Journal of Vascular Research最新文献_第7页

Perivascular Adipose Tissue Compensation for Endothelial Dysfunction in the Superior Mesenteric Artery of Female SHRSP.Z-Leprfa/IzmDmcr Rats 血管周围脂肪组织对雌性SHRSP.Z-Leprf/IzmDmcr大鼠肠系膜上动脉内皮功能障碍的补偿

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-04-29 DOI: 10.1159/000524187

S. Kagota, Risa Futokoro, Kana Maruyama-Fumoto, J. McGuire, K. Shinozuka

{"title":"Perivascular Adipose Tissue Compensation for Endothelial Dysfunction in the Superior Mesenteric Artery of Female SHRSP.Z-Leprfa/IzmDmcr Rats","authors":"S. Kagota, Risa Futokoro, Kana Maruyama-Fumoto, J. McGuire, K. Shinozuka","doi":"10.1159/000524187","DOIUrl":"https://doi.org/10.1159/000524187","url":null,"abstract":"Regulation of arterial tone by perivascular adipose tissue (PVAT) differs between sexes. In male SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF), PVAT exerts a compensatory relaxation effect for the loss of endothelium-mediated vasorelaxation, which occurs during the early stages of metabolic syndrome. However, this effect deteriorates by 23 weeks of age. Here, therefore, we compared the effects of PVAT in female and male SHRSP.ZF. Acetylcholine-induced relaxation in superior mesenteric artery without PVAT did not differ between 23-week-old females and males. However, the presence of PVAT enhanced relaxation in 23-week-old females, but not in males. The mRNA levels of angiotensin II type 1 receptor (AT1R) in PVAT did not differ between sexes, but AT1R-associated protein (ATRAP) and apelin levels were higher in females than in males. We observed a positive relationship between differences in artery relaxation with and without PVAT and ATRAP or apelin mRNA levels. In 30-week-old females, PVAT-enhanced relaxation disappeared, and mRNA levels of AT1R increased, while apelin levels decreased compared to 23-week-old females. These results demonstrated that in SHRSP.ZF, PVAT compensation for endothelium dysfunction extended to older ages in females than in males. Apelin and AT1R/ATRAP expression in PVAT may be predictors of favorable effects.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 1","pages":"209 - 220"},"PeriodicalIF":1.7,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43713316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vivo Evidence of Arterial Dynamic Properties Alteration in Atherosclerotic Rabbit 动脉粥样硬化兔动脉动态特性改变的体内证据

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-04-19 DOI: 10.1159/000523898

C. Vayssettes-Courchay, C. Ragonnet, M. Isabelle, M. Bourguignon, S. Chimenti

{"title":"In vivo Evidence of Arterial Dynamic Properties Alteration in Atherosclerotic Rabbit","authors":"C. Vayssettes-Courchay, C. Ragonnet, M. Isabelle, M. Bourguignon, S. Chimenti","doi":"10.1159/000523898","DOIUrl":"https://doi.org/10.1159/000523898","url":null,"abstract":"Objectives: Atherosclerosis severely damages the arterial wall. The aim of this study was to assess in vivo, for the first time, arterial dynamic properties, reactivity, and stiffness in atherosclerotic (ATH) rabbits. Methods: The rabbits were fed with 0.3% cholesterol diet. Femoral artery (FA) or abdominal aorta (AA) diameter was recorded by echotracking, together with blood pressure. Arterial reactivity after local administration of agents and stiffness were measured as diameter or pulsatile diameter changes. Results: FA dilation induced by acetylcholine was reduced in the function of diet duration (9–65 weeks). With mid-term diet duration (35–45 weeks), the dilation to nitroprusside was greatly reduced; the constriction to norepinephrine was reduced but not that to serotonin, thromboxane agonist, or angiotensin II. After 17- and 28-week diet AA and FA stiffness were increased while distensibility was reduced. Arterial stiffness measured by regional pulse wave velocity was unaltered. We observed that after 28-week diet, FA exhibited a stiffened wall at the plaque level and higher distensibility at the upstream site. Discussion/Conclusion: Arterial reactivity and compliance were greatly modified by atherosclerosis, at various degrees dependent on diet duration. ATH rabbit is therefore a suitable model for in vivo investigations of treatments targeting dynamic properties of arterial wall.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 1","pages":"239 - 250"},"PeriodicalIF":1.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46359861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications 斑马鱼糖尿病及其微血管并发症模型的建立

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-04-04 DOI: 10.1159/000522471

Changsheng Chen, Dong Liu

引用次数: 4

Front & Back Matter 正面和背面

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-03-01 DOI: 10.1159/000524211

C. Wit, A. Heagerty

引用次数: 0

A Novel ex vivo Method for Investigating Vascularization of Transplanted Islets. 一种研究移植胰岛血管形成的体外新方法。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 DOI: 10.1159/000523925

Robert Dolan, Arinola O Lampejo, Jorge Santini-González, Nicholas A Hodges, Edward A Phelps, Walter L Murfee

{"title":"A Novel ex vivo Method for Investigating Vascularization of Transplanted Islets.","authors":"Robert Dolan, Arinola O Lampejo, Jorge Santini-González, Nicholas A Hodges, Edward A Phelps, Walter L Murfee","doi":"10.1159/000523925","DOIUrl":"https://doi.org/10.1159/000523925","url":null,"abstract":"Revascularization of transplanted pancreatic islets is critical for survival and treatment of type 1 diabetes. Questions concerning how islets influence local microvascular networks and how networks form connections with islets remain understudied and motivate the need for new models that mimic the complexity of real tissue. Recently, our laboratory established the rat mesentery culture model as a tool to investigate cell dynamics involved in microvascular growth. An advantage is the ability to observe blood vessels, lymphatics, and immune cells. The objective of this study was to establish the rat mesentery tissue culture model as a useful tool to investigate islet tissue integration. DiI-labeled islets were seeded onto adult rat mesentery tissues and cultured for up to 3 days. Live lectin labeling enabled time-lapse observation of vessel growth. During culture, DiI-positive islets remained intact. Radial lectin-positive capillary sprouts with DiI labeling were observed to form from islets and connect to host networks. Lectin-positive vessels from host networks were also seen growing toward islets. PECAM and NG2 labeling confirmed that vessels sprouting from islets contained endothelial cells and pericytes. Our results introduce the rat mesentery culture model as a platform for investigating dynamics associated with the initial revascularization of transplanted islets.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 4","pages":"229-238"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308658/pdf/nihms-1788808.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9334374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follicle-Stimulating Hormone Accelerates Atherosclerosis by Activating PI3K/Akt/NF-κB Pathway in Mice with Androgen Deprivation. 促卵泡激素通过激活PI3K/Akt/NF-κB通路加速雄激素剥夺小鼠动脉粥样硬化

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 DOI: 10.1159/000527239

Jingyu Piao, Yifan Yin, Yaru Zhao, Yi Han, Huixia Zhan, Duosheng Luo, Jiao Guo

{"title":"Follicle-Stimulating Hormone Accelerates Atherosclerosis by Activating PI3K/Akt/NF-κB Pathway in Mice with Androgen Deprivation.","authors":"Jingyu Piao, Yifan Yin, Yaru Zhao, Yi Han, Huixia Zhan, Duosheng Luo, Jiao Guo","doi":"10.1159/000527239","DOIUrl":"https://doi.org/10.1159/000527239","url":null,"abstract":"Objective: Follicle-stimulating hormone (FSH) level changes may be another reason for increasing the risk of cardiovascular disease. In this study, we aimed to investigate the role of FSH in atherosclerosis and its underlying mechanism.Methods: ApoE-/- mice were divided into 4 groups, namely, the sham group, bilaterally orchidectomized group, FSH group, and testosterone-only group. Blood lipid and hormone levels were tested, aorta Oil Red O staining; the levels of NF-κB, Akt, eNOS, and FSH receptors in the aorta were measured by Western blotting. Expression of VCAM-1 was detected via Western blotting and immunohistochemical staining. Human umbilical vein endothelial cells (HUVECs) were used to induce endothelial injury model by adding FSH, and the levels of NF-κB, Akt, eNOS, and FSHR were tested in HUVECs.Results: FSH treatment exacerbated atherosclerotic lesions in ApoE-/- mice. Moreover, FSH could promote the expression of VCAM-1 protein in HUVECs, and this effect was possibly mediated by the activation of NF-κB, while NF-κB activation was further enhanced by the activation of the PI3K/Akt/eNOS pathway. FSH failed to activate Akt and NF-κB in the presence of the PI3K inhibitor LY294002 in HUVECs.Conclusion: FSH promoted the development of atherosclerosis by increasing VCAM-1 protein expression via activating PI3K/Akt/NF-κB pathway.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 6","pages":"358-368"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10442754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling. VEGF独立血管生成因子:超越VEGF/VEGFR2信号传导。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 Epub Date: 2022-02-11 DOI: 10.1159/000521584

Ryoji Eguchi, Jun-Ichi Kawabe, Ichiro Wakabayashi

{"title":"VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling.","authors":"Ryoji Eguchi, Jun-Ichi Kawabe, Ichiro Wakabayashi","doi":"10.1159/000521584","DOIUrl":"https://doi.org/10.1159/000521584","url":null,"abstract":"Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent microenvironment. Tumor angiogenesis has been believed to be induced primarily by the secretion of vascular endothelial growth factor-A (VEGF-A) from various tumors. VEGF-A binds to VEGF receptor 2 (VEGFR2), resulting in subsequent activation of cellular substances regulating cell proliferation, survival, and angiogenesis. Antiangiogenic therapies targeting the VEGF-A/VEGFR2 axis, including bevacizumab and ramucirumab, humanized monoclonal antibodies against VEGF-A and VEGFR2, respectively, have been proposed as a promising strategy aimed at preventing tumor growth, invasion, and metastasis. Phase III clinical trials using bevacizumab and ramucirumab have shown that not all tumor patients benefit from such antiangiogenic agents, and that some patients who initially benefit subsequently become less responsive to these antibodies, suggesting the possible existence of VEGF-independent angiogenic factors. In this review, we focus on VEGF-independent and VEGFR2-dependent tumor angiogenesis, as well as VEGFR2-independent tumor angiogenesis. Additionally, we discuss VEGF-independent angiogenic factors which have been reported in previous studies. Various molecular targeting drugs are currently being evaluated as potential antitumor therapies. We expect that precision medicine will permit the development of innovative antiangiogenic therapies targeting individual angiogenic factors selected on the basis of the genetic screening of tumors.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 2","pages":"78-89"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39619296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities. ADAMTS-4在动脉粥样硬化和血管壁异常中的作用。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 Epub Date: 2022-01-20 DOI: 10.1159/000521498

Rudjer Novak, Stela Hrkac, Grgur Salai, Josko Bilandzic, Luka Mitar, Lovorka Grgurevic

{"title":"The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities.","authors":"Rudjer Novak, Stela Hrkac, Grgur Salai, Josko Bilandzic, Luka Mitar, Lovorka Grgurevic","doi":"10.1159/000521498","DOIUrl":"https://doi.org/10.1159/000521498","url":null,"abstract":"Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review focuses on the emerging role which ADAMTS-4 might play in vascular pathology, which has implications for atherosclerosis and vessel wall abnormalities, as well as for the resulting diseases, such as cardiovascular and cerebrovascular disease, aortic aneurysms, and dissections. Major substrates of ADAMTS-4 are proteoglycans expressed physiologically in smooth muscle cells of blood vessels. Good examples are versican and aggrecan, principal vessel wall proteoglycans that are targeted by ADAMTS-4, driving blood vessel atrophy, which is why this metzincin protease was implicated in the pathophysiology of vascular diseases with an atherosclerotic background. Despite emerging evidence, it is important not to exaggerate the role of ADAMTS-4 as it is likely only a small piece of the complex atherosclerosis puzzle and one that could be functionally redundant due to its high structural similarity to other ADAMTS family members. The therapeutic potential of inhibiting ADAMTS-4 to halt the progression of vascular disease after initialization of treatment is unlikely. However, it is not excluded that it might find a purpose as a biomarker of vascular disease, possibly as an indicator in a larger cytokine panel.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 2","pages":"69-77"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury. 基质血管分数逆转损伤后血管重建中与年龄相关的损伤。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 DOI: 10.1159/000526002

Gabrielle Rowe, David S Heng, Jason E Beare, Nicholas A Hodges, Evan P Tracy, Walter L Murfee, Amanda J LeBlanc

{"title":"Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury.","authors":"Gabrielle Rowe, David S Heng, Jason E Beare, Nicholas A Hodges, Evan P Tracy, Walter L Murfee, Amanda J LeBlanc","doi":"10.1159/000526002","DOIUrl":"https://doi.org/10.1159/000526002","url":null,"abstract":"Adipose-derived stromal vascular fraction (SVF) has emerged as a potential regenerative therapy, but few studies utilize SVF in a setting of advanced age. Additionally, the specific cell population in SVF providing therapeutic benefit is unknown. We hypothesized that aging would alter the composition of cell populations present in SVF and its ability to promote angiogenesis following injury, a mechanism that is T cell-mediated. SVF isolated from young and old Fischer 344 rats was examined with flow cytometry for cell composition. Mesenteric windows from old rats were isolated following exteriorization-induced (EI) hypoxic injury and intravenous injection of one of four cell therapies: (1) SVF from young or (2) old donors, (3) SVF from old donors depleted of or (4) enriched for T cells. Advancing age increased the SVF T-cell population but reduced revascularization following injury. Both young and aged SVF incorporated throughout the host mesenteric microvessels, but only young SVF significantly increased vascular area following EI. This study highlights the effect of donor age on SVF angiogenic efficacy and demonstrates how the ex vivo mesenteric-window model can be used in conjunction with SVF therapy to investigate its contribution to angiogenesis.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"59 6","pages":"343-357"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780192/pdf/nihms-1845606.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10536673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2022-01-01 DOI: 10.1159/000526589

引用次数: 0