Journal of the American Academy of Dermatology最新文献

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IL-36A axis suppression associates with clinical response to stapokibart in head and neck atopic dermatitis-An exploratory proteomic study. IL-36A轴抑制与头颈部特应性皮炎的临床反应相关-一项探索性蛋白质组学研究
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-07 DOI: 10.1016/j.jaad.2026.04.018
Yan Yang, Bingyang Xu, Kaijing Zhang, Yuxin Qing, Yuanqin Wang, Tong Xiao, Peiwen Yang, Biao Yu, Hong Sun, Na Wu, Tianxiao Zhang, Shengxiang Xiao, Jiawen Wu
{"title":"IL-36A axis suppression associates with clinical response to stapokibart in head and neck atopic dermatitis-An exploratory proteomic study.","authors":"Yan Yang, Bingyang Xu, Kaijing Zhang, Yuxin Qing, Yuanqin Wang, Tong Xiao, Peiwen Yang, Biao Yu, Hong Sun, Na Wu, Tianxiao Zhang, Shengxiang Xiao, Jiawen Wu","doi":"10.1016/j.jaad.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.018","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost Dynamics of Biologic Switching for Psoriasis: A MarketScan Analysis. 银屑病生物转换的成本动态:市场分析。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1992
Q Wilton Sun, Jeffrey M Cohen
{"title":"Cost Dynamics of Biologic Switching for Psoriasis: A MarketScan Analysis.","authors":"Q Wilton Sun, Jeffrey M Cohen","doi":"10.1016/j.jaad.2026.04.1992","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1992","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Ruxolitinib Cream in Patients With Lichen Sclerosus: Results From a Phase 2, Randomized, Double-Blind, Vehicle-Controlled Study. Ruxolitinib乳膏对硬化地衣患者的疗效和安全性:一项随机、双盲、载体对照的2期研究结果
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1993
Andrew T Goldstein, Zhihong Lai, Rong Rong, Haq Nawaz, Melissa M Mauskar
{"title":"Efficacy and Safety of Ruxolitinib Cream in Patients With Lichen Sclerosus: Results From a Phase 2, Randomized, Double-Blind, Vehicle-Controlled Study.","authors":"Andrew T Goldstein, Zhihong Lai, Rong Rong, Haq Nawaz, Melissa M Mauskar","doi":"10.1016/j.jaad.2026.04.1993","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1993","url":null,"abstract":"<p><strong>Background: </strong>Effective nonsteroidal treatment options for patients with lichen sclerosus (LS) are limited.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of 1.5% ruxolitinib cream in adult women with anogenital LS.</p><p><strong>Methods: </strong>This phase 2 study (NCT05593445) enrolled women with LS affecting ≤10% of their body surface area, Investigator's Global Assessment score ≥2, and baseline Itch Numerical Rating Scale (NRS) ≥4. Patients were randomized 1:1 to twice-daily application of 1.5% ruxolitinib cream or vehicle for 12 weeks, after which all patients applied ruxolitinib cream (once or twice daily) through Week 24. The primary endpoint was ≥4-point improvement from baseline in Itch NRS (Itch NRS4) at Week 12.</p><p><strong>Results: </strong>Sixty-one patients were randomized. At Week 12, similar proportions of patients in the ruxolitinib cream and vehicle groups achieved Itch NRS4 (35.7% vs 40.0%, P=0.737). The ruxolitinib cream group had greater reductions in total Clinical Lichen Sclerosus Score versus vehicle (-5.79 vs -3.03; P=0.019). Application site reactions were infrequent (n=4; grade 1/2), and no serious adverse events were reported with ruxolitinib cream.</p><p><strong>Limitations: </strong>Treatment duration was relatively short.</p><p><strong>Conclusion: </strong>Ruxolitinib cream significantly improved clinical signs of LS, but not itch, versus vehicle and was generally well tolerated in women with LS.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Medicolegal Precedents of Neuromodulators and Soft-Tissue Fillers 2008-2025. 神经调节剂和软组织填充物的医学先例分析2008-2025。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1987
Ghassan Barnawi, Elsa Awad, Ahmad AlAbdulkareem, Ammar Saed-Aldein, Tiffany Onyejiaka, Saud Aleissa, Mathew Avram, Shari R Lipner
{"title":"Analysis of Medicolegal Precedents of Neuromodulators and Soft-Tissue Fillers 2008-2025.","authors":"Ghassan Barnawi, Elsa Awad, Ahmad AlAbdulkareem, Ammar Saed-Aldein, Tiffany Onyejiaka, Saud Aleissa, Mathew Avram, Shari R Lipner","doi":"10.1016/j.jaad.2026.04.1987","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1987","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Zheng et al., "Reevaluating Survival Outcomes of Mohs Surgery vs. Wide Local Excision in Sebaceous Carcinoma: Insights from SEER with Propensity Score Matching". 对Zheng等人“重新评估Mohs手术与皮脂腺癌广泛局部切除的生存结果:来自倾向评分匹配的SEER的见解”的回应。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.2000
Maggie H Zhou, Vijay Kodumudi, Nima Gharavi, Amanda Rosenthal
{"title":"Response to Zheng et al., \"Reevaluating Survival Outcomes of Mohs Surgery vs. Wide Local Excision in Sebaceous Carcinoma: Insights from SEER with Propensity Score Matching\".","authors":"Maggie H Zhou, Vijay Kodumudi, Nima Gharavi, Amanda Rosenthal","doi":"10.1016/j.jaad.2026.04.2000","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.2000","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On Learning to See: When Illness Changes What the Eye Can Hold. 学习看:当疾病改变了眼睛能看的东西。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.2001
Sabine Obagi
{"title":"On Learning to See: When Illness Changes What the Eye Can Hold.","authors":"Sabine Obagi","doi":"10.1016/j.jaad.2026.04.2001","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.2001","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocautery-guided nail plate division to enhance precision in partial nail avulsion. 电灼引导下甲板分割提高局部撕脱术的精度。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1995
Sunil Kumar Gupta, Kavita Swami, Sriramanan Anand Babu, Ravi Daiya
{"title":"Electrocautery-guided nail plate division to enhance precision in partial nail avulsion.","authors":"Sunil Kumar Gupta, Kavita Swami, Sriramanan Anand Babu, Ravi Daiya","doi":"10.1016/j.jaad.2026.04.1995","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1995","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reevaluating Survival Outcomes of Mohs Surgery vs. Wide Local Excision in Sebaceous Carcinoma: Insights from SEER with Propensity Score Matching. 重新评估Mohs手术与皮脂腺癌广泛局部切除的生存结果:来自倾向评分匹配的SEER的见解。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1999
Yuan Zheng, Qihao Sun, Di Zhang
{"title":"Reevaluating Survival Outcomes of Mohs Surgery vs. Wide Local Excision in Sebaceous Carcinoma: Insights from SEER with Propensity Score Matching.","authors":"Yuan Zheng, Qihao Sun, Di Zhang","doi":"10.1016/j.jaad.2026.04.1999","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1999","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival Outcomes and Prognostic Factors of Vulvar Dermatofibrosarcoma Protuberans: A National Cancer Database study. 外阴皮肤纤维肉瘤隆突的生存结局和预后因素:一项国家癌症数据库研究。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1991
Hue T T Tran, Jack B Newcomer, Duc V Le, Ray Guo, Clark C Otley, Jamie N Bakkum-Gamez, Giang Huong Nguyen
{"title":"Survival Outcomes and Prognostic Factors of Vulvar Dermatofibrosarcoma Protuberans: A National Cancer Database study.","authors":"Hue T T Tran, Jack B Newcomer, Duc V Le, Ray Guo, Clark C Otley, Jamie N Bakkum-Gamez, Giang Huong Nguyen","doi":"10.1016/j.jaad.2026.04.1991","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1991","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical Vessel Proportion as a Predictor of Vascular-Targeted Photodynamic Therapy Efficacy in Port-wine Stains: A Prospective Observational Study. 垂直血管比例作为葡萄酒斑血管靶向光动力治疗效果的预测指标:一项前瞻性观察研究。
IF 11.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2026-05-06 DOI: 10.1016/j.jaad.2026.04.1989
Yidi Liu, Defu Chen, Ying Wang, Jing Zeng, Biao Chang, Hongyou Zhao, Xiwan Zhang, Yushi Lin, Ying Gu, Haixia Qiu
{"title":"Vertical Vessel Proportion as a Predictor of Vascular-Targeted Photodynamic Therapy Efficacy in Port-wine Stains: A Prospective Observational Study.","authors":"Yidi Liu, Defu Chen, Ying Wang, Jing Zeng, Biao Chang, Hongyou Zhao, Xiwan Zhang, Yushi Lin, Ying Gu, Haixia Qiu","doi":"10.1016/j.jaad.2026.04.1989","DOIUrl":"https://doi.org/10.1016/j.jaad.2026.04.1989","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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