0.024% w/v的拉坦前列汀治疗开角型青光眼:短期疗效、安全性和眼血变化

IF 0.1 Q4 OPHTHALMOLOGY
Hyun Woo Kim, Chong Eun Lee, Sam Seo, Kyoo Won Lee, Chang Hoon Lee
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引用次数: 0

摘要

目的:观察0.005% w/v拉坦前列素转换为0.024% w/v拉坦前列素后短期内眼压(IOP)降低效果及视神经头(ONH)血流改善情况。方法:这项前瞻性研究于2022年5月至2022年12月进行,包括40例开角型青光眼患者,他们从0.005% w/v的拉坦前列素切换到0.024% w/v的拉坦前列素。转换后3个月测量IOP、ONH血流量、结膜充血、角膜糜烂和眼睑色素沉着状况。我们记录了所有可能的副作用。结果:基线IOP在3个月时由17.53±6.49下降至16.00±8.06 mmHg (p = 0.032)。最佳矫正视力无明显变化(0.24±0.19 ~ 0.23±0.16);眼睑色素沉着(1.16±0.78 ~ 1.16±0.82)和角膜糜烂评分(0.58±0.85 ~ 0.39±0.76)均无显著差异。结膜充血由2.00±0.69降至1.67±0.63 (p = 0.010)。全像血管密度和乳头周围血管密度均无明显变化。但改变后瘙痒明显加重(p = 0.008)。结论:在短期内,0.024% w/v的拉坦前列素比0.005% w/v的拉坦前列素能更有效地降低眼压。然而,切换后ONH血流量没有明显变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Latanoprostene Bunod 0.024% w/v Treatment of Open-anlge Glaucoma: Short-term Effects, Safety, and Changes in Ocular Blood
Purpose: To study the short-term intraocular pressure (IOP)-lowering effect and optic nerve head (ONH) blood flow improvement after switching from latanoprost 0.005% w/v to latanoprostene bunod 0.024% w/v.Methods: This prospective study ran from May 2022 to December 2022 and included 40 patients with open-angle glaucoma who switched from latanoprost 0.005% w/v to latanoprostene bunod 0.024% w/v. The IOP, ONH blood flow, and conjunctival hyperemia, corneal erosion, and eyelid pigmentation status were measured 3 months after switching. We recorded all possible side effects.Results: The baseline IOP significantly dropped from 17.53 ± 6.49 to 16.00 ± 8.06 mmHg at 3 months (p = 0.032). The best-corrected visual acuity did not significantly change (0.24 ± 0.19 to 0.23 ± 0.16); neither did eyelid pigmentation (1.16 ± 0.78 to 1.16 ± 0.82) nor the corneal erosion score (0.58 ± 0.85 to 0.39 ± 0.76). Conjunctival hyperemia significantly decreased from 2.00 ± 0.69 to 1.67 ± 0.63 (p = 0.010). Neither the whole-image vessel density nor the peripapillary vessel density significantly changed. However, pruritus became significantly worse after the change (p = 0.008).Conclusions: In the short term, latanoprostene bunod 0.024% w/v lowered the IOP more effectively than did latanoprost 0.005% w/v. However, there was no significant change in ONH blood flow after the switch.
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CiteScore
0.20
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