Journal of Vascular Research最新文献_第7页

Connexin 40-Mediated Regulation of Systemic Circulation and Arterial Blood Pressure. Connexin40介导的系统循环和动脉血压调节。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-06-16 DOI: 10.1159/000531035

Mónica Márquez, Matías Muñoz, Alexandra Córdova, Mariela Puebla, Xavier F Figueroa

{"title":"Connexin 40-Mediated Regulation of Systemic Circulation and Arterial Blood Pressure.","authors":"Mónica Márquez, Matías Muñoz, Alexandra Córdova, Mariela Puebla, Xavier F Figueroa","doi":"10.1159/000531035","DOIUrl":"10.1159/000531035","url":null,"abstract":"Vascular system is a complex network in which different cell types and vascular segments must work in concert to regulate blood flow distribution and arterial blood pressure. Although paracrine/autocrine signaling is involved in the regulation of vasomotor tone, direct intercellular communication via gap junctions plays a central role in the control and coordination of vascular function in the microvascular network. Gap junctions are made up by connexin (Cx) proteins, and among the four Cxs expressed in the cardiovascular system (Cx37, Cx40, Cx43, and Cx45), Cx40 has emerged as a critical signaling pathway in the vessel wall. This Cx is predominantly found in the endothelium, but it is involved in the development of the cardiovascular system and in the coordination of endothelial and smooth muscle cell function along the length of the vessels. In addition, Cx40 participates in the control of vasomotor tone through the transmission of electrical signals from the endothelium to the underlying smooth muscle and in the regulation of arterial blood pressure by renin-angiotensin system in afferent arterioles. In this review, we discuss the participation of Cx40-formed channels in the development of cardiovascular system, control and coordination of vascular function, and regulation of arterial blood pressure.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"60 2","pages":"87-100"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization. RhoA/ROCK信号传导与病理性视网膜新生血管形成有关。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-09-01 DOI: 10.1159/000533321

Fen Tang, Kongqian Huang, Biyan Peng, Wen Deng, Ning Su, Fan Xu, Mingyuan Zhang, Haibin Zhong

{"title":"RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization.","authors":"Fen Tang, Kongqian Huang, Biyan Peng, Wen Deng, Ning Su, Fan Xu, Mingyuan Zhang, Haibin Zhong","doi":"10.1159/000533321","DOIUrl":"10.1159/000533321","url":null,"abstract":"Objective: The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro.Methods: C57BL/6 was used to establish an OIR model. First, RhoA/ROCK expression was first examined and compared between OIR and healthy controls. Then, we evaluated the effect of Fasudil on pathological retinal NV. Whole-mount retinal staining was performed. The percentage of NV area, the number of neovascular tufts (NVT), and branch points (BP) were quantified. Finally, human umbilical vein endothelial cells (HUVECs) were used to investigate the effect of Fasudil on angiogenesis.Results: Real-time PCR and Western blotting showed that ROCK expression in retinal tissue was statistically upregulated in OIR. Furthermore, we found that Fasudil attenuated the percentage of NV area, the number of NVT, and BP significantly. In addition, Fasudil could suppress the proliferation and migration of HUVECs induced by VEGF.Conclusions: RhoA/ROCK might be involved in the pathogenesis of OIR. And its inhibitor Fasudil could suppress retinal NV in vivo and angiogenesis in vitro. Fasudil may be a potential treatment strategy for retinal vascular diseases.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"183-192"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contents, Vol. 60, 2023. 内容，第 60 卷，2023 年。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-12-18 DOI: 10.1159/000535661

引用次数: 0

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists. 流动受试者灌注、血流和血管结构的评估:转化研究科学家指南。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 DOI: 10.1159/000527765

Zachariah G Schonberger, Sophie J Y Huang, Radhika N Thakkar, Amar A Mamone, Daniyal I Khan, Natalie L Y Chow, Moeiz Ahmed, Namashi Sivaram, Yuki Bao, Vihirthan Kesavan, Jordan Côté, Clara Sun, Jashnoor Chhina, Brayden D Halvorson, Gabrielle H Alimorad, Nithin J Menon, Daniel Goldman, Stephanie J Frisbee

{"title":"Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists.","authors":"Zachariah G Schonberger, Sophie J Y Huang, Radhika N Thakkar, Amar A Mamone, Daniyal I Khan, Natalie L Y Chow, Moeiz Ahmed, Namashi Sivaram, Yuki Bao, Vihirthan Kesavan, Jordan Côté, Clara Sun, Jashnoor Chhina, Brayden D Halvorson, Gabrielle H Alimorad, Nithin J Menon, Daniel Goldman, Stephanie J Frisbee","doi":"10.1159/000527765","DOIUrl":"https://doi.org/10.1159/000527765","url":null,"abstract":"Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"60 1","pages":"12-68"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Is Next for Connexin and Pannexin? 康乃馨和潘乃馨的下一步是什么？

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-08-16 DOI: 10.1159/000533281

Timothy M Sveeggen, Anna Kosmach, Pooneh Bagher

引用次数: 0

Methyl Palmitate Modulated NMDA-Induced Cerebral Hyperemia in Hypertensive Rats. 棕榈酸甲酯调节NMDA诱导的高血压大鼠脑高脂血症。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-06-07 DOI: 10.1159/000529916

Chun-Kai Hsu, Shang-Jen Chang, Li-Yi Lim, Hsi-Hsien Chang, Stephen Shei-Dei Yang

{"title":"Methyl Palmitate Modulated NMDA-Induced Cerebral Hyperemia in Hypertensive Rats.","authors":"Chun-Kai Hsu, Shang-Jen Chang, Li-Yi Lim, Hsi-Hsien Chang, Stephen Shei-Dei Yang","doi":"10.1159/000529916","DOIUrl":"10.1159/000529916","url":null,"abstract":"N-methyl-D-aspartate (NMDA) receptors were found to be dysfunctional in hypertensive rats. Methyl palmitate (MP) has been shown to diminish the nicotine-induced increase in blood flow in the brainstem. The aim of this study was to determine how MP modulated NMDA-induced increased regional cerebral blood flow (rCBF) in normotensive (WKY), spontaneously hypertensive (SHR), and renovascular hypertensive (RHR) rats. The increase in rCBF after the topical application of experimental drugs was measured using laser Doppler flowmetry. Topical NMDA application induced an MK-801-sensitive increase in rCBF in anesthetized WKY rats, which was inhibited by MP pretreatments. This inhibition was prevented by pretreatment with chelerythrine (a PKC inhibitor). The NMDA-induced increase in rCBF was also inhibited by the PKC activator in a concentration-dependent manner. Neither MP nor MK-801 affected the increase in rCBF induced by the topical application of acetylcholine or sodium nitroprusside. Topical application of MP to the parietal cortex of SHRs, on the other hand, increased basal rCBF slightly but significantly. MP enhanced the NMDA-induced increase in rCBF in SHRs and RHRs. These results suggested that MP had a dual effect on the modulation of rCBF. MP appears to play a significant physiological role in CBF regulation.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"137-147"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9583634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Implications of Exercise Training on Pannexin Expression and Function. 运动训练对Pannexin表达和功能的潜在影响。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2022-11-10 DOI: 10.1159/000527240

Brent Wakefield, Silvia Penuela

{"title":"Potential Implications of Exercise Training on Pannexin Expression and Function.","authors":"Brent Wakefield, Silvia Penuela","doi":"10.1159/000527240","DOIUrl":"10.1159/000527240","url":null,"abstract":"Pannexins (PANX1, 2, 3) are channel-forming glycoproteins that are expressed throughout the cardiovascular and musculoskeletal system. The canonical function of these proteins is to release nucleotides that act as purinergic signalling at the cell membrane or Ca2+ channels at the endoplasmic reticulum membrane. These two forms of signalling are essential for autocrine and paracrine signalling in health, and alterations in this signalling have been implicated in the pathogenesis of many diseases. Many musculoskeletal and cardiovascular diseases are largely the result of a lack of physical activity which causes altered gene expression. Considering exercise training has been shown to alter a wide array of gene expression in musculoskeletal tissues, understanding the interaction between exercise training, gene function and expression in relevant diseases is warranted. With regards to pannexins, multiple publications have shown that exercise training can influence pannexin expression and may influence the significance of its function in certain diseases. This review further discusses the potential interaction between exercise training and pannexin biology in relevant tissues and disease models. We propose that exercise training in relevant animal and human models will provide a more comprehensive understanding of the implications of pannexin biology in disease.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"60 2","pages":"114-124"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vascular Dysfunction in Polycystic Kidney Disease: A Mini-Review. 多囊肾病的血管功能障碍：一项小型综述。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-08-03 DOI: 10.1159/000531647

Melissa R Dennis, Paulo W Pires, Christopher T Banek

引用次数: 0

European Society for Microcirculation Conference 2023. 2023年欧洲微循环学会会议。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 Epub Date: 2023-11-03 DOI: 10.1159/000533846

引用次数: 0

Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall. 体外血流模型的验证，包括磁共振成像，研究血管内治疗对动脉壁的影响。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2023-01-01 DOI: 10.1159/000529115

Raúl Devia Rodriguez, Eline Huizing, Çağdaş Ünlü, Frank F J Simonis, Reinoud P H Bokkers, Jean-Paul P M de Vries, Richte C L Schuurmann, Dalibor Nakladal, Hendrik Buikema, Jan-Luuk Hillebrands, Henri G D Leuvenink

{"title":"Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall.","authors":"Raúl Devia Rodriguez, Eline Huizing, Çağdaş Ünlü, Frank F J Simonis, Reinoud P H Bokkers, Jean-Paul P M de Vries, Richte C L Schuurmann, Dalibor Nakladal, Hendrik Buikema, Jan-Luuk Hillebrands, Henri G D Leuvenink","doi":"10.1159/000529115","DOIUrl":"https://doi.org/10.1159/000529115","url":null,"abstract":"Endovascular revascularization is the preferred treatment for peripheral arterial disease. Restenosis often occurs as a response to procedure-induced arterial damage. Reducing vascular injury during endovascular revascularization may improve its success rate. This study developed and validated an ex vivo flow model using porcine iliac arteries, obtained from a local abattoir. Twenty arteries (of 10 pigs) were equally allocated to two groups: a mock-treated control group and an endovascular intervention group. Arteries of both groups were perfused with porcine blood for 9 min, including 3 min of balloon angioplasty in the intervention group. Vessel injury was assessed by calculating the presence of endothelial cell denudation, vasomotor function, and histopathological analysis. MR imaging displayed balloon positioning and inflation. Endothelial cell staining showed 76% of denudation after ballooning compared to 6% in the control group (p < 0.001). This was confirmed by histopathological analysis, showing a significantly reduced endothelial nuclei count after ballooning compared to the controls (median: 22 vs. 37 nuclei/mm, p = 0.022). In the intervention group, vasoconstriction and endothelium-dependent relaxation were significantly reduced (p < 0.05).We present an ex vivo flow model to test the effects of endovascular therapy on the vessel's wall morphology, endothelial denudation, and endothelial-dependent vasomotor function under physiological conditions. Additionally, it allows the future testing of human arterial tissue.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"60 1","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0