{"title":"Interactions of Corneal Endothelial Cells with Stromal Cells during Corneal Endothelial Injury","authors":"Kyung Wook Kim, Young Joo Shin","doi":"10.3341/jkos.2024.65.2.98","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.98","url":null,"abstract":"Purpose: To investigate the interaction of corneal endothelial cells (CECs) with corneal stromal cells (CSCs) on the healing of chemically induced corneal endothelial injury.Methods: Twenty-five rabbits were divided into two groups: rabbits exposed to NaOH and controls. Rabbits were clinically evaluated and sacrificed at 1 day, 1 week, 2 weeks, and 4 weeks after endothelial injury. Corneal endothelial cells and corneal stromal cells were cultured and the wound healing rate of the corneal endothelium and cytokines in the culture medium were analyzed with and without co-culture in the Transwell system.Results: Corneal edema and opacity scores were higher in all rabbits exposed to NaOH than in controls. Corneal endothelial apoptosis with little effect on CSCs was observed in rabbits exposed to NaOH at day 1. Two weeks after injury, CECs migrated from the periphery. CSCs were aligned in parallel to Descemet's membrane, which exhibited the presence of CECs. Transforming factor-β1 and interleukin-6 secretion was lower in the co-culture system than in individual cultures of CECs or CSCs.Conclusions: These results revealed intracameral NaOH injection is a model of corneal endothelial injury with minimal impact on the stroma. Communication between CECs and CSCs during wound healing may lead to the modulation of cytokine production, which is necessary for an enhanced healing process of corneal endothelial injury.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interactions of Corneal Endothelial Cells with Stromal Cells during Corneal Endothelial Injury","authors":"Kyung Wook Kim, Young Joo Shin","doi":"10.3341/jkos.2024.65.2.98","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.98","url":null,"abstract":"Purpose: To investigate the interaction of corneal endothelial cells (CECs) with corneal stromal cells (CSCs) on the healing of chemically induced corneal endothelial injury.Methods: Twenty-five rabbits were divided into two groups: rabbits exposed to NaOH and controls. Rabbits were clinically evaluated and sacrificed at 1 day, 1 week, 2 weeks, and 4 weeks after endothelial injury. Corneal endothelial cells and corneal stromal cells were cultured and the wound healing rate of the corneal endothelium and cytokines in the culture medium were analyzed with and without co-culture in the Transwell system.Results: Corneal edema and opacity scores were higher in all rabbits exposed to NaOH than in controls. Corneal endothelial apoptosis with little effect on CSCs was observed in rabbits exposed to NaOH at day 1. Two weeks after injury, CECs migrated from the periphery. CSCs were aligned in parallel to Descemet's membrane, which exhibited the presence of CECs. Transforming factor-β1 and interleukin-6 secretion was lower in the co-culture system than in individual cultures of CECs or CSCs.Conclusions: These results revealed intracameral NaOH injection is a model of corneal endothelial injury with minimal impact on the stroma. Communication between CECs and CSCs during wound healing may lead to the modulation of cytokine production, which is necessary for an enhanced healing process of corneal endothelial injury.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Adolescent Case of Unilateral Papillophlebitis Treated with Intravitreal Bevacizumab","authors":"Bo Kang Seo, Jaehyuk Lee, Jihae Park","doi":"10.3341/jkos.2024.65.2.167","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.167","url":null,"abstract":"Purpose: To report a case of papillophlebitis treated with an intravitreal bevacizumab injection in an adolescent patient.Case summary: A 15-year-old female with no medical history presented with a 3-day history of blurred vision and a floating sensation. The initial visual acuity (VA) was 0.0 logarithm of minimal angle of resolution (logMAR) in the left eye. A fundus examination revealed a blurry disc margin, peripapillary hemorrhage, and venous engorgement. Optical coherence tomography indicated subretinal fluid (SRF) accumulation. Both color vision and pupillary reactions were normal in bilateral eyes. Blood tests revealed no significant abnormalities. Brain magnetic resonance imaging (MRI) showed mild focal papillitis, but the patient did not report eye movement pain or discomfort. The diagnosis was papillophlebitis; however, high-dose steroid treatment was not initiated due to the absence of a significant decrease in VA. A single injection of intravitreal bevacizumab was administered to address the SRF. At the 9-month follow-up, VA remained at 0.0 logMAR, and the retina demonstrated anatomical stabilization after complete absorption of the SRF without recurrence.Conclusions: Papillophlebitis can manifest during adolescence. Treatment of a 15-year-old patient with intravitreal bevacizumab obviated the need for high-dose steroid therapy and produced favorable outcomes, including preservation of VA and anatomical stabilization of the retina.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jong Hoon Lee, Hyo Ju Jang, Sung Sun Kim, K. Yoon, H. Yoon
{"title":"A Case of MALToma Masquerading as a Lacrimal Caruncular Granuloma","authors":"Jong Hoon Lee, Hyo Ju Jang, Sung Sun Kim, K. Yoon, H. Yoon","doi":"10.3341/jkos.2024.65.2.157","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.157","url":null,"abstract":"Purpose: To report a case of mucosa-associated lymphoid tissue lymphoma (MALToma) that presented as a lacrimal caruncular granuloma.Case summary: A 38-year-old woman presented with a mass in the right lacrimal caruncle and had a history of incision and drainage. Examination revealed a 4-mm elevated mass at the lacrimal caruncle, which resembled a granuloma. The mass was excised under local anesthesia and a MALToma was diagnosed based on the histopathological examination.Conclusions: Although rare, a MALToma can present as a granuloma-like lacrimal caruncular mass. Excision and biopsy of the lacrimal caruncular mass are essential to obtain a definitive diagnosis.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acquired Nonaccommodative Esotropia in Older Children","authors":"Inkee Kim, Nam Yeo Kang","doi":"10.3341/jkos.2024.65.2.145","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.145","url":null,"abstract":"Purpose: To evaluate the clinical findings and surgical outcomes in older children with acquired nonaccommodative esotropia (ANAET).Methods: A retrospective review was conducted on the medical records of 9 patients (aged 9-17 years) who were diagnosed with ANAET between 2014 and 2021. The age of onset, angle of deviation, presence of symptomatic diplopia, fusional state, stereo-acuity, and surgical results were analyzed.Results: The mean age at onset was 12.0 ± 2.8 years, and the mean duration of esodeviation was 11.8 ± 14.4 months. The mean follow-up period was 32.0 ± 19.5 months. Five of 9 patients presented with symptomatic diplopia accompanying esotropia, and two complained diplopia only. The mean angles of deviation were 32.0 ± 11.5 prism diopters (PD) for near and 31.8 ± 12.4 PD for distance. Six patients showed progressive esotropia, and none had neurological or intracranial disorders. Surgical correction was performed at 17.1 ± 15.0 months after the onset. At the final follow-up, all patients resolved diplopia, and 88.9% achieved successful motor alignment. Improved stereopsis was observed in all patients, with 77.8% demonstrating fusion at both near and far distant. However, only 44.4% gained normal 60 arcsec stereopsis.Conclusions: Diplopia with estropia was the main presenting symptom of ANAET in older children. Surgical treatment was effective in achieving good postoperative motor alignment and fusion, but recovery of fine steropsis was limited.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alterations in Ocular Biometrics Following Ahmed Valve Implantation","authors":"Yunseog Choi, Kyong Jin Cho, Yuli Park","doi":"10.3341/jkos.2024.65.2.132","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.132","url":null,"abstract":"Purpose: We assessed changes in ocular biometrics following Ahmed valve implantation.Methods: We conducted a retrospective analysis involving 76 eyes of 76 glaucoma patients who underwent Ahmed valve implantation; these patients were followed up for 6 months. Preoperative data, including age, intraocular pressure (IOP), refractive status, axial length, central corneal thickness, anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior and posterior keratometry, were evaluated preoperatively and at 1 week, 1 month, and 6 months postoperatively.Results: The mean IOP exhibited a significant reduction from 39.17 ± 14.06 mmHg preoperatively to 11.43 ± 3.25 mmHg (p < 0.001), 13.18 ± 4.64 mmHg (p < 0.001), and 12.95 ± 4.37 mmHg (p < 0.001) at 1 week, 1 month, and 6 months postoperatively, respectively. Furthermore, the axial length exhibited a significant post-surgery reduction, measuring 23.74 ± 2.01 mm preoperatively and 23.48 ± 1.86 mm (p < 0.001), 23.57 ± 1.94 mm (p < 0.001), and 23.61 ± 1.98 mm (p = 0.002) at 1 week, 1 month, and 6 months postoperatively, respectively. However, no significant changes were observed in various other parameters, such as anterior and posterior keratometry, refractive status, ACA, ACD, or ACV, at 6 months post-surgery (p > 0.05).Conclusions: Ahmed valve implantation resulted in a significant reduction in axial length. Furthermore, it had transient but non-significant effects on keratometry, refractive status, ACA, ACD, and ACV at 6 months after surgery.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyoung Hae Kang, C. Kim, Jong Woo Kim, Jae Hui Kim
{"title":"Injection Frequency and Differences in Visual Outcomes based on Diagnosis Year in Neovascular Age-related Macular Degeneration","authors":"Kyoung Hae Kang, C. Kim, Jong Woo Kim, Jae Hui Kim","doi":"10.3341/jkos.2024.65.2.117","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.117","url":null,"abstract":"Purpose: To evaluate the changes in injection frequency based on the diagnosis year in neovascular age-related macular degeneration (AMD) and the differences in visual outcomes associated with these changes.Methods: This retrospective study included 667 patients (667 eyes) diagnosed with treatment-naïve neovascular AMD and polypoidal choroidal vasculopathy in 2013, 2015, 2017, and 2019. The number of anti-vascular endothelial growth factor (VEGF) injections and degree of changes in visual acuity during the first 24 months after diagnosis were compared among the 4 years.Results: The 2013, 2015, 2017, and 2019 groups had a mean of 5.7 ± 2.7, 6.0 ± 2.8, 6.6 ± 3.0, and 6.9 ± 3.3 anti-VEGF injections, respectively. The number of injections was significantly higher in 2019 than in 2013 and 2015 (p < 0.001). The mean degree of visual change during the 24-month follow-up period was 0.07 ± 0.55, 0.01 ± 0.51, 0.08 ± 0.50, and 0.04 ± 0.48 in 2013, 2015, 2017, and 2019, respectively. There was a significant difference in the degree of visual change among the four groups (p = 0.020).Conclusions: Patients diagnosed more recently tend to receive more injections and have better visual outcomes. We speculate that more injections contributed to these results. This trend should be considered when predicting the future socioeconomic burden of neovascular AMD.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Mun, Yong-Kyu Kim, Sung Pyo Park, Kyoung Lae Kim
{"title":"Subjective Visual Floaters after Intravitreal Injection and Effect of the Inverse Tapping Technique","authors":"J. Mun, Yong-Kyu Kim, Sung Pyo Park, Kyoung Lae Kim","doi":"10.3341/jkos.2024.65.2.125","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.125","url":null,"abstract":"Purpose: To analyze the incidence of vitreous floaters after intravitreal antivascular endothelial growth factor injection and the effectiveness of the inverse tapping technique, which involves tapping the syringe with the needle downwards to prevent the entry of air bubbles during injection.Methods: The study enrolled patients undergoing their first intravitreal injection for exudative age-related macular degeneration or diabetic macular edema. The patients were divided into two groups: those who received an injection after inverse tapping (IT group) and controls who received the injection without tapping. Patients who consented to the study were randomly assigned to the IT group and the control group through block randomization. One week after injection, a questionnaire was used to assess the presence of vitreous floaters; those who reported them were examined via optical coherence tomography and wide fundus photography.Results: Of the 39 patients in the IT group, two (5.1%) reported floaters 1 week after injection. By contrast, eight (20.5%) of the 39 controls reported them, with a significant difference (p = 0.042). Patients with floaters were significantly younger. Posterior vitreous detachment, as evaluated by pre-injection optical coherence tomography, was observed in 10.0% of those with floaters and 76.5% of those without them.Conclusions: The occurrence of vitreous floaters after intravitreal injection is related to age and the presence of posterior vitreous detachment. The use of the inverse tapping technique may help reduce these after intravitreal injection.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyoung Hae Kang, C. Kim, Jong Woo Kim, Jae Hui Kim
{"title":"Injection Frequency and Differences in Visual Outcomes based on Diagnosis Year in Neovascular Age-related Macular Degeneration","authors":"Kyoung Hae Kang, C. Kim, Jong Woo Kim, Jae Hui Kim","doi":"10.3341/jkos.2024.65.2.117","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.117","url":null,"abstract":"Purpose: To evaluate the changes in injection frequency based on the diagnosis year in neovascular age-related macular degeneration (AMD) and the differences in visual outcomes associated with these changes.Methods: This retrospective study included 667 patients (667 eyes) diagnosed with treatment-naïve neovascular AMD and polypoidal choroidal vasculopathy in 2013, 2015, 2017, and 2019. The number of anti-vascular endothelial growth factor (VEGF) injections and degree of changes in visual acuity during the first 24 months after diagnosis were compared among the 4 years.Results: The 2013, 2015, 2017, and 2019 groups had a mean of 5.7 ± 2.7, 6.0 ± 2.8, 6.6 ± 3.0, and 6.9 ± 3.3 anti-VEGF injections, respectively. The number of injections was significantly higher in 2019 than in 2013 and 2015 (p < 0.001). The mean degree of visual change during the 24-month follow-up period was 0.07 ± 0.55, 0.01 ± 0.51, 0.08 ± 0.50, and 0.04 ± 0.48 in 2013, 2015, 2017, and 2019, respectively. There was a significant difference in the degree of visual change among the four groups (p = 0.020).Conclusions: Patients diagnosed more recently tend to receive more injections and have better visual outcomes. We speculate that more injections contributed to these results. This trend should be considered when predicting the future socioeconomic burden of neovascular AMD.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Mun, Yong-Kyu Kim, Sung Pyo Park, Kyoung Lae Kim
{"title":"Subjective Visual Floaters after Intravitreal Injection and Effect of the Inverse Tapping Technique","authors":"J. Mun, Yong-Kyu Kim, Sung Pyo Park, Kyoung Lae Kim","doi":"10.3341/jkos.2024.65.2.125","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.125","url":null,"abstract":"Purpose: To analyze the incidence of vitreous floaters after intravitreal antivascular endothelial growth factor injection and the effectiveness of the inverse tapping technique, which involves tapping the syringe with the needle downwards to prevent the entry of air bubbles during injection.Methods: The study enrolled patients undergoing their first intravitreal injection for exudative age-related macular degeneration or diabetic macular edema. The patients were divided into two groups: those who received an injection after inverse tapping (IT group) and controls who received the injection without tapping. Patients who consented to the study were randomly assigned to the IT group and the control group through block randomization. One week after injection, a questionnaire was used to assess the presence of vitreous floaters; those who reported them were examined via optical coherence tomography and wide fundus photography.Results: Of the 39 patients in the IT group, two (5.1%) reported floaters 1 week after injection. By contrast, eight (20.5%) of the 39 controls reported them, with a significant difference (p = 0.042). Patients with floaters were significantly younger. Posterior vitreous detachment, as evaluated by pre-injection optical coherence tomography, was observed in 10.0% of those with floaters and 76.5% of those without them.Conclusions: The occurrence of vitreous floaters after intravitreal injection is related to age and the presence of posterior vitreous detachment. The use of the inverse tapping technique may help reduce these after intravitreal injection.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}