Journal of Health Sciences and Medicine最新文献_第2页

Pctx1 venom in the treatment of vasospasm due to experimental subarachnoidal hemorrhage Pctx1 毒液治疗实验性蛛网膜下腔出血引起的血管痉挛

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1345021

Mehmet Yiğit Akgün, Mehmet Hüseyin Akgül

{"title":"Pctx1 venom in the treatment of vasospasm due to experimental subarachnoidal hemorrhage","authors":"Mehmet Yiğit Akgün, Mehmet Hüseyin Akgül","doi":"10.32322/jhsm.1345021","DOIUrl":"https://doi.org/10.32322/jhsm.1345021","url":null,"abstract":"Aims: We aimed to investigate the role of neuron damage in experimental animals following vasospasm, by increasing perfusion of neuronal tissue through vasodilation using the venom of PcTx1, and to determine its effectiveness in reducing neuron damage after vasospasm. Methods: Thirty adult male Wistar albino rats weighing between 300 and 400 grams were used and divided into three groups: the Sham group (Group 1, n=10), to which no application was made; the SAH (control) group (Group 2, n=10), in which a double SAH model was created and 1 cc of saline was administered intraperitoneally; and the SAH+PcTx1 group (Group 3, n=10), in which a double SAH model was created and 1 cc/kg of PcTx1 venom was administered intraperitoneally daily. Basilar artery diameter and immunochemical measurements were performed histopathologically, and neurohistopathological findings were scored semiquantitatively in terms of vascular changes, neuron degeneration, gliosis, and bleeding criteria using a scale of 0 (none), 1 (mild), 2 (moderate), or 3 (severe). eNOS immunopositivity was also evaluated. The detection of apoptosis in the brain was performed by evaluating the effector enzyme caspase-3 immunoreactivity of the exogenous apoptosis pathway. Results: The most severe vascular spasm and degeneration-necrosis of brain tissue gray matter neurons were seen in Group 2, whereas the vascular narrowing was less severe in Group 3. Brain parenchyma and neuron and neuroglial reactions were milder in Group 3. eNOS expression was detected at a higher level in Group 1, Group 2, and Group 3, respectively. For apoptosis and caspase-3 immunoreactivity of the exogenous apoptosis pathway, no immunopositive reactions were observed in Group 1. Conclusion: For the occurrence and formation mechanisms of vasospasm after subarachnoid hemorrhage, this pathological condition is thought to result from multifactorial and various biochemical reactions. In our study, it was found that psalmotoxin effectively prevented vasospasm and significantly reduced tissue damage after vasospasm.","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between nursing students' mental health literacy levels and holistic nursing competencies 护理专业学生的心理健康知识水平与整体护理能力之间的关系

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1338674

Kısmet DURAN GÜL, Havva Akpinar

引用次数: 0

Distribution of bacteria isolated from urine cultures and resistance pattern of Escherichia coli strains in community-acquired urinary tract infections 社区获得性尿路感染中从尿培养物中分离出的细菌分布和大肠埃希菌菌株的耐药性模式

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1350956

D. Bulut, H. Karakoç

{"title":"Distribution of bacteria isolated from urine cultures and resistance pattern of Escherichia coli strains in community-acquired urinary tract infections","authors":"D. Bulut, H. Karakoç","doi":"10.32322/jhsm.1350956","DOIUrl":"https://doi.org/10.32322/jhsm.1350956","url":null,"abstract":"Aims: Urinary tract infections are one of the most common among community-acquired infections. Escherichia coli (E. coli) is the most common cause of community-acquired urinary tract infections. In our study, we aimed to determine the correct empirical treatment by determining the resistance profile of E. coli strains isolated from urine cultures in our hospital, thus both establishing an effective treatment and preventing the development of resistance. Methods: Urine cultures of 3145 patients with urinary tract infection symptoms who applied to the infection and clinical microbiology outpatient clinic of our hospital between January 2019 and December 2019 were analyzed retrospectively. Patients with a history of catheter, a history of urinary operations, a history of hospitalization in the last 15 days, contamination in their cultures, and patients under the age of 18 were excluded from the study, and 422 urine cultures with growth were included in the study. Results: The mean age of the patients included in the study was 49.8±14.7 years, and the gender distribution consisted of 301 females (71.3%) and 121 males (28.7%). E. coli was isolated in 313 (77.6%) of these cultures. The antibiotic with the highest resistance rate was trimethoprim-sulfametoxazole (34.8%), while the antibiotics with the lowest resistance rates were fosfomycin and imipenem (0.6%). Conclusions: Considering that the resistance profiles of microorganisms are different from each other on the basis of country, region, and city, revealing regional resistance patterns can make an important contribution to both establishing effective treatment and preventing the development of antibiotic resistance.","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic myomectomy is safe in patients with previous abdominal surgery 腹腔镜子宫肌瘤切除术对曾接受过腹部手术的患者是安全的

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1363658

B. Varlı, Şahin Kaan Baydemi̇r, Y. E. Şükür, B. Berker

{"title":"Laparoscopic myomectomy is safe in patients with previous abdominal surgery","authors":"B. Varlı, Şahin Kaan Baydemi̇r, Y. E. Şükür, B. Berker","doi":"10.32322/jhsm.1363658","DOIUrl":"https://doi.org/10.32322/jhsm.1363658","url":null,"abstract":"Aims: The excision of myomas is commonly carried out in symptomatic women who choose to preserve their uterus, either using an open or minimally invasive (hysteroscopy, laparoscopy, robotic) approach. Patient selection is a critical factor in achieving a successful laparoscopic myomectomy. Prior abdominal surgery was not defined as a risk factor, however, the safest approach in these cases is still the subject of intense debate The aim of this study was to evaluate the safety of laparoscopic myomectomy in patients with previous abdominal surgery. Methods: A retrospective cohort study was conducted on the files and operative notes of the patients who underwent laparoscopic myomectomy operation in a university-hospital based gynaecology department between January 2012 and March 2017. The patients were classified into two groups; Group 1 consisted of 34 patients who had previously undergone abdominal surgery, whereas the Group 2 comprised 118 patients who had not undergone any abdominal surgery. Results: There were no significant difference between patients with and without a history of abdominal surgery in terms of operation time, postoperative hospital stays, blood loss, rate of operative complications, or conversion rate to open surgery. Conclusion: A history of abdominal surgery seems to have no negative impact on the safety of a subsequent laparoscopic myomectomy.","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of 18F-FDG PET/CT findings on prognosis in patients with diffuse large B cell lymphoma 18F-FDG PET/CT 检查结果对弥漫大 B 细胞淋巴瘤患者预后的影响

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1364480

Seda Yilmaz, M. Erol

{"title":"The effect of 18F-FDG PET/CT findings on prognosis in patients with diffuse large B cell lymphoma","authors":"Seda Yilmaz, M. Erol","doi":"10.32322/jhsm.1364480","DOIUrl":"https://doi.org/10.32322/jhsm.1364480","url":null,"abstract":"Aims: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), plays an important role in both staging at the time of diagnosis and follow-up of treatment response in lymphoma. Our aim was to investigate the effect of different quantitative metabolic parameters, which are not used in routine practice, on treatment response and overall survival (OS) in patients with diffuse large B-cell lymphoma. Methods: A total of 26 patients were included in our retrospective cohort study. Deauville 5-point scale (5-PS), and cut-off values for changes in maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), metabolic tumor volume (MTV)(2.5-%41- PERCIST -aort) and total lesion glycolysis index (TLG) (2.5-%41- PERCIST-aort) effect of metabolic parameters on treatment response and OS was investigated. Results: Metabolic parameters did not predict treatment response, while TLGPERCIST (p=0.034), TLGAORT (p=0.040), MTV41 (p=0.040) and TLG41 (p=0.034) parameters were statistically significant for OS. Median OS (months) was statistically significant in TLGPERCIST groups (p=0.047). While the median OS (months) in the TLGPERCIST","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenteric panniculitis clinical presentations, management, and outcomes: a single institute experience of 89 patients 肠系膜泛发性炎的临床表现、处理和结果：一家研究所收治 89 名患者的经验

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1348835

Belma Çevi̇k, B. Kasapoglu, A. Yozgat, Murat Keki̇lli̇

{"title":"Mesenteric panniculitis clinical presentations, management, and outcomes: a single institute experience of 89 patients","authors":"Belma Çevi̇k, B. Kasapoglu, A. Yozgat, Murat Keki̇lli̇","doi":"10.32322/jhsm.1348835","DOIUrl":"https://doi.org/10.32322/jhsm.1348835","url":null,"abstract":"Aims: Mesenteric panniculitis is a rare, non-specific, chronic inflammatory disease with a reported incidence of 0.16-3.3% that primarily involves the mesenteric adipose tissue. We aimed to retrospectively analyze the clinical features of patients diagnosed with mesenteric panniculitis. Methods: We retrospectively analyzed the reports of 941 patients who were examined in the Gastroenterology Clinic of Lokman Hekim Hospital and underwent abdominal computerized tomography (CT) between January 2019 and December 2021. Results: Among CT scan reports of 941 patients, the diagnosis of mesenteric panniculitis was present in 89 (9.45%) patients (55 male and 34 female). The reasons for obtaining a CT scan in those patients were as follows: severe abdominal pain in 53 (59.6%) patients, weight loss in 16 (17.9%) patients, bloating, distention, and suspicion of sub-ileus in 12 (13.5%) patients, and alterations in abdominal movements (constipation or diarrhea) in 8 (8.9%) patients. Among patients with mesenteric panniculitis, autoimmune diseases were also analyzed 21 were having Hashimoto thyroiditis, 2 were having vitiligo, 2 were having Sjögren’s disease, 1 was having primary biliary cholangiopathy, and 1 was having a diagnosis of celiac disease. Conclusion: Mesenteric panniculitis is not a very rare disease, diagnosed with mainly CT findings. Although the disease may be associated with some autoimmune diseases and malignancies, the disease outcomes are generally fine. However, there are still many unknown points, especially about the etiology and outcomes of the disease.","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive importance of systemic inflammation response index in de novo brain metastatic small cell lung cancer patients 全身炎症反应指数对新发脑部转移性小细胞肺癌患者的重要预测作用

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1343077

Mustafa Büyükkör, Necati Alkiş

{"title":"Predictive importance of systemic inflammation response index in de novo brain metastatic small cell lung cancer patients","authors":"Mustafa Büyükkör, Necati Alkiş","doi":"10.32322/jhsm.1343077","DOIUrl":"https://doi.org/10.32322/jhsm.1343077","url":null,"abstract":"Aims: The subtype of lung cancer, known as small cell lung cancer (SCLC), tends to have a highly fatal course, especially in advanced stages. In particular, the overall survival durations further decrease in cases of brain metastases in SCLC. There is increasing evidence for the role of systemic inflammation parameters in predicting cancer prognosis, and they appear likely to become potential target markers for clinical treatments in the future. We aimed to evaluate the systemic inflammation response index (SIRI), a novel inflammatory laboratory marker that could predict long-term survival and serve as a potential target marker for clinical treatment, in patients with de novo brain metastatic small cell lung carcinoma (DNBM SCLC).\" Methods: Clinicopathological features of adult patients diagnosed with DNBM SCLC were recorded from the patient registry of the hospital. Patients without medical records were not included in the study. Investigations were carried out to assess the prognostic effect of the SIRI parameter in predicting the 12-month overall survival (OS12) in DNBM SCLC patients, by determining a cut-off value and conducting appropriate statistical analyses, considering p-values (","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the COVID-19 pandemic on mode of delivery COVID-19 大流行对分娩方式的影响

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1341972

E. Gündogdu, Elif ÜNLÜGEDİK SAYIN, Medine KAHRAMAN KAYA

{"title":"Impact of the COVID-19 pandemic on mode of delivery","authors":"E. Gündogdu, Elif ÜNLÜGEDİK SAYIN, Medine KAHRAMAN KAYA","doi":"10.32322/jhsm.1341972","DOIUrl":"https://doi.org/10.32322/jhsm.1341972","url":null,"abstract":"Aims: The first case of COVID-19 was reported on March 11th, 2020, in Turkey, and the measures taken by the state to prevent the spread of the virus were put on hold by March 2022. The purpose of this study is to present information with special focus on mode of delivery among pregnant women during COVID-19 pandemic. We aimed to assess the effect of pandemic on the rates of normal vaginal delivery and C-section. Methods: This is a restrospective cohort study including all pregnant women at more than 20 weeks of gestation admitted to labour and delivery unit in an academic tertiary care hospital. Records of patients two years before the pandemic and two years of the pandemic were extracted. The number of pregnants admitted to the labour and delivery, the mode of delivery, selected method of anesthesia, total expenses of the patients, the length of hospital stay, indications for cesarian section were compared between the two periods. Results: A total of 9048 patients were identified, of which 4745 were before the pandemic and 4303 during the pandemic. The most striking finding was the decrease in C-section rates during pandemic which was mostly due to decrease in number of primary C-sections. The length of hospital stay was shorter during pandemic as well. The mean age, route of anesthetics, surgery length did not differ between the two groups. Conclusion: The available evidence on COVID-19’s potential impact on C-section rates is conflicting. Some suggest that there might be evidence indicating a possible link between COVID-19 and increased rates of C-section. However, this study showed that when all the deliveries are included pandemic caused a significant decrease in the rates of primary C-section which might be due to decreased interventions of the healthcare professionals.","PeriodicalId":176872,"journal":{"name":"Journal of Health Sciences and Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation between impaired coronary microvascular circulation and plasma atherogenic index in patients with ankylosing spondylitis 强直性脊柱炎患者冠状微血管循环受损与血浆致动脉粥样硬化指数之间的关系

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1343245

Eyüp Özkan, Y. Yilmaz, Fatma Betul Celik, Ş. Keleşoğlu, Yasemin Doğan, Erkan Demirci, E. Kasapoğlu, Ümmühan Zeynep Bi̇lgi̇li̇, Mustafa Caliskan

引用次数: 0

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study 血液图参数在儿童特应性皮炎的诊断、严重程度和病程中的诊断权重：一项以证据为重点的全面研究

Journal of Health Sciences and Medicine Pub Date : 2023-10-29 DOI: 10.32322/jhsm.1364897

Fatih Çiçek, Ibrahim Kandemir, M. Köle

引用次数: 0