Journal of the Endocrine Society最新文献

{"title":"Embryonic exposure to environmental levels of roundup affects neurodevelopment in zebrafish.","authors":"Rachel Lacroix, Valentina Almanza, Sophie McKenzie, Mataea Armstrong, Deborah Kurrasch","doi":"10.1210/jendso/bvag067","DOIUrl":"https://doi.org/10.1210/jendso/bvag067","url":null,"abstract":"<p><p>N-(phosphonomethyl)glycine (glyphosate) is the most sprayed herbicidal chemical in the world. Although glyphosate is considered safe in humans and higher animals due to its targeting of the shikimate pathway found only in plants and microorganisms, recent in vivo and in vitro studies show evidence of toxicity across a range of systems, including the vertebrate brain. Given that developing brains with immature blood-brain barriers can be especially sensitive to environmental contaminants, here we test the effects of embryonic exposure to environmental levels of glyphosate or its commercial formulation, Roundup®. Embryonic zebrafish exposed to an environmental concentration of Roundup (10 µg/L acid equivalent) from 10 to 48 hours postfertilization (hpf) showed defects in morphology, respiratory capacity, and hatching at 48 hpf as well as changes in locomotion, light-startle response, and thigmotaxis behaviors at 5 days postfertilization (dpf), with some effects lasting in the juvenile. To understand neurodevelopmental changes underlying these behavioral abnormalities, we tested for changes to the timing of neurogenesis and conducted bulk RNA sequencing. We found increased neurogenesis and uncovered dysregulation of axonogenesis pathways, which was confirmed using immunohistochemistry. Finally, to test if axonal deficits might manifest as dysregulation of neuronal circuits, we observed changes in phospho-extracellular signal-regulated kinases levels and Ca²⁺ dynamics as indicators of activity disruptions at 5 dpf following embryonic exposure to Roundup. These results suggest that Roundup at current environmental levels may not be safe for organismal exposure, and glyphosate toxicity warrants closer attention.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 5","pages":"bvag067"},"PeriodicalIF":3.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective cohort study of the factors associated with recurrence in young patients with thyroid cancer.","authors":"Koki Shio, Satoshi Suzuki, Yoshiko Matsumoto, Yurie Kobashi, Yukie Yamaya, Mizuki Sekino, Erina Suzuki, Akihiko Ozaki, Satoru Suzuki, Hiroki Shimura, Susumu Yokoya, Yuko Hashimoto, Tetsuya Ohira, Fumihiko Furuya, Shinichi Suzuki","doi":"10.1210/jendso/bvag068","DOIUrl":"https://doi.org/10.1210/jendso/bvag068","url":null,"abstract":"<p><strong>Context: </strong>The incidence of thyroid cancer in young people has increased over the past 40 years. While prognosis is favorable, recurrence rates may reach 20%. We previously reported the pathological characteristics of 220 young patients with thyroid cancer; here, we evaluated their long-term outcomes and recurrence risk.</p><p><strong>Objective: </strong>To identify predictors of recurrence in pediatric and adolescent thyroid cancer.</p><p><strong>Design setting and patients: </strong>A prospective cohort of 213 patients aged 5-19 years who underwent initial surgery at Fukushima Medical University Hospital between 2012 and 2020.</p><p><strong>Main outcome measures: </strong>Recurrence was defined as cytological evidence of cancer in the thyroid remnant or lymph nodes after initial surgery or the appearance of new tumor lesions on imaging of other organs after surgery.</p><p><strong>Results: </strong>Seventeen of 213 patients (8.0%) experienced recurrence during a median follow-up of 8 years. In the overall cohort, younger age was the strongest predictor of recurrence, particularly in patients younger than 15 years. Other pathological features such as lymph node metastasis and pathological intra-thyroidal dissemination (ITD) showed associations in univariate analysis but lost significance after adjustment for age.</p><p><strong>Conclusion: </strong>Unilateral lobectomy was not associated with an increased risk of recurrence. Recurrence was most frequent in patients <15 years and occurred more often in those with multifocal disease, advanced stage, N1b nodes, or ITD. These findings provide clinically relevant prognostic insights that may help refine clinical management in young patients with thyroid cancer.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag068"},"PeriodicalIF":3.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in utilization of high-volume thyroid surgeons for Graves disease: a statewide analysis.","authors":"Steven Xie, Catherine B Jensen, Aayushi Sinha, Elizabeth M Bacon, Lauren N Krumeich, Hunter J Underwood, David T Hughes, Paul G Gauger, Hari Nathan, Michael A Rubyan, Susan C Pitt","doi":"10.1210/jendso/bvag051","DOIUrl":"10.1210/jendso/bvag051","url":null,"abstract":"<p><strong>Context: </strong>For patients with Graves disease undergoing surgery, the American Thyroid Association guidelines recommend referral to a high-volume thyroid surgeon (HVTS). However, factors limiting patient utilization of an HVTS are poorly understood.</p><p><strong>Objective: </strong>This study aimed to identify factors associated with utilization of an HVTS for patients with Graves.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed adults with Graves who underwent thyroidectomy from January 2015 to December 2022 in a statewide claims registry. Surgeons were categorized as HV (>25 thyroidectomies/year) or low-volume (LVTS; ≤25 thyroidectomies/year). Logistic regression evaluated patient demographics, travel distance to treating HVTS hospital and closest endocrinologist, household income, area deprivation index, and education.</p><p><strong>Results: </strong>Among 764 patients treated by 130 surgeons, 17 HVTSs performed the majority (60.4%) of thyroidectomies. Most patients were female (84.3%) and White (51.0%). Patients treated by an HVTS traveled 16.8 miles farther (<i>P</i> < .001). On multivariable analysis, distance traveled to the treating hospital (odds ratio [OR] 1.01; 95% CI, 1.003-1.014) and education of a patient's home zip code (OR 0.87; 95% CI, 0.83-0.91) were significant predicators of using an HVTS. Proximity to an endocrinologist was not associated with utilization (<i>P</i> = .45). Surgery by an HVTS was associated with lower rates of hypocalcemia (18.2% vs 24.8%; <i>P</i> = .03) and cardiac events (10.4% vs 17.2%; <i>P</i> = .008).</p><p><strong>Conclusion: </strong>Just more than half of patients with Graves disease received guideline-concordant surgical care by an HVTS. Enhancing patient knowledge and awareness of the benefits of HVTS care and solving transportation barriers may improve Graves patients' use of HVTS and outcomes.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 5","pages":"bvag051"},"PeriodicalIF":3.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A worldwide perspective on clinical characteristics and treatment of youth with monogenic diabetes in the SWEET registry.","authors":"Lily Deng, Stefanie Lanzinger, Kristina Casteels, Fred Cavallo, Luisa De Sanctis, Ana Laura Fitas, Carol Huang, Jaehyun Kim, Konstantina Patouni, Stepanka Pruhova, Craig E Taplin, Martin Tauschmann, Mansa Krishnamurthy","doi":"10.1210/jendso/bvag064","DOIUrl":"https://doi.org/10.1210/jendso/bvag064","url":null,"abstract":"<p><strong>Aims: </strong>To characterize youth with monogenic diabetes worldwide in the SWEET database and define trends in clinical care and outcomes.</p><p><strong>Methods: </strong>Youth with monogenic diabetes between the ages of 0 and 21 years from 44 worldwide centers in the SWEET registry divided into global regions were studied in this retrospective analysis. This included 690 youth with data at diabetes diagnosis and/or follow-up at 1 year and 214 patients with data at both time points. Demographics, comorbidities, and treatments were evaluated.</p><p><strong>Results: </strong>Globally, mean age and hemoglobin A1c (HbA1c) at diagnosis were 10.1 years (SD 4.57 years) and 6.9% (52 mmol/mol) (SD 1.7%, 18 mmol/mol), respectively. At 1-year follow-up, mean HbA1c decreased by 0.4%. Average body mass index (BMI) at diabetes diagnosis was in the normal range (World Health Organization BMI SD score 0.31). At diabetes diagnosis, 3.6% presented in diabetic ketoacidosis (DKA). Seven percent were treated with oral antidiabetes medications or glucagon-like peptide-1 receptor agonists at diabetes diagnosis, increasing to 15.3% at follow-up. Overall, treatment with insulin increased by 10% at follow-up.</p><p><strong>Conclusion: </strong>Worldwide, patients with monogenic diabetes typically present during late childhood/early adolescence with mild elevation in HbA1c, normal BMI, and lack of DKA. Regional differences in demographics and treatment modalities highlight heterogeneity in presentation and management of monogenic diabetes, impacting clinical care.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag064"},"PeriodicalIF":3.1,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social deprivation, race, and metabolic syndrome in patients with polycystic ovary syndrome.","authors":"Iris T Lee, Shakira King, Naria Sealy, John Rees, Sunni L Mumford, Stefanie N Hinkle, Anuja Dokras","doi":"10.1210/jendso/bvag063","DOIUrl":"https://doi.org/10.1210/jendso/bvag063","url":null,"abstract":"<p><strong>Context: </strong>Social determinants of health (SDoH) are a key contributor to cardiovascular disease (CVD) risk, including metabolic syndrome (MetSyn), as well as racial disparities in that risk. It is unknown if SDoH are associated with MetSyn in women with polycystic ovary syndrome (PCOS), who have a high risk of CVD. Furthermore, it is unclear if SDoH contributes to the Black-White disparity in MetSyn among women with PCOS.</p><p><strong>Objective: </strong>To assess the association between the Social Deprivation Index (SDI; a proxy for SDoH) and the development of new-onset MetSyn in women with PCOS and whether SDI plays a role in the racial disparity in MetSyn.</p><p><strong>Design: </strong>Longitudinal cohort study.</p><p><strong>Setting: </strong>Tertiary care center.</p><p><strong>Patients or other participants: </strong>Women with hyperandrogenic PCOS and 2+ assessments for MetSyn 3 years apart.</p><p><strong>Interventions: </strong>None.</p><p><strong>Main outcome measures: </strong>Development of new-onset MetSyn; proportion of association between race and MetSyn attributable to SDI.</p><p><strong>Results: </strong>Two hundred twenty-two participants were followed for a median of 7 years; 43.7% developed new-onset MetSyn. High SDI, indicating greater social deprivation, was associated with an increased risk of developing MetSyn (adjusted relative risk 1.42, 95% confidence interval 1.07-1.91 adjusting for age), as was Black race. The proportion of the association between race and new-onset MetSyn explained by SDI was 21%.</p><p><strong>Conclusion: </strong>High social deprivation is associated with increased risk of new-onset MetSyn and may contribute to the higher risk in Black compared to White women with PCOS. These results highlight the importance of considering SDoH, particularly in an already high-risk population.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag063"},"PeriodicalIF":3.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antenatal exposure to a mixture of endocrine disruptors on attentional and executive functions in children.","authors":"Christophe Barrea, Patrice Dufour, Catherine Pirard, Corinne Charlier, Fanny Brévers, Anne-Simone Parent, Laurence Rousselle","doi":"10.1210/jendso/bvag057","DOIUrl":"10.1210/jendso/bvag057","url":null,"abstract":"<p><strong>Context: </strong>Numerous studies indicate negative associations between early life exposure to endocrine-disrupting chemicals and various aspects of neurodevelopment. However, few have focused on specific cognitive processes. Additionally, toxicants are often analyzed individually, without accounting for their combined effects.</p><p><strong>Objective: </strong>This study aimed at investigating the impact of prenatal exposure to a mixture of endocrine disruptors on attention and executive functions in young children and comparing their effects with those reported in the literature.</p><p><strong>Methods: </strong>Two polychlorinated biphenyls (PCBs) and 4 perfluoroalkyl substances (PFASs) were measured in the cord blood from 55 children enrolled in a longitudinal Belgian cohort study. At 6 years of age, attentional and executive functions were assessed using specific neuropsychological tests. Associations between a mixture of toxicants and cognitive performance were analyzed using the principal components approach and weighted quantile sum regression, while accounting for sex differences.</p><p><strong>Results: </strong>Higher prenatal exposure to PCB mixtures was significantly associated with an increased number of omissions in the Divided Attention test. In sex-stratified analyses, this association remained significant but was observed only in boys. Additionally, boys exhibited reduced working memory and planning abilities following exposure to a mixture of PCBs and PFASs. In contrast, antenatal exposure to a mixture of PCBs and PFASs in girls was associated with reduced behavioral regulation, including inhibition control, as assessed by parent-reported questionnaires screening executive functioning in daily life.</p><p><strong>Conclusion: </strong>These results support associations between antenatal exposure to a mixture of endocrine disruptors and attention and executive development, emphasizing a sex-specific effect.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag057"},"PeriodicalIF":3.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13026415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal dynamics of fasting plasma uridine in the preclinical stage of type 1 diabetes.","authors":"Qiutang Xiong, Chelsea Jang, Kevin Wang, Ling Fu, Lu Ding, Zhao V Wang, Ping Wang, Yingfeng Deng","doi":"10.1210/jendso/bvag059","DOIUrl":"10.1210/jendso/bvag059","url":null,"abstract":"<p><strong>Context: </strong>Elevated blood uridine levels have been reported in children with newly diagnosed type 1 diabetes (T1D); however, their relevance to disease onset remains unclear.</p><p><strong>Objective: </strong>To explore whether changes in plasma uridine are associated with the development of T1D in at-risk individuals.</p><p><strong>Methods: </strong>Pre- and post-T1D-onset oral glucose tolerance test plasma samples from 45 cases and matched controls in the Diabetes Prevention Trial-Type 1 trial were examined for uridine concentrations using LC-MS/MS. Cases with age > 21, BMI > 25, HbA1c > 5.7%, or interval from screening to T1D diagnosis < 1 year were excluded due to the potential confounding effects of aging, obesity, and insulin resistance on uridine homeostasis. Twenty-three matched case-control pairs were used to evaluate associations between uridine levels and T1D risk.</p><p><strong>Results: </strong>Individuals who later developed T1D (cases) exhibited an increase in plasma uridine around the onset of T1D (5.03 ± 0.86 µM before and 6.10 ± 1.40 µM after T1D diagnosis, <i>P</i> = .001), whereas individuals who did not develop T1D (controls) showed a decrease (6.20 ± 1.32 µM at Visit 1 and 5.20 ± 1.33 µM at Visit 2, <i>P</i> < .001). The receiver operating characteristic curve indicates that baseline fasting uridine demonstrates discriminatory performance for T1D (area under the curve = 0.773). Mixed-effects modeling identifies a significant time × group interaction, with group-specific uridine dynamics evident prior to T1D onset in humans.</p><p><strong>Conclusion: </strong>Our findings suggest that fasting uridine changes precede T1D onset and may serve as an early biomarker.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 5","pages":"bvag059"},"PeriodicalIF":3.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation.","authors":"Chihiro Ishizawa, Takehiro Hiraoka, Shizu Aikawa, Xueting He, Daiki Hiratsuka, Yamato Fukui, Mitsunori Matsuo, Tomoko Makabe, Gentaro Izumi, Miyuki Harada, Osamu Wada-Hiraike, Yasushi Hirota","doi":"10.1210/jendso/bvag056","DOIUrl":"https://doi.org/10.1210/jendso/bvag056","url":null,"abstract":"<p><p>Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological interventions in certain cases-particularly those resistant to hormone therapies-underscores the urgent need for deeper mechanistic insights and the development of novel therapeutic strategies. Progress in this field, however, has been hampered by the scarcity of suitable experimental models, as adenomyosis is primarily a human disease. In this study, we demonstrate a preclinical platform for therapeutic evaluation using a mouse model of mechanically induced adenomyosis, which recapitulates the key pathological features observed in humans. By integrating high-resolution three-dimensional (3D) tissue imaging, we successfully visualized the invagination and expansion of adenomyosis lesions spatiotemporally. This approach enabled the clear-cut and efficient assessment of progestin efficacy in situ. We propose that the combination of a mechanistically relevant mouse model and advanced 3D histological analysis constitutes a concise and robust system for therapeutic validation and compound screening, thereby facilitating the discovery of effective treatments for adenomyosis.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 5","pages":"bvag056"},"PeriodicalIF":3.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.","authors":"Jinyan Cao, Sagi Enicole A Gillera, William P Marinello, Heather B Patisaul","doi":"10.1210/jendso/bvag050","DOIUrl":"10.1210/jendso/bvag050","url":null,"abstract":"<p><p>We investigated how developmental exposure to the commercial flame retardant (FR) mixture Firemaster 550 (FM 550) affects estrogen receptor alpha (ERα) expression in key brain regions related to sociosexual behavior. We used prairie voles, a socially monogamous, biparental rodent species of high translational human relevance. This study used adult siblings from a prior behavioral study showing developmental FM 550 exposure impaired a range of socioemotional behaviors in adults including loss of partner preference in males. Dams were exposed to FM 550 (500, 1000, or 2000 µg/day) via subcutaneous injections throughout gestation, and pups were directly exposed from birth to weaning. ERα immunoreactive (ERα-ir) neuron numbers and mRNA expression levels were quantified in subregions of the social brain neural network (SBNN). As anticipated, FM 550 impacts were sex-, dose-, and region-specific, with FM 550 tending to increase ERα-ir cell numbers in the anterior hypothalamus regardless of sex, but decrease them in the female mediobasal hypothalamus, amygdala, and extended amygdala. These studies demonstrate that developmental FR exposure impacts adult SBNN ERα availability and provide support that disrupted ERα action in the SBNN may be a mechanism underlying disruption of socioemotional behavior, energy balance, and related neuroendocrine physiology. Impacted ERα neuronal populations are also influenced by other receptors, neuropeptides, neurosteroids, and signaling molecules to govern prosocial behaviors, which is the ongoing direction of this work. Collectively, these data add to growing evidence that FM 550 FRs are neuroendocrine disruptors that can induce persistent impacts across developing socioemotional pathways and systems.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag050"},"PeriodicalIF":3.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free testosterone independently predicts metabolic syndrome severity in U.S. adolescent girls aged 12-19 years.","authors":"Christopher R McCartney, Aaron F Pannone, Su Hee Kim, Matthew J Gurka, Mark D DeBoer, Christine M Burt Solorzano","doi":"10.1210/jendso/bvag055","DOIUrl":"https://doi.org/10.1210/jendso/bvag055","url":null,"abstract":"<p><strong>Context: </strong>Hyperandrogenemia is associated with increased risks for metabolic syndrome in asymptomatic women and women with polycystic ovary syndrome. The relationship between hyperandrogenemia and metabolic syndrome in adolescent girls remains poorly defined.</p><p><strong>Objective: </strong>The aim of this study was to assess whether free testosterone concentrations predict metabolic syndrome severity (MSS) in adolescent girls.</p><p><strong>Design/setting: </strong>Using data from the U.S. National Health and Nutrition Examination Survey (2013-2016), we performed weighted regression analysis to evaluate whether free testosterone predicts MSS z-score after adjusting for body fat percentage, chronological age, and gynecological age. Similar analyses were performed using either total testosterone or sex hormone-binding globulin (SHBG) as the primary predictor variable.</p><p><strong>Participants: </strong>287 girls aged 12-19 years.</p><p><strong>Main outcome measure: </strong>MSS z-score.</p><p><strong>Results: </strong>In simple regression analyses, free testosterone and percent body fat predicted MSS z-score (<i>R</i> ² = 0.11 and 0.35, respectively; <i>P</i> < .0001 for both), but chronological age and gynecological age did not. In the multivariable regression model (<i>R</i> ² = 0.41), higher free testosterone and percent body fat were independently associated with higher MSS z-score (<i>P</i> = .0081 and < .0001, respectively), with no significant independent associations with chronological age or gynecological age. While SHBG was an independent predictor of MSS z-score (<i>P</i> = .0104) in a multivariable regression model, total testosterone was not (<i>P</i> = .77).</p><p><strong>Conclusion: </strong>Higher free testosterone predicts greater MSS in a nationally representative sample of adolescent girls aged 12-19 years. This relationship at least partly reflects the relationship between MSS z-score and SHBG.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"10 4","pages":"bvag055"},"PeriodicalIF":3.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}