Journal of The Korean Ophthalmological Society最新文献

The Diagnosis and Treatment of a Post-traumatic Iris Cyst Referred as an Iris Tumor 外伤后虹膜囊肿转诊为虹膜瘤的诊断与治疗

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-06-15 DOI: 10.3341/jkos.2024.65.6.400

Ji Hyun Yoon, Y. Yoon, Sun Kyoung Park, Woong-Joo Whang, H. Hwang, Hyun Seung Kim, K. Na

{"title":"The Diagnosis and Treatment of a Post-traumatic Iris Cyst Referred as an Iris Tumor","authors":"Ji Hyun Yoon, Y. Yoon, Sun Kyoung Park, Woong-Joo Whang, H. Hwang, Hyun Seung Kim, K. Na","doi":"10.3341/jkos.2024.65.6.400","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.6.400","url":null,"abstract":"Purpose: We report the diagnosis and treatment of a secondary iris cyst in a patient referred for an iris tumor.Case summary: A 29-year-old man diagnosed with an anterior chamber mass of the left eye was referred to our center for further evaluation and management. Twenty years previously, he suffered a penetrating ocular injury of his left eye and underwent primary closure. He had no underlying systemic disease. At his initial visit, the best corrected visual acuity of his left eye was 0.5. A whitish-gray mass was observed within the anterior chamber from 1 o'clock to 5 o'clock, obscuring the pupil. Anterior segment optical coherence tomography revealed a cystic mass touching the retrocorneal surface. No other lesions were seen on orbital imaging or ocular ultrasonography. Ultimately, it was diagnosed as an iris cyst that occurred secondary to ocular trauma. After needle aspiration and intracystic injection of 99% ethanol, the cyst collapsed fully. However, a cataract developed within a few months, and phacoemulsification and intraocular lens implantation were performed. Seven months after cyst aspiration, the uncorrected visual acuity of the left eye had recovered to 0.5. The cyst still adhered to the corneal endothelium, remaining in its collapsed state. The current corneal endothelial cell density is 871 cells/mm2.Conclusions: A secondary iris cyst was diagnosed in a patient with a history of penetrating eye trauma and surgery. It was treated successfully with needle aspiration and intracystic alcohol injection.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Ischemic Optic Neuropathy after Extracorporeal Membrane Oxygenation (ECMO) 两例体外膜氧合（ECMO）后缺血性视神经病变病例

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-06-15 DOI: 10.3341/jkos.2024.65.6.412

Kwang Eon Han, Sang Yoon Kim, Su Jin Kim

{"title":"Two Cases of Ischemic Optic Neuropathy after Extracorporeal Membrane Oxygenation (ECMO)","authors":"Kwang Eon Han, Sang Yoon Kim, Su Jin Kim","doi":"10.3341/jkos.2024.65.6.412","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.6.412","url":null,"abstract":"Purpose: We report two cases of non-arteritic ischemic optic neuropathy (NAION) following extracorporeal membrane oxygenation (ECMO) treatment.Case summary: (Case 1) A 36-year-old man underwent ECMO treatment. Upon regaining consciousness, he complained of a darkened peripheral visual field and was subsequently referred to an ophthalmologist. His best-corrected visual acuity was 0.9 in the right eye and 0.8 in the left eye. The intraocular pressure measured 12 mmHg in the right eye and 10 mmHg in the left eye; color vision was normal. A visual field test demonstrated concentric visual field defects in both eyes, and a fundus examination revealed a pale optic disc. Optical coherence tomography (OCT) indicated a decrease in retinal nerve fiber layer (RNFL) thickness. (Case 2) A 48-year-old woman underwent ECMO treatment. After regaining consciousness, she reported decreased vision in her right eye. Her best-corrected visual acuity was limited to hand motion in the right eye and was 1.2 in the left eye. A relative afferent pupillary defect in the right eye was observed. Color vision in the right eye was compromised, and a fundus examination revealed a pale optic disc. A visual field test demonstrated total visual field defect in the right eye, while OCT showed decreases in both the RNFL thickness and the ganglion cell-inner plexiform layer thickness of the right eye. Magnetic resonance imaging (MRI) revealed high signal intensity and abnormal enhancement in the right retrobulbar optic nerve.Conclusions: In cases where vision loss and visual field defects are observed following ECMO treatment, differential diagnoses for ischemic optic neuropathy are warranted.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Results of Prosthetic Eye Wear in Patients with Congenital Microphthalmos 先天性小眼症患者佩戴义眼的临床效果

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-06-15 DOI: 10.3341/jkos.2024.65.6.386

Phil Kyu Lee, W. Cho, ji-Sun Paik, Suk-Woo Yang

{"title":"Clinical Results of Prosthetic Eye Wear in Patients with Congenital Microphthalmos","authors":"Phil Kyu Lee, W. Cho, ji-Sun Paik, Suk-Woo Yang","doi":"10.3341/jkos.2024.65.6.386","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.6.386","url":null,"abstract":"Purpose: To report the long-term clinical outcomes of non-surgical treatment involving prosthetic eye wear in patients diagnosed with congenital microphthalmos.Methods: A retrospective review of the medical records of 20 patients was conducted. In total, 21 eyes were diagnosed with congenital microphthalmos between May 2008 and December 2022 at Seoul St. Mary’s Hospital in Korea.Results: This study included 20 patients (12 males and 8 females) with an average age of 4 months at diagnosis. The observed ophthalmic anomalies included two cases of congenital cataract, one of posterior embryotoxon, one of corneo-iris strand, four of iris coloboma, five of central corneal opacity, one of Peter's anomaly, and one of retrobulbar cyst. Accompanying systemic abnormalities were noted, such as lateral ventricle atrophy, corpus callosum atrophy, patent ductus arteriosus, atrial septal defect, and developmental language disorder. Genetic anomalies included anti SS-A/Ro antibody positivity, a 1:100 titer of anti-nuclear antibody, and a PAX6 mutation identified through next-generation sequencing. No specific family histories or pregnancy-related factors were noted. The average follow-up duration was 5.94 years (range: 1 month to 18 years), the average corneal diameter was 4.6 mm, the average axial length was 17.44 mm, the average age for first artificial eye trial was 5.96 years (range: 7 months to 19 years), and the average interval for artificial eye replacement was 22 months (range: 4 months to 5 years and 8 months).Conclusions: Twenty patients with congenital microphthalmos underwent gradual expansion of their prosthetic eyes by regular replacement and size increase without severe complications. This approach led to aesthetically and emotionally positive outcomes for the patients.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assessment of Visual Acuity Using a Smartphone Application 使用智能手机应用程序自我评估视力

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-06-15 DOI: 10.3341/jkos.2024.65.6.378

Sejung Kim, Yuhyun Kim, M. Oh, Sunghyuk Moon

{"title":"Self-assessment of Visual Acuity Using a Smartphone Application","authors":"Sejung Kim, Yuhyun Kim, M. Oh, Sunghyuk Moon","doi":"10.3341/jkos.2024.65.6.378","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.6.378","url":null,"abstract":"Purpose: We evaluated the accuracy and usefulness of self-assessment of visual acuity (VA) using a smartphone application for Korean users and explored its potential application in screening eye diseases.Methods: In total, 52 participants aged ≥ 20 years were included in the study. Of these participants, 31 used Jin Yong-Han’s VA chart and the smartphone application to measure their distant visual acuity (DVA), whereas 21 used Han Chun-Seok’s near visual acuity chart and the application to measure their near visual acuity (NVA). The results and time required for VA measurement using both methods were compared. VA was converted to logarithm of the minimum angle of resolution (logMAR) for analysis. The voice recognition rate of the application for numbers 2-9 was assessed.Results: The mean NVA was 0.29 ± 0.28 using Han’s chart and 0.30 ± 0.43 using the application with no significant difference (p = 1.00). The mean DVA was 0.19 ± 5.89 using Jin's chart and 0.20 ± 0.27 using the application with no significant difference (p = 0.19). The average time spent for measuring NVA and DVA was 19 seconds (s) using Han’s and Jin's charts, whereas it was 42 and 38 s for measuring NVA and DVA using the application. The voice recognition rate of the application was 87% on average for numbers 2-9, with the highest rate for number 7 (79%) and the lowest rate for number 4 (91%).Conclusions: Self-assessment of VA using a smartphone application exhibited similar results to conventional VA measurement methods. Although the measurement time varied, DVA and NVA could be measured at home using a smartphone, and would be particularly useful for those who have difficulty visiting a hospital.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an Instrument for Slit-lamp Examination of Donor Corneas in Preservation Medium 开发用于对保存介质中的捐献角膜进行裂隙灯检查的仪器

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.108

Ga Hee Nam, Da Ran Kim, Y. Yoon, Soonwon Yang, Woong-Joo Whang, Y. Byun, H. Hwang, K. Na, Hyun Soo Lee, So Hyang Chung, Eun Chul Kim, Y. Cho, Hyun Seung Kim, Ho Sik Hwang

{"title":"Development of an Instrument for Slit-lamp Examination of Donor Corneas in Preservation Medium","authors":"Ga Hee Nam, Da Ran Kim, Y. Yoon, Soonwon Yang, Woong-Joo Whang, Y. Byun, H. Hwang, K. Na, Hyun Soo Lee, So Hyang Chung, Eun Chul Kim, Y. Cho, Hyun Seung Kim, Ho Sik Hwang","doi":"10.3341/jkos.2024.65.2.108","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.108","url":null,"abstract":"Purpose: To evaluate the effectiveness of an instrument devised for slit-lamp examination of donor corneas suspended in preservation medium.Methods: The study examined two donor corneas received at Yeouido St. Mary's Hospital in February 2023 and March 2023. The instrument has three main components: a plastic holder to hold the preservation medium bottle, a cube with a mirror for reflecting the slit beam, and a stand to attach the device to the slit-lamp. Using the instrument, the donor corneas were examined via slit-lamp: microscopy with the endothelium facing upward and downward. Specular microscopy and anterior segment optical coherence tomography (OCT) were also performed on the preserved donor corneas.Results: Slit-lamp examination of donor corneas in preservation medium using the instrument showed overall corneal buttoning and optical sections of the donor cornea. Using specular reflection and retroillumination, the endothelial layer was partially visible. However, specular microscopy and anterior segment OCT could not examine the donor cornea in preservation medium using the instrument.Conclusions: The devised instrument facilitates slit-lamp examination of donor corneas in preservation medium, enabling a qualitative assessment of donor corneas before corneal transplantation surgery.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Occlusive Vasculitis after Intravitreal Injection of Brolucizumab 玻璃体内注射布卢珠单抗后的视网膜闭塞性血管炎

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.161

Jong Hoon Lee, T. Moon, Yong-Sok Ji

{"title":"Retinal Occlusive Vasculitis after Intravitreal Injection of Brolucizumab","authors":"Jong Hoon Lee, T. Moon, Yong-Sok Ji","doi":"10.3341/jkos.2024.65.2.161","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.161","url":null,"abstract":"Purpose: To report two instances of retinal arterial occlusive vasculitis following intravitreal injection of brolucizumab.Case summary: Two patients noted decreased visual acuity approximately one month after receiving intravitreal brolucizumab injections to treat wet age-related macular degeneration. In case 1, an 85-year-old male reported a reduction in visual acuity in his left eye, declining from a Snellen measurement of 0.2 to hand motion. In case 2, a 70-year-old female experienced a decline in visual acuity in her right eye from 0.4 to finger count at 50 cm. Both patients presented with anterior chamber reactions, and fluorescein angiography demonstrated delayed retinal artery filling time, leading to the diagnosis of retinal occlusive vasculitis. They were treated with both topical and systemic corticosteroids. For case 1, a subsequent vitrectomy was performed to remove the inflammatory membrane located behind the intraocular lens. However, despite aggressive interventions, neither patient showed visual improvement.Conclusions: Retinal occlusive vasculitis, which can result from intraocular inflammation, may occur after intravitreal brolucizumab injection. This condition can lead to significant visual impairment even with aggressive treatment.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an Instrument for Slit-lamp Examination of Donor Corneas in Preservation Medium 开发用于对保存介质中的捐献角膜进行裂隙灯检查的仪器

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.108

Ga Hee Nam, Da Ran Kim, Y. Yoon, Soonwon Yang, Woong-Joo Whang, Y. Byun, H. Hwang, K. Na, Hyun Soo Lee, So Hyang Chung, Eun Chul Kim, Y. Cho, Hyun Seung Kim, Ho Sik Hwang

{"title":"Development of an Instrument for Slit-lamp Examination of Donor Corneas in Preservation Medium","authors":"Ga Hee Nam, Da Ran Kim, Y. Yoon, Soonwon Yang, Woong-Joo Whang, Y. Byun, H. Hwang, K. Na, Hyun Soo Lee, So Hyang Chung, Eun Chul Kim, Y. Cho, Hyun Seung Kim, Ho Sik Hwang","doi":"10.3341/jkos.2024.65.2.108","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.108","url":null,"abstract":"Purpose: To evaluate the effectiveness of an instrument devised for slit-lamp examination of donor corneas suspended in preservation medium.Methods: The study examined two donor corneas received at Yeouido St. Mary's Hospital in February 2023 and March 2023. The instrument has three main components: a plastic holder to hold the preservation medium bottle, a cube with a mirror for reflecting the slit beam, and a stand to attach the device to the slit-lamp. Using the instrument, the donor corneas were examined via slit-lamp: microscopy with the endothelium facing upward and downward. Specular microscopy and anterior segment optical coherence tomography (OCT) were also performed on the preserved donor corneas.Results: Slit-lamp examination of donor corneas in preservation medium using the instrument showed overall corneal buttoning and optical sections of the donor cornea. Using specular reflection and retroillumination, the endothelial layer was partially visible. However, specular microscopy and anterior segment OCT could not examine the donor cornea in preservation medium using the instrument.Conclusions: The devised instrument facilitates slit-lamp examination of donor corneas in preservation medium, enabling a qualitative assessment of donor corneas before corneal transplantation surgery.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the Preoperative Fat-to-ratio on the Outcome of Endoscopic Orbital Decompression 术前脂肪比率与内窥镜眼眶减压术效果的关系

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.91

Tae Young Park, Sung Mo Kang

{"title":"Association of the Preoperative Fat-to-ratio on the Outcome of Endoscopic Orbital Decompression","authors":"Tae Young Park, Sung Mo Kang","doi":"10.3341/jkos.2024.65.2.91","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.91","url":null,"abstract":"Purpose: To investigate the association of the preoperative fat-to-orbit ratio on the outcome of endoscopic orbital decompression in patients with thyroid-associated orbitopathy (TAO).Methods: Between January 2021 and December 2022, 36 patients with TAO, 72 eyes in total, underwent endoscopic orbital decompression at our hospital’s ophthalmology department. We calculated fat-to-orbit ratios using two-dimensional facial computed tomography scans, and conducted both preoperative and postoperative measurements of proptosis and the prism cover test. We used binominal logistic regression analysis to examine the correlation between the ratios and postoperative complications (diplopia, strabismus, lid retraction) following the surgery. Furthermore, simple linear regression analysis was used to assess the relationship between the ratios and change in exophthalmos.Results: The regression indicated significant associations between the ratio and the onset of postoperative complications such as new-onset postoperative diplopia (NOPD) (β = -0.098, p = 0.029), postoperative strabismus (β = -0.123, p = 0.009), and eyelid retraction (β = -0.188, p = 0.002), particularly in cases requiring subsequent strabismus or eyelid retraction surgery after the initial procedure.Conclusions: The preoperative fat-to-orbit ratio is a significant predictor of postoperative complications such as NOPD, strabismus surgery and eyelid retraction surgery in patients undergoing endoscopic orbital decompression for thyroid eye disease. Therefore, it should be considered a valuable indicator of surgical outcomes and complications in such patients.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139776076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of MALToma Masquerading as a Lacrimal Caruncular Granuloma 一个伪装成泪腺肉芽肿的 MALToma 病例

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.157

Jong Hoon Lee, Hyo Ju Jang, Sung Sun Kim, K. Yoon, H. Yoon

引用次数: 0

Effect of Latanoprostene Bunod on the Permeability of Trabecular Meshwork Cells 拉坦前列腺素布诺对小梁网细胞渗透性的影响

IF 0.1

Journal of The Korean Ophthalmological Society Pub Date : 2024-02-15 DOI: 10.3341/jkos.2024.65.2.139

Hyeong Seok Park, Jae Woo Kim

{"title":"Effect of Latanoprostene Bunod on the Permeability of Trabecular Meshwork Cells","authors":"Hyeong Seok Park, Jae Woo Kim","doi":"10.3341/jkos.2024.65.2.139","DOIUrl":"https://doi.org/10.3341/jkos.2024.65.2.139","url":null,"abstract":"Purpose: To investigate the effects of latanoprostene bunod (LBN) on nitric oxide (NO) production and permeability in human trabecular meshwork cells (HTMC).Methods: HTMC were treated with 50 and 100 µM LBN and latanoprost free acid (LAT) for 30 minutes. Additionally, 100 µM LBN was co-exposed to 0.5 mM L-NAME (N-Nitroarginine methyl ester). Cellular viability and NO production were measured using MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) and Griess assays. The permeability and resistance of the HTMC monolayer were evaluated by trans-endothelial electrical resistance (TEER) and carboxyfluorescein permeability.Results: Exposure to 100 µM LBN led to increased NO production, whereas co-exposure to L-NAME reduced NO production. Treatment with 100 µM LBN decreased the TEER of the HTMC monolayer. LBN exposure heightened carboxyfluorescein permeability, but co-exposure to 100 µM LBN and L-NAME reduced permeability. LAT treatment did not affect NO production or permeability.Conclusions: LBN increased the permeability of the HTMC monolayer and increased NO production. Therefore, LBN might increase trabecular outflow in addition to promoting uveoscleral outflow.","PeriodicalId":17341,"journal":{"name":"Journal of The Korean Ophthalmological Society","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0