Gut Microbiota Metabolite TMAO and Adolescent Cardiometabolic Health: A Cross-sectional Analysis.

IF 3 Q2 ENDOCRINOLOGY & METABOLISM

Journal of the Endocrine Society Pub Date : 2025-04-05 eCollection Date: 2025-05-01 DOI:10.1210/jendso/bvaf055

Fernando de Quadros Iorra, Paula Godinho Rodrigues, Patrícia Martins Bock, Marina Petrasi Guahnon, Sarah Eller, Tiago Franco de Oliveira, Leticia Birk, Patricia de Souza Schwarz, Michele Drehmer, Katia V Bloch, Felipe Vogt Cureau, Beatriz D Schaan

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Abstract

Background: Trimethylamine N-oxide (TMAO) is a metabolite derived from gut microbiota that has been associated with cardiovascular and metabolic disease risk in adults. However, its role in assessing cardiometabolic risk in adolescents is unclear.

Objective: This study investigates the association between serum TMAO levels and cardiometabolic health indicators in Brazilian adolescents.

Materials and methods: This is a multicenter, cross-sectional analysis involving 4446 participants aged 12 to 17 years from four Brazilian cities. Serum TMAO levels were quantified using liquid chromatography-tandem mass spectrometry, and associations with clinical, metabolic, and inflammatory variables were evaluated through multivariate linear regression analyses.

Results: After adjusting for potential confounders, being in the highest tertile of serum TMAO was positively associated with waist circumference [β 1.45; 95% confidence interval (CI) 0.77, 2.14; P < .001], body mass index Z-score (β .19; 95% CI 0.10, 0.27; P < .001), and C-reactive protein (β .24; 95% CI 0.13, 0.34; P < .001). A negative association between the highest tertile of TMAO and fasting plasma glucose was also observed (β -1.22; 95% CI -1.77, -0.66; P < .001).

Conclusion: TMAO may serve as an emerging biomarker for cardiometabolic risk assessment in adolescents.

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肠道微生物代谢物TMAO与青少年心脏代谢健康：横断面分析

背景：三甲胺n -氧化物（TMAO）是一种来自肠道微生物群的代谢物，与成人心血管和代谢性疾病的风险相关。然而，它在评估青少年心脏代谢风险中的作用尚不清楚。目的：研究巴西青少年血清氧化三甲胺水平与心脏代谢健康指标的关系。材料和方法：这是一项多中心、横断面分析，涉及来自巴西四个城市的4446名年龄在12至17岁的参与者。采用液相色谱-串联质谱法定量测定血清TMAO水平，并通过多变量线性回归分析评估其与临床、代谢和炎症变量的关系。结果：在对潜在混杂因素进行校正后，血清TMAO最高分位数与腰围呈正相关[β 1.45；95%置信区间（CI） 0.77, 2.14；P < .001]，体重指数Z-score (β .19；95% ci 0.10, 0.27；P < .001)， c反应蛋白(β .24；95% ci 0.13, 0.34；P < 0.001)。TMAO最高分位数与空腹血糖呈负相关(β -1.22；95% ci -1.77, -0.66；P < 0.001)。结论：TMAO可作为青少年心脏代谢风险评估的新兴生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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