenic bladder.","authors":"Seung-June Oh","doi":"10.4111/kju.2015.56.8.545","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.545","url":null,"abstract":"The number of patients with neuropathy is growing as the population ages. Not surprisingly, most of these patients suffer from lower urinary tract dysfunction (LUTD). Neurogenic LUTD, whether its cause is traumatic or degenerative, is one of the most complicated conditions to physicians. This is because there is a relative lack of quality information in this area. In addition, this field has been relatively underfocused and underfunded. \u0000 \u0000Dysfunction of the urinary bladder and urethral sphincter imposes detrimental impacts on patient life. Physicians should understand the active dynamics of the emptying and storage of the lower urinary tract. A better understanding of these urodynamics truly helps to attain two paramount treatment goals: kidney preservation and patients' quality of life (QoL). Physicians primarily aim for kidney preservation while patients seek medical help to solve their QoL problems. There are indeed some dilemmas when these two issues are incompatible. In the evaluation and management of these patients, both aspects should not only be taken into discreet account but also be balanced. \u0000 \u0000Most patients with LUTD face various problems. Many practical issues need resolution, including catheter issues, QoL-related issues, and newer treatment agents. These issues will be able to be resolved through intensive basic and clinical research. Korean Journal of Urology is committed to making valuable contributions to the medical community by providing quality information on neurogenic LUTD.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"545"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34098210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The authors reply: Predictive role of hematologic parameters in testicular torsion.","authors":"Mustafa Güneş, Mehmet Umul, Muammer Altok","doi":"10.4111/kju.2015.56.8.603","DOIUrl":"https://doi.org/10.4111/kju.2015.56.8.603","url":null,"abstract":"To the Editor: \u0000 \u0000Some hematologic markers, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and mean platelet volume (MPV), have gained popularity as possible predictive factors in oncologic and nononcologic inflammatory processes [1,2,3]. We have read the letter about our recently published report, \"Predictive Role of Hematologic Parameters in Testicular Torsion\" [4]. We thank the authors for their contribution about our article. We agree that hematologic parameters including the NLR and MPV may be affected by malignant or nonmalignant systemic diseases such as diabetes mellitus, hypertension, and thyroid disorders. However, our study population consisted of testicular torsion (TT) patients who had undergone scrotal exploration in emergency conditions. Therefore, routine evaluation of thyroid function tests had not been performed. Moreover, as we mentioned in our article, the mean age in our TT and control groups was 14 and 15 years, respectively. It can be appreciated that systemic inflammatory disorders do not usually occur in the early part of life. Besides, our control group comprised age-matched healthy subjects. We did not detect a significant difference between the groups in terms of malignant and nonmalignant inflammatory disorders [4]. \u0000 \u0000Finally, in agreement with the authors, all systemic 2015inflammatory diseases may affect the level of hematologic markers. Further studies investigating the possible predictive role of these markers on various processes should consider the accompanying conditions that may influence the results.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"56 8","pages":"603"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4111/kju.2015.56.8.603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33995141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}