Journal of the International Society of Antioxidants in Nutrition & Health最新文献_第9页

Curcumin increases BDNF levels and decreases nitrotyrosine content in hippocampus and frontal cortex and improvements spatial memory deficits in diabetic db/db mice 姜黄素增加糖尿病db/db小鼠海马和额叶皮层BDNF水平，降低硝基酪氨酸含量，改善空间记忆缺陷

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1360

J. Ramírez-Emiliano, Martha S Solís-Ortiz, Atenea Vázquez-Sánchez, E. Franco-Robles, V. Pérez-Vázquez

{"title":"Curcumin increases BDNF levels and decreases nitrotyrosine content in hippocampus and frontal cortex and improvements spatial memory deficits in diabetic db/db mice","authors":"J. Ramírez-Emiliano, Martha S Solís-Ortiz, Atenea Vázquez-Sánchez, E. Franco-Robles, V. Pérez-Vázquez","doi":"10.18143/JISANH_V3I4_1360","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1360","url":null,"abstract":"We investigated the effects of curcumin (CUR) on BDNF levels and nitrotyrosine (3-NT) content in the hippocampus (HP) and frontal cortex (FC), and on the cognitive performance of db/db diabetic mice (DM). DM did have decreased-BDNF levels and increased-3-NT content in HP and FC (0.72 ± 0.09 and 0.61 ± 0.07 ng of BDNF/mg protein; 3042.27 and 11418.03 of 3-NT) as compared with wild-type (WT) mice (1.5 ± 0.09 and 0.94 ± 0.14 ng of BDNF/mg protein, p < 0.001); whereas curcumin improved or restored BDNF levels to normal levels (1.17 ± 0.03 and 1.21 ± 0.2 ng of BDNF/mg protein, respectively) and decreased 3-NT content in these brain regions of DM (438.28 and 1629 of 3-NT, respectively). In addition, CUR increased BDNF levels in HP and FC of WT mice (1.6 ± 0.14 and 1.84 ± 0.36 ng of BDNF/mg protein, respectively) as compared with untreated WT mice (p = 0.3 and p = 0.013, respectively). With respect to spatial memory deficits, curcumin-treated mice performed better the exploratory skills. These results suggest that curcumin has beneficial effect on the BDNF levels and nitrosactive damage in HP and FC, improving exploration and memory skills.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"60 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91479224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant phenolics as chemopreventive agents of colorectal cancer 植物酚类物质作为结直肠癌的化学预防剂

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1341

Manuel A. R. Ferreira, C. Pereira‐Wilson, M. Fernandes-Ferreira

{"title":"Plant phenolics as chemopreventive agents of colorectal cancer","authors":"Manuel A. R. Ferreira, C. Pereira‐Wilson, M. Fernandes-Ferreira","doi":"10.18143/JISANH_V3I4_1341","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1341","url":null,"abstract":"The progression of colorectal neoplasia from adenoma to carcinoma results from a step-wise accumulation of several mutations in genes responsible for molecular components that induce cell proliferation through the upregulation of the PI3K/Akt and MAPK/ERK pathways and/or downregulation of the apoptosis pathways. Other important players are cyclooxygenase 2 (COX-2), nuclear factor Kappa B (NF-kB), survivin, and insulin-like growth factor-I (IGF-I). Together, they constitute potential targets for CRC prevention. In this work, an overview of some of the most promising plant phenolics as inhibitors of colorectal tumorigenesis will be presented, emphasizing the results of preclinical or clinical trials and discussing the respective action mechanisms. Two human CRC cell lines harboring mutations in different genes coding for different components of the PI3K/Akt and MAPK/ERK pathways were used, in order to evaluate the potential CRC prevention of Salvia and Hypericum phenolic extracts and some of their constituents. The results showed that both extracts and components regulated differently the expression of key components of PI3K/Akt and MAPK/ERK pathways and apoptosis pathways depending of mutated gene harbored by the target cell line. In conclusion, the CRC prevention efficacy depends from the kind of respective target component and the kind of the CRC mutated genes.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Storage on the Physicochemical Properties of Acidified Milk Gels Fortified with Polyphenols 贮藏对加多酚酸化乳凝胶理化性质的影响

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1330

M. Bayraktar, N. Harbourne, C. Fagan

{"title":"Impact of Storage on the Physicochemical Properties of Acidified Milk Gels Fortified with Polyphenols","authors":"M. Bayraktar, N. Harbourne, C. Fagan","doi":"10.18143/JISANH_V3I4_1330","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1330","url":null,"abstract":"Understanding the impact of storage on the properties of dairy products containing polyphenols is important. The objective of this study was to determine the impact of storage (28 days, 4°C) on the properties of acidified milk gels fortified with green tea, white grape, tannic acid, or gallic acid (1 mg ml-1). Polyphenols were added to pasteurised skim-milk which was heat treated (85oC, 30 min), acidification was achieved by addition of GDL (1.7% w/w, 30°C, 3.75 hours). Samples (n=80) were analysed for total phenolic content (TPC) and antioxidant capacity (AC), syneresis capacity, pH, textural properties, and colour, in 7 day intervals. The TPC, AC and syneresis capacity of the gels, except tea, did not change during storage (P>0.05). The hardness of the tea and grape samples significantly increased (P=0.01-0.05) during storage. However, no change in the hardness of control, tannic and gallic were observed. Phenolic addition and storage influenced the colour parameters. Overall the tea sample tended towards a red colour (+a*) with the others similar to the control (-a*). During storage the lightness and pH of all samples, except gallic lightness, decreased. In conclusion, polyphenols may be added to milk gels with minimal impact on physicochemical properties during storage.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88544102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APPLE POMACE AQUEOUS EXTRACT AS A FOOD INGREDIENT 苹果渣水萃取物作为食品原料

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1344

P. A. Fernandes, Sónia S. Ferreira, Beatriz Elvas, António Pinto, F. Gonçalves, M. Coimbra, Dulcineia F. Wessel, S. Cardoso

{"title":"APPLE POMACE AQUEOUS EXTRACT AS A FOOD INGREDIENT","authors":"P. A. Fernandes, Sónia S. Ferreira, Beatriz Elvas, António Pinto, F. Gonçalves, M. Coimbra, Dulcineia F. Wessel, S. Cardoso","doi":"10.18143/JISANH_V3I4_1344","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1344","url":null,"abstract":"The present work aimed to assess the potential of apple pomace (AP) as a low priced source of food ingredients rich in bioactive compounds. In order to determine its safety, AP was evaluated regarding Total Aerobic Mesophiles (TAM), Yeasts and Moulds (YM) and Enterobacteriaceae (ENT). A hot water extract of AP was investigated concerning total phenolic content (TPC) by the Folin-Ciocalteu method and its antioxidant capacity by the hydroxyl scavenging (OH˙) and ABTS˙+ methods. The extract was incorporated into a yoghurt and its microbiological parameters, antioxidant activity and sensorial acceptability were evaluated. AP had very acceptable microbial levels respecting the TAM, YM and ENT, potentiating its valuation as a source of food ingredients. The AP extract presented a TPC of ≈11 µg of GAE/g, which resulted in the capability to inhibit OH˙ radical and the ABTS˙+ radicals. These properties were reflected by an increased antioxidant activity of the yoghurts fortified with the extract, reaching more than twice of the controls. This was achieved without affecting the native yoghurt lactic acid bacteria and sensorial acceptance. Although the present strategy proves to be very promising for the valuation of AP, further studies are required in order to better elucidate the extracts’ bioactivity.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76883475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural table olives phenolic extract counteract the harmful effects of oxidative stress in human intestinal cells. 天然橄榄酚提取物抵消了人体肠道细胞氧化应激的有害影响。

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1334

G. Serreli, A. Incani, A. Atzeri, A. Angioni, M. Campus, E. Cauli, R. Zurru, S. Zodio, M. Deiana

{"title":"Natural table olives phenolic extract counteract the harmful effects of oxidative stress in human intestinal cells.","authors":"G. Serreli, A. Incani, A. Atzeri, A. Angioni, M. Campus, E. Cauli, R. Zurru, S. Zodio, M. Deiana","doi":"10.18143/JISANH_V3I4_1334","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1334","url":null,"abstract":"Table olives are recognized as a valuable source of natural phenolic antioxidants. In this study we analyzed the ability of the phenolic fraction of a Sardinian cultivar of naturally fermented table olives, “Tonda di Cagliari”, to protect Caco-2 cell monolayers against oxidative stress and membrane disruption induced by tert-butil hydroperoxide (TBH). TBH exposure resulted in an alteration of cellular redox status, with an increase of ROS and a decrease of GSH intracellular level, which led over time to a loss of the epithelial integrity, as indicated by the decrease of the transepithelial electrical resistance (TEER) value. Pretreatment of Caco-2 cells with the olives phenolic extract at non-toxic concentrations (10 – 50 µg/mL) prevented ROS generation, GSH depletion and the loss of the epithelial integrity. The protective action of the extract is likely due to the ability of its main components, hydroxytyrosol, oleuropein and verbascoside, to scavenge TBH generated radicals or intermediate of reaction metabolites. Olives phenolic compounds concentrate in the intestinal lumen, where they may contribute, together with their metabolites, to protect the intestinal mucosa against the damage caused by oxidative species.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85068213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of synergism between leucine and quercetin: a new strategy against metabolic disorders 亮氨酸和槲皮素的协同作用:对抗代谢紊乱的新策略

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-06 DOI: 10.18143/JISANH_V3I4_1342

Mayara F Moreno, F. F. Anhê, R. Nachbar, P. St-Pierre, L. Oyama, A. Marette

{"title":"Effect of synergism between leucine and quercetin: a new strategy against metabolic disorders","authors":"Mayara F Moreno, F. F. Anhê, R. Nachbar, P. St-Pierre, L. Oyama, A. Marette","doi":"10.18143/JISANH_V3I4_1342","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1342","url":null,"abstract":"The aim of this study was to investigate the effects of quercetin and/or leucine on the intestinal permeability and metabolic endotoxemia in diet-induced obese mice. C57Bl/6J mice were divided into five groups: Chow diet; high-fat high-sucrose diet (HFHS); HFHS+quercetin 83mg/kg bw/day; HFHS+leucine 1.4g/kg bw/day; or HFHS with a combination of both doses for 12 weeks. Co-administration of quercetin and leucine did not prevent weight gain or adipose tissue deposition. However, quercetin and leucine supplementation was associated with a trend towards preventing obesity-induced hyperinsulinemia during fasting and significantly prevented the increase of free 8-isoprostane fractions in plasma. Furthermore, co-administration of quercetin and leucine significantly increased the Fiaf and Muc2 genes, which have been associated with beneficial changes in the gut microbiota. Our findings indicate that quercetin and leucine exert beneficial metabolic synergistic effects that could be associated with changes in the intestinal physiology. More research is needed to evaluate the therapeutic applicability of quercetin and leucine in the treatment of insulin resistance and whether these changes are associated with functional or taxonomic changes in the gut microbiota. FAPESP2013/12366-0","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82399562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Characterization of the oxidative stress response in yeast cells protected by gamma-glutamylcysteine instead of glutathione γ -谷氨酰半胱氨酸代替谷胱甘肽保护酵母细胞氧化应激反应的表征

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-05 DOI: 10.18143/JISANH_V3I3_1273

E. Hatem, Gilles Lagniela, H. Jean-Jacques, J. Labarre, L. Kuras, S. Chédin

{"title":"Characterization of the oxidative stress response in yeast cells protected by gamma-glutamylcysteine instead of glutathione","authors":"E. Hatem, Gilles Lagniela, H. Jean-Jacques, J. Labarre, L. Kuras, S. Chédin","doi":"10.18143/JISANH_V3I3_1273","DOIUrl":"https://doi.org/10.18143/JISANH_V3I3_1273","url":null,"abstract":"Redox homeostasis is achieved by antioxidant systems, involving a large collection of enzymes that scavenge or degrade Reactive Oxygen Species (ROS) produced endogenously at low levels during cell growth. Besides the enzymatic protection against ROS, cells also contain small antioxidant molecules, such as glutathione (GSH). With an intracellular concentration between 1 and 10 mM, GSH is the most abundant non-protein thiol in the cell and is considered as the major redox buffer of the cell. In a previous study, we showed that only scarce amounts of intracellular GSH are required to protect yeast nuclear activities during oxidative stress. Surprisingly, such protection is sufficient for cell survival despite the strong oxidation of cytosolic proteins and the complete inhibition of protein synthesis (Hatem et al., 2014). GSH synthesis is a two-step process involving the gamma-glutamylcysteine (g-GC) synthetase Gsh1, which produces the g-GC intermediate from glutamate and cysteine, and the glutathione synthetase Gsh2, which adds a glycine to g-GC to release the final tripeptide. Deletion of GSH2 leads to yeast cells accumulating abnormal amounts of g-GC. It has been suggested that this molecule could replace GSH during oxidative stress exposure as the viability of ∆gsh2 cells, unable to synthesize GSH, is only mildly affected in oxidative stress conditions. Because our previous study revealed that the antioxidant protection of all cellular components and activities is not strictly required to preserve cell viability during oxidative stress, we decided to better characterize the physiological response of ∆gsh2 cells submitted to hydrogen peroxide treatments. Here we present the main results of this study and discuss the potential role of g-GC in the cellular protection against oxidative injury, compare to GSH.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78878408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Smart Chocolate as a Platform for New Generation of Functional Food 智能巧克力作为新一代功能食品的平台

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-05 DOI: 10.18143/JISANH_v3i4_1324

I. Petyaev, V. Tsibezov, N. Kyle, N. Chalyk, V. Klochkov

{"title":"Smart Chocolate as a Platform for New Generation of Functional Food","authors":"I. Petyaev, V. Tsibezov, N. Kyle, N. Chalyk, V. Klochkov","doi":"10.18143/JISANH_v3i4_1324","DOIUrl":"https://doi.org/10.18143/JISANH_v3i4_1324","url":null,"abstract":"We have developed a process, which can protect cocoa flavanols by embedding them into lycopene, or other carotenoids. This results in an increase in their ‘survival’ in the digestive tract, and consequently in an improvement in their absorption and efficacy. Clinical studies demonstrated that our process can improve the bioavailability of these molecules and increase their efficacy so that a piece of 5-10g has the power of 100g of unmodified dark chocolate. We used this enriched cocoa flavanol Smart Chocolate as a platform to combine other food bioactive molecules with established physiological properties. They included lycopene to protect plasma lipoproteins, lutein and zeaxanthin to support neuron tissues, and astaxanthin to boost mitochondria respiration. Results of clinical validation demonstrated their superior efficacy above unmodified dark chocolate and conventional supplementation. In addition we combined this platform with trans-resveratrol. The main problem in clinical application of this molecule is that in isolated form its bioavailability 100 to 1,000 lower than when it is consumed with red wine. By using our technology we developed chocolate with bioavailability of t-RSV boosted to the level of red wine.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79214254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of pasteurisation and storage on bioactive compounds in Roselle (Hibiscus sabdariffa) from a beverage perspective 从饮料的角度看，巴氏灭菌和储存对芙蓉中生物活性化合物的影响

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-03 DOI: 10.18143/JISANH_V3I4_1336

Esereosa D. Omoarukhe, N. Harbourne, P. Jauregi

{"title":"Effect of pasteurisation and storage on bioactive compounds in Roselle (Hibiscus sabdariffa) from a beverage perspective","authors":"Esereosa D. Omoarukhe, N. Harbourne, P. Jauregi","doi":"10.18143/JISANH_V3I4_1336","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1336","url":null,"abstract":"Hibiscus Sabdariffa (Roselle) is popular as a beverage in countries within Africa, Asia and South America. Benefits of Roselle, demonstrated in vivo, include lowering cholesterol and reducing raised blood pressure. These benefits have been attributed to Roselle phenolic compounds; Anthocyanins in particular. This study monitors the effects of processing and storage life on these compounds in a Roselle extract. An aqueous extract of Roselle (90oC,20mins) was pasteurised (85oC,25mins) and stored for 90days at room(21oC), refrigeration(4oC) and freezing(-21oC) temperatures and analysed for total phenolic (TP) content, total anthocyanins (TA) and antioxidant properties at different time points. Initial values for TA, antioxidant capacity (FRAP) and TP contents were 42.3±4.57 mg Cyanidin-3-Glycoside/L Roselle extract, 140.23±21.42 g Ascorbic Acid Equivalent/L and 132.75±3.32 mg Gallic acid equivalent/L respectively. Overall, there was no effect of pasteurisation on TP, TA and antioxidant activity. However, there was a significant effect of storage temperature and time particularly evident extracts stored at room temperature; resulting in a 70% loss of TA from initial. There was also an effect of storage time on TA content and antioxidant capacity. Pasteurisation with cold temperature storage within 90 days did not result in significant changes in Roselle bioactive.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82132782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTS OF GUAVA LEAF (PSIDIUM GUAJAVA L.) EXTRACT ON ENDOTHELIUM DYSFUNCTION IN OBESE MICE 番石榴叶的药理作用提取物对肥胖小鼠内皮功能障碍的影响

Journal of the International Society of Antioxidants in Nutrition & Health Pub Date : 2016-06-03 DOI: 10.18143/JISANH_V3I4_1358

Elixabet Díaz‐de‐Cerio, A. Rodríguez‐Nogales, F. Algieri, M. Romero, V. Verardo, A. Segura‐Carretero, J. Duarte, J. Gálvez

{"title":"EFFECTS OF GUAVA LEAF (PSIDIUM GUAJAVA L.) EXTRACT ON ENDOTHELIUM DYSFUNCTION IN OBESE MICE","authors":"Elixabet Díaz‐de‐Cerio, A. Rodríguez‐Nogales, F. Algieri, M. Romero, V. Verardo, A. Segura‐Carretero, J. Duarte, J. Gálvez","doi":"10.18143/JISANH_V3I4_1358","DOIUrl":"https://doi.org/10.18143/JISANH_V3I4_1358","url":null,"abstract":"Objectives: Recent studies showed that Spanish guava leaves are a source of phenolic compounds that have been related to the prevention and treatment of Diabetes Mellitus[1],[2]. Thus, the aim of this work was to evaluate the effects of an extract from guava leaves, on vascular dysfunction in obese mice. Methodology: an extract from guava leaves was characterized by HPLC-DAD-ESI-TOF-MS, and it was tested on obese mice fed a high fat-rich diet to evaluate the vascular dysfunction. Results: Firstly, the analysis of the extract by HPLC-DAD-ESI-TOF-MS revealed that flavonols represented a 49.2 % from the sum of phenolic in the leaves, followed by gallic/ ellagic acid derivatives (29.3 %) and flavan-3-ols (21.5 %). Moreover, major compounds were the isomers reynoutrin, guajaverin and avicularin. Secondly, the administration of the extract (5 mg/kg) to obese mice did not alter weight evolution, but improved the glucose tolerance test. Also, it caused a significant amelioration in all the metabolic markers evaluated in plasma. Moreover, the endothelial dysfunction was reversed in the extract-treated group. Conclusions: the beneficial effects in obese mice of guava leaf extract, related to its phenolic composition, were associated to an improvement in the altered vascular functions that occur in obesity.","PeriodicalId":17323,"journal":{"name":"Journal of the International Society of Antioxidants in Nutrition & Health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75737824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0