Journal of The Korean Ophthalmological Society最新文献

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Inflammatory Factors Predicting Dry Eye Syndrome in a Model Using Osmotic Pressure 利用渗透压模型预测干眼症的炎症因素
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1191
Keon Woo Park, Jae Woong Koh
{"title":"Inflammatory Factors Predicting Dry Eye Syndrome in a Model Using Osmotic Pressure","authors":"Keon Woo Park, Jae Woong Koh","doi":"10.3341/jkos.2023.64.12.1191","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1191","url":null,"abstract":"Purpose: To identify inflammatory factors that may serve as biomarkers for dry eye syndrome using a hyperosmotic dry eye syndrome model.Methods: Cultured human conjunctival epithelial cells were subjected to 400, 450, 500, and 550 mOsm/L NaCl, and cell viability was assessed in response to osmolarity. The relative expression of inflammatory factors was evaluated by real-time polymerase chain reaction of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, metalloproteinase (MMP)-2, and MMP-9 according to the NaCl concentration.Results: An increase in the concentration of NaCl led to a notable decrease in cell viability (p < 0.05). IL-8, TNF-α, and MMP-9 expression levels increased significantly in proportion to NaCl concentration (p < 0.05).Conclusions: IL-8, TNF-α, and MMP-9 may serve as effective biomarkers in dry eye studies.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"78 4","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Anterior Segment Measurements Between Swept-source Optical Coherence Tomography and Schiempflug Coherence Interferometer 横扫光源光学相干断层扫描与施普弗鲁格相干干涉仪的前段测量比较
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1158
Jiyun Song, Kyung Sun Na
{"title":"Comparison of Anterior Segment Measurements Between Swept-source Optical Coherence Tomography and Schiempflug Coherence Interferometer","authors":"Jiyun Song, Kyung Sun Na","doi":"10.3341/jkos.2023.64.12.1158","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1158","url":null,"abstract":"Purpose: To assess the agreement between anterior segment measurements obtained using swept-source optical coherence tomography (Anterion®, Heidelberg Engineering Inc., Heidelberg, Germany) and Scheimpflug partial coherence interferometry (Pentacam HR®, OCULUS, Wetzlar, Germany).Methods: We analyzed the anterior and posterior corneal keratometry, Cartesian astigmatism (J0), oblique astigmatism (J45), anterior chamber depth (ACD), and central corneal thickness (CCT) measurements obtained using the two devices in 65 eyes of 43 subjects.Results: The mean differences between the anterior flat K, anterior steep K, anterior mean K, anterior J0, anterior J45, posterior flat K, posterior steep K, posterior mean K, posterior J0, posterior J45, ACD, and CCT measurements were -0.13 ± 0.34, -0.02 ± 0.33, -0.05 ± 0.31, -0.03 ± 0.39, -0.06 ± 0.35, 0.12 ± 0.09, 0.07 ± 0.08, 0.10 ± 0.06, -0.02 ± 0.14, 0.01 ± 0.16, 0.04 ± 0.06, and -3.51 ± 7.42, respectively. All measurements except posterior J0 and J45 had interclass correlation coefficients greater than 0.75.Conclusions: The mean differences and 95% limits of agreement in this study are consistent with previously reported values. There was a high level of agreement between Anterion® and Pentacam HR®. However, considering the statistically significant differences and limits of agreement for certain measurements, caution should be exercised when assuming interchangeability between these devices.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"55 5","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Outcomes in Patients with Intermittent Exotropia with Siblings Who Underwent Surgery by the Same Surgeon 有兄弟姐妹的间歇性外斜患者接受同一外科医生手术的手术结果
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1245
Chae Won Lim, Won Jae Kim
{"title":"Surgical Outcomes in Patients with Intermittent Exotropia with Siblings Who Underwent Surgery by the Same Surgeon","authors":"Chae Won Lim, Won Jae Kim","doi":"10.3341/jkos.2023.64.12.1245","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1245","url":null,"abstract":"Purpose: We evaluated surgical outcomes in pediatric patients with intermittent exotropia with and without a family history of exotropia surgery performed by the same surgeon.Methods: We conducted a retrospective review of the medical records of pediatric patients aged ≤ 18 years who underwent surgery for intermittent exotropia between September 2015 and December 2021. We compared surgical outcomes between patients with and without a family history of exotropia surgery performed using 1:1 propensity score matching. A successful surgical outcome was defined as achieving alignment between an exodeviation of 10 prism diopters (PD) and an esodeviation of 4 PD.Results: This study included 60 patients with a family history of exotropia surgery and 60 matched controls with no such history. Notably, the log-rank test revealed no significant differences in surgical outcomes between the two groups (p = 0.622). Furthermore, clinical characteristics, including the onset of exotropia, degree of ocular deviation, and age at surgery, were similar between first- and second-born siblings. Furthermore, no significant differences were observed in surgical outcomes between the two groups (p= 0.540).Conclusions: Patients with a family history of exotropia surgery do not exhibit significantly different surgical outcomes compared to those with no such history. In addition, no significant differences were observed in surgical outcomes between the first- and second-born siblings.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"318 7","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors of Meibomian Gland Loss in Dry Eye Disease 干眼症患者睑板腺功能丧失的风险因素
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1152
Ye-Tao Jin, Jong Hyuck Lee, Sun Woong Kim
{"title":"Risk Factors of Meibomian Gland Loss in Dry Eye Disease","authors":"Ye-Tao Jin, Jong Hyuck Lee, Sun Woong Kim","doi":"10.3341/jkos.2023.64.12.1152","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1152","url":null,"abstract":"Purpose: To determine the risk factors of meibomian gland loss in dry eye disease.Methods: The medical charts of 229 dry eye disease patients who had a meibography were retrospectively reviewed. They were divided into 4 groups according to the degree of meibomian gland loss. Telangiectasia and irregularity of eyelid margin, Ocular Surface Disease Index (OSDI), non invasive breakup time (NIBUT), lipid layer thickness (LLT) and tear meniscus height (TMH) were compared. Age, gender, history of eyeline tattoo, history of hypertension, diabetes, dyslipidemia, chemotherapy, radiation therapy, hormone therapy and autoimmune diseases were also investigated to analyze the correlation with the severe meibomian gland loss. Severe meibomian gland loss was defined as loss of more than 75% of the conjunctival area, and risk factors were evaluated using logistic regression analysis.Results: Comparing the four groups divided according to the degree of meibomian gland loss, the group with severe meibomian gland loss was older (p = 0.001), had lower LLT (p < 0.001), had a higher frequency of eyeline tattoos. The ratio of hyperlipidemia (p < 0.001) and chemotherapy (p < 0.001) was also high in the group with severe meibomian gland loss. As a result of multiple logistic regression analysis, age, eyeline tattoo, hyperlipidemia, and chemotherapy were variables that had a significant effect on sever meibomian gland loss. (p < 0.05)Conclusions: Age and history of eyeline tattoo, hyperlipidemia, and chemotherapy are significant variables that cause severe meibomian gland loss in dry eye disease patients. J Korean Ophthalmol Soc 2023;64(12):1152-1157","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"70 4","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Contact Lens-related Bacterial Keratitis According to Culture Positivity: A 25-year Retrospective Study 根据培养阳性率比较分析与接触镜相关的细菌性角膜炎:25 年回顾性研究
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1168
Sunggeun Son, Cheol-Won Moon, C. Cho, Sang-Bumm Lee
{"title":"Comparative Analysis of Contact Lens-related Bacterial Keratitis According to Culture Positivity: A 25-year Retrospective Study","authors":"Sunggeun Son, Cheol-Won Moon, C. Cho, Sang-Bumm Lee","doi":"10.3341/jkos.2023.64.12.1168","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1168","url":null,"abstract":"Purpose: This study investigated the microbiological profile and clinical characteristics of culture positive (CP) contact lens-related bacterial keratitis (CLBK) and compared them to culture negative (CN) cases.Methods: We retrospectively analyzed 142 CLBK patients hospitalized between January 1998 and December 2022. The CP and CN groups consisted of 79 eyes (100 isolates) and 63 eyes, respectively. We investigated the microbiological profile in the CP group and compared the epidemiology, predisposing factors, clinical characteristics, and treatment outcomes between the CP and CN groups. Poor treatment outcomes were defined as a final best-corrected visual acuity (BCVA) ≤ 0.5, worsened BCVA after treatment, or the need for surgical intervention. We evaluated the risk factors for poor treatment outcomes in the entire cohort through two-proportional Z-test analysis.Results: In CP group, gram-negative bacteria accounted for 85%, and common isolates were Pseudomonas (27%) and Serratia (26%) species. There were significant differences in mean age (27.0 years vs. 33.8 years, p = 0.009) and a history of therapeutic bandage contact lens wear (13.9% vs. 28.6%, p = 0.031) between the CP and CN groups. However, there were no significant differences in symptom duration, prior use of topical antibiotics, sleeping with wearing CL, epithelial defect size, hypopyon, and poor treatment outcomes. Significant risk factors for poor treatment outcomes in the entire group included deep infiltration (Z = 2.88), epithelial healing time ≥ 7 days (Z = 2.30), initial BCVA < 0.1 (Z = 2.20), over date use of contact lens (Z = 2.10), and epithelial defect size ≥ 5 mm2 (Z = 2.05).Conclusions: There were no significant differences in clinical characteristics and treatment outcomes between the CP and CN groups. Poor initial clinical findings and over date use of contact lens were associated with poor treatment outcomes in both groups. J Korean","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"185 3","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Longitudinal Analysis of Subfoveal Choroidal Thickness Following Sulodexide Treatment in Diabetic Retinopathy Patients 糖尿病视网膜病变患者接受舒洛地特治疗后眼底脉络膜厚度的长期纵向分析
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1208
Chang Min Cha, Jae Wan Lim, C. Kim, Seung Uk Lee, Sang Joon Lee
{"title":"Long-term Longitudinal Analysis of Subfoveal Choroidal Thickness Following Sulodexide Treatment in Diabetic Retinopathy Patients","authors":"Chang Min Cha, Jae Wan Lim, C. Kim, Seung Uk Lee, Sang Joon Lee","doi":"10.3341/jkos.2023.64.12.1208","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1208","url":null,"abstract":"Purpose: To evaluate the two-year longitudinal changes in subfoveal choroidal thickness (CT) following sulodexide treatment in patients with diabetic retinopathy.Methods: Thirty-eight eyes from patients with diabetic retinopathy, followed for a minimum of two years after sulodexide administration, were included. Subfoveal CT, measured using optical coherence tomography, was analyzed prospectively. Variables including age, sex, duration of diabetes mellitus, HbA1c, blood pressure, sulodexide treatment duration, refractive error, axial length, central macular thickness (CMT), visual acuity, laser photocoagulation, and intravitreal anti-vascular endothelial growth factor injections were evaluated for potential effects on CT. CMT, subfoveal CT, and choroidal vascularity index were compared at baseline and at 6, 12, and 24 months after sulodexide.Results: Of the 38 eyes, 10 belonged to males and 28 to females. The mean data were as follows: age, 67.18 ± 8.87 years; duration of diabetes, 18.11 ± 7.57 years; HbA1c, 8.76 ± 1.60 mmol/L; systolic blood pressure, 134.69 ± 14.68 mmHg; diastolic blood pressure, 73.72 ± 11.90 mmHg; duration of sulodexide, 25.79 ± 3.17 months; refractive error, 0.22 ± 2.19 diopters (D); and axial length, 23.32 ± 0.89 mm. During the observation period, 15 eyes underwent laser photocoagulation and 17 eyes received intravitreal anti-vascular endothelial growth factor injections. The mean subfoveal CT was 216.00 ± 64.23 μm before sulodexide administration and increased to 223.87 ± 62.18 μm, 225.53 ± 62.02 μm, and 225.76 ± 63.62 μm at 6, 12, and 24 months, respectively (p = 0.0377, p = 0.0159, p = 0.0135). The CMT was 318.14 ± 102.28 μm initially and changed to 313.08 ± 77.47 μm, 314.97 ± 88.32 μm, and 320.03 ± 97.36 μm at the aforementioned intervals, with no significant variation (p = 0.904, p = 0.736, p = 0.892).Conclusions: Sulodexide administration led to a significant rise in subfoveal CT over a 2-year follow-up. This change in CT was not mirrored in the CMT.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"130 4","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Outcomes of Hammer-Chisel and Drill Techniques to Create Superior Bony Ostium During Endoscopic Dacryocystorhinostomy 内镜下泪囊鼻腔造口术中采用锤凿和钻孔技术创建上骨膜的手术效果
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1127
Hye Jin Lee, Jun Ho Oh, Yong Koo Kang, Dai Woo Kim, Byeong Jae Son
{"title":"Surgical Outcomes of Hammer-Chisel and Drill Techniques to Create Superior Bony Ostium During Endoscopic Dacryocystorhinostomy","authors":"Hye Jin Lee, Jun Ho Oh, Yong Koo Kang, Dai Woo Kim, Byeong Jae Son","doi":"10.3341/jkos.2023.64.12.1127","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1127","url":null,"abstract":"Purpose: We introduce a “cold steel” hammer-chisel technique for endoscopic dacryocystorhinostomy, then compare postoperative outcomes between this technique and a drill technique.Methods: This study included 191 patients (297 eyes) with nasolacrimal duct stenoses or obstructions who underwent endoscopic dacryocystorhinostomy using the hammer-chisel or drill technique. Surgical outcomes were compared via follow-up screening for epiphora and anatomical complications such as granuloma and fibrous membrane formation, canalicular obstruction, and synechiae.Results: Postoperative anatomical complications occurred in 29 eyes (18.6%) in the hammer-chisel group and 51 eyes (36.2%) in the drill group (p = 0.001). The anatomical failure rate was higher in the drill group [28 eyes (19.9%)] than in the hammer-chisel group [18 eyes (11.5%); p = 0.038]. Functional failure was observed in 13 eyes (8.3%) in the hammer-chisel group and 13 eyes (9.2%) in the drill group (p = 0.787). The mean operation time was significantly longer in the drill group (35.5 ± 10.4 minutes vs. 25.4 ± 9.1 minutes) (p < 0.001).Conclusions: During endoscopic dacryocystorhinostomy, osteotomy with a hammer-chisel is more successful and leads to fewer complications than osteotomy with a drill.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"315 5","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and Clinical Features Analysis of Orbital and Adnexal Lymphoma in the Western Area of Gyeongsangnam-do 庆尚南道西部地区眼眶和附件淋巴瘤的流行病学和临床特征分析
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1136
I. Jeong, Seong-Jae Kim, S. Seo
{"title":"Epidemiology and Clinical Features Analysis of Orbital and Adnexal Lymphoma in the Western Area of Gyeongsangnam-do","authors":"I. Jeong, Seong-Jae Kim, S. Seo","doi":"10.3341/jkos.2023.64.12.1136","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1136","url":null,"abstract":"Purpose: We compared the epidemiology and clinical features of patients with orbital and adnexal lymphoma in western Gyeongsangnam-do with those reported previously, domestically and internationally.Methods: Of the 25 patients diagnosed with lymphoproliferative disorder, a retrospective analysis was conducted on 21 patients with orbital and adnexal lymphoma between January 2010 and December 2021.Results: In total, 21 patients were diagnosed with orbital and adnexal lymphoma, with an average annual incidence rate of 0.18 per 100,000 people, exceeding the national average in Korea. The median age of the patients was 57 years and the ratio of 1.1 to 1. The most common presenting symptoms included proptosis, conjunctival mass, conjunctival injection, eyelid swelling and epiphora. Primary and metastatic lesions accounted for 85.7% and 14.3% of cases, respectively. Histologically, the most common subtype was extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (90.4%). Furthermore, diffuse large B-cell lymphoma and NK/T-cell lymphoma of T-cell origin each accounted for 4.8% of cases.Conclusions: The reported incidence rate in the present study exceeded the national average in Korea. However, no significant differences were observed in clinical symptoms, primary and metastatic lesions, histological classification, or post-treatment effects compared to findings from domestic and international studies.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"137 5","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Cases of Sudden Intraocular Pressure Elevation in Children after Steroid Treatment 两例类固醇治疗后眼压突然升高的儿童病例
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1268
Minjeong Kim, K. Kim, J. Jeong, Nam Ju Moon, Y. Chun
{"title":"Two Cases of Sudden Intraocular Pressure Elevation in Children after Steroid Treatment","authors":"Minjeong Kim, K. Kim, J. Jeong, Nam Ju Moon, Y. Chun","doi":"10.3341/jkos.2023.64.12.1268","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1268","url":null,"abstract":"Purpose: We report two cases of sudden intraocular pressure (IOP) elevation in children after steroid treatment.Case summary: (Case 1) An 8-year-old boy visited the hospital with vomiting and headache that had begun 3 days after application of dexamethasone eyedrops. IOPs were 55 and 62 mmHg in the right and left eyes, respectively; both anterior chambers were normal. The eyedrops were stopped and timolol/dorzolamide was applied twice daily. After intravenous mannitol injection, the IOPs of both eyes decreased to 18 mmHg within 24 hours. (Case 2) A 10-year-old boy diagnosed with coronavirus disease 2019 three days prior had been prescribed methylprednisolone 4 mg twice daily; he visited the hospital with headache, eye pain, and decreased vision that began 1 day after medication. IOPs were 41 and 54 mmHg in the right and left eyes, respectively; both anterior chambers were normal. After drug discontinuation, timolol/dorzolamide, brimonidine, and latanoprost eyedrops were applied. Subsequently, after intravenous mannitol injection, the IOPs decreased within 24 hours to 7 and 16 mmHg in the right and left eyes, respectively; they remained stable. However, thinning was observed in the retinal nerve fiber and ganglion cell-inner plexiform layer.Conclusions: Children can develop rapid IOP elevation after even 1 day of steroid use; residual structural damage may be present, despite prompt treatment. Clinicians must closely monitor such patients for atypical IOP elevation.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"84 S2","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Tear Osmolarity and Dry Eye Signs in Patients with Obstructive Meibomian Gland Dysfunction 泪液渗透压与睑板腺功能障碍患者干眼症状之间的关系
IF 0.1
Journal of The Korean Ophthalmological Society Pub Date : 2023-12-15 DOI: 10.3341/jkos.2023.64.12.1183
Han Sol Choi, Si Hyung Lee
{"title":"Association Between Tear Osmolarity and Dry Eye Signs in Patients with Obstructive Meibomian Gland Dysfunction","authors":"Han Sol Choi, Si Hyung Lee","doi":"10.3341/jkos.2023.64.12.1183","DOIUrl":"https://doi.org/10.3341/jkos.2023.64.12.1183","url":null,"abstract":"Purpose: To explore the correlations between tear osmolarity, as measured using I-PEN® (I-MED Pharma, Inc., Dollard-des-Ormeaux, QC, Canada), and various dry eye indicators, including the Schirmer test, tear break-up time (TBUT), Oxford scale, and Ocular Surface Disease Index (OSDI), in patients with obstructive meibomian gland dysfunction (MGD).Methods: The medical records of 44 cases of obstructive MGD were reviewed. Tear osmolarity was obtained using I-PEN® (I-MED Pharma, Inc.). The TBUT, Schirmer test, Oxford scale, OSDI, and MGD grade were used to assess the cases, and their correlations with tear osmolarity were analyzed.Results: Spearman and Pearson correlation analyses showed a significant correlation between tear osmolarity and MGD grade (p < 0.001) and OSDI (p = 0.005). However, the results of the TBUT, Schirmer test, and Oxford scale were not significantly related to tear osmolarity. The patients were divided according to MGD severity into those with MGD grades ≤ 2 and those with MGD grades ≥ 3. Tear osmolarity (p < 0.001) and OSDI (p = 0.014) showed significant differences between the two groups.Conclusions: In patients with obstructive MGD, tear osmolarity, assessed using I-PEN® (I-MED Pharma, Inc.), is significantly correlated with MGD grade and OSDI.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":"210 5","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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