International Journal of Medical Biochemistry最新文献

{"title":"Ischemia modified albumin level and thiol disulphide homeostasis in the etiology of tinnitus","authors":"Huseyin Kurku","doi":"10.14744/ijmb.2021.92485","DOIUrl":"https://doi.org/10.14744/ijmb.2021.92485","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122961850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapter protein - fadd bridges the apoptosis","authors":"F. Marikar","doi":"10.14744/ijmb.2023.85619","DOIUrl":"https://doi.org/10.14744/ijmb.2023.85619","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123961028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Inflammation Markers in Different Severities of Covid-19 Disease","authors":"M. Katar","doi":"10.14744/ijmb.2021.39358","DOIUrl":"https://doi.org/10.14744/ijmb.2021.39358","url":null,"abstract":"Objectives: We retrospectively analyzed COVID-19 patients for clinical and hematologic features and tried to define the most appropriate markers to diagnose and predict the severity. Methods: This is a retrospective cross-sectional study. All 4443 patients included were diagnosed with reverse trancription-polymerase chain reaction between January 1 and December 30, 2020. We classified patients according to their mode of treatment: outpatient, inpatient in the ward, or inpatients in the intensive care unit (ICU). Results: The mean age of 2283 (51.4%) women and 2160 (48.6%) men included in the study was determined to be 39.77±17.30. Of the 4443 patients, 3985 (89.7%) were outpatients, 330 (7.4%) were inpatients, and 128 (2.9%) patients were treated in the ICU. The mean hospital stay was 8.36±4.55 days for the survivors in the ward group and 2.67±1.53 days for those who died (p=0.031). The mean hospitalization time of the survivors in the ICU group was 19.97±12.09 days, and the mean hospitalization time of the deceased was 13.10±9.99 days (p=0.001). Age, ferritin, D-dimer, glucose, ALT, AST, urea, creatinine, CRP, HgA1c, IMG, IMG%, and RDW-SD showed a gradual and significant increase in outpa-tient, ward, and ICU groups (p<0.001). Na, K, Neu, Neu%, MCV, RDW-CV, MPV, NLR, PLR, and NMR increased gradually from the outpatient group to the service and ICU groups, whereas Ca, RBC, Hgb, and Hct values decreased significantly (p<0.001). WBC, lymph%, and RDW were highest in the ICU group. Conclusion: Advanced age and being male are important risk factors for hospitalization. Indexes such as NLR, PLR, LCR, NMR, and LMR can be used to predict the severity of the disease. © 2022, Kare Publishing. All rights reserved.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124118186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dysnatremia on prognosis and mortality in critically ill patients with COVID-19","authors":"Sinem Bayrakçı","doi":"10.14744/ijmb.2023.58070","DOIUrl":"https://doi.org/10.14744/ijmb.2023.58070","url":null,"abstract":"is a good Objectives: Sodium disorders, the most common electrolyte disorders in hospitalized patients, are common in hospitalized patients with pneumonia. Numerous studies have shown that sodium abnormalities are independent risk factors for mortality, medical intensive care unit (ICU) admission, and prolonged hospital stay. The aim of the study was to investigate the prevalence of dysnatremia and the effect of dysnatremia on prognosis and mortality in critically ill COVID-19 patients. Methods: This retrospective study was performed between June 1, 2021, and July 30, 2021, in COVID-19 ICUs. 149 critically ill, laboratory-confirmed COVID-19 patients admitted to the ICU were included in the study. The collected data included demographic data, comorbidities, severity of illness, and laboratory tests (serum C-reactive protein, lymphocyte, ferritin, sodium, chloride, and potassium levels). The prognosis was evaluated in terms of mortality, need for mechanical ventilation, and length of ICU stay. Results: At ICU admission, hyponatremia was present in 33 (22.1%) patients, whereas hypernatremia was detected in 14 (9.5%) patients. 102 (68.4%) patients had normal sodium levels. The mortality rate for normonatremic, hypona-tremic, and hypernatremic patients was 50.0%, 57.7%, and 78.6%, respectively. These results indicated a statistically significantly higher mortality rate in patients with baseline hypernatremia (p=0.05). Conclusion: Among critically ill COVID-19 patients in the ICU, dysnatremia was common at admission and hyponatremia was more common than hypernatremia. Hypernatremia was related to mortality. Admission sodium levels can be a predictor of mortality in COVID-19 patients who are critically ill.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121413100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Detecting Hyperlipidemia in Children and Adolescents to Manage Cardiovascular Risk: A Cross-Sectional Study","authors":"A. Kaytaz","doi":"10.14744/ijmb.2021.28190","DOIUrl":"https://doi.org/10.14744/ijmb.2021.28190","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127112816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the distribution of thyroid dysfunction in the geriatric patient population in Corum province","authors":"M. Şahin","doi":"10.14744/ijmb.2019.54254","DOIUrl":"https://doi.org/10.14744/ijmb.2019.54254","url":null,"abstract":"61 Sahin, Thyroid dysfunction in the geriatric population / doi: 10.14744/ijmb.2019.54254 hypothyroidism is the most common thyroid function disorder in geriatric patients [2, 3]. Hyperthyroidism is observed at a rate of 0.5% to 6% in geriatric patients and affects mainly the cardiovascular system (atrial fibrillation, congestive heart failure) and bones (increased bone cycle, osteopenia) [4]. The incidence of goiter, an enlarged thyroid gland, has been reported to reach 70% in the aging population in regions with iodine deficiency [5]. Yet the diagnosis and treatment of thyroid diseases, particularly in geriatric patients, can be difficult. The symptoms and values may not be the same as those typically seen in young adults. This may be further complicated by comorbidities, which often leads to delayed diagnosis and more serious disease progression, making treatment more difficult. It has been recommended that all individuals in the geriatric age group be screened for thyroid dysfunction since these symptoms and findings may remain hidden [6]. The aim of the present study was to identify and analyze the incidence of thyroid dysfunction in patients over 65 years of age in Corum province, Turkey. Materials and Methods The demographic and laboratory results of patients aged over 65 years living in Corum province, Turkey, who presented at Hitit University Corum Erol Olcok Education and Research Hospital for any reason were used in the study. Permission was granted for the study by the Hitit University Non-Interventional Research Ethics Committee, dated and numbered 29/01/201943. The results of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) tests as well as demographic characteristics of 220 randomized patients were retrospectively investigated. Patients with total or partial thyroidectomy surgery and those receiving any medical thyroid treatment were excluded from the study. Thyroid function tests (TFT) were measured using the electrochemiluminescence method on a Siemens Advia Centaur XP model immunoassay autoanalyzer (Siemens Healthineers, Erlangen, Germany). The normal intervals for TFT at this center are TSH 0.35–5.50 μIU/mL, FT4 0.89–1.76 ng/dL, and FT3 2.30–4.20 pg/mL. Hypothyroidism was defined as FT4 <0.89 ng/dL and TSH >5.50 μIU/mL, with subclinical hypothyroidism defined as normal free hormone levels and a TSH >5.50 μIU/mL. Hyperthyroidism was defined as FT4 >1.76 ng/dL and TSH <0.35 μIU/mL, while subclinical hyperthyroidism was defined as normal free hormone levels and TSH <0.35 μIU/mL. Patients were divided into 5 groups: subclinical hypothyroidism, hypothyroidism, euthyroid, subclinical hyperthyroidism, and hyperthyroidism. Statistical analysis All of the statistical analyses were performed using the IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp.; Armonk, NY, USA). Demographic and biochemical features were presented as continuous or categorical variables, as appropriate. The Kolmogorov-S","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128338314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of The Circulating Soluble Endothelial Cell Adhesion Molecules and Pentraxin 3 Levels in Predicting Preterm Delivery Within 72 Hours","authors":"E. Davutoğlu","doi":"10.14744/ijmb.2022.55477","DOIUrl":"https://doi.org/10.14744/ijmb.2022.55477","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134498917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Thalassemia Trait in Balikesir Province According to Trait Type and Age Groups","authors":"U. Ercin","doi":"10.14744/ijmb.2021.20982","DOIUrl":"https://doi.org/10.14744/ijmb.2021.20982","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"29 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131334632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can additional information be obtained in the diagnosis of heart failure in type 2 diabetics by evaluating the hematological indices?","authors":"Z. Doğan","doi":"10.14744/ijmb.2022.29484","DOIUrl":"https://doi.org/10.14744/ijmb.2022.29484","url":null,"abstract":"","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"571 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131769144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of miRNAs in prostate cancer cell lines and prostate epithelial cell lines","authors":"E. Balkan","doi":"10.14744/ijmb.2023.26878","DOIUrl":"https://doi.org/10.14744/ijmb.2023.26878","url":null,"abstract":"Objectives: Prostate cancer (PCa) is among the most frequently diagnosed cancers and a leading cause of cancer-related deaths in men. Although prostate-specific antigen (PSA) testing has become routine in screening and early detection, PSA has high false-positive rates and poorly correlates with disease stage. Consequently, other diagnostic and prognostic markers for PCa are urgently needed. MicroRNAs (miRNAs) modulate gene expression at the transcriptional level and are known to play key roles in various physiological events. Growing evidence indicates that miRNA dysregulation is involved in the initiation and progression of many diseases, including PCa. Various miRNAs have been associated with PCa pathogenesis, suggesting that miRNA expression profiles have potential utility in the prognosis, diagnosis, and treatment of this disease. miRNA expression levels have been investigated in prostate epithelial cells by PCa cell culture. Methods: The present study compared the expression levels of selected prognostic miRNAs targeting that have been implicated in the pathogenesis of PCa. Using cDNA obtained from the C4-2 human PCa and PNT1a normal prostate epithelial cell lines, miRNA expression levels were quantitatively analyzed via melting curve analysis using the miScript SYBR Green kit in a Rotor-Gene Q real-time polymerase chain reaction (PCR) device. Results: Reverse transcription quantitative PCR analyses have demonstrated miRNA expression levels in the C4-2 PCa cell line and PNT1a prostate epithelial cell line. MiR-125, -145, -200, and -222 were found to be overexpressed in the PCa cell line (p<0.05), while there were no statistically significant differences in miR-32 expression of miR-21, -26, Let-7, -34, or -221 between PCa cells and PNT1a cells (p>0.05). Conclusion: Considering the variation in expression level of miRNAs targeting genes responsible for the etiopathogenesis of PCa. Provides information on the use of miRNAs as prognostic markers in PCa.","PeriodicalId":176166,"journal":{"name":"International Journal of Medical Biochemistry","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128217106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}