What are the best Salvia miltiorrhiza injection classes for treatment of unstable angina pectoris? A systematic review and network Meta-analysis

IF 2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine Pub Date : 2018-06-01 DOI:10.1016/S0254-6272(18)30623-X

Liu Shi , Wu Jiarui , Zhang Dan , Tan Di

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引用次数: 5

Abstract

OBJECTIVE

To undertake a systematic review and network meta-analysis (NMA) to compare the effectiveness among the different regimens of Salvia miltiorrhiza injection classes (SMICs) for unstable angina pectoris (UAP) treatment.

METHODS

A systematic retrieval was conducted in several literature databases to identify randomized controlled trials focusing on the different regimens of SMICs for UAP treatment until January 2016. The quality assessment was accomplished according to the Cochrane risk of bias tool. Pair-wise meta-analyses were carried out by RevMan 5.3. A random-effects model of NMA was used to compare the different regimens of SMICs with regard to efficacy by STATA 13.0.

RESULTS

A total of 111 studies involving 10 500 patients were included in the NMA. The methodological quality of included studies was not high. Current evidence shows that salvianolate (SI) is the optimal treatment for UAP in improving the total efficacy against UAP. Guanxingning (GXN) is the optimal treatment for UAP for improving the total effectiveness of electrocardiography.

CONCLUSION

SMICs have advantages in preventing cardiovascular events. GXN, SI, and Danhong had the greatest probability of being the best treatment in the total efficacy against UAP and for improving the total effectiveness of electrocardiography.

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丹参注射液治疗不稳定型心绞痛的最佳剂型有哪些?系统综述和网络元分析

目的通过系统评价和网络meta分析(NMA)比较丹参注射液类(SMICs)不同治疗方案对不稳定型心绞痛(UAP)的疗效。方法系统检索多个文献数据库，以确定截至2016年1月的不同SMICs治疗UAP方案的随机对照试验。根据Cochrane偏倚风险工具完成质量评估。采用RevMan 5.3进行双元分析。采用STATA 13.0，采用NMA随机效应模型比较SMICs不同治疗方案的疗效。结果NMA共纳入111项研究，涉及10500例患者。纳入研究的方法学质量不高。目前的证据表明，丹参酚酸(SI)是改善UAP总疗效的最佳治疗方法。冠心宁(GXN)是提高心电图总疗效的最佳治疗方法。结论smics具有预防心血管事件的优势。GXN、SI和丹红在抗UAP总疗效和提高心电图总疗效方面最有可能成为最佳治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.40

自引率

3.80%

发文量

32269

审稿时长

2 months

期刊介绍： Journal of Traditional Chinese Medicine（JTCM） is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.