Journal of the Hellenic Veterinary Medical Society最新文献_第9页

Occurrence, antibiogram, high-level vancomycin and aminoglycosides resistance and potential virulence factors of enterococci in dogs in Nigeria 尼日利亚犬肠球菌的发生、抗生素谱、高水平万古霉素和氨基糖苷类耐药性和潜在毒力因素

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-21 DOI: 10.12681/jhvms.27783

MU Anyanwu, UU Eze, JC Nnamani, NH Ikenna-Ezeh, P. Akpa, OJ Okorie-kanu, B.M. Anene

{"title":"Occurrence, antibiogram, high-level vancomycin and aminoglycosides resistance and potential virulence factors of enterococci in dogs in Nigeria","authors":"MU Anyanwu, UU Eze, JC Nnamani, NH Ikenna-Ezeh, P. Akpa, OJ Okorie-kanu, B.M. Anene","doi":"10.12681/jhvms.27783","DOIUrl":"https://doi.org/10.12681/jhvms.27783","url":null,"abstract":"AbstractThis study was conducted to isolate enterococci from dogs in Nigeria, and to determine the potential virulence, antibiotic susceptibility, phenotypic vancomycin (VAN), high-level ampicillin (AMP) and aminoglycosides susceptibility profile of the isolates. Rectal swabs were collected from 295 randomly-selected, clinically-healthy dogs. The isolation of enterococci was done using Slanetz and Bartley enterococcal selective medium. The resistance of 150 non-repetitive isolates was determined using disc diffusion method. VAN resistance was assessed by high-level disc diffusion and agar-screening methods. High-level AMP and aminoglycosides (gentamicin and streptomycin) resistance was determined by agar-screening method. Potential virulence factors were assayed using phenotypic methods. Out of 295 samples, 234 (80.7%) gave positive growth. From these, 250 enterococcal isolates comprised 229 (91.6%) non-pigmented and 21 (8.4%) pigmented strains, were obtained. Resistance of the isolates was 89% to erythromycin, 92% to rifampicin, 77% to chloramphenicol, 83% to tetracycline, 64% to ciprofloxacin, 32.7% to VAN, 24.7% to high-level streptomycin (HLS) and 6% to high-level gentamicin (HLG). Among 150 non-repetitive resistant isolates, 144 (96%), including all the VAN-, HLS- and HLG-resistant strains, exhibited resistance to at least 3 classes of antibiotics. The mean multiple antibiotic resistance index was 0.54 (range = 0.22 – 0.89). Of these 150 isolates, 94 (62.7%), including all the VAN-, HLS- and HLG-resistant strains, displayed virulence potentials as biofilm (44.7%), surface-layer (13.8%), haemolysin (21.3%), gelatinase (40.4%), caesinase (10.6%) and deoxyribonuclease (12.8%) activities. This study showed that dogs in Nigeria are potential reservoirs and disseminators of potentially-virulent, multidrug-, VAN- and high-level aminoglycosides-resistant enterococci.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48004591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotic potential and anti-quorum sensing activity of Enterococcus faecalis and Lactobacillus kunkeei isolates from Apis mellifera 蜜蜂中粪肠球菌和昆克乳杆菌的益生菌潜力和抗群体感应活性

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-21 DOI: 10.12681/jhvms.26743

M. Kiymaci, D. Simsek, KC Tok, D. Dirican, M. Gumustas

引用次数: 0

The effect of reduced dose of PGF2α on certain reproductive parameters in awassi yearlings in anestrus synchronisation protocol following the end of the of the breeding season 低剂量PGF2α对繁殖季结束后无月经同步试验中赤潮仔某些生殖参数的影响

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.27399

I. Ozbilek, Y. Ergun, A. Gözer, O. Bahan, S. Alaşahan

{"title":"The effect of reduced dose of PGF2α on certain reproductive parameters in awassi yearlings in anestrus synchronisation protocol following the end of the of the breeding season","authors":"I. Ozbilek, Y. Ergun, A. Gözer, O. Bahan, S. Alaşahan","doi":"10.12681/jhvms.27399","DOIUrl":"https://doi.org/10.12681/jhvms.27399","url":null,"abstract":"The aim of this study was to investigate the effect of the administration of half or full dose of prostaglandinF2α (PGF2α; Gestavet Prost, d-cloprostenol, HIPRA®) injection in a routine synchronization protocol following theend of the breeding period including intravaginal sponge (medroxyprogesterone acetate; Espanjovet, HIPRA®) andeCG (Oviser 500, HIPRA®) on certain fertility parameters in ewes.Two hundred thirty-eight Awassi yearlings (agedone year old) divided into two groups:116 ewes received a half dose (HSDP; 37.5 μg) of PGF2α and 122 ewes receivedfull dose (FSDP;75 μg).The pregnancy rates were 67.2% and 72.1% for HSDP and FSDP, respectively (P>0.05).The lambing rates were 64.7% and 63.9% for HSDP and FSDP, respectively (P>0.05).The single lambing rate inHSDP(94.7%) was higher (P<0.05) compared to that in FSDP (73.1%). The twin and multiple birth rates of FSDPwas higher (P<0.05) than HSDP. As a result, it was inferred that aHSDP could be used in Awassi yearlings withoutexperience of lamb care and in a herd in which single lambing was preferable. Moreover, due to the fact that it is moreaffordable and not detrimentalto fertility, it was concluded that HSDPcan offer an advantage in large flocks and can beused for manipulating fecundity ratesin yearlings.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49265322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of some acute phase proteins, cytokines and hepcidin values in feline enteric corona virus antibodies and feline infectious peritonitis antigen positive cats 猫肠道冠状病毒抗体和猫传染性腹膜炎抗原阳性猫急性期蛋白、细胞因子及hepcidin值的研究

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.24162

S. Sahinduran, M. Albay, M. Karaca, MÇ Karakurum, R. Kiyici

{"title":"Investigation of some acute phase proteins, cytokines and hepcidin values in feline enteric corona virus antibodies and feline infectious peritonitis antigen positive cats","authors":"S. Sahinduran, M. Albay, M. Karaca, MÇ Karakurum, R. Kiyici","doi":"10.12681/jhvms.24162","DOIUrl":"https://doi.org/10.12681/jhvms.24162","url":null,"abstract":"Feline Infectious Peritonitis (FIP) is a fatal disease caused by feline coronaviruses. The causative agent is Feline Infectious Peritonitis Virus, a mutation of Feline Enteric Coronavirus. Feline Corona Virus is very common in the cat population. In Feline Corona Virus infected cats, the development of FIP depends on the cat's immune response. FIP disease is more common in young and old cats because young and old animals have a weaker immune system. The acute phase response is a complex systemic reaction that occurs as a response to acute or chronic inflammatory processes such as infection, neoplasia or immunological disorders, tissue damage, trauma and surgery. The study material included 15 cat with presumptive FIP (study group) and 10 healthy cats (control group). Of the 15 cats, 9 (60%) showed dry and 6 (40%) effusive form. Serum amyloid A (SAA), haptoglobin (Hp), α1-acid glycoprotein (AGP), albumin, interleukin-6 (IL-6), hepcidin, alanine-amino transferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen(BUN), and creatinine levels were measured in the serum collected from both groups. There were no difference between the wet and dry FIP in albumin values; haptoglobin, α1-acid glycoprotein, SAA and hepcidin values were significantly different between the two groups. IL-6, showed significant difference in both wet and dry FIP groups. It was also concluded that hepcidin may be used as a biomarker in Feline Infectious Peritonitis disease like other acute phase proteins.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41625959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sero-epidemiology of brucellosis in small ruminants on rangeland in northern Mexico 墨西哥北部牧场小反刍动物布鲁氏菌病的血清流行病学研究

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.23288

M. Mellado, A. Almanza, J. Mellado, Jessica D. Garcia, U. Macías-Cruz, L. Avendaño-Reyes

{"title":"Sero-epidemiology of brucellosis in small ruminants on rangeland in northern Mexico","authors":"M. Mellado, A. Almanza, J. Mellado, Jessica D. Garcia, U. Macías-Cruz, L. Avendaño-Reyes","doi":"10.12681/jhvms.23288","DOIUrl":"https://doi.org/10.12681/jhvms.23288","url":null,"abstract":"The seroprevalence of Brucella antibodies in serum of goats and sheep reared on semi-arid pastoral systems of northeastern Mexico was assessed. Additionally, species, gender, and predominant breed were evaluated as risk factors for seropositivity to brucellosis. Data were from 375 flocks of goats or co-mingled goats and sheep. Serum samples from 11001 goats and 4741 sheep collected between 2016 and 2019 were analyzed with the brucellosis card test. The disease affected 12% of flocks. The overall prevalence of brucellosis seropositivity in goats and sheep were estimated at 2.1% (95% CI = 1.78-2.31) and 0.8% (95% CI = 0.58-1.10), respectively. Brucellosis seropositivity was two times more likely (p < 0.01) in goats than sheep. The risk of seropositivity to brucellosis for goats and sheep was 2.3 and 3.2 times higher (p < 0.01) in females than males. Toggenburg goats were more likely (p < 0.01) to be seropositive to brucellosis than all other breeds of goats, whereas criollo sheep were more likely to be seropositive to brucellosis compared to hair sheep composite breeds. The current study revealed that, despite the absence of Brucella vaccination, brucellosis is not widely distributed in the study area. Also of all animals screened, seropositivity to Brucella infection was highest in Toggenburg when compared to other dairy and meat breeds; Criollo sheep also presented the highest seropositivity to brucellosis compared to hair sheep composite breeds. Finally, females compared to males had increased odds of testing positive for brucellosis.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46034682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-lactam and Fluoroquinolone Resistant Extraintestinal Escherichia coli from Broiler Chickens and Ducks: Public Health Threat 来自肉鸡鸭的β -内酰胺和氟喹诺酮类耐药肠外大肠杆菌:公共卫生威胁

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.27341

M. A. Abo Hashem, H. El-Mahallawy, M. Moursi, R. Abd El-Fattah, M. Enany

{"title":"Beta-lactam and Fluoroquinolone Resistant Extraintestinal Escherichia coli from Broiler Chickens and Ducks: Public Health Threat","authors":"M. A. Abo Hashem, H. El-Mahallawy, M. Moursi, R. Abd El-Fattah, M. Enany","doi":"10.12681/jhvms.27341","DOIUrl":"https://doi.org/10.12681/jhvms.27341","url":null,"abstract":"Escherichia coli (E. coli) is a zoonotic bacterial pathogen commonly found in human, birds and animals. The widespread use of broad-spectrum beta-lactams for poultry treatment, has resulted in the production of extended spectrum β-lactamases (ESBLs) in E. coli. In this study, we analyzed the antimicrobial resistance pattern of E. coli isolates from broiler chickens and ducks with clinical colibacillosis, and investigated the presence of beta-lactam (blaTEM, blaSHV, ampC, and blaCTX-M) and fluoroquinolone (qnrS and qepA) resistance genes using PCR. E. coli isolates showed a higher resistance against beta-lactams: penicillin G and ceftriaxone (97.5%), cephalexin (92.5%), ampicillin (77.5%), amoxicillin/clavulanic acid (62.5%), with somewhat lower resistance for nalidixic acid (45%), ciprofloxacin (35%), and norfloxacin (32.5%) from fluoroquinolone group. Isolates showed considerable sensitivity to cefotaxime (65%) and levofloxacin (55%). All tested isolates carried blaTEM, blaSHV and ampC resistance genes, and this was associated with the phenotypic resistance too. Although some isolates showed phenotypic intermediate resistance to fluoroquinolones, or resistance to only one agent from this class, the qnrS (83.3%) has been detected with high frequency. The blaCTX-M (27.87%) and qepA (16.7%) showed the lowest occurrence and had been detected in isolates from broiler chickens only. The occurrence of these resistant E. coli serotypes in broiler chickens and ducks pose a potential threat to poultry industry, and constitutes a public health risk to human consumers, slaughterhouse and poultry packing plant workers due to dissemination of beta-lactam and fluoroquinolone resistant E. coli serotypes.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49190528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriospermia assessment and its relationship with conventional seminal parameters in stud dogs ejaculates (Canis familiaris) 种犬精液中细菌精子的测定及其与常规精液参数的关系

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.27558

S. Agudelo-Yepes, J. Puerta-Suárez, D.F. Carrillo-Gonzalez, W. C. Cardona Maya

{"title":"Bacteriospermia assessment and its relationship with conventional seminal parameters in stud dogs ejaculates (Canis familiaris)","authors":"S. Agudelo-Yepes, J. Puerta-Suárez, D.F. Carrillo-Gonzalez, W. C. Cardona Maya","doi":"10.12681/jhvms.27558","DOIUrl":"https://doi.org/10.12681/jhvms.27558","url":null,"abstract":"The objective of this work was to determine the frequency of bacteriospermia and its effect on the seminal quality in canines. Dogs were divided into two groups according to weight: small dogs between 1 and 10 kg (Group 1) and dogs with more than 10 kg (Group 2). The foreskin was disinfected in each animal (n=15), and the semen sample was collected by the gloved hand method. Sperm motility, morphology, viability, and concentration were evaluated using a 40x microscope. A 10µL of semen drop was cultured by diffusion method on blood agar and MacConkey agar. Colony-forming units (CFU) were quantitatively evaluated, and biochemical identification was carried out after 48 hours at 37°C. Conventional PCR was performed on the semen samples to evaluate the presence/absence of 11 bacteria. Bacterial growth was found in all samples. The CFU/mL in blood agar were 34042.8 for group 1 and 107714.3 for group 2, while on MacConkey agar were 142.9 CFU/mL, and 21328.6 CFU/mL, respectively. Coagulase-negative Staphylococcus was the most frequent bacteria isolated by conventional culture (64.3%), and Staphylococcus aureus and Klebsiella spp. were the most common bacteria found by conventional PCR. Between both groups, only a statistically significant difference was found in normal sperm morphology. A negative correlation was observed between viability and morphology with CFU on MacConkey agar. One dog was ruled out because he had azoospermia. Canine seminal bacteriospermia is quite frequent and could alter its quality. The presence of Gram-negative bacteria is associated with greater alteration in the semen analysis.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45081013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular identification of virulence features of Salmonella enterica isolated from fresh chicken meat sold at retail shops and markets in Peshawar, Pakistan 从巴基斯坦白沙瓦零售商店和市场销售的新鲜鸡肉中分离的肠沙门氏菌毒力特征的分子鉴定

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.27474

Shaista Rahat, K. Ahmad, Amjad Ali

{"title":"Molecular identification of virulence features of Salmonella enterica isolated from fresh chicken meat sold at retail shops and markets in Peshawar, Pakistan","authors":"Shaista Rahat, K. Ahmad, Amjad Ali","doi":"10.12681/jhvms.27474","DOIUrl":"https://doi.org/10.12681/jhvms.27474","url":null,"abstract":"Salmonella enterica is an important agent of food borne illnesses in humans. Poultry meat and products are easily contaminated with different strains of Salmonella enterica. Consumption of such food causes salmonellosis in human. The main aim of present investigation was to survey the prevalence of virulence associated genes of Salmonella enterica isolated from fresh chicken meat available in retail shops and markets at District Peshawar, Pakistan. Fresh chicken meat samples were collected from retail shops and markets at District Peshawar, Pakistan. The samples were processed for isolation of Salmonella enterica using selective media. Presumptive isolates were confirmed as Salmonella enterica via different biochemical tests and by amplification of invA gene. Isolates were tested for the presence of eight different virulence genes invA, spiA, cdtB, prgH, orgA, lpfC, sopB, and pefA. Amongst all isolates, 90(100%) had invA gene, 44(48.8%) had lfpC gene, 40(44.4%) had sopB gene, 27(30%) had orgA gene, 24(26.6%) hand spiA gene, 19(21.1%) had pefA gene, 18(20%) had prgH gene and 6(6.6%) had cdtB gene. 15.5% of the isolates had five virulence genes and 21.1% had four virulence genes. The findings of this study highlight an alarming public health risk and demand for strict bio-safety hygiene measures to be taken.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45645971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of phenotypic and genotypic characteristics of isolated Vibrio anguillarum strains in rainbow trout cage farms in Kahramanmaraş city of Turkey 土耳其kahramanmaraku市虹鳟鱼网箱养殖中鳗鲡弧菌分离株表型和基因型特征的调查

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.22851

M. Özcan, E. Donat

{"title":"Investigation of phenotypic and genotypic characteristics of isolated Vibrio anguillarum strains in rainbow trout cage farms in Kahramanmaraş city of Turkey","authors":"M. Özcan, E. Donat","doi":"10.12681/jhvms.22851","DOIUrl":"https://doi.org/10.12681/jhvms.22851","url":null,"abstract":"Bu çalışma, Kahramanmaraş, Türkiye bölgesindeki kafes çiftliklerinde kültürlenen gökkuşağı alabalığındaki Vibrio anguillarum suşlarının fenotipik ve genotipik özelliklerinin izolasyonu ve incelenmesi ile ilgilidir . Bu amaç için, karaciğer, dalak, böbrek ve bağırsak örnekleri fenotipik özelliklerini ve biyokimyasal kimlik incelemek üzere Haziran 2014 farklı kafes çiftliklerinde yaklaşık 250-300 g ağırlığında alabalık farklı gökkuşağı alınmıştır V. anguillarum , Biolog Sistemi, gökkuşağı alabalığından alınan örneklerden elde edilen saf vibrio suşlarına uygulandı. 20 V. anguillarumu doğrulamak için spesifik bir primer ile polimeraz zincir reaksiyon tekniği kullanıldıfenotipik ve biyokimyasal özelliklere göre belirlenen suşlar. Daha sonra, bunların hepsinin V. anguillarum olduğu doğrulandı . Örneklerden elde edilen V. anguillarum suşlarının sekans analizi gerçekleştirildi ve daha sonra bunların karşılık gelen verileri yorumlandı. Bu çalışmanın sonucunda V. anguillarum bakterileri iki farklı alabalık kafesi çiftliğinde tespit edilmiştir. V. anguillarum'un tanımlanma süresi kültür yöntemi ile üç hafta sürerken , kısa sürede PCR tekniği ile yapıldı. ","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42826833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Chitosan on Oxidative Stress in Liver of Rats Loaded With Lead Acetate 壳聚糖对醋酸铅负载大鼠肝脏氧化应激的影响

IF 0.4 4区农林科学

Journal of the Hellenic Veterinary Medical Society Pub Date : 2023-01-20 DOI: 10.12681/jhvms.24541

U. Ozdek, H. Toz, AU Kömüroğlu, L. Mis, Y. Değer

{"title":"The Impact of Chitosan on Oxidative Stress in Liver of Rats Loaded With Lead Acetate","authors":"U. Ozdek, H. Toz, AU Kömüroğlu, L. Mis, Y. Değer","doi":"10.12681/jhvms.24541","DOIUrl":"https://doi.org/10.12681/jhvms.24541","url":null,"abstract":"This study was conducted to determine the impact of chitosan on lead (Pb)-induced hepatotoxicity. Thus, lead acetate was administered intraperitoneally (50 mg/kg for 5 days) and chitosan was given as 200 mg/kg via oral gavage for 28 days. When the trial was terminated, it was determined that aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in serum as well as Pb, 8-hydroxy-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels and catalase (CAT) activity in liver tissue significantly increased, however reduced glutathione (GSH) and ceruloplasmin (Cp) levels in liver and high density lipoproteins (HDL) in serum had a significant decrease in the Pb group when compared to the control group. The administration of chitosan significantly prevented Pb-induced changes in serum liver enzyme activities, 8-OHdG and MDA levels. In addition, chitosan showed a statistically insignificant effect on reduced GSH, Cp, HDL levels and CAT activity. Accordingly, administration of chitosan can strengthen the antioxidant defence system of liver tissue and may decrease oxidative stress.","PeriodicalId":17314,"journal":{"name":"Journal of the Hellenic Veterinary Medical Society","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46177191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0