Journal of vascular surgery. Venous and lymphatic disorders最新文献

{"title":"Proximal tumescence during treatment of saphenous veins with polidocanol endovenous microfoam provides successful ablation of larger veins and predicts reduced microfoam volume","authors":"Alexandra Natalie Ascher MD , Enrico Ascher MD , Anil Hingorani MD , John Fang DO","doi":"10.1016/j.jvsv.2025.102362","DOIUrl":"10.1016/j.jvsv.2025.102362","url":null,"abstract":"<div><h3>Background</h3><div>Perivenous tumescence with saline or a dilute lidocaine solution is used routinely for thermal ablation of refluxing superficial lower extremity veins to displace sensitive structures away from the thermal probe and provide better contact with the treated venous endothelium. In this study, we introduce an adjunctive technique of tumescence infiltration at the most efferent segment of refluxing saphenous veins treated with 1% polidocanol endovenous microfoam (PEM). We hypothesize that, by reducing the vein diameter, proximal tumescence (PT) prolongs apposition time of PEM to the endothelium by delaying venous outflow and microfoam propagation speed. We evaluated PT effects on vein closure and volume of PEM used as well as the incidence of superficial venous thrombosis and ablation-related thrombus extension (ARTE).</div></div><div><h3>Methods</h3><div>A single institution retrospective study was performed with PEM ablations for the above-knee great saphenous vein (GSV), below-knee GSV, and small saphenous vein (SSV) by two operators over a 12-month period. Duplex ultrasound (DUS) within 3 to 7 days after ablation followed by a serial surveillance DUS schedule were used to evaluate for vein closure, venous thrombosis, and ARTE per institutional protocol. Any treated vein segment found to be completely or partially patent with reflux after treatment was deemed an ablation failure. Demographics and outcomes of tumescent PEM (T-PEM) ablations were compared with nontumescent PEM (NT-PEM) ablations through univariate and generalized estimating equation modeling.</div></div><div><h3>Results</h3><div>Between June 2023 and May 2024, 183 adult patients (64 male, 119 female) treated with 1% PEM in 246 lower extremities (113 right, 133 left) met the study criteria. Nineteen patients without documented follow-up DUS examinations were excluded from this study. Overall, 293 ablations (23 above-knee SV, 199 below-knee GSV, 71 small saphenous vein) were performed with a mean PEM volume of 2.8 ± 0.6 mL per ablation with a combined closure rate of 91.8% (269 of 293). One hundred nineteen ablations (40.6%) were augmented with PT (mean tumescence volume, 6 ± 2.4 mL; range, 3-16 mL). Veins treated with T-PEM were significantly larger (mean vein diameter, 4.8 ± 1.3 mm) than veins treated with NT-PEM (mean vein diameter, 4.0 ± 0.9 mm; <em>P</em> < .001). There were no significant differences in patient age (<em>P</em> = .37), sex (<em>P</em> = .06), laterality (<em>P</em> = .29), preoperative Clinical-Etiology-Anatomy-Pathophysiology clinical severity scores (<em>P</em> = .34), PEM volume used (<em>P</em> = .09), venous thrombosis (<em>P</em> = .65), ARTE (<em>P</em> = .41), or rate of treatment success (<em>P</em> = .16) on univariate comparison of T-PEM and NT-PEM ablations. Generalized estimating equation regression predicts lower microfoam volume use with PT (B = −0.4; <em>P</em> = .003) and similar treatment success rates when correct","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102362"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association studies in chronic venous disease: A systematic review","authors":"Chien Lin Soh MBBChir, MA(Cantab), MRCS,&nbsp;Matthew Tan MBBS, BSc(Hons), PhD, MRCS, FHEA,&nbsp;Alun H. Davies DM, FRCS, MA, DSc, FHEA, FEBVS, FACPH, BM, BCh,&nbsp;Sarah Onida BSc(Hons), MD, PhD, FRCS","doi":"10.1016/j.jvsv.2025.102365","DOIUrl":"10.1016/j.jvsv.2025.102365","url":null,"abstract":"<div><h3>Background</h3><div>Chronic venous disease (CVD) arises from venous hypertension secondary to impaired venous return, causing significant morbidity and diminished quality of life. Genetic factors are likely important in the pathogenesis and susceptibility of a patient to develop CVD. This systematic review summarizes genome-wide association studies (GWASs) that investigate the link between genetic variants and CVD.</div></div><div><h3>Methods</h3><div>A systematic review was conducted in accordance with the PRISMA guidelines, with the search dates ranging from January 1, 1994, to July 17, 2025. Abstract and full-text screening were completed by two independent reviewers, with any conflicts referred to a third senior reviewer. GWASs in adults investigating links between genetic variants and CVD were included. Exclusion criteria included patients with venous thromboembolism, arterial or diabetic disease, or animal models.</div></div><div><h3>Results</h3><div>Thirteen studies were included after screening 517 studies from a search of PubMed, EMBASE, and Ovid. Database sources included UK Biobank, FinnGen, PopGen, and country- or hospital-specific databases with a majority Caucasian and European patient cohort. A total of 602,760 patients were identified with varicose veins and 3,664,604 control cases that were studied with GWASs and other statistical methods including a two-sample Mendelian randomization approach, functional mapping, and genetic correlations. A variety of statistically significant genetic polymorphisms were identified that can be attributed to the heritability of varicose veins affecting inflammation and immunity (eg, PPP3R1, EBF1, and GATA2), hypertension (eg, CASZ1), and vascular architecture (eg, CASZ1, PIEZO1, and STIM2). Protective variants (eg, GJD3, MMP10, and 4EBP1) were also identified in Finnish populations. However, replication studies showed that these genetic polymorphisms are not generalizable to specific populations.</div></div><div><h3>Conclusions</h3><div>This systematic review highlights genes contributing to the development of CVD that have been identified in the literature. An improved understanding of genetic contributions to the pathogenesis of CVD may inform future diagnostics, prognostics, and personalized treatment. Further larger scale studies representative of global populations, including meta-analyses of genome-wide association datasets, are required owing to individual GWASs being statistically insufficient to draw generalizable conclusions.</div></div>","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102365"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombectomy Reduces Pulmonary Embolism Mortality But Unequal Access and Outcomes Persist by Race and Income","authors":"Brett Cohen DO ,&nbsp;Saran Singh MD ,&nbsp;Nicholas Roma MD ,&nbsp;Mary Sundo MD ,&nbsp;Megan Pattoli DO ,&nbsp;Mitchell Schwocho DO ,&nbsp;Michael Durkin MD","doi":"10.1016/j.jvsv.2025.102434","DOIUrl":"10.1016/j.jvsv.2025.102434","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102434"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral Vein Pulsatility Signals Right-sided Cardiovascular Pathology: Implications for Echocardiographic Screening","authors":"Mouhammad Halabi MD ,&nbsp;Michael Lee MD ,&nbsp;Hassan Chamseddine MD ,&nbsp;Alexander Shepard MD ,&nbsp;Timothy Nypaver MD ,&nbsp;Mitchell Weaver MD ,&nbsp;Sachin Parikh MD ,&nbsp;James Lee MD ,&nbsp;Ryan Shelters ,&nbsp;Loay Kabbani MD","doi":"10.1016/j.jvsv.2025.102401","DOIUrl":"10.1016/j.jvsv.2025.102401","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102401"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Outcomes of the VenoValve in Patients With Chronic Venous Disease and Deep Venous Reflux: Two Years of Follow-up","authors":"Mikayla Lowenkamp MD ,&nbsp;Cassius Iyad Ochoa Chaar MD, MPH, MS ,&nbsp;Matthew Smeds MD ,&nbsp;Marc Glickman MD ,&nbsp;Eric Hager MD","doi":"10.1016/j.jvsv.2025.102413","DOIUrl":"10.1016/j.jvsv.2025.102413","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102413"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Trousseau to artificial intelligence: The future of occult cancer detection in unprovoked venous thromboembolism","authors":"Ioannis Tsouknidas MD ,&nbsp;Arjun Jayaraj MD, FACS","doi":"10.1016/j.jvsv.2026.102443","DOIUrl":"10.1016/j.jvsv.2026.102443","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102443"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Efficacy of Advanced Flush Endovenous Laser Ablation in Reducing Groin Recurrences: One-year Follow-up","authors":"Roman Lunin Dr,&nbsp;Uldis Maurins Professor,&nbsp;Andrejs Vanags Dr med,&nbsp;Marija Petrovica Surgeon,&nbsp;Alise Didrihsone Surgeon","doi":"10.1016/j.jvsv.2025.102400","DOIUrl":"10.1016/j.jvsv.2025.102400","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102400"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Junctional Reflux Impact the Effectiveness of Endovenous Ablation in Patients With Isolated Insufficiency of the Great Saphenous Vein","authors":"Chandu Vemuri MD, MBA ,&nbsp;Kathleen Gibson MD ,&nbsp;Mikel Sadek MD ,&nbsp;Cassius Ochoa-Chaar MD ,&nbsp;Antonios Gasparis MD ,&nbsp;Andrea Obi MD ,&nbsp;Windsor Ting MD ,&nbsp;Nicolas Mouawad MD ,&nbsp;Yana Etkin MD ,&nbsp;Shreef Said MD ,&nbsp;Anuj Mahajan MD ,&nbsp;Bjarnason Haraldur MD ,&nbsp;Shalini Sahoo PhD ,&nbsp;John Sorkin MD, PhD ,&nbsp;Brajesh Lal MD","doi":"10.1016/j.jvsv.2025.102395","DOIUrl":"10.1016/j.jvsv.2025.102395","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102395"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental Insights Into Left Common Iliac Vein Compression: A Comparative Cadaveric Study in Fetuses and Adult","authors":"Miguel Amore MD","doi":"10.1016/j.jvsv.2025.102393","DOIUrl":"10.1016/j.jvsv.2025.102393","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102393"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Thermal and Nonthermal Ablation for the Treatment of Venous Leg Ulcers","authors":"Nicholas Wells MA ,&nbsp;Jennifer Ellis MD ,&nbsp;Nicholas Osborne MD ,&nbsp;Alisha Oropallo MD ,&nbsp;Neil Khilnani MD ,&nbsp;Thomas O'Donnell MD ,&nbsp;Peter Lawrence MD ,&nbsp;Cassius Iyad Ochoa Chaar MD, MPH, MS","doi":"10.1016/j.jvsv.2025.102389","DOIUrl":"10.1016/j.jvsv.2025.102389","url":null,"abstract":"","PeriodicalId":17537,"journal":{"name":"Journal of vascular surgery. Venous and lymphatic disorders","volume":"14 2","pages":"Article 102389"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}