International Journal of Medical Biochemistry最新文献

{"title":"Synthesis of novel iron chelating and heme-interacting acridone derivatives to prevent free heme- and ironmediated protein oxidation","authors":"chinmay pal","doi":"10.14744/ijmb.2023.47450","DOIUrl":"https://doi.org/10.14744/ijmb.2023.47450","url":null,"abstract":"Objectives: Various diseases are associated with the accumulation of oxidized proteins. In certain pathological conditions, the breakdown of hemoproteins, such as hemoglobin, leads to the formation of heme. Heme possesses pro-oxidant properties, which contribute to oxidative stress, inflammation","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132655115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF SARS-COV-2 WUHAN AND ALPHA VARIANTS: CLINICAL AND LABORATORY HIGHLIGHTS","authors":"D. Timur, U. Demirpek, E. Ertek, O. Aydin, T. Karabiyik, H. Kayadibi","doi":"10.1101/2022.05.17.22275188","DOIUrl":"https://doi.org/10.1101/2022.05.17.22275188","url":null,"abstract":"Since December 2019, after the declaration of new cases regarding novel coronavirus disease, many variants have emerged as a consequence of the viral evolution. Though the SARS-CoV-2 variants have been studied for molecular basis, the clinical and pathologic disparities of them have been understood inadequately. The aim of this research was to figure out the differences between the SARS-CoV-2 Alpha (B1.1.7) variant and the classical Wuhan groups on the clinical basis and laboratory results of the COVID-19 patients who had positive PCR test. The study was done retrospectively inclusive of epidemiological, laboratory data and clinical symptoms of patients who were admitted to the emergency service between February 15 and March 15, 2021 and had positive COVID-19 PCR test results. Though there was no statistically significant difference in symptoms between SARS-CoV-2 Alpha variant and classical variant (Wuhan type) groups; C-reactive protein (CRP), lymphocyte and leukocyte counts were statistically significantly higher in the Wuhan type group; prothrombin time (PT), International Normalized Ratio (INR) and serum creatinine values were statistically significantly higher in the Alpha group. Studies such as ours that investigate both the clinical features and laboratory data of SARS-CoV-2 variants will close the knowledge gaps, so better decisions may be made by health policy makers. Additional studies in this area will increase the understanding of the topic.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133844624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the analytical performance of two vitamin D immunoassay methods","authors":"Ö. Yis","doi":"10.14744/IJMB.2019.29491","DOIUrl":"https://doi.org/10.14744/IJMB.2019.29491","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121112044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Flavonoids on Cholesterol Efflux Capability","authors":"M. Ayoub","doi":"10.14744/ijmb.2022.96977","DOIUrl":"https://doi.org/10.14744/ijmb.2022.96977","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125866451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of fetuin-A, CRP and CRP/fetuin-A values in COVID-19 patients","authors":"Nezahat Kurt","doi":"10.14744/ijmb.2022.83097","DOIUrl":"https://doi.org/10.14744/ijmb.2022.83097","url":null,"abstract":"Objectives: Fetuin-A, a glycoprotein with several functions, is also a negative acute phase reactant. The purpose of this study was to investigate levels of serum fetuin-A in coronavirus disease 2019 (COVID-19) patients, its association with disease severity, and whether it has superiority over C-reactive protein (CRP). Methods: The research comprised 56 individuals with COVID-19(+) and 30 healthy controls. The COVID-19(+) patient population was split into three subgroups: mild, moderate, and severe. All participants' serum concentrations of fetuin-A, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured using ELISA commercial test kits. In addition, CRP and other biochemical values from biochemistry laboratory data were gathered, and the CRP/fetuin-A ratio was calculated. Results: The fetuin-A concentration of the COVID-19(+) patient group was shown to be statistically lower than that of the healthy control group. TNF-α and IL-6 levels were found to be significantly different in both groups. While fetuin-A had a higher area under the curve (AUC) value than CRP (0.875 and 0.800, respectively), CRP/fetuin-A had the strongest AUC (0.933). Conclusion: Low serum fetuin-A concentrations in COVID-19 patients suggest that fetuin-A is a negative acute phase reactant for severe acute respiratory syndrome coronavirus 2. Furthermore, fetuin-A alone and CRP/fetuin-A value are both contenders for being more remarkable markers than CRP. [ FROM AUTHOR] Copyright of International Journal of Medical Biochemistry is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124136989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated glomerular filtration rate in identifying illness severity in newly admitted patients with COVID-19: A single-center study","authors":"Fatma Tuba Engindeniz","doi":"10.14744/ijmb.2021.60783","DOIUrl":"https://doi.org/10.14744/ijmb.2021.60783","url":null,"abstract":"Objectives: Early prediction of risk factors for serious illness and death in patients with coronavirus disease 2019 (COVID-19) appears to be a priority. This study aimed to examine whether a single estimated glomerular filtration rate (eGFR) at triage predicts the need for intensive care unit (ICU) admission of patients with COVID-19. Methods: This retrospective study included data from patients with COVID-19 at the Bursa Yuksek Ihtisas Training and Research Hospital until October 2020. Patients were assigned to two groups according to their eGFR level at admission: group 1 (eGFR >60 mL/min/1.73 m2) and group 2 (eGFR=30-60 mL/min/1.73 m2). Results: The results of 1447 consecutive patients diagnosed with COVID-19 were analyzed at hospital admissions. Of these, 1001 patients who met the study criteria were included in the study. The median age of group 2 was higher than group 1: 69 interquartile range (IQR 23) years versus 39 (IQR 23) years (p<0.01). Patients with an eGFR <60 mL/min/1.73 m2 had lower lymphocyte counts while having higher C-reactive protein, d-dimer, lactate dehydrogenase, and fibrino-gen levels. The ICU admissions were significantly higher in patients with a baseline eGFR <60 mL/min/1.73 m2 (42.85%) compared with an eGFR >60 mL/min/1.73 m2 (6.42%, p<0.001). There was a weak negative correlation between eGFR and ICU admission (rho=-0.291, p<0.001). Conclusion: The eGFR at admission was strongly correlated with the severity of the disease. Therefore, measuring eGFR in all patients at admission may warrant appropriate triage. © 2022, Kare Publishing. All rights reserved.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130082729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and molecular mechanisms that underlies the formation of atherosclerotic plaque and plaque rupture-review","authors":"Yiglet Mebrat","doi":"10.14744/ijmb.2023.78309","DOIUrl":"https://doi.org/10.14744/ijmb.2023.78309","url":null,"abstract":"by genetic","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133469842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) and Mean Platelet Volume (MPV) with disease activity in patients with Ankylosing Spondylitis (AS)","authors":"A. Sheoran","doi":"10.14744/ijmb.2021.15013","DOIUrl":"https://doi.org/10.14744/ijmb.2021.15013","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134620182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procalcitonin in the diagnosis of sepsis and its correlations with upcoming novel diagnostic markers","authors":"M. E. Sitar","doi":"10.14744/IJMB.2019.30502","DOIUrl":"https://doi.org/10.14744/IJMB.2019.30502","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114956580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between plasma viscosity and endotel markers in patients with ascending aortic aneurysms: a pilot study","authors":"B. Kurt","doi":"10.14744/ijmb.2019.88598","DOIUrl":"https://doi.org/10.14744/ijmb.2019.88598","url":null,"abstract":"55 Ercan, Plasma viscosity in ascending aortic aneurysms / doi: 10.14744/ijmb.2019.88598 terms of tissue perfusion. Alterations in these hemorheological parameters directly affect endothelial function through an alternating shear force profile on the endothelial wall [7]. Furthermore, blood viscosity is known to be a function of shear rate and has an impact on wall shear stress [8], which has been reported to be strongly associated with aneurysm formation, progression, and risk of rupture [9]. PV is an important contributing factor to whole blood viscosity [10]. Since endothelial cells are in a state of constant contact with shear stress and plasma, plasma components have a major role in endothelial changes occurring due to PV [11]. Plasma is the blood component remaining once red and white blood cells, as well as other cellular elements, have been removed. Macromolecular components and water content play a role in the viscosity of plasma, which is a concentrated protein solution. The molecular structure and weight of a protein such as fibrinogen affect PV. Greater molecular weight and aggregating capacity, and less spheroid formation contribute to greater PV [12]. Nitric oxide (NO), released by vascular endothelial cells, is also believed to play a role in aneurysm formation [13]. Asymmetric dimethylarginine (ADMA), a potential marker of endothelial dysfunction, is an endogenous inhibitor of both endothelial and inducible nitric oxide synthase (NOS), and has been associated with mortality in several acute and chronic vascular conditions [14, 15]. The aim of this study was to investigate change in PV and the endothelial markers of fibrinogen, nitrite and NOx, and ADMA before and after AsAA surgery and to compare the results with those of healthy patients. Materials and Methods Subjects and study design The study group included a total of 23 patients who underwent surgical repair for AsAA (mean age: 63±8 years), and the control group consisted of 30 healthy patients without diabetes, hypoor hyperlipidemia, or heart disease (mean age: 72±10 years). The mean ascending aorta diameter was 3.60±0.20 cm in the control group. The mean diameter of the ascending aorta in the study group was 6.00±1.80 cm. The exclusion criteria included the presence of congenital valve disease (bicuspid, unicuspid, or quadricuspid aortic valve, etc.), a hereditary connective tissue disorder (Marfan, Ehlers-Danlos, Loeys-Dietz syndromes, etc.), reoperation, or a dissecting aortic aneurysm. The plasma creatinine and glycated hemoglobin levels were within normal limits in all of the control and study group patients. In the study group, 17 patients had been diagnosed with hypertension and were on metoprolol 50 mg once daily. Eight patients were current tobacco smokers (1 packet/day). All of the operations in the study group were elective procedures. The study protocol was approved by the Republic of Turkey Ministry of Health, Public Hospitals Administration of Turkey, Kartal Ko","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116869191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}