{"title":"Design and Finite Element Analysis of an Electrothermally Actuated Microgripper for Biomedical Applications","authors":"Teferi Sitotaw Yallew, M. F. Pantano, A. Bagolini","doi":"10.1109/dtip54218.2021.9568685","DOIUrl":"https://doi.org/10.1109/dtip54218.2021.9568685","url":null,"abstract":"Micromanipulation devices are becoming fundamental tools to study and understand cell biology and cell mechanics. Indeed, to study the individual cell behaviors and interactions, cell samples need to be grasped and moved to testing devices. In recent years, micromanipulators have been demonstrated as an effective means to provide precise sample manipulation. In this paper, a detailed overview of designing and simulation of a biocompatible electro-thermally actuated microgripper with rotary capacitive position sensor is presented. The microgripper is actuated by a chevron-shaped thermal actuator with thin hinges and a rotary capacitive position sensor is integrated with the links of the microgripper in order to sense the microgripper tweezers position. The microgripper herein reported can manipulate biological samples in the size range between 50 µm to 150 µm. Based on the sensitivity calculation of the rotary capacitive position sensors, the sensitivity of the displacement measurement is 102 fF/µm.","PeriodicalId":173313,"journal":{"name":"2021 Symposium on Design, Test, Integration & Packaging of MEMS and MOEMS (DTIP)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126728544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On-chip measurement of pH using a microcantilever: a biomimetic design approach","authors":"Alireza Tajeddin, N. Mustafaoglu, M. Yapici","doi":"10.1109/dtip54218.2021.9568499","DOIUrl":"https://doi.org/10.1109/dtip54218.2021.9568499","url":null,"abstract":"In vitro organ models used for drug discovery and delivery must recapitulate actual physiological parameters, including pH, for more reliable results. Monitoring pH is both important and challenging in many processes. At the scale of physiological environments of microfluidic organ chip models, additional fluctuations in pH can lead to organ dysfunction and there are natural mechanisms to control this. In this work, a microfluidic pH sensor-embedded chip was designed to monitor pH that can be connected to the main organ-on-chip culture. The mechanism consists of separation and sensing with a buffer system that is also found in the cell cytoplasm, so it is a biomimetic approach. The deflection of the pH-sensing cantilever was improved by applying finite element methods to obtain better sensitivity and wider detection range for different concentrations of hydrogen ions in the buffer reaction chamber.","PeriodicalId":173313,"journal":{"name":"2021 Symposium on Design, Test, Integration & Packaging of MEMS and MOEMS (DTIP)","volume":"147 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114049232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}