Journal of The Chinese Institute of Chemical Engineers最新文献_第2页

Effect of mycelial morphology on bioreactor performance and avermectin production of Streptomyces avermitilis in submerged cultivations 菌丝形态对阿维菌链霉菌生物反应器性能和阿维菌素产量的影响

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.04.008

Peng Yin, Yong-Hong Wang, Si-Liang Zhang, Ju Chu, Ying-Ping Zhuang, Ning Chen, Xin-Feng Li, Yan-Bin Wu

引用次数: 29

Discovery of novel inhibitors for c-Met by virtual screening and pharmacophore analysis 通过虚拟筛选和药效团分析发现新的c-Met抑制剂

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.05.009

Calvin Yu-Chian Chen

{"title":"Discovery of novel inhibitors for c-Met by virtual screening and pharmacophore analysis","authors":"Calvin Yu-Chian Chen","doi":"10.1016/j.jcice.2008.05.009","DOIUrl":"10.1016/j.jcice.2008.05.009","url":null,"abstract":"<div>The overexpression of human c-Met tyrosine kinase induces the tumor proliferation and migration. Commercial drug is still not available for inhibiting this target. The structure of human c-Met was simulated and validated by molecular modeling. Compounds from our laboratory database, including natural products and anticancer agents, were employed for the docking analysis. De Novo drug design was further performed for three compounds with highest DockScore value to discover the novel inhibitors. Through the adsorption, distribution, metabolism, excretion and toxicity (ADMET) descriptor, only compounds A2, B3, C2 and C5 were selected. Through the pharmacophore analysis, ARG1086, HIS1088, ARG1208, ASN1209, ALA1226, ARG1227, ASP1228, TYR1230, and GLU1233 were suggested as the key residues because of strong pharmacophore features. In addition, the pharmacophore features of candidates consisted with the active site properties. The added fragments produced the strong interaction with the surrounding residues and yielded hydrogen bonds (HBs). Thus, the interaction energy between the ligand and the receptor was enhanced. Besides, the values of several scoring functions (PLP1, PLP2, and DockScore) of candidates were comparatively higher than compounds A, B, C, and Kirin. According to the aforementioned analyses, compounds A, A2, B, B3, C, C2 and C5 were suggested as the potent c-Met inhibitors. Besides, the scaffolds of compounds A, B, and C provided the direction for further drug design.</div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.05.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86478348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Kinetic study of S-alkylation of 2-mercaptobenzimidazole by allyl bromide in the presence of potassium hydroxide 氢氧化钾存在下烯丙基溴s -烷基化2-巯基苯并咪唑的动力学研究

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.05.013

Maw-Ling Wang , Yen-Chun Liu

{"title":"Kinetic study of S-alkylation of 2-mercaptobenzimidazole by allyl bromide in the presence of potassium hydroxide","authors":"Maw-Ling Wang , Yen-Chun Liu","doi":"10.1016/j.jcice.2008.05.013","DOIUrl":"10.1016/j.jcice.2008.05.013","url":null,"abstract":"<div>The S-alkylation (substitution on sulfur atom) of 2-mercaptobenzimidazole (MBI or ArSH) by allyl bromide (RBr) was successfully carried out in an aqueous solution of KOH/organic solvent two-phase medium. The reaction, which may take place either in the organic phase or on the interface, is greatly enhanced in the presence of KOH without the aid of quaternary salts as the catalyst to promote the reaction. No product was obtained from N-alkylation (substitution on nitrogen atom) during or after the reaction period by using a limited amount of allyl bromide (RBr) relative to that of MBI. Based on the experimental evidence, the kinetic behaviors and the characteristics of the reaction are sufficiently described by the pseudo-first-order rate law. The effects of the reaction conditions, including the agitation speed, the amount of KOH, volume of water, volume of dichloromethane, amount of allyl bromide, amount of 2-mercaptobenzimidazole, organic solvents and temperature on the conversion of allyl bromide and the apparent rate constants (kapp) were investigated in detail. Peculiar result is obtained in studying the effect of the volume of water on the conversion (or the reaction rate) in this work. Rational explanations are provided for the observed phenomena from experimental results.</div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.05.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89523195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Membrane extraction in rectangular modules with external recycle 外循环矩形模组膜萃取

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.06.001

Ho-Ming Yeh

引用次数: 2

Application of internal reflux in the raffinate phase for membrane extraction in cross-flow rectangular modules 内回流法在横流式矩形模块中膜萃取的应用

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.05.010

Ho-Ming Yeh

引用次数: 3

Use of surface response methodology to optimize culture conditions for iturin A production by Bacillus subtilis in solid-state fermentation 利用表面响应法优化枯草芽孢杆菌固态发酵产iturin A的培养条件

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.05.005

Ing-Lung Shih , Chia-Yu Kuo , Feng-Chia Hsieh , Suey-Sheng Kao , Chienyan Hsieh

{"title":"Use of surface response methodology to optimize culture conditions for iturin A production by Bacillus subtilis in solid-state fermentation","authors":"Ing-Lung Shih , Chia-Yu Kuo , Feng-Chia Hsieh , Suey-Sheng Kao , Chienyan Hsieh","doi":"10.1016/j.jcice.2008.05.005","DOIUrl":"10.1016/j.jcice.2008.05.005","url":null,"abstract":"<div>Response surface methodology (RSM) was employed to optimize the cultivation conditions of Bacillus subtilis S3 for the enhancement of iturin A, a lipopeptide antibiotic used as biological pesticide, production in solid-state fermentation (SSF). The statistic experimental model predicted a maximum iturin production of 11.435mg/g-wet solid material. Verification of the calculated maximum was done with experiments that were performed in the culture media representing the optimum combination found, and the iturin A production of 11.447mg/g-wet solid material (average of three repeats) was obtained when B. subtilis S3 was cultivated at 25°C for 5 days in solid fermentation containing high gluten flour 10g and rice bran 50g in addition to glucose 1.15%, KH2PO4 1.27mM, MgSO4 5.08mM, peanut oil 1.01%, inoculum 19.49% and water content 44.97%. The iturin A production by B. subtilis S3 was increased significantly by 23%, from 9.26mg/g-wet solid material to 11.447mg/g-wet solid material when the strain was cultivated in the optimal medium developed by surface response methodology, as compared to medium conventionally developed by one-factor-at-a-time. The yield of iturin A (11.447mg/g-wet solid material, with 45% moisture content) produced by B. subtilis S3 reported in this study is the highest reported to date for B. subtilis species in SSF. In addition, the use of rice bran as a substrate in solid-state fermentation for iturin A production by B. subtilis is unique.</div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.05.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79126371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Ultrasonic extraction of ferulic acid from Ligusticum chuanxiong 超声波提取川芎中阿魏酸的研究

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.05.012

Yongyue Sun , Wenhua Wang

引用次数: 28

Design and operation of a modified silica gel column chromatography 改进硅胶柱色谱法的设计与操作

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.06.006

Setiyo Gunawan, Suryadi Ismadji, Yi-Hsu Ju

{"title":"Design and operation of a modified silica gel column chromatography","authors":"Setiyo Gunawan, Suryadi Ismadji, Yi-Hsu Ju","doi":"10.1016/j.jcice.2008.06.006","DOIUrl":"10.1016/j.jcice.2008.06.006","url":null,"abstract":"<div>Liquid–solid chromatography (LSC) is the oldest of the various liquid chromatography methods. Despite the fact that high-performance liquid chromatography (HPLC) operation leads to better separation and analysis, classical column chromatography and thin-layer chromatography (TLC) are still widely practiced because of their convenience. In this study, a modified silica gel column chromatography was designed with the objective of reducing the amount of solvent required to achieve the same degree of separation as the classical silica gel column chromatography. The separation of squalene and fatty acid steryl esters (FASEs) from non-polar lipid fraction (NPLF) of soybean oil deodorizer distillate (SODD) was employed as a model system to test the effectiveness of this new design. Modified silica gel column chromatography process is feasible from economic point of view compare to classical silica gel column chromatography because it significantly reduces the amount of solvent and time required to achieve the same degree of separation. By employing modified silica gel column chromatography to obtain the squalene-rich fraction, the mobile phase volume and elution time required as fractions of those needed in classical silica gel column chromatography are 1/73 and 1/18, respectively. To obtain the FASEs-rich fraction, the corresponding mobile phase volume and elution time are 1/221 and 1/23, respectively of those needed in classical silica gel column chromatography.</div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83782772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Ternary diffusion coefficients of monoethanolamine and N-methyldiethanolamine in aqueous solutions 单乙醇胺和n -甲基二乙醇胺在水溶液中的三元扩散系数

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.04.007

Chih-Chiang Ko, Wen-Haur Chang, Meng-Hui Li

引用次数: 7

Decolorization of Brilliant Blue G dye mediated by degradation of the microbial consortium of Galactomyces geotrichum and Bacillus sp. 半乳菌与芽孢杆菌联合降解对亮蓝G染料脱色的影响。

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-11-01 DOI: 10.1016/j.jcice.2008.06.003

Sheetal U. Jadhav , Mital U. Jadhav , Anuradha N. Kagalkar , Sanjay P. Govindwar

{"title":"Decolorization of Brilliant Blue G dye mediated by degradation of the microbial consortium of Galactomyces geotrichum and Bacillus sp.","authors":"Sheetal U. Jadhav , Mital U. Jadhav , Anuradha N. Kagalkar , Sanjay P. Govindwar","doi":"10.1016/j.jcice.2008.06.003","DOIUrl":"10.1016/j.jcice.2008.06.003","url":null,"abstract":"<div>A consortium-GB containing two microorganisms Galactomyces geotrichum MTCC 1360 and Bacillus sp. VUS was able to degrade sulfur-containing dye Brilliant Blue G, optimally at pH 9 and temperature at 50°C. The ability of consortium-GB to work at higher temperature and pH ranges will help in using this consortium for removal of the dye from textile effluent. Malt extract, peptone and beef extract were found to be the best additional carbon and nitrogen sources. Brilliant Blue G caused enhancement of the riboflavin reductase among the enzyme activities studied. Biodegradation was confirmed by analyzing the product using UV–vis, HPLC, and FTIR. The GC–MS study revealed a pathway of Brilliant Blue G with release of (4-ethoxy-phenyl)-phenyl-amine and 3-ethylaminomethyl-benzenesulfonic acid as final metabolites formed by the consortium-GB. GC–MS analysis indicated the formation of 3-{[ethyl-(3-methyl-cyclohexa-2,5-dienyl)-amino]-methyl}-benzenesulfonic acid as a product by G. geotrichum MTCC 1360 alone and (4-benzylidene-3-methyl-cyclohexa-2,5-dienylidene)-methyl-amine by Bacillus sp. VUS alone. Phytotoxicity revealed nontoxic nature of the metabolites. These results indicate the high potential of the consortium-GB to serve as an excellent biomass for the use in Brilliant Blue G dye removal.</div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80086973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 106