Journal of the American Academy of Dermatology最新文献

A multivariable disease specific model enhances prognostication beyond current Merkel cell carcinoma staging: an international cohort study of 10,958 patients. 多变量疾病特异性模型超越了目前的梅克尔细胞癌分期，提高了预后效果：一项对 10958 名患者进行的国际队列研究。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.10.096

Tom W Andrew, Sophie Erdmann, Mogdad Alrawi, Ruth Plummer, Sophia Z Shalhout, Vern Sondak, Isaac Brownell, Penny E Lovat, Aidan Rose

{"title":"A multivariable disease specific model enhances prognostication beyond current Merkel cell carcinoma staging: an international cohort study of 10,958 patients.","authors":"Tom W Andrew, Sophie Erdmann, Mogdad Alrawi, Ruth Plummer, Sophia Z Shalhout, Vern Sondak, Isaac Brownell, Penny E Lovat, Aidan Rose","doi":"10.1016/j.jaad.2024.10.096","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.10.096","url":null,"abstract":"Background: Merkel cell carcinoma (MCC) is a highly aggressive cutaneous malignancy for which accurate prognostication is necessary to support clinical management.Objective: 1. To determine which survival endpoint - disease-specific-death (DSD) or overall survival (OS)- was better stratified by MCC AJCC 8th edition staging. 2. To develop a multivariable model for enhanced MCC survival predictions.Methods: Retrospective analysis of 10,958 histologically confirmed MCC between January 2000 and December 2020 was performed. Patient and tumor features were analysed from two cohorts: a US cohort and an external validation UK cohort. A multivariable Fine and Gray Competing Risk (FG) model was utilised to account for competing risk.Results: DSD demonstrated greater discriminatory power as a survival endpoint when compared to OS. Multivariate FG analysis identified the most impactful features for DSD: truncal lesions (subdistribution hazard ratios (SHR) 1.96, p<.001), age >84 years (SHR 1.79, p<.001), male sex (SHR 1.34, p<.001) and marital status (SHR 1.09, p<.001). A second FG model incorporating those impactful features enhanced survival predictions beyond current MCC staging criteria alone in both US (C-index 0.75 vs 0.64, p<.001) and external validation cohorts. cohort (C-index 0.77).Conclusions: MCC staging can stratify DSD better than OS. Additional patient and tumour features enhanced prognostication beyond current staging systems.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nevus-associated acral melanoma has lower risk of recurrence and mortality than de novo acral melanoma: A multicenter, retrospective analysis of 482 patients. 痣相关尖锐湿疣黑色素瘤的复发风险和死亡率低于新生尖锐湿疣黑色素瘤：对 482 例患者进行的多中心回顾性分析。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.11.029

Yiqun Zhang, Jin Wu, Xin Cai, Kui Jiang, Weizhen Zhang, Hongfeng Zhou, Zhongwu Li, Shijie Lan, Jiwei Liu, Fang Liu, Yan Wang, Hongxue Meng, Zhen Guo, Liang Guo, Xiang Ji, Mei Xiang, Xinxin Yang, Yongqi Li, Lu Feng, Yuhuan Mao, Di Wu

{"title":"Nevus-associated acral melanoma has lower risk of recurrence and mortality than de novo acral melanoma: A multicenter, retrospective analysis of 482 patients.","authors":"Yiqun Zhang, Jin Wu, Xin Cai, Kui Jiang, Weizhen Zhang, Hongfeng Zhou, Zhongwu Li, Shijie Lan, Jiwei Liu, Fang Liu, Yan Wang, Hongxue Meng, Zhen Guo, Liang Guo, Xiang Ji, Mei Xiang, Xinxin Yang, Yongqi Li, Lu Feng, Yuhuan Mao, Di Wu","doi":"10.1016/j.jaad.2024.11.029","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.11.029","url":null,"abstract":"Background: It is unknown whether acral melanomas (AM) associated with pre-existing nevi have similar risk to other acral melanomas.Objective: To compare risk of recurrence and death between AM associated with pre-existing nevi and de novo AM.Methods: We conducted a multicenter retrospective cohort study involving patients diagnosed with AM between February 2011 and November 2022.Results: 164 patients (34.0%) had nevus-associated acral melanoma (NAAM). NAAM has lower risk of recurrence (HR 0.69, 95% CI 0.52-0.91, P = 0.008) and mortality (HR 0.53, 95% CI 0.37-0.76, P < 0.001) than de novo acral melanoma (DNAM). The five-year recurrence-free survival (RFS) was 55.1% for NAAM compared to 42.3% for DNAM. The five-year overall survival (OS) was 75.1% for NAAM and 63.2% for DNAM. Multivariate analyses identified Breslow thickness, nevus association, and sentinel node status as independent predictors of RFS. Age, Breslow thickness, nevus association, lymphovascular invasion, ulceration, and sentinel node status were independent predictors of OS.Limitations: The study's limitations included its retrospective design and missing data.Conclusion: Patients with nevus-associated AM had significantly better RFS and OS compared to those with de novo AM. Nevus association was an independent prognostic factor for both RFS and OS.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced Disease-Specific Mortality in Melanoma in situ Patients Treated with Mohs Surgery over Wide Local Excision: A Study of the Surveillance, Epidemiology, and End Results Database. 采用莫氏手术治疗原位黑色素瘤患者的疾病特异性死亡率低于广泛局部切除术：监测、流行病学和最终结果数据库研究》。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.11.021

Mitchell A Taylor, Divya Sharma, Sierra Thomas, Erin X Wei, Vanessa B Voss

引用次数: 0

Celiac Disease Associated with Alopecia Areata: A multicenter case control study. 与脱发有关的乳糜泻：多中心病例对照研究

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.11.023

Rashwan Alameddine, Nabeel Ahmad, Zaryab Alam, Omar Pacha

{"title":"Celiac Disease Associated with Alopecia Areata: A multicenter case control study.","authors":"Rashwan Alameddine, Nabeel Ahmad, Zaryab Alam, Omar Pacha","doi":"10.1016/j.jaad.2024.11.023","DOIUrl":"https://doi.org/10.1016/j.jaad.2024.11.023","url":null,"abstract":"Background: Celiac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten, which leads to inflammation and damage to the small intestine. CD is widely associated with various cutaneous disorders, such as Dermatitis Herpetiformis, however, a cross-sectional study with 300 participants conducted by Dev et al1 hypothesized that it could also be associated with Alopecia Areata (AA).Objective: This case control study aims to investigate the potential association between Celiac Disease and the prevalence of Alopecia Areata after initial diagnosis.Methods: Our case control study utilized TriNetX to identify 509,910 patients with Celiac Disease and compared them to 622,747 controls to measure differences in risk outcome for Alopecia Areata.Results: Our analyses suggests that patients with CD (N=495,211), compared to controls (N=495,112), have an elevated risk in developing Alopecia Areata with an odds ratio of 1.25(1.129-1.385) and p<0.0001.Limitations: Limitations in this study include analyzing the United States population, potential errors in charting, misdiagnoses, and the erroneous filing of ICD codes to patient charts due to TriNetX utilizing AI to search for patient data.Conclusion: The large sample size leveraged in this study substantiates an association that was previously suggested but not well established. The compelling degree of association found, even with the possible errors inherent in large, automatically compiled databases, affirms the long suspected association between CD and increased risk of AA.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Becker's nevi are associated with neurological abnormalities. 贝克尔痣与神经系统异常有关。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.09.085

Pablo Lopez-Balboa, Nicole Knöpfel, Mitesh Ramwani, Noreen Muwanga-Nanyonjo Ms, Claire O'Neill, Debra Lomas, Thomas Cullup, S Polubothu, Veronica A Kinsler

引用次数: 0

This Month in JAAD Reviews: February 2025: Apremilast and Immune Checkpoint Inhibitor Associated Psoriasis. 本月 JAAD 评论：2025年2月阿普瑞米拉斯特与免疫检查点抑制剂相关银屑病》（Apremilast and Immune Checkpoint Inhibitor Associated Psoriasis.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-20 DOI: 10.1016/j.jaad.2024.11.027

Shari R Lipner

引用次数: 0

Response to Yamaguchi et al.'s "Anti-SS-A antibody is a potential predictor of severe Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective cohort study". 对 Yamaguchi 等人的 "抗-SS-A 抗体是严重史蒂文斯-约翰逊综合征和中毒性表皮坏死症的潜在预测因子：回顾性队列研究"。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-19 DOI: 10.1016/j.jaad.2024.09.082

Sweta Subhadarshani, Taylor Griffith

引用次数: 0

Oysters, Limpets, and Elephants: A Literature Review of the Hyperkeratotic Psoriasis Variants. 牡蛎、蜥蜴和大象：角化过度型银屑病变异的文献综述。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-19 DOI: 10.1016/j.jaad.2024.11.018

Richard Bindernagel, Emily Woolhiser, Arpita Patel, Richard Miller

引用次数: 0

Turning Our Attention to Melanoma Risk in Turner Syndrome. 关注特纳综合征的黑色素瘤风险。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-19 DOI: 10.1016/j.jaad.2024.11.024

Warren R Heymann

引用次数: 0

Innovative low-cost, lightweight Follicular unit extraction micromotor device. 创新的低成本、轻型卵泡单位提取微电机装置。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2024-11-19 DOI: 10.1016/j.jaad.2024.11.016

Sanjeev Gupta, Ravi Shankar Jangra, Saurabh Swaroop Gupta, Rohit Singla, Aditi Dabhra

引用次数: 0