Journal of Thoracic Oncology最新文献

{"title":"OA02.01 Selective Translation of PBK (PDZ-Binding Kinase) is a Novel Mechanism of Drug Tolerance to Targeted Therapies in EGFR-Mutant Lung Cancer","authors":"Camille Léonce , Anne-Laure Desage , Nour El-Houda Mourksi , Geneviève De Souza , Béatrice Vanbervliet , Camille Charrondière , Constance Nicq , Aurélie Swalduz , Gabriel Ichim , Jean-Jacques Diaz , Christine Lovly , Julien Mazières , Mayeul Tabutin , Maurice Pérol , Sylvie Lantuejoul , Olivier Calvayrac , Fabien Forest , Virginie Marcel , Pierre Saintigny , Sandra Ortiz- Cuaran","doi":"10.1016/j.jtho.2025.03.005","DOIUrl":"10.1016/j.jtho.2025.03.005","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S1"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.01 Oncogenic Signaling is Rewired to Support Nucleotide Metabolism in Acquired Resistance to Targeted Therapies in NSCLC","authors":"Jaime L. Schneider , Yutong Dai , Ishita Dhiman , Jingpeng Chen , Shakchhi Joshi , Kiran Kurmi , Morgan Payne , Brandon Gassaway , Steven Gygi , Jessica J. Lin , Aaron Hata , Marcia Haigis","doi":"10.1016/j.jtho.2025.03.009","DOIUrl":"10.1016/j.jtho.2025.03.009","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S3"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.16 Ixazomib Overcomes Platinum Resistance and Induces Autophagy-Mediated Cell Death in Lung Adenocarcinoma","authors":"Muthamil Iniyan Appadurai , Zahraa Wajih Alsafwani , Sanjib Chaudhary , Ashu Shah , Pranay Somavarapu , Sriman N. Dooshety , Ben S. Kubicek , Surinder K. Batra , Imayavaramban Lakshmanan , Apar Kishor Ganti","doi":"10.1016/j.jtho.2025.03.023","DOIUrl":"10.1016/j.jtho.2025.03.023","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S9"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma-First Testing in Advanced Lung Cancer: Evidence and Implications","authors":"Kaushal Parikh M.B.B.S. , Ayesha Hashmi M.B.B.S. , Pradeep S. Chauhan PhD , Aadel A. Chaudhuri MD, PhD","doi":"10.1016/j.jtho.2025.01.014","DOIUrl":"10.1016/j.jtho.2025.01.014","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages 411-414"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Response to the Letter to the Editor: “Equipoise Is No Longer a Major Consideration in the Ethical Evaluation of Phase 3 Randomized Controlled Trials Involving Precision Oncology Approaches in NSCLC”","authors":"Jennifer W. Carlisle MD, Rebecca D. Pentz PhD, Suresh S. Ramalingam MD","doi":"10.1016/j.jtho.2025.01.025","DOIUrl":"10.1016/j.jtho.2025.01.025","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page e53"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Response to the Letter to the Editor: “Linear Versus Non-Linear: Debunking Critiques on PCA Use in Molecular Subgrouping of Pulmonary Carcinoids”","authors":"Daphne J.G. Leunissen MSc, Laura Moonen PhD, Nicolas Alcala PhD, Ernst-Jan M. Speel PhD, Jules L. Derks MD, PhD","doi":"10.1016/j.jtho.2025.01.012","DOIUrl":"10.1016/j.jtho.2025.01.012","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages e55-e56"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.13 Temporal Immune Evolution in a Murine EML4-ALK NSCLC Model: Genomic, Proteomic, and Drug Co-Culture Characterization","authors":"Marisa E. Aikins , Abdullah Saeed , Derek Nancarrow , Sydney Malawer , Tejas Thiyagarajan , Andrew Yu , Sofia E. Merajver , Kiran Lagisetty","doi":"10.1016/j.jtho.2025.03.020","DOIUrl":"10.1016/j.jtho.2025.03.020","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages S7-S8"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.03 Characterization of Mutated KRAS Genotype and Clinical Outcomes in Patients With Advanced NSCLC Treated With Mecbotamab Vedotin, a CAB-AXL-ADC","authors":"Julia Rotow , Grace K. Dy , Edwin Yau , Elaine Shum , Mariam Alexander , Karen L. Reckamp , Roland Leung , Dariusz M. Kowalski , Jose Fuentes Pradera , Jon Zugazagoitia Fraile , Kyechin Chen , Kartik Aysola , D. Ross Camidge","doi":"10.1016/j.jtho.2025.03.011","DOIUrl":"10.1016/j.jtho.2025.03.011","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages S3-S4"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.08 Pilot Study to Evaluate the Potential of the Tumor-Educated Platelets (TEP) as the Tool to Detect Minimal Residual Disease and Drug Resistance","authors":"Shuta Ohara , Kenichi Suda , Kazuko Sakai , Junko Tanaka , Takamichi Muramatsu , Chihiro Uematsu , Yasuhiro Tsutani , Kazuto Nishio , Tetsuya Mitsudomi","doi":"10.1016/j.jtho.2025.03.016","DOIUrl":"10.1016/j.jtho.2025.03.016","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Page S6"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Final Overall Survival and Long-Term Safety of Lorlatinib in Patients With ALK-Positive NSCLC From the Pivotal Phase 2 Study: A Brief Report","authors":"Sai-Hong Ignatius Ou MD, PhD ,&nbsp;Benjamin J. Solomon M.B.B.S., PhD ,&nbsp;Benjamin Besse MD, PhD ,&nbsp;Alessandra Bearz MD ,&nbsp;Chia-Chi Lin MD, PhD ,&nbsp;Rita Chiari MD, PhD ,&nbsp;D. Ross Camidge MD, PhD ,&nbsp;Jessica J. Lin MD ,&nbsp;Antonello Abbattista BSc ,&nbsp;Francesca Toffalorio MD, PhD ,&nbsp;Ross A. Soo M.B.B.S., FRACP, PhD","doi":"10.1016/j.jtho.2024.11.021","DOIUrl":"10.1016/j.jtho.2024.11.021","url":null,"abstract":"<div><h3>Introduction</h3><div>Lorlatinib is a potent, brain-penetrant, third-generation inhibitor of anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases with broad coverage of <em>ALK</em> resistance mutations. We present the overall survival (OS) and long-term safety of lorlatinib in patients with advanced <em>ALK</em>-positive NSCLC from the final analyses of the pivotal phase 2 study.</div></div><div><h3>Methods</h3><div>Adults with <em>ALK</em>-positive NSCLC, enrolled in expansion cohorts (EXPs) on the basis of prior therapy (EXP1-5), received lorlatinib 100 mg orally once daily in continuous 21-day cycles. The primary endpoint was the objective response rate; secondary endpoints included OS and safety.</div></div><div><h3>Results</h3><div>Thirty patients were enrolled in EXP1 (treatment naïve), 59 in EXP2-3A (disease progression after crizotinib ± chemotherapy), 28 in EXP3B (disease progression after one second-generation ALK tyrosine kinase inhibitor [TKI] ± chemotherapy), 111 in EXP4-5 (disease progression after ≥2 ALK TKIs ± chemotherapy), and 139 in EXP3B-5 (disease progression after ≥1 ALK TKI ± chemotherapy). Median OS was not reached (NR) (95% confidence interval [CI]: NR–NR) in EXP1, NR (95% CI: 51.5–NR) in EXP2-3A, 37.4 months (95% CI: 12.3–NR) in EXP3B, 19.2 months (95% CI: 15.4–30.2) in EXP4-5, and 20.7 months (95% CI: 16.1–30.3) in EXP3B-5. All-cause adverse events leading to dose reduction were reported in 77 patients (28%), temporary treatment discontinuation in 158 patients (57%), and permanent discontinuation in 35 patients (13%).</div></div><div><h3>Conclusions</h3><div>After a minimum follow-up of five years, final analyses from the global phase 2 study confirmed substantial activity, prolonged OS, and generally consistent safety findings with lorlatinib in treatment-naïve and previously treated patients with <em>ALK</em>-positive NSCLC. <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> NCT01970865</div></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 4","pages":"Pages 513-520"},"PeriodicalIF":21.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}