Highly diastereoselective synthesis of annulated 2-acyl-2,3-dihydrofurans

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of The Chinese Chemical Society Pub Date : 2025-03-24 DOI:10.1002/jccs.70002

Juhua Feng, Juanhong Li, Qilin Huang, Wenjie Zou, Ailin Huang, Jinxiang Feng, Li Lin, Guizhou Yue, Jun Yang, Kuan Liu

引用次数: 0

Abstract

A simple and convenient method to synthesize annulated 2-acyl-2,3-dihydrofuran derivatives by Michael addition-alkylation reaction of α-bromochalcones and 5,5-dimethylcyclohexane-1,3-dione is described. This transformation was well compatible with various α-bromochalcones, and the corresponding 2-acyl-2,3-dihydrofurans were obtained in yields of up to 98%.

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高非对映选择性合成环状 2-酰基-2,3-二氢呋喃

介绍了α-溴查尔酮与5,5-二甲基环己烷-1,3-二酮的Michael加成-烷基化反应合成环状2-酰基-2,3-二氢呋喃衍生物的简便方法。该转化反应与多种α-溴查尔酮具有良好的相容性，得到相应的2-酰基-2,3-二氢呋喃，产率高达98%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of The Chinese Chemical Society 化学-化学综合

CiteScore

3.40

自引率

11.10%

发文量

216

审稿时长

7.5 months

期刊介绍： The Journal of the Chinese Chemical Society was founded by The Chemical Society Located in Taipei in 1954, and is the oldest general chemistry journal in Taiwan. It is strictly peer-reviewed and welcomes review articles, full papers, notes and communications written in English. The scope of the Journal of the Chinese Chemical Society covers all major areas of chemistry: organic chemistry, inorganic chemistry, analytical chemistry, biochemistry, physical chemistry, and materials science.