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FRONTIER-2: A phase 2b, long-term extension, dose-ranging study of oral JNJ-77242113 for the treatment of moderate-to-severe plaque psoriasis. FRONTIER-2：口服 JNJ-77242113 治疗中重度斑块状银屑病的 2b 期长期扩展剂量范围研究。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-14 DOI: 10.1016/j.jaad.2024.10.076
Laura K Ferris, Jerry Bagel, Yu-Huei Huang, Andrew E Pink, Stephen K Tyring, Georgios Kokolakis, Amy M DeLozier, Shu Li, Yaung-Kaung Shen, Charles Iaconangelo, Takayuki Ota, Robert Bissonnette
{"title":"FRONTIER-2: A phase 2b, long-term extension, dose-ranging study of oral JNJ-77242113 for the treatment of moderate-to-severe plaque psoriasis.","authors":"Laura K Ferris, Jerry Bagel, Yu-Huei Huang, Andrew E Pink, Stephen K Tyring, Georgios Kokolakis, Amy M DeLozier, Shu Li, Yaung-Kaung Shen, Charles Iaconangelo, Takayuki Ota, Robert Bissonnette","doi":"10.1016/j.jaad.2024.10.076","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.076","url":null,"abstract":"<p><strong>Background: </strong>More patients with moderate-to-severe plaque psoriasis achieved responses with JNJ-77242113, a targeted oral peptide inhibiting interleukin (IL)-23 receptor signaling, versus placebo at Week(W)16 of the phase 2 FRONTIER-1 study.</p><p><strong>Objective: </strong>FRONTIER-2, a long-term extension of FRONTIER-1, evaluated JNJ-77242113 through 1 year.</p><p><strong>Methods: </strong>FRONTIER-1 participants received JNJ-77242113 at doses from 25mg once daily (QD) to 100mg twice daily (BID) or placebo, through W16. Patients completing FRONTIER-1 could enroll in FRONTIER-2 and continue JNJ-77242113 at the same dose through W52. Those on placebo crossed over to JNJ-77242113 100mg QD for W16-52. Safety follow-up continued through W56.</p><p><strong>Results: </strong>Most (89%) FRONTIER-1 patients continued to FRONTIER-2. Across outcomes, response rates were maintained from W16-52. The highest response rates generally occurred with JNJ-77242113 100mg BID. At W52, 76% of patients achieved up to 75% improvement in Psoriasis Area and Severity Index (PASI75) with 100mg BID; rates of clear or almost clear skin were 64% (PASI90), 74% (Investigator's Global Assessment [IGA]0/1), 40% (PASI100), and 43% (IGA 0). From W16-56, 59% of JNJ-77242113-treated patients had ≥1 adverse events (AEs). Serious AEs, considered unrelated to treatment by investigators, occurred in 4% of patients.</p><p><strong>Limitations: </strong>The study was limited by the small number of patients in each treatment group and the descriptive nature of the longer-term data.</p><p><strong>Conclusion: </strong>Rates of skin clearance with JNJ-77242113 were durable to 1 year and no safety signals were identified.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAAD Game Changers: "A retrospective study of squamous cell carcinoma of the nail unit diagnosed in a Belgian general hospital over a 15-year period". JAAD Game Changers："对比利时一家综合医院 15 年间诊断出的指甲鳞状细胞癌的回顾性研究"。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-14 DOI: 10.1016/j.jaad.2024.10.089
Faramarz Samie
{"title":"JAAD Game Changers: \"A retrospective study of squamous cell carcinoma of the nail unit diagnosed in a Belgian general hospital over a 15-year period\".","authors":"Faramarz Samie","doi":"10.1016/j.jaad.2024.10.089","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.089","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-steroidal Immune Modulating Therapies and Reduced Risk of Adverse Cardiovascular Events in Dermatomyositis and Polymyositis: A Cohort Study in the All of Us Research Program. 非类固醇免疫调节疗法与降低皮肌炎和多发性肌炎不良心血管事件的风险：我们所有人研究计划的队列研究》。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.10.075
Jill T Shah, Keya T Shah, Soutrik Mandal, Michael S Garshick, Alisa N Femia
{"title":"Non-steroidal Immune Modulating Therapies and Reduced Risk of Adverse Cardiovascular Events in Dermatomyositis and Polymyositis: A Cohort Study in the All of Us Research Program.","authors":"Jill T Shah, Keya T Shah, Soutrik Mandal, Michael S Garshick, Alisa N Femia","doi":"10.1016/j.jaad.2024.10.075","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.075","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of 8th edition AJCC staging changes on sentinel lymph node biopsy practices in melanoma. 第 8 版 AJCC 分期变化对黑色素瘤前哨淋巴结活检操作的影响。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.09.077
Gabriella N Tortorello, Neha Shafique, Anushka Dheer, Emily Y Chu, Michael E Ming, John T Miura, Giorgos C Karakousis
{"title":"Impact of 8<sup>th</sup> edition AJCC staging changes on sentinel lymph node biopsy practices in melanoma.","authors":"Gabriella N Tortorello, Neha Shafique, Anushka Dheer, Emily Y Chu, Michael E Ming, John T Miura, Giorgos C Karakousis","doi":"10.1016/j.jaad.2024.09.077","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.09.077","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the role of dietary glycemic factors and antioxidant capacity, metabolic status, and oxidative stress in seborrheic dermatitis: A case-control study. 调查膳食血糖因素和抗氧化能力、代谢状态及氧化应激在脂溢性皮炎中的作用：病例对照研究。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.10.078
Yavuz Semiz, Ezgi Aktaş
{"title":"Investigating the role of dietary glycemic factors and antioxidant capacity, metabolic status, and oxidative stress in seborrheic dermatitis: A case-control study.","authors":"Yavuz Semiz, Ezgi Aktaş","doi":"10.1016/j.jaad.2024.10.078","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.078","url":null,"abstract":"<p><strong>Background: </strong>The etiopathogenesis of seborrheic dermatitis (SD) remains unexplained, although several factors have been considered in this regard.</p><p><strong>Objective: </strong>The aim of this study is to investigate diet, metabolic status, and oxidative stress in SD patients.</p><p><strong>Methods: </strong>This prospective, single-center, case-control study included 49 SD patients and 40 gender- and age-matched healthy controls.</p><p><strong>Results: </strong>Dietary total antioxidant capacity values ​​were significantly lower in SD patients than among the controls (7.16 ± 2.66 vs. 12.85 ± 4.26; p < 0.001). Glycemic load (GL) values ​​were significantly higher in SD patients (187.2 ± 57.2 vs. 110.6 ± 46.5; p < 0.001). The glycemix index (GI) and GL values ​​of patients with severe SD were significantly higher than those with mild SD (p = 0.014, p = 0.017; respectively).</p><p><strong>Limitations: </strong>The cross-sectional design, small sample size, and the relatively short duration of questioning dietary habits are the limitations of the study.</p><p><strong>Conclusion: </strong>A diet rich in antioxidants and with low GI/GL content may be beneficial in the treatment of SD.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of nail gutter therapy and topical timolol for treating epidermal growth factor receptor inhibitor-induced nail changes: a randomized, single-blind, intra-individual study. 甲沟炎疗法和外用噻吗洛尔治疗表皮生长因子受体抑制剂引起的甲变化的有效性和安全性：一项随机、单盲、个体内研究。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.11.006
Isara Yenyuwadee, Sasitorn Yenyuwadee, Chuda Rujitharanawong, Charussri Leeyaphan, Sasima Eimpunth, Suthinee Ithimakin, Leena Chularojanamontri
{"title":"Efficacy and safety of nail gutter therapy and topical timolol for treating epidermal growth factor receptor inhibitor-induced nail changes: a randomized, single-blind, intra-individual study.","authors":"Isara Yenyuwadee, Sasitorn Yenyuwadee, Chuda Rujitharanawong, Charussri Leeyaphan, Sasima Eimpunth, Suthinee Ithimakin, Leena Chularojanamontri","doi":"10.1016/j.jaad.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.11.006","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blastic plasmacytoid dendritic cell neoplasm: Extensive disease, Langer lines, and blood burden in a retrospective study of 66 cases. 大疱性浆细胞树突状细胞瘤：66 例病例回顾性研究中的广泛性疾病、朗格系和血液负担。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.11.010
Christopher J Fay, Jesse P Hirner, Shai Shimony, Ai-Tram Bui, Andrew A Lane, Nicole R LeBoeuf
{"title":"Blastic plasmacytoid dendritic cell neoplasm: Extensive disease, Langer lines, and blood burden in a retrospective study of 66 cases.","authors":"Christopher J Fay, Jesse P Hirner, Shai Shimony, Ai-Tram Bui, Andrew A Lane, Nicole R LeBoeuf","doi":"10.1016/j.jaad.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.11.010","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAAD Game Changers: "Consumption of dairy in teenagers with and without acne". JAAD Game Changers："有痤疮和没有痤疮的青少年食用奶制品的情况"。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.10.093
Eden Lake
{"title":"JAAD Game Changers: \"Consumption of dairy in teenagers with and without acne\".","authors":"Eden Lake","doi":"10.1016/j.jaad.2024.10.093","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.093","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of the COVID-19 Pandemic and the iPLEDGE REMS Update on Isotretinoin Prescription Delays and Interruptions: An Interrupted Time Series Analysis. COVID-19 大流行和 iPLEDGE REMS 更新对异维A酸处方延迟和中断的影响：中断时间序列分析》。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.10.077
Emma Beagles, Hye Jin Chung, Allen Shih
{"title":"The Impact of the COVID-19 Pandemic and the iPLEDGE REMS Update on Isotretinoin Prescription Delays and Interruptions: An Interrupted Time Series Analysis.","authors":"Emma Beagles, Hye Jin Chung, Allen Shih","doi":"10.1016/j.jaad.2024.10.077","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.077","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAAD Game Changers: "Aesthetic outcome and complications of simple interrupted versus running subcuticular sutures in facial surgery: A randomized controlled trial". JAAD Game Changers："面部手术中简单间断缝合与行式皮下缝合的美学效果和并发症：随机对照试验"。
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jaad.2024.10.091
Andrew Patterson
{"title":"JAAD Game Changers: \"Aesthetic outcome and complications of simple interrupted versus running subcuticular sutures in facial surgery: A randomized controlled trial\".","authors":"Andrew Patterson","doi":"10.1016/j.jaad.2024.10.091","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.091","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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