Journal of the Indian Medical Association最新文献_第3页

Myotonia congenita.

Journal of the Indian Medical Association Pub Date : 2019-11-11 DOI: 10.32388/418095

A. Chakravarti

引用次数: 0

Muscular Dystrophies 肌营养不良

Journal of the Indian Medical Association Pub Date : 2019-10-02 DOI: 10.4135/9781483392271.n332

Lawrence C. Joseph, Musole, Phosphogen, Innervation, logy, ey

引用次数: 1

TRIGEMINAL NEURALGIA. 三叉神经痛。

Journal of the Indian Medical Association Pub Date : 2019-01-01 DOI: 10.1891/9780826159311.0170

B. Chakravorty

引用次数: 0

Tay-Sachs disease 家族黑蒙性白痴病

Journal of the Indian Medical Association Pub Date : 2019-01-01 DOI: 10.1036/1097-8542.679470

Hongjie Chen

引用次数: 0

Cervical cancer. 子宫颈癌。

Journal of the Indian Medical Association Pub Date : 2018-10-08 DOI: 10.1201/9781315378381-46

Indra J. Das, N. Sanfilippo, A. Fogliata, L. Cozzi

{"title":"Cervical cancer.","authors":"Indra J. Das, N. Sanfilippo, A. Fogliata, L. Cozzi","doi":"10.1201/9781315378381-46","DOIUrl":"https://doi.org/10.1201/9781315378381-46","url":null,"abstract":"“Koilocyte” diagnostic of HPV infection. The koilocyte has a collapse of its keratins peripherally, leaving an empty space around the nucleus. The nucleus also shows increased amounts of hematoxylin staining, reflecting increased DNA content due to unscheduled DNA synthesis from the HPV . Biopsies of gross lesions are done. Colposcopy with biopsy of abnormal areas may be done as indicated. Endocervical curettage and cold knife conization (CKC) are often performed to determine depth of invasion and presence of lymphovascular space invasion in early stage cervical cancers with a normal appearing cervix by inspection and pelvic examination only. A CKC involves an excision of the transformation zone in a cone-shaped specimen with the apex of the cone pointed toward the endocervical canal beyond the transformation zone. Loop excisional electrocautery (LEEP) is typically used to treat CIN II-III. Compared to a LEEP, the CKC (in which cautery is only used after the excision to stop bleeding), preserves the morphology of the tissue to allow an accurate evaluation of the extent of disease by pathologists. The extent of the primary tumor, evident in a CKC is part of the information defined by the term “stage”, and the stage of a cervical cancer then determines the necessity for additional treatment. Cystoscopy and proctoscopy can be done to evaluate for a higher stage tumor defined by invasion of tumor into the bladder or rectum, respectfully. cervical intraepithelial neoplasia to cervical carcinoma in situ to invasive cervical cancer and human papillomavirus infection is central to the development of cervical cancer. These three facts mean that the appearance of invasive cancer can be prevented with early intervention.","PeriodicalId":17244,"journal":{"name":"Journal of the Indian Medical Association","volume":"95 2 1","pages":"62-3"},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47171169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary tract infection 尿路感染

Journal of the Indian Medical Association Pub Date : 2018-08-01 DOI: 10.1093/med/9780199568741.003.0158

W. Herrington, A. Chakera, C. O'Callaghan

引用次数: 1

Mechanisms of T cell organotropism. T 细胞有机生长的机制

IF 8

Journal of the Indian Medical Association Pub Date : 2016-08-01 Epub Date: 2016-04-01 DOI: 10.1007/s00018-016-2211-4

Hongmei Fu, Eleanor Jayne Ward, Federica M Marelli-Berg

引用次数: 0

A futile exercise: The International Peace Monitoring Team in Solomon Islands, 2000–02 徒劳无功:2000 - 2002年所罗门群岛国际和平监测队

Journal of the Indian Medical Association Pub Date : 2016-07-15 DOI: 10.1017/CBO9781139196390.022

B. Breen

引用次数: 0

Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance. 人类前列腺癌中频繁出现的 HLA I 类改变：分子机制和临床意义。

IF 5.8

Journal of the Indian Medical Association Pub Date : 2016-01-01 Epub Date: 2015-11-26 DOI: 10.1007/s00262-015-1774-5

Francisco Javier Carretero, Ana Belen Del Campo, Jose Francisco Flores-Martín, Rosa Mendez, Cesar García-Lopez, Jose Manuel Cozar, Victoria Adams, Stephen Ward, Teresa Cabrera, Francisco Ruiz-Cabello, Federico Garrido, Natalia Aptsiauri

{"title":"Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance.","authors":"Francisco Javier Carretero, Ana Belen Del Campo, Jose Francisco Flores-Martín, Rosa Mendez, Cesar García-Lopez, Jose Manuel Cozar, Victoria Adams, Stephen Ward, Teresa Cabrera, Francisco Ruiz-Cabello, Federico Garrido, Natalia Aptsiauri","doi":"10.1007/s00262-015-1774-5","DOIUrl":"10.1007/s00262-015-1774-5","url":null,"abstract":"<p><p>Reduced expression of HLA class I is an important immune escape mechanism from cytotoxic T cells described in various types of malignancy. It often correlates with poor prognosis and resistance to therapy. However, current knowledge about the frequency, underlying molecular mechanisms, and prognostic value of HLA class I and II alterations in prostate cancer (PC) is limited. Immunohistochemical analysis demonstrated that 88 % of the 42 studied cryopreserved prostate tumors have at least one type of HLA alteration as compared to adjacent normal prostate epithelium or benign hyperplasia. Total loss of HLA-I expression found in 50 % of tumors showed an association with increased incidence of tumor relapse, perineural invasion, and high D'Amico risk. The remaining HLA-I-positive tumors demonstrated locus and allelic losses detected in 26 and 12 % of samples, respectively. Loss of heterozygosity at chromosome 6 was detected in 32 % of the studied tumors. Molecular analysis revealed a reduced expression of B2M, TAP2, tapasin and NLRC5 mRNA in microdissected HLA-I-negative tumors. Analysis of twelve previously unreported cell lines derived from neoplastic and normal epithelium of cancerous prostate revealed different types of HLA-I aberration, ranging from locus and/or allelic downregulation to a total absence of HLA-I expression. The high incidence of HLA-I loss observed in PC, caused by both regulatory and structural defects, is associated with more aggressive disease development and may pose a real threat to patient health by increasing cancer progression and resistance to T-cell-based immunotherapy. </p>","PeriodicalId":17244,"journal":{"name":"Journal of the Indian Medical Association","volume":"37 1","pages":"47-59"},"PeriodicalIF":5.8,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11029306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72679688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HEREDITARY ectodermal dysplasia. 遗传性外胚层发育不良。

Journal of the Indian Medical Association Pub Date : 2015-08-01 DOI: 10.1016/j.oooo.2015.02.159

Robeci Alves Macedo Filho, F. D. Verli, D. J. Sarmento, S. Carvalho, G. Agripino, M. GORDÓN-NÚÑEZ, S. A. Marinho

引用次数: 0