Journal of The Chinese Chemical Society最新文献_第7页

Developing tyrosine phosphoproteome libraries and dual quantification using a hybrid DIA approach 利用混合 DIA 方法开发酪氨酸磷酸化蛋白质组文库并进行双重定量

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-19 DOI: 10.1002/jccs.202400136

Chiao-Chun Chang, Irene-Ya Tai, Shen-Shian Chan, Yu-Hsuan Lin, Yu-Ju Chen, Yi-Ju Chen

{"title":"Developing tyrosine phosphoproteome libraries and dual quantification using a hybrid DIA approach","authors":"Chiao-Chun Chang, Irene-Ya Tai, Shen-Shian Chan, Yu-Hsuan Lin, Yu-Ju Chen, Yi-Ju Chen","doi":"10.1002/jccs.202400136","DOIUrl":"10.1002/jccs.202400136","url":null,"abstract":"Protein tyrosine phosphorylation plays a critical role in initiating upstream cellular signaling transduction. However, the challenge in biological samples is the variability in relative concentrations (0.1%) of site-specific tyrosine phosphorylation on proteins. To navigate these fluctuations and accurately quantify the absolute levels of tyrosine phosphosites among different samples, we reported a hybrid data-independent acquisition-parallel reaction monitoring (DIA-PRM) MS technique for the robust identification and quantification of the phosphoproteome, the establishment of a comprehensive library of tyrosine phosphosites, and the specific assessment of changes in tyrosine phosphorylation. In our model study on non-small cell lung cancer cells, our PRM strategy accomplished by a spiked-in synthetic heavy phosphopeptide demonstrated reliable targeted quantification of the pY1197 on EGFR, revealing levels of 2.5, 4.9, and 5.3 fmol in pervanadate (PV)-treated cells at 0, 15, and 30 min, respectively. Additionally, DIA-extensive phosphoproteomic analysis provided 2765 tyrosine phosphosites within 14,961 global phosphosites corresponding to 1536 phosphoproteins, contributing to the phospho-library establishment and relative quantification of phosphorylation level, especially in the PV-treated time-dependent increase of ErbB signaling pathway. This hybrid DIA-PRM approach will advance the application of precise measurement of changes in multiple phosphotyrosine residues and enhance our understanding of phosphoproteomic dynamics in drug-resistant cascades.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141512650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Preview: Journal of the Chinese Chemical Society 06/2024 预览：中国化学会志 06/2024

IF 1.8 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-17 DOI: 10.1002/jccs.202406001

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Contents and Masthead: Journal of the Chinese Chemical Society 06/2024 内容和刊头：中国化学会志 06/2024

IF 1.8 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-17 DOI: 10.1002/jccs.1846

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Cover: Journal of the Chinese Chemical Society 06/2024 封面：中国化学会志 06/2024

IF 1.8 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-17 DOI: 10.1002/jccs.1845

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Pyrene-based ratiometric fluorescent chemosensor for sensitive detection of hypochlorite in a perfect aqueous solution 基于芘的比率荧光化学传感器，用于灵敏检测完美水溶液中的次氯酸盐

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-14 DOI: 10.1002/jccs.202400074

Munseok Kang, Jae Jun Lee, Dongkyun Gil, Sooseong Lee, Cheal Kim

{"title":"Pyrene-based ratiometric fluorescent chemosensor for sensitive detection of hypochlorite in a perfect aqueous solution","authors":"Munseok Kang, Jae Jun Lee, Dongkyun Gil, Sooseong Lee, Cheal Kim","doi":"10.1002/jccs.202400074","DOIUrl":"10.1002/jccs.202400074","url":null,"abstract":"We synthesized a pyrene-based sensitive fluorescent chemosensor, TPA-Cl ((E)-N,N,N-trimethyl-2-oxo-2-(2-(pyren-1-ylmethylene)hydrazinyl)ethan-1-aminium chloride), to detect hypochlorite in a perfect aqueous solution. TPA-Cl showed high selectivity for hypochlorite through fluorescence color change from sky blue to blue. The detection limit for hypochlorite was calculated as 0.27 μM, which is a quite low value. Moreover, the presence of other anions or ROS hardly hindered the sensing of hypochlorite by TPA-Cl. Furthermore, TPA-Cl could be applied successfully as a test kit for the simple recognition of hypochlorite. Surprisingly, TPA-Cl is the first pyrene-based fluorescent chemosensor that can detect ClO− by using the TPA-Cl-coated test kit. Moreover, TPA-Cl could achieve the quantification of ClO− in various environmental water samples. The hydrolytic cleavage and oxidation mechanism of TPA-Cl by hypochlorite was elucidated through UV–vis and fluorescent spectroscopy, 1H NMR titration, ESI-MS analysis and DFT calculation.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis, biological evaluation, and computational studies of thiazolyl hydrazone derivatives as triple mutant allosteric EGFR inhibitors 作为三重突变异构表皮生长因子受体抑制剂的噻唑腙衍生物的合成、生物学评价和计算研究

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-11 DOI: 10.1002/jccs.202400084

Sonali S. Shinde, Aniket P. Sarkate, Sanket S. Rathod, Jaydeo T. Kilbile, Somdatta Y. Chaudhari, Rajesh Yadala, Smita C. Pawar, Pravin S. Wakte

{"title":"Synthesis, biological evaluation, and computational studies of thiazolyl hydrazone derivatives as triple mutant allosteric EGFR inhibitors","authors":"Sonali S. Shinde, Aniket P. Sarkate, Sanket S. Rathod, Jaydeo T. Kilbile, Somdatta Y. Chaudhari, Rajesh Yadala, Smita C. Pawar, Pravin S. Wakte","doi":"10.1002/jccs.202400084","DOIUrl":"10.1002/jccs.202400084","url":null,"abstract":"Herein, new thiazole-2-yl-based hydrazone derivatives were synthesized and assessed for in vitro anticancer activity against wild type A549, MCF7, DU145, and mutant H1975 cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all, 4-(4-Chlorophenyl)-2-(2-((4-methylthiazol-5-yl)methylene)hydrazineyl)thiazole (4b) elicited prominent anticancer activity against wild-type epidermal growth factor receptor (WT-EGFR) MCF7 cancer cell line with an IC50 value of 9.57 ± 1.80 μM, whereas 4-Methyl-5-((2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazineylidene)methyl)thiazole (4c) showed appreciable activity with an IC50 value of 11 ± 0.7 μM against the mutated EGFR H1975 lung cancer cells. Doxorubicin and Osimertinib were used as the standard drugs for comparison of activity. Compound (4b) significantly increased early apoptosis (30.2%) and late apoptosis (7.6%) at a 5 μM concentration in comparison with the control (early apoptosis 2.5%, late apoptosis 1.2%). The molecular docking study was performed against mutant EGFR (T790M/C797S) (PDB: 5D41) enzyme to gain information about interactions of synthesized molecules with binding pockets. Moreover, ADME study and molecular dynamic simulation studies were accomplished to gain insight into drug-likeness and conformational stability, respectively. The findings demonstrate a promising alignment between the observed anticancer effects and computational analyses.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141357302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Polyoxometalates for carbon dioxide activation: Current progress and perspective 用于二氧化碳活化的聚氧化金属盐：当前进展与前景

IF 1.8 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-05 DOI: 10.1002/jccs.202300248

Hadia Ahsan, Muhammad Saeed, Waleed Ahmad, Abdul Rehman, Abdul Haseeb Bashir, Vaneeza Aiman, Tasmia Irshad, Tuba Irtza, Usman Zahid

{"title":"Polyoxometalates for carbon dioxide activation: Current progress and perspective","authors":"Hadia Ahsan, Muhammad Saeed, Waleed Ahmad, Abdul Rehman, Abdul Haseeb Bashir, Vaneeza Aiman, Tasmia Irshad, Tuba Irtza, Usman Zahid","doi":"10.1002/jccs.202300248","DOIUrl":"10.1002/jccs.202300248","url":null,"abstract":"The elevated level of carbon dioxide (CO2) in the troposphere is playing a crucial role in changing the earth's climatic system. Excess CO2 concentration is trapping a substantial proportion of heat imparting adverse range of environmental effects like extreme weather events, agricultural impacts and disruption of the ecosystem. Strategies such as CO2 capturing and storage are being pursued using polyoxometalates (POMs) to mitigate the elevated level of CO2 and their efficient conversion into useful chemicals. This review outlines the importance of CO2 reduction by electrocatalytic and photocatalytic reduction of CO2. POMs have several advantages for CO2 activation because of their promising catalytic activity, high selectivity and versatility for incorporating different metal ions and ligands. The efficient redox active metal center facilitates the conversion of CO2 by providing sufficient activation energy. Their robust structure also enables them resist harsh conditions, including high temperature and acidic or basic conditions. Owing to these properties, POMs can be a catalyst, co-catalyst, photosensitizer or multielectron donor for CO2 reduction. Finally, we stated the challenges and future insight for CO2 activation using POMs.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141257425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enhancement of electrical properties by CuS–PVP nanocomposite on the ZnO/polymer heterojunction 氧化锌/聚合物异质结上的 CuS-PVP 纳米复合材料可增强电学特性

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-04 DOI: 10.1002/jccs.202400044

Bandhna Verma, Jehova Jire L. Hmar, H. C. Swart, Vinay Kumar

{"title":"Enhancement of electrical properties by CuS–PVP nanocomposite on the ZnO/polymer heterojunction","authors":"Bandhna Verma, Jehova Jire L. Hmar, H. C. Swart, Vinay Kumar","doi":"10.1002/jccs.202400044","DOIUrl":"10.1002/jccs.202400044","url":null,"abstract":"A nanocomposite matrix of covellite–polyvinylpyrrolidone (CuS–PVP) was synthesized through a solution processing method and applied via spin coating onto hydrothermally grown zinc oxide (ZnO) nanorods. Characterization techniques, including X-ray powder diffraction and scanning electron microscopy, confirmed the successful decoration of chain-like CuS–PVP polymer composites onto hexagonal ZnO nanorods. The UV-vis spectroscopy revealed an absorption peak at 372 nm, indicating excitonic absorption of ZnO, and a reduction in the band gap from 3.11 to 2.59 eV upon CuS–PVP polymer decoration, enhancing light harvesting efficiency. Photoluminescence spectra demonstrated the lowest charge carrier recombination rate in the ZnO/CuS–PVP sample, promoting efficient charge separation and transportation, supported by Fourier-transform infrared analysis indicating chemical bonding. Subsequently, the impact of CuS–PVP as an insertion layer in the ZnO/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) inorganic–organic heterojunction was investigated. Favorable band alignment between ZnO, CuS–PVP, and PEDOT:PSS improved conduction, increasing current from 0.3394 to 1.14 mA for D2 (poly-ethyleneterephthalate/Indium tin oxide/ZnO/PEDOT:PSS/Al) and D1 (poly-ethyleneterephthalate/Indium tin oxide/ZnO/CuS–PVP/PEDOT:PSS/Al) at a +2 V bias. Transient photo-responses (J–t) at 0 V bias revealed decreased rise and fall times from 0.382 and 1.154 s to 0.301 and 0.229 s for D2 and D1 devices, respectively. This novel approach provides control over charge carrier transport characteristics at the interface, potentially benefiting self-powered photo-detection in optoelectronic devices.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141258097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Magnetic solid phase adsorption of ceftiofur sodium in water by deep eutectic solvent modified banana peel-MnFe2O4 biochar 深共晶溶剂改性香蕉皮-锰铁氧化物生物炭对水中头孢噻呋钠的磁性固相吸附

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-06-03 DOI: 10.1002/jccs.202400087

Jing Chen, Hanyue Luo, Rui Lei, Cuiping Li, Xueqin Ding

{"title":"Magnetic solid phase adsorption of ceftiofur sodium in water by deep eutectic solvent modified banana peel-MnFe2O4 biochar","authors":"Jing Chen, Hanyue Luo, Rui Lei, Cuiping Li, Xueqin Ding","doi":"10.1002/jccs.202400087","DOIUrl":"10.1002/jccs.202400087","url":null,"abstract":"Magnetic solid phase adsorption separation (MSPA) technology is an efficient and convenient separation method, which can simplify the separation step and shorten the separation time. It has wide application value in the purification of antibiotic pollutants in water. In this study, a novel magnetic biochar adsorbent (DES1@MnFe2O4-BBC) with strong selectivity and high adsorption capacity was synthesized. It was composed of banana peel as the biochar source, Mn/Fe bimetallic oxide as the magnetic source and deep eutectic solvent (DES) as the functional monomer. The physicochemical properties of DES1@MnFe2O4-BBC were systematically characterized by nitrogen adsorption–desorption, synchronous thermal analyzer, vibrating sample magnetometer, X-ray diffractometer, X-ray photoelectron spectroscopy, and field emission electron microscopy. The adsorption conditions were optimized by the single-factor optimization method. Also, under the optimal adsorption conditions, the maximum adsorption capacity of DES1@MnFe2O4-BBC for ceftiofur sodium was 75.01 mg·g−1. The test of adsorption thermodynamics and kinetics illustrated that the Langmuir isotherm adsorption model and pseudo-second-order kinetic equation were suitable well with the adsorption system established in this article. Adsorbent regeneration cycle experiment revealed that the DES1@MnFe2O4-BBC was an efficient and reusable adsorbent. In the end, all research proves the novel magnetic adsorbent synthesized in this study can provide a new idea for the removal of antibiotics in water.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141259760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficient electrochemical immunosensor for detection of bovine interferon gamma-based gold nanoparticles/chitosan composite 基于金纳米粒子/壳聚糖复合材料的检测牛干扰素γ的高效电化学免疫传感器

IF 1.6 4区化学

Journal of The Chinese Chemical Society Pub Date : 2024-05-30 DOI: 10.1002/jccs.202400098

Yuru Wang, Jiayin Li, Juan Yang, Linan Yang, Qingwen Chen, Yan Long, Liuyang Cao, Zhanjun Yang, Hui Chen, Juan Li

{"title":"Efficient electrochemical immunosensor for detection of bovine interferon gamma-based gold nanoparticles/chitosan composite","authors":"Yuru Wang, Jiayin Li, Juan Yang, Linan Yang, Qingwen Chen, Yan Long, Liuyang Cao, Zhanjun Yang, Hui Chen, Juan Li","doi":"10.1002/jccs.202400098","DOIUrl":"10.1002/jccs.202400098","url":null,"abstract":"Interferon gamma (IFN-γ) released by T lymphocytes, plays an important role in immune regulation and is also an important biomarker for the early diagnosis of bovine tuberculosis. In this work, an electrochemical immunosensor based on gold nanoparticles (AuNPs)/chitosan composite was developed for highly sensitive determination of bovine IFN-γ. AuNPs/chitosan composite shows high surface area and good hydrophilicity. The bovine IFN-γ immunosensor was prepared by immobilizing IFN-γ antibody on AuNPs/chitosan composite-modified glassy carbon electrode. The immunosensors were characterized by scanning electron microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry (CV). Using horseradish peroxidase (HRP)-labeled IFN-γ antibody as amplification probe, the concentration of bovine IFN-γ can be monitored via the increasing current signal, which can be attributed to the specific immune binding between bovine IFN-γ antigen and HRP-labeled IFN-γ antibody, as well as the efficient catalysis reaction between thionine and HRP with the presence of H2O2. The developed electrochemical immunosensor exhibited a wide linear range of 0.01 to 30 ng/mL, and low detection limit of 0.003 ng/mL with good specificity and stability. This study provides a simple and promising method for diagnosis of bovine tuberculosis, which can be expanded to determine other biomarkers.","PeriodicalId":17262,"journal":{"name":"Journal of The Chinese Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141194314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0