Journal of Research in Nanoscience and Nanotechnology最新文献

{"title":"Advances in Synthesis Techniques and Environmental Applications of TiO2 Nanoparticles for Wastewater Treatment: A Review","authors":"H. Hamrayev, Serdar Korpayev, K. Shameli","doi":"10.37934/jrnn.12.1.124","DOIUrl":"https://doi.org/10.37934/jrnn.12.1.124","url":null,"abstract":"Worldwide, humanity has long grappled with the ongoing issue of environmental pollution, especially concerning water contamination. Contaminated water contains a range of pollutants, such as heavy metals, organic dyes, and pharmaceuticals, all of which pose harmful effects on both animals and humans due to their toxicity. As clean water sources continue to dwindle, there is an increasing demand for efWorldwide, humanity has long grappled with the ongoing issue of environmental pollution, especially concerning water contamination. Contaminated water contains a range of pollutants, such as heavy metals, organic dyes, and pharmaceuticals, all of which pose harmful effects on both animals and humans due to their toxicity. As clean water sources continue to dwindle, there is an increasing demand for effective treatment methods for polluted water. In response to this pressing need, nanotechnology has emerged as a promising avenue and attracted significant global attention due to its multifaceted applications. Titanium dioxide nanoparticles (TiO2-NPs) are commonly used in daily life and can be synthesized through a variety of physical, chemical, and environmentally friendly methods. Notably, TiO2-NPs stand out for their high surface area-to-volume ratio and their ability to catalyse the degradation of pollutants through photocatalysis. In light of these advancements, this review explores recent progress in TiO2-NPs synthesis and their environmental applications in wastewater treatment.fective treatment methods for polluted water. In response to this pressing need, nanotechnology has emerged as a promising avenue and attracted significant global attention due to its multifaceted applications. Titanium dioxide nanoparticles (TiO2-NPs) are commonly used in daily life and can be synthesized through a variety of physical, chemical, and environmentally friendly methods. Notably, TiO2-NPs stand out for their high surface area-to-volume ratio and their ability to catalyse the degradation of pollutants through photocatalysis. In light of these advancements, this review explores recent progress in TiO2-NPs synthesis and their environmental applications in wastewater treatment.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"10 s2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Guaiacum officinale L. Leaf Extract Silver Nanoparticles for Potential Antioxidant and Anticancer Activity","authors":"Purohit Rangavitala, T. Taranath","doi":"10.37934/jrnn.12.1.2540","DOIUrl":"https://doi.org/10.37934/jrnn.12.1.2540","url":null,"abstract":"The green synthesis of AgNPs using ultrasonic-assisted hydroacetonic Guaiacum officinale L. leaf extract (GoLE), which contains phytochemicals, can play a substantial role in bio-reduction, capping, and stabilization of the nanoparticles. The colour change was observed from light yellow to brown indicating the synthesis of Guaiacum officinale leaf extract silver nanoparticles (GoLE-AgNPs). The absorption maxima (λ max) of AgNPs at 411 nm were confirmed by UV-vis spectroscopy. FTIR data revealed the functional groups involved in the reduction and capping of AgNPs. Powder XRD and SAED images confirmed crystallinity. HR-TEM images showed spherical, ⁓ 18-25 nm sized nanoparticles and EDS spotted the strong peak of silver at 3 KeV. DLS spectra results the surface zeta potential of stable nanoparticles at -37.3 mV, +35.4 nm particle size in hydrodynamic solution. Polyphenolic content of GoLE-AgNPs was demonstrated by TPC and TFC. Dose-dependent radical scavenging activity of AgNPs was performed by the DPPH method. GoLE-AgNPs were treated with human bone marrow neuroblastoma (SH-SY5Y) cancer cells at 12.5-200 μg/mL concentration. The effective cell viability of 24.05 ± 0.029% was observed using an MTT assay. GoLE-AgNPs induced 66.13% of apoptosis in cancer cells. Present research results revealed the better antioxidant and anticancer activity of AgNPs.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"142 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Chemical Composition and Antioxidant Activity of Extracted Zingiberaceae Rhizome using Subcritical Water Extraction","authors":"Mariam Firdhaus Mad Nordin, Nurin Zulaikha Zulfadhly, Norrashidah Mokhtar, Nurul ‘Uyun Ahmad, Pauziah Muhamad, Yvan Gariépy, G.S. Vijaya Raghavan","doi":"10.37934/jrnn.8.1.1322","DOIUrl":"https://doi.org/10.37934/jrnn.8.1.1322","url":null,"abstract":"In Malaysia, many local herbs can take advantage of their benefit for health products, cosmetics, and food production. In this research, fresh Zingiberacea rhizomes including Curcuma Longa, Curcuma Zedoaria, Curcuma Xanthorrhiza, Zingiber Officinale, and Zingiber Zerumbet rhizomes were extracted using the subcritical water extraction (SWE) unit located at AM Zaideen Ventures Sdn Bhd in Kuala Lumpur (Malaysia). The focus of this research is to analyze the freeze-dried powder extracts from the fresh Zingiberaceae rhizome for the phytochemical screening and bioactive compounds. Operating parameter used in the extraction process was fixed at temperature of 110°C, pressure at 10 bar and extraction time of 15 minutes. The freeze-dried powder extracts were screened for its phytochemicals inclusive alkaloids, steroids, terpenoids, glycosides, tannin and saponin. For bioactive compounds analysis, extracts were evaluated for Total Phenolic Content, Total Flavonoid Content, DPPH scavenging activity assay, and bioactive compound using Gas-Chromatography Mass Spectrophotometry analysis. The results show that there was a different presence of phytochemicals compounds in different Zingiberaceae extracts. At 10mg/ml concentration of powder extract, Zingiberaceae rhizomes showed variations in total phenol and flavonoid content, ranging from 134.65 to 285.19 mg GAE/g and from 22.58 to 181.62 mg QE/g, respectively. For DPPH radical scavenging activity, observed at 10mg/ml of freeze-dried extract, all Zingiberacea demonstrated significance antioxidant activity of more than 85% inhibition. Bioactive compounds detected in Zingiberaceae rhizomes shows significance quality. This finding supports the exploration of indigenous herbs market in Malaysia and the potential of water-based extracts on fresh Zingiberaceae rhizomes.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Molecular Docking Simulation of Chromolaena Odorata Phytoconstituents Against Matrix Metalloproteinase Proteins – 9 (MMP-9)","authors":"","doi":"10.37934/jrnn.7.1.16","DOIUrl":"https://doi.org/10.37934/jrnn.7.1.16","url":null,"abstract":"The purpose of this study is to investigate the potential ligands of Chromolaena Odorata plants which contributes to the wound healing process. The ligands involved were phytol, ß-Caryophyllene, and 3,3-Dimethyl-1,2,4-cyclopentanetrione. This work addressed molecular docking simulations between the chosen ligands and Matrix Metalloproteinases (MMP) as the primary viral protein/receptor. The binding modes of the protein-ligand interactions were analysed. 9 poses of docking modes were obtained from the simulation. The ligand-receptor with the lowest interaction energy is the potential candidate for wound healing treatment. In summary, 3,3-Dimethyl-1,2,4-cyclopentanetrionehas been chosen to be the best docked complexes as it shows the lowest energy among the other ligands with value of -7.1 kcal/mol.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133820380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Ionically Cross-Linked Chitosan Nanoparticles","authors":"Hemra Hamrayev, Kamyar Shameli","doi":"10.37934/jrnn.7.1.713","DOIUrl":"https://doi.org/10.37934/jrnn.7.1.713","url":null,"abstract":"Chitosan is an amino polysaccharide with exciting scientific uses because of its distinct structure and several various functions. High biocompatibility, strong biodegradability, and low toxicity are some of the chitosan's most notable characteristics. Chitosan holds great promise for biomedical uses including targeted delivery of drugs. Therefore, this research suggests tripolyphosphate (TPP)-based ionically cross-linked chitosan nanoparticles. XRD and FTIR analysis methods were used to characterize the acquired samples. The outcomes proved that chitosan nanoparticles have an XRD pattern similar to an amorphous polymer. Additionally, FTIR verified that the nanoparticles included chitosan ammonium groups linked to tripolyphosphoric groups of TPP.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133752793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant Extract Loaded Sodium Alginate Nanocomposites for Biomedical Applications: A Review","authors":"Rashmeera Siva Vijian, Mostafa Yusefi, Kamyar Shameli","doi":"10.37934/jrnn.6.1.1430","DOIUrl":"https://doi.org/10.37934/jrnn.6.1.1430","url":null,"abstract":"The advancement of clinical medicine established exceptionally in today’s era is used to cure many infectious diseases. Unfortunately, the negative aftermath associated with synthetic drugs has caused many to turn their attention towards an alternative, which is natural plant-extract drugs. Plant-based drugs have a vast number of benefits and applications in the biomedical field and are further formulated with nanocomposite hydrogel, namely sodium alginate. Sodium alginate is a biopolymer that is water-soluble, non-toxic, biocompatible, and biodegradable, therefore having a high demand in the medical field. The objective of this review is to highlight the nanotechnology development that is used in the medical field to enhance the therapeutic effects of naturally occurring drugs. This review will discuss the use of sodium alginate nanocomposite to create a nanohybrid drug loaded with plant extracts.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"96 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131672442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin Extract Loaded with Chitosan Nanocomposite for Cancer Treatment","authors":"Mohamad Dzulhilmi Zulkifli, Mostafa Yusefi, Kamyar Shameli","doi":"10.37934/jrnn.6.1.113","DOIUrl":"https://doi.org/10.37934/jrnn.6.1.113","url":null,"abstract":"Cancer has become the root of problems in this era especially during this modern medicine time and because of that anticancer treatment had been developed to cure the patient suffering from this disease and for that an adoption of curcumin extract becomes a great deal of interest because of its anticancer properties. A recent study had been done aimed at determining the potential anticancer properties by chitosan in nanoparticle form. Furthermore, curcumin's weak water solubility enables it to accumulate in high concentrations, lowering its permeability to the cell. Curcumin is reduced via a variety of methods. With improving medicinal and research capabilities, nowadays the nano-pharmaceutics became an important field of science to develop an improve efficacy of different drugs specifically that target cancer diseases. In the present review, we focus on the plant extract of curcumin from Curcuma Longa plant and chitosan which derived from chitin in the exoskeletons of crustaceans which then be encapsulated into a nanocarrier formulation that can overcome this cancer. Thus, curcumin's potential preventative and therapeutic applications, as well as several forms of bio-nanocarriers that can be employed to effectively deliver curcumin to various target areas, will be reviewed.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117133739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degradation Behaviour of Arrowroot Fibre (Maranta Arundinacea) Reinforced Arrowroot Starch Biocomposite Films","authors":"J. Tarique, S.M. Sapuan, E.S. Zainudin, A. Khalina, R.A. Ilyas","doi":"10.37934/jrnn.5.1.98102","DOIUrl":"https://doi.org/10.37934/jrnn.5.1.98102","url":null,"abstract":"This research is being driven by environmental legislation that requires the consumption and usage of environmentally friendly products. The focus of this research is to develop and characterize thermoplastic arrowroot starch (TPAS) based biocomposite films incorporating arrowroot fibre (AF) at various compositions (0–10 wt.%) using the solution casting method. The biodegradation behaviour of newly developed composite films was examined. The average degradation rates of TPAS and TPAS/AF–10 films were 8 and 9.84%/day, respectively. The soil burial results revealed that the weight loss of TPAS/AF biocomposite films was higher compared to TPAS film. The biocomposite films revealed arrowroot fibre, a novel waste resource that is both eco-friendly and simple to produce. Overall, incorporating arrowroot fibre with TPAS film improves biodegradability, making them more suitable for environmentally friendly food packaging.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116581032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Application of Cross-linked Alginate Nanoparticles as Drug Carrier: A Review","authors":"Jing Jie Chia, K. Shameli, Mostafa Yusefi, R. R. Ali, Vekes, Balasundram, Sin-Yeang Teow","doi":"10.37934/jrnn.5.1.111","DOIUrl":"https://doi.org/10.37934/jrnn.5.1.111","url":null,"abstract":"Nanotechnology also called as nanotech is referring to the science, technology and engineering to synthesis, manipulation and investigation of materials and devices at nanoscales. Nanoparticles (NPs) owns a special place in nanotechnology due to their extreme-small size, multifunctionality, and modifiable surface for wide range of applications especially in new drug delivery application as the stability, solubility, biocompatibility and drugs releasing of NPs are highly controllable. The variation of nanomaterials with different physiochemical and morphological properties will affect the materials-living cells interaction and determination of the route of clearance and potential toxic effects. Thus, it requires more cross-disciplinary research on the designing and developing of drugs delivery NPs based on the diagnosis and treatment of devastating diseases. Biopolymers-based NPs have gained great attention for drug delivery system over the past few decades compared to other materials-based NPs such as liposomes, ceramics and lipids as well as magnetic NPs. There are extensive studies and developments of biopolymers-based NPs for drug delivery and tissue engineering as it capable of controlling the release of drugs, stabilizing labile molecules from degradation, and site-specific drug targeting. Alginate is an anionic copolymer that extracted from algae. The NPs composed alginate have become one of the most extensively researched materials for biomedical applications such as tissue engineering, wound dressing, protein/enzyme carrier and drug delivery due to its biodegradability, biocompatibility, non-toxicity and mucoadhesive properties. Furthermore, by physiochemical crosslinking and cooperating with other polymers, the mechanical strength, cell affinity and drug release profile can be modified and improved. In this brief review paper, several aspects about using alginate or crosslinked alginate for drug delivery application will be discussed, mainly focus on the structure and properties of alginate such as biocompatibility, immunogenicity and biodegradability, as well as the effect of mucoadhesion and pH sensitivity of using alginate in drug delivery nanoparticles developments.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114326919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-linked Chitosan-Based Hydrogels Nanocomposites for Treatment of Disease","authors":"Kamyar Shameli, Syamim Arsyad Saiful, Mostafa Yusefi","doi":"10.37934/jrnn.5.1.6597","DOIUrl":"https://doi.org/10.37934/jrnn.5.1.6597","url":null,"abstract":"Chitosan nanoparticles can be used in many types of applications such as food packaging, cosmetics and biomedical field. Chitosan can be modified to form chitosan-based hydrogels for antiviral purpose. Chitosan-based hydrogels are commonly used in wound healing, tissue engineering and drug delivery. This study explains about the properties and the applications of chitosan-based hydrogels since there were not much paper or research about chitosan-based hydrogels used as antiviral agent. Usually, many researchers did some studies about antiviral application focusing only on chitosan itself but not specifically into chitosan-based hydrogels. The properties of chitosan are also not well explained in some research. The purpose of this study is to investigate the antiviral application of chitosan-based hydrogels based on chitosan properties.","PeriodicalId":173619,"journal":{"name":"Journal of Research in Nanoscience and Nanotechnology","volume":"111 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115762929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}