Journal of the American Academy of Dermatology最新文献_第8页

Teledermatology's Impact on Concordance in Bagamoyo, Tanzania: A Retrospective Study.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-28 DOI: 10.1016/j.jaad.2025.02.078

Michael Esson, Omar Juma, Gasper Mmbaga, Jane Mcharo, Sara Bertan, Miquela Teske, Helen Lozier, Nina Punyamurthy, Stephen Humphrey, Karolyn A Wanat

引用次数: 0

Nivolumab/relatlimab-associated cutaneous immune-related adverse events in patients treated for advanced melanoma: A multicenter retrospective cohort study. 晚期黑色素瘤患者中与 Nivolumab/relatlimab 相关的皮肤免疫相关不良事件：一项多中心回顾性队列研究。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-28 DOI: 10.1016/j.jaad.2025.02.080

Baraa A Hijaz, Natalie Braun, Kerry L Reynolds, Yevgeniy R Semenov, Nicole R LeBoeuf, Steven T Chen

引用次数: 0

riSCC: A personalized risk model for the development of poor outcomes in cutaneous squamous cell carcinoma.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-28 DOI: 10.1016/j.jaad.2025.02.076

Anokhi Jambusaria-Pahlajani, Vincent Jeanselme, David M Wang, Nina A Ran, Emily E Granger, Javier Cañueto, David G Brodland, David R Carr, Joi B Carter, John A Carucci, Kelsey E Hirotsu, Emily E Karn, Shlomo A Koyfman, Aaron R Mangold, Fabio Muradás Girardi, Kathryn T Shahwan, Divya Srivastava, Allison T Vidimos, Tyler J Willenbrink, Ashley Wysong, William Lotter, Emily S Ruiz

{"title":"riSCC: A personalized risk model for the development of poor outcomes in cutaneous squamous cell carcinoma.","authors":"Anokhi Jambusaria-Pahlajani, Vincent Jeanselme, David M Wang, Nina A Ran, Emily E Granger, Javier Cañueto, David G Brodland, David R Carr, Joi B Carter, John A Carucci, Kelsey E Hirotsu, Emily E Karn, Shlomo A Koyfman, Aaron R Mangold, Fabio Muradás Girardi, Kathryn T Shahwan, Divya Srivastava, Allison T Vidimos, Tyler J Willenbrink, Ashley Wysong, William Lotter, Emily S Ruiz","doi":"10.1016/j.jaad.2025.02.076","DOIUrl":"10.1016/j.jaad.2025.02.076","url":null,"abstract":"Background: Cutaneous squamous cell carcinoma (CSCC) is a prevalent disease for which improved risk stratification strategies are needed.Objective: To develop a novel prognostic model (herein \"riSCC\") for CSCC and compare riSCC performance to Brigham and Women's Hospital and American Joint Committee on Cancer Staging eighth edition T staging systems.Methods: Retrospective 12-center, multinational cohort study of CSCCs from 1991 to 2023. Clinical and pathologic risk factors, treatments, and outcomes were collected. Fine-Gray model was employed for each outcome with inverse probability of treatment weighting. A final model was trained for prospective use and estimation of hazard ratios.Results: Twenty-three thousand one hundred sixty-six localized CSCC tumors were included. riSCC prognostic model performed superiorly to American Joint Committee on Cancer eighth edition and Brigham and Women's Hospital T staging for all outcomes. At 5 years, the C-index for riSCC ranged from 0.74 for local recurrence to 0.87 for disease specific death.Limitations: Retrospective study design.Conclusion: riSCC prognostic model offers fine-grained risk estimates and improved stratification for important CSCC outcomes compared to T staging systems.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red scrotum syndrome: Clinical characteristics with a focus on treatment responses and outcomes in a case-series of 38 patients.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-28 DOI: 10.1016/j.jaad.2025.02.071

Charbel Skayem, Romain Salle, Sebastien Fouere, Jean-David Bouaziz, Tu-Anh Duong, Jean-Noel Dauendorffer

引用次数: 0

CTLA-4 inhibitors are associated with a higher risk of cardiovascular events than PD-1 inhibitors in Patients with Melanoma.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jaad.2025.02.074

Ching-Chung Chang, Shao-Wei Lo, Hua-Ching Chang, Junmin Song, Yu-Cheng Chang, Kevin Yang, Kuan-Yu Chi, Yu Chang, Cho-Hung Chiang, Cho-Han Chiang

引用次数: 0

Evaluation and diagnosis of longitudinal melanonychia: A clinical review by a nail expert group.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jaad.2025.02.075

Jose W Ricardo, Jane S Bellet, Nathaniel Jellinek, Dongyoun Lee, Christopher J Miller, Bianca Maria Piraccini, Bertrand Richert, Adam I Rubin, Shari R Lipner

{"title":"Evaluation and diagnosis of longitudinal melanonychia: A clinical review by a nail expert group.","authors":"Jose W Ricardo, Jane S Bellet, Nathaniel Jellinek, Dongyoun Lee, Christopher J Miller, Bianca Maria Piraccini, Bertrand Richert, Adam I Rubin, Shari R Lipner","doi":"10.1016/j.jaad.2025.02.075","DOIUrl":"10.1016/j.jaad.2025.02.075","url":null,"abstract":"Longitudinal melanonychia (LM), a brown-black band on 1 or multiple nails, is commonly encountered in clinical practice. Benign LM may be due to exogenous (external, blood, bacterial, mycotic) or endogenous (melanin) pigment. Histopathologically, melanin-derived LM may result from overproduction of melanin by a normal number of melanocytes (melanocytic activation) due to physiologic, local, systemic, iatrogenic, syndromic, and drug-induced causes, or from benign (nail matrix nevus and lentigo) or malignant (nail unit melanoma [NUM]) melanocyte hyperplasia. A high index of suspicion is necessary to differentiate benign LM and NUM secondary to similarities in clinical presentation, especially in pediatric patients. Benign pediatric LM may exhibit clinical and onychoscopic features resembling adult NUM; thus, a conservative approach with close follow-up is recommended. Onychoscopy and histopathologic examination of nail clippings are useful initial diagnostic tools for LM, avoiding a biopsy or aiding in biopsy planning and patient triage. Nail matrix excisional biopsy is the gold standard for diagnosing/ruling out NUM. For suspicious LM, a nail matrix tangential excisional biopsy is recommended. A longitudinal excision is recommended for cases with a high-likelihood of invasive NUM, which provides information on tumor extension. Herein, we review the current literature to describe the evaluation and diagnosis of LM.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective cohort analysis comparing comorbid conditions in palmoplantar pustular psoriasis and intrinsic hand dermatitides.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jaad.2024.11.088

Cody J Rasner, Connor R Buechler, Rebecca Freese, Karen Baker-James, David R Pearson

引用次数: 0

Characterization and treatment outcomes of biologic therapy in super-responders and biologic-refractory psoriasis patients: A single-center retrospective study in China.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jaad.2025.02.063

Yizhang Liu, Kun Hu, Yongfang Duan, Xiang Chen, Mi Zhang, Yehong Kuang

{"title":"Characterization and treatment outcomes of biologic therapy in super-responders and biologic-refractory psoriasis patients: A single-center retrospective study in China.","authors":"Yizhang Liu, Kun Hu, Yongfang Duan, Xiang Chen, Mi Zhang, Yehong Kuang","doi":"10.1016/j.jaad.2025.02.063","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.063","url":null,"abstract":"Background: Despite advances in the availability of effective biologics in psoriasis over the past decade, clinical characteristics, persistence, and safety associated with treatment response have never been systematically investigated.Objectives: To evaluate the factors, persistence, and safety associated with super response (super-responder, SR) or refractory (biologic-refractory patient, BRP) to biologic agents.Methods: This retrospective analysis included psoriasis patients who initiated their first biologic therapy. Multivariable logistic regression analysis identified predictors for SRs and BRPs. Drug survival used Kaplan-Meier plot analysis.Results: 737 patients were included (140 SRs [19.0%], 34 BRPs [4.6%]). Body mass index (BMI) <25, lower Charlson Comorbidity Index, without psoriatic arthritis, with family history of psoriasis, and lower insulin resistance level were significantly associated with SRs, whereas BMI ≥30, with non-alcoholic fatty liver disease, higher psoriasis area and severity index, and higher erythrocyte sedimentation rate level were independent predictors of BRPs. SRs were associated with treatment persistence of biologics, but BRPs were linked with poor persistence and higher incidences of adverse events-particularly paradoxical eczema.Limitations: Single-center study with limited patients.Conclusion: Our study identified predictors of response that may facilitate accurate drug targeting with good persistence and reassuring safety for psoriasis patients.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

This Month in JAAD International: May 2025: Body dysmorphic disorder and the theoretical underpinnings of a complex disease.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jaad.2025.02.070

Jonathan Kantor

引用次数: 0

This Month in JAAD Case Reports: May 2025.

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jaad.2025.02.069

Abby Susan Van Voorhees

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