International Journal of Medical Biochemistry最新文献

{"title":"Evaluation of Vitamin D Status and Its Association with Thyroid Disease","authors":"R. Nar","doi":"10.14744/ijmb.2019.92486","DOIUrl":"https://doi.org/10.14744/ijmb.2019.92486","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120951169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of coagulation parameters according to serum CRP levels in early stage COVID-19 patients","authors":"sema kardeşler","doi":"10.14744/ijmb.2023.77698","DOIUrl":"https://doi.org/10.14744/ijmb.2023.77698","url":null,"abstract":"Objectives: An increase in the levels of inflammatory biomarkers is observed in coronavirus disease (COVID-19). Coagulopathy occurring during the course of the disease has also been associated with inflammation. In our study, we aimed to evaluate the coagulation parameters according to the severity of inflammation in patients with early stage COVID-19 disease. Methods: The study was carried out retrospectively in a third-level hospital between April 8 and August 20, 2020. The patients were divided into two groups according to polymerase chain reaction (PCR) results. Non-COVID-19 group consisted of 72 patients with negative, and COVID-19 group consisted of 247 patients with positive PCR results. According to the serum C-reactive protein (CRP) levels the COVID-19 patients were divided into three groups as follows: Group1 (CRP<10 mg/L;n=105), Group 2 ( CRP 10-50 mg/L;n=72), and Group 3 (CRP >50 mg/L;n=70). Age, CRP, and coagulation parameters including fibrinogen, D-dimer, aPTT, and PT were compared between the groups. Results: There were significant differences between the non-COVID-19 and COVID-19 patients in terms of age, CRP and coagulation parameters. Likewise, there was a significant difference among 3 groups regarding coagulation parameters. In the multinomial logistic regression analysis, only level of D-dimer was an independent risk factor among all groups, while PT was an independent risk factor between Groups 1, and 3. Conclusion: Our findings suggest that coagulopathy occurs in the early stage in relation to the severity of inflammation. For the diagnosis of COVID-19 disease and the detection of thrombotic complications;it is important to monitor results of the coagulation tests along with markers of inflammation from the early stages of the disease. [ FROM AUTHOR] Copyright of International Journal of Medical Biochemistry is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121527379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Generation Oral Anticoagulants May Cause Unreliable Results in Routine Coagulation Testing","authors":"A. Gedikbaşı","doi":"10.14744/IJMB.2019.33043","DOIUrl":"https://doi.org/10.14744/IJMB.2019.33043","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"73 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116249962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review Article – Metal binding protein: Metallothionein","authors":"F. Marikar","doi":"10.14744/ijmb.2022.94834","DOIUrl":"https://doi.org/10.14744/ijmb.2022.94834","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131945933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19)","authors":"Ç. Deniz","doi":"10.14744/ijmb.2021.57070","DOIUrl":"https://doi.org/10.14744/ijmb.2021.57070","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132686688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis","authors":"Aslı Kutlu","doi":"10.14744/ijmb.2022.18199","DOIUrl":"https://doi.org/10.14744/ijmb.2022.18199","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126012596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irreversible Neurological Effects of Late Diagnosis Phenylketonuria- A Case Presentation","authors":"K. Gupta","doi":"10.14744/ijmb.2023.54376","DOIUrl":"https://doi.org/10.14744/ijmb.2023.54376","url":null,"abstract":"phenyl-lactate, and phenylpyruvate. In untreated patients, these biochemical metabolites get accumulated in the central nervous system and are hypothesized to cause neurological deficits and impaired transport of other aromatic amino acids like tryptophan. This disease shows the phenomenon of pleiotropy meaning one gene contributes to multiple phenotypic effects such as light skin, musty body odor, seizures, and intellectual disability. Strict adherence to diet restricted of phenylalanine is fortu-itously deterrent against foreseen neurological complications. Phenylketonuria (PKU) is an autosomal recessive hereditary disorder due to deficiency of enzyme phenylalanine hydroxylase or the cofactor tetrahydrobiopterin. Its late manifestation leads to irreversible neurological changes. The aim of our work is to emphasize the difference in presentation in late diagnosis of the disease verses classical presentation making it difficult to correctly diagnose and also point out the reasons for late diagnosis and missed cases in India. A 9-year-old patient presented with global developmental delay and severe behavioral problems. Hypertonia and spasticity with low intelligence quotient (IQ) were seen. Baseline investigations such as renal function, thyroid function, electrolytes, uric acid, folate, and blood adrenocorticotropic hormone level were within range; hence, magnetic resonance imaging (MRI) was advised which revealed areas of bilateral demyelination suggesting metabolic leukodystro-phy. PKU was thereafter confirmed with metabolic profile and clinical exome study. Early routine screening of all new-borns for common inherited and metabolic disorders should be mandatory to later prevent irreversible damage. Cases of delayed diagnosis deviate considerably from classical clinical and radiological findings of the disease making correct and prompt diagnosis difficult. Education of parents and prenatal counseling should be encouraged.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132302159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency status in Turkey: A meta-analysis","authors":"Medine Alpdemir","doi":"10.14744/IJMB.2019.04127","DOIUrl":"https://doi.org/10.14744/IJMB.2019.04127","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125724957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Optimization of A New Aptamer-Based Method for P-Selectin (CD62p) Measurement","authors":"Ö. Çevik","doi":"10.14744/ijmb.2021.25238","DOIUrl":"https://doi.org/10.14744/ijmb.2021.25238","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123862322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic health status and cardiovascular risk of different ABO blood group phenotypes","authors":"I. Anioke","doi":"10.14744/ijmb.2019.54154","DOIUrl":"https://doi.org/10.14744/ijmb.2019.54154","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128342913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}