Journal of Traditional Chinese Medicine最新文献

{"title":"Clinical practice guidelines for treating headache with Traditional Chinese Medicine: quality assessment with the appraisal of guidelines for research and evaluation II instrument","authors":"Luo Hao ,&nbsp;Li Hui ,&nbsp;Wang Yangyang ,&nbsp;Yao Sha ,&nbsp;Xu Wenjie","doi":"10.1016/S0254-6272(18)30624-1","DOIUrl":"https://doi.org/10.1016/S0254-6272(18)30624-1","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To critically appraise the methodological quality of clinical practice guidelines for headache produced over the last two decades, including those covering specific interventions using Traditional Chinese Medicine.</p></div><div><h3>METHODS</h3><p>The guidelines on headache disorders were obtained by searching a number of databases, including PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, and Wanfang database, three guideline-related databases [Guideline-International Network, National Guideline Clearinghouse, and Medlive], and the records of organizations that develop guidelines. The publication date was limited to the period from January 1996 to June 2015. The search terms “headache”, “headache disorders”, “cephalalgia”, “migraine”, “tension-type headache”, “practice guideline”, “consensus “, “statement”, “regulation”, and “recommendation” were used in the “MeSH” and “Free-text” fields. The guidelines were independently appraised by four researchers using the Appraisal of Guidelines for Research and Evaluation II instrument.</p></div><div><h3>RESULTS</h3><p>A total of 23 guidelines published between 1998 and 2014 were reviewed. The overall consistency of the four appraisers was good [interclass correlation coefficient 0.84; 95% confidence interval (<em>CI</em>) 0.82–0.86]. The mean (standard deviation) scores for scope and purpose, stakeholder involvement, rigor of development, clarity of presentation, applicability, and editorial independence were 52.1 (18.0), 39.5 (17.1), 33.4 (21.0), 49.8 (21.9), 23.8 (19.3), and 24.2 (23.7). Only two guidelines were recommended, 12 were recommended with modification, and nine were not recommended.</p></div><div><h3>CONCLUSION</h3><p>Physical Traditional Chinese Medicine therapies were recommended to treat headache. The overall quality of headache guidelines was low in China, but evidence-based guidelines are gradually becoming mainstream. Guideline developers should carefully consider, in particular, three domains: rigor of development, applicability, and editorial independence.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 339-350"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30624-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91615216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway","authors":"Chen Shaofang ,&nbsp;Liang Huiqing ,&nbsp;Chen Shaodong ,&nbsp;Huang Yanping ,&nbsp;Wan Shichuan ,&nbsp;Huang Yanxia","doi":"10.1016/S0254-6272(18)30633-2","DOIUrl":"10.1016/S0254-6272(18)30633-2","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effect of Banxia Xiexin decoction (BXD) on Helicobacter pylori (Hp)-related peptic ulcers (PUs) and the possible mechanism underlying BXD actions <em>via</em> the transforming growth factor-β/small mothers against decapentaplegic (TGF-β/Smad) signaling pathway.</p></div><div><h3>METHODS</h3><p>PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured <em>in vitro</em> and randomly divided into the following seven groups: control, model, healthy, Western Medicine, prior treatment, low dosage, and high dosage. After 72 h of treatment with the corresponding serum, the mRNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.</p></div><div><h3>RESULTS</h3><p>The mRNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells, and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.</p></div><div><h3>CONCLUSION</h3><p>BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 419-426"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30633-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46113117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalp-cluster acupuncture with electrical stimulation can improve motor and living ability in convalescent patients with post-stroke hemiplegia","authors":"Wang Xiaohong ,&nbsp;Zhang Qi ,&nbsp;Cui Baojuan ,&nbsp;Sun Junhua ,&nbsp;Ye Lan ,&nbsp;Huang Laigang ,&nbsp;Wang Daoqing","doi":"10.1016/S0254-6272(18)30638-1","DOIUrl":"10.1016/S0254-6272(18)30638-1","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To determine whether patients with post-stroke hemiplegia could benefit from long-term treatment with scalp cluster (SC) acupuncture combined with electrical stimulation (ES) and to evaluate the feasibility of this treatment to improve motor and living abilities.</p></div><div><h3>METHODS</h3><p>Twenty patients were enrolled and divided into two groups: SC acupuncture and SC acupuncture with ES (SC and SC + ES, respectively). All participants also received rehabilitation training. All participants were blindly evaluated using the Fugl-Meyer assessment scale for motor ability, the modified Barthel Index for living ability, and a scale for the degree of neurological deficits. Outcome was assessed at three points before randomized grouping, at the beginning or treatment, and after 4 weeks of treatment.</p></div><div><h3>RESULTS</h3><p>Following 4 weeks treatment, all the patients exhibited significant improvements in aspects of motor ability, living ability, and the severity of neurological deficits. The experimental group (SC + ES) scored higher on the Fugl-Meyer assessment scale (68 ± 12) and the modified Barthel Index (49 ± 9) than the control (SC) group (50 ± 13, 36 ± 13, respectively).</p></div><div><h3>CONCLUSION</h3><p>When patients with post-stroke hemiplegia are treated using SC acupuncture with ES, motor and living ability can improve more than if they were treated with SC acupuncture alone.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 452-456"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30638-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48655117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on neutrophil-to-lymphocyte ratio and quality of life in patients with non-small-cell lung cancer: A randomized, controlled trial","authors":"Zhang Mengxue,&nbsp;Guan Ling,&nbsp;Wang Lili,&nbsp;Li Ying","doi":"10.1016/S0254-6272(18)30636-8","DOIUrl":"10.1016/S0254-6272(18)30636-8","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the effect of heat stimulation <em>via</em> scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on the neutrophil-to-lymphocyte ratio (NLR) and quality of life in patients with non-small-cell lung cancer (NSCLC).</p></div><div><h3>METHODS</h3><p>Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) every day for 6 weeks, while group B received no intervention (control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.</p></div><div><h3>RESULTS</h3><p>Five participants dropped out, leaving a final total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B (<em>P</em> &lt; 0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life (<em>P</em> &lt; 0.001) and function (<em>P</em> &lt; 0.05), and significantly lower in terms of symptoms (<em>P</em> &lt; 0.05).</p></div><div><h3>CONCLUSION</h3><p>The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli (ST 36) and Feishu (BL 13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 439-446"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30636-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45758900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the best Salvia miltiorrhiza injection classes for treatment of unstable angina pectoris? A systematic review and network Meta-analysis","authors":"Liu Shi ,&nbsp;Wu Jiarui ,&nbsp;Zhang Dan ,&nbsp;Tan Di","doi":"10.1016/S0254-6272(18)30623-X","DOIUrl":"10.1016/S0254-6272(18)30623-X","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To undertake a systematic review and network meta-analysis (NMA) to compare the effectiveness among the different regimens of Salvia miltiorrhiza injection classes (SMICs) for unstable angina pectoris (UAP) treatment.</p></div><div><h3>METHODS</h3><p>A systematic retrieval was conducted in several literature databases to identify randomized controlled trials focusing on the different regimens of SMICs for UAP treatment until January 2016. The quality assessment was accomplished according to the Cochrane risk of bias tool. Pair-wise meta-analyses were carried out by RevMan 5.3. A random-effects model of NMA was used to compare the different regimens of SMICs with regard to efficacy by STATA 13.0.</p></div><div><h3>RESULTS</h3><p>A total of 111 studies involving 10 500 patients were included in the NMA. The methodological quality of included studies was not high. Current evidence shows that salvianolate (SI) is the optimal treatment for UAP in improving the total efficacy against UAP. Guanxingning (GXN) is the optimal treatment for UAP for improving the total effectiveness of electrocardiography.</p></div><div><h3>CONCLUSION</h3><p>SMICs have advantages in preventing cardiovascular events. GXN, SI, and Danhong had the greatest probability of being the best treatment in the total efficacy against UAP and for improving the total effectiveness of electrocardiography.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 321-338"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30623-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus in Chinese patients: A Meta-analysis","authors":"Yang Hongchang ,&nbsp;Wu Xueping ,&nbsp;Wang Min","doi":"10.1016/j.jtcm.2018.04.002","DOIUrl":"10.1016/j.jtcm.2018.04.002","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To systematically evaluate the effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus (T2DM) in Chinese patients.</p></div><div><h3>METHODS</h3><p>A literature search was conducted in PubMed, Medline, Embase, China National Knowledge Infrastructure Database, Wanfang and China Science and Technology Journal Database until on January 2017. In this Meta-analysis, enrolled were the studies, including experimental group (with conventional medical treatment plus Qigong therapy) and control group (with conventional medical treatment plus diet control or other exercises). Then, the standardized mean differences (SMDs) of fasting blood-glucose (FBG), 2-hplasmaglucose (2hPG), hemoglobinAlc (HbAlc), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low density lipoprotein (LDL), as well as their 95% confidence interval (<em>CIs</em>) were calculated to evaluate the effect of Qigong on patients with T2DM by RevMan 5.2 and Stata 11.0 software.</p></div><div><h3>RESULTS</h3><p>Totally 834 cases of T2DM from 11 studies were included in this review. The pooled SMDs with its 95% <em>CIs</em> of FBG, 2hPG, HbAlc, TG, TC, HDL and LDL were – 0.70 (– 0.93, – 0.47), – 0.66 (– 1.11, – 0.21), – 0.73 (– 0.96, – 0.50), – 1.05 (– 1.67, – 0.43), – 0.42 (– 1.12, 0.28), 0.69 (0.19, 1.19), and – 0.26 (– 0.69, 0.18), respectively. The pooled data showed significantly difference between Qigong and the levels of FBG, 2hPG, HbA1c, TG, and HDL in patients with T2DM (<em>P</em> &lt; 0.05).</p></div><div><h3>CONCLUSION</h3><p>Combining with conventional medical treatment, Qigong exercise might have significant effect on T2DM in Chinese patients.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 167-174"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48556239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dahuang Zhechong pills on long non-coding RNA growth arrest specific 5 in rat models of hepatic fibrosis","authors":"Gong Zhenghua ,&nbsp;Deng Chaowen ,&nbsp;Xiang Tianxin ,&nbsp;Tao Lili ,&nbsp;Xiao Hongbo ,&nbsp;Peng Yanzhong ,&nbsp;Zheng Jie ,&nbsp;Hu Guoxin","doi":"10.1016/j.jtcm.2018.04.007","DOIUrl":"10.1016/j.jtcm.2018.04.007","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the involvement of growth arrest specific 5 (GAS5), a long non-coding RNA, in the anti-hepatic fibrosis process induced by Dahuang Zhechong pill (DHZCP) in rats.</p></div><div><h3>METHODS</h3><p>Thirty adult rats were divided into three groups, including a control group, a CCl₄-induced fibrosis group and a DHZCP-treated fibrosis group. Hematoxylin-eosin and Masson staining were used for histopathological study. Serum enzymes, cytokines and cell proliferation were assayed using commercially available kits. A GAS5 lenti-virus vector was constructed to further investigate the role of GAS5 in the anti-hepatic fibrosis effect of DHZCP in rats.</p></div><div><h3>RESULTS</h3><p>Our results revealed that the proliferation of hepatic stellate cells cultured in serum derived from rats treated with DHZCP was significantly decreased, compared with cells treated with serum from the untreated rats. DHZCP alleviated the CCl₄-induced hepatic fibrosis. Additionally, DHZCP can restore the expression of GAS5, which was significantly decreased in the CCl₄-induced group, and markedly suppress the expression of p-p38 and p-Erk induced by CCl_4, but not p-Jnk. Cell proliferation was significantly arrested when cells overexpressed GAS5. Thus, DHZCP can inhibit the expression of p-p38 and p-Erk, while GAS5 can only inhibit the expression of p-Erk.</p></div><div><h3>CONCLUSIONS</h3><p>DHZCP can alleviate hepatic fibrosis by increasing the expression of GAS5 to suppress p-Erk and regulating other factors to inhibit p-p38.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 190-196"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44625930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the methods used for subjective evaluation of De Qi","authors":"Yuan Hongwen ,&nbsp;Wang Pei ,&nbsp;Hu Nijuan ,&nbsp;Zhang Peng ,&nbsp;Li Chunhua ,&nbsp;Liu Yuqi ,&nbsp;Ma Liangxiao ,&nbsp;Zhu Jiang","doi":"10.1016/j.jtcm.2017.03.001","DOIUrl":"10.1016/j.jtcm.2017.03.001","url":null,"abstract":"<div><p>De <em>Qi</em> refers to a series of sensations experienced when acupuncture is performed at acupoints. De <em>Qi</em> comprises needling sensations felt by the patient, and the sensations perceived by the acupuncturist. Classical Traditional Chinese Medicine theory states that De <em>Qi</em> is closely related to curative effect. In modern studies, the main index that researchers have used to evaluate De <em>Qi</em> was the needling sensation reported by the patient. Between 1st Aug and 31st Oct 2014, we conducted an electronic database search of all fields in Chinese and English to select literature assessing acupuncture needle sensations. We then reviewed the methods used within these studies to evaluate De <em>Qi.</em> The methods included simple evaluation, and the use of a De <em>Qi</em> scale/questionnaire. The simple evaluation, a qualitative evaluation, was judged by typical sensations felt by the patient after needling at acupoints, such as soreness, numbness, fullness, and heaviness. This method was easy and practicable, and had been adopted widely by Chinese researchers. In contrast, the De <em>Qi</em> scale/questionnaire, a quantitative evaluation, had multiple compiling methods available for evaluating the intensity of De <em>Qi.</em> The standardization and objectification of the De <em>Qi</em> scale/questionnaire effectively improved the quality of studies on De <em>Qi</em>, thereby these scales/questionnaires have been acknowledged and applied by most researchers. The present review analyzed and compared the scales/questionnaires used to evaluate De <em>Qi</em>; furthermore, we provided suggestions for the development and improvement of these questionnaires through integration with classical De <em>Qi</em> theory.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 309-314"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2017.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42001126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles: A randomized clinical trial","authors":"Peng Longping ,&nbsp;Hong Zhiwei ,&nbsp;Shen Jiaming ,&nbsp;Hu Xuechun ,&nbsp;Shao Yong ,&nbsp;Jing Jun ,&nbsp;Lu Jinchun ,&nbsp;Yao Bing","doi":"10.1016/j.jtcm.2018.04.001","DOIUrl":"10.1016/j.jtcm.2018.04.001","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation (PE) and an increased anterior-posterior diameter (APD) of the seminal vesicles (SVs).</p></div><div><h3>METHODS</h3><p>Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool (PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.</p></div><div><h3>RESULTS</h3><p>Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group (12.1 ± 2.5 <em>vs</em> 8.6 ± 3.2, <em>P</em> &lt; 0.001, respectively) and control group (12.9 ± 2.6 <em>vs</em> 10.3 ±1.6, <em>P</em> &lt; 0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group (8.6 ± 3.2 <em>vs</em> 10.3 ± 1.6, <em>P</em> = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) <em>vs</em> (12.9 ± 2.2) mm, <em>P</em> = 0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.</p></div><div><h3>CONCLUSION</h3><p>These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule, and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 266-271"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48466529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of herb-partitioned moxibustion at Qihai (CV 6) and bilateral Tianshu (ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn's disease","authors":"Zhang Dan ,&nbsp;Wei Kai ,&nbsp;Ma Xiaopeng ,&nbsp;Wu Huangan ,&nbsp;Hong Jue ,&nbsp;Zhang Cuihong ,&nbsp;Wu Lingxiang ,&nbsp;Yan Huang ,&nbsp;Liu Jie ,&nbsp;Zhu Yi ,&nbsp;Yang Ling","doi":"10.1016/j.jtcm.2018.04.004","DOIUrl":"10.1016/j.jtcm.2018.04.004","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To observe the effect of stimulating Qihai (CV 6) and bilateral Tianshu (ST 25) with herb-partitioned moxibustion (HPM) in rats with Crohn's disease (CD), and to investigate the possible anti-inflammatory mechanism of HPM.</p></div><div><h3>METHODS</h3><p>Forty rats were randomly divided into four groups (<em>n</em> = 10 rats per group): normal control (NC), model control (MC), mesalamine (MES), and HPM. The CD rat model was established in the MC, MES, and HPM groups by administering a mixture of trinitrobenzenesulfonic acid and alcohol via enema. The HPM group received HPM on Qihai (CV 6) and bilateral Tianshu (ST 25), while the MES group received intragastric mesalamine. Colonic histomorphological scores, and serum concentrations of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) were assessed to evaluate the effects of HPM on colonic reparation and anti-inflammation. The expressions of Toll-like receptor 4 (TLR-4), nuclear factor κB inhibitor α (IkB-α), IkB kinase α/β (Iκκα/β), and NF-κB p65 were further analyzed to investigate the regulatory effects of the interventions on the TLR4/NF-κB pathway.</p></div><div><h3>RESULTS</h3><p>CD rats showed inflammatory colonic damage and increased serum concentrations of TNF-α and IL-1β. The expressions of TLR4, IKKα/β, and NF-κB p65 in the colons of CD rats were significantly increased compared with the NC group, while the expression of IκBα (a key negative regulator of NF-κB p65) was decreased. HPM significantly mitigated colonic damage and reduced the serum concentrations of TNF-α and IL-1β. HPM downregulated the expressions of TLR4, IKKα/β, and NF-κB p65 in the colon, and upregulated the expression of IκBα. The effects of HPM in CD rats were similar to those of mesalamine.</p></div><div><h3>CONCLUSION</h3><p>HPM alleviates colonic inflammation in CD rats. This may be achieved through regulation of TLR4, which induces NF-κB signal transduction.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 218-226"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49047923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}