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Journal of the American Academy of Dermatology最新文献

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Cutaneous toxicities associated with epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor (MET) dual blockade via bispecific antibody amivantamab.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jaad.2025.02.007
Isabel Arana, Grant J Riew, Adam Rock, Vinod E Nambudiri, Badri Modi, Connie R Shi
{"title":"Cutaneous toxicities associated with epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor (MET) dual blockade via bispecific antibody amivantamab.","authors":"Isabel Arana, Grant J Riew, Adam Rock, Vinod E Nambudiri, Badri Modi, Connie R Shi","doi":"10.1016/j.jaad.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.007","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of developing sleep disorders and psychologic comorbidity in children with inflammatory skin diseases - a population-based study.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jaad.2025.02.001
Caroline Mann, Andreas Wollenberg, Sascha Ständer, Petra Staubach, Diamant Thaçi, Henner Zirpel
{"title":"Risk of developing sleep disorders and psychologic comorbidity in children with inflammatory skin diseases - a population-based study.","authors":"Caroline Mann, Andreas Wollenberg, Sascha Ständer, Petra Staubach, Diamant Thaçi, Henner Zirpel","doi":"10.1016/j.jaad.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.001","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory skin diseases such as atopic dermatitis (AD), psoriasis and urticaria are associated with impaired mental health and sleep. In children the risk of developing these comorbidities is still poorly evaluated.</p><p><strong>Methods: </strong>Retrospective data analysis of a US Collaborative Network including children of 55 Health care providers was performed. Data from electronic health records of patients with a diagnosis of either AD, psoriasis, or urticaria, as well as a control cohort were retrieved in an anonymized batch format and propensity score matched.</p><p><strong>Results: </strong>Children with psoriasis had a 3.2-fold higher risk for hypersomnia, 2.1-fold higher for sleep apnea, 1.8-fold higher for fatigue and 1.9-fold higher for depression. Children with urticaria (acute or chronic) and AD had a 1.7-fold higher risk for sleep disorders, 1.6 higher for anxiety disorders and 1.4-fold higher for insomnia. AD children had a 1.5-fold higher risk for anxiety disorders.</p><p><strong>Limitations: </strong>Electronic health insurance data are not subject to random sampling of the general population and potential misdiagnosis is possible.</p><p><strong>Conclusion: </strong>Children with inflammatory skin diseases were at a higher risk for sleep psychological disorders. Thus, regularly performed screenings and appropriate treatment initiation might potentially prevent mental and physical health consequences and secure improved life quality.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of cutaneous immune-related adverse events with improved overall survival among patients with cutaneous squamous cell carcinoma treated with palliative PD-1 inhibition.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jaad.2025.02.005
Frederick T Gibson, Nina A Ran, Ann W Silk, Emily S Ruiz
{"title":"Association of cutaneous immune-related adverse events with improved overall survival among patients with cutaneous squamous cell carcinoma treated with palliative PD-1 inhibition.","authors":"Frederick T Gibson, Nina A Ran, Ann W Silk, Emily S Ruiz","doi":"10.1016/j.jaad.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.005","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of metastasis at presentation and disease-specific death for desmoplastic and spindle cell melanoma: a SEER database analysis.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jaad.2025.02.004
Frederick T Gibson, Nina A Ran, Chrysalyne D Schmults, Emily S Ruiz
{"title":"Risk of metastasis at presentation and disease-specific death for desmoplastic and spindle cell melanoma: a SEER database analysis.","authors":"Frederick T Gibson, Nina A Ran, Chrysalyne D Schmults, Emily S Ruiz","doi":"10.1016/j.jaad.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.004","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An International Multicenter, Retrospective Cohort Study of 203 Patients with Pediatric Androgenetic Alopecia.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jaad.2025.02.002
Tyan Shin Lee, Mara O'Connor, Leslie Castelo-Soccio, Dawn Eichenfield, Danny Lee, Amy S Paller, Manuel Valdebran, Jenna Vroman, Angela Yang, Grace L Lee, Megan Craddock, Cathryn Sibbald
{"title":"An International Multicenter, Retrospective Cohort Study of 203 Patients with Pediatric Androgenetic Alopecia.","authors":"Tyan Shin Lee, Mara O'Connor, Leslie Castelo-Soccio, Dawn Eichenfield, Danny Lee, Amy S Paller, Manuel Valdebran, Jenna Vroman, Angela Yang, Grace L Lee, Megan Craddock, Cathryn Sibbald","doi":"10.1016/j.jaad.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.002","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is a nonscarring alopecia with increasing prevalence in pediatric populations. Published data in pediatrics is limited.</p><p><strong>Objective: </strong>To perform a multi-center review of pediatric patients with AGA to study clinical presentation, comorbidities, and treatment recommendations.</p><p><strong>Methods: </strong>A retrospective review of patients presenting with AGA at age <18 years with adequate documentation for data extraction.</p><p><strong>Results: </strong>In total, 203 patients were included. The mean age of AGA onset was 12.9 ± 2.7 years, and at diagnosis was 14.5 ± 2.1 years. Prepubertal onset occurred in 17 patients, 70.6% female. The majority had a family history of AGA. Of 145 patients with anthropometric data, 24.1% were obese (>95<sup>th</sup> percentile) and 24.8% overweight (85-95<sup>th</sup> percentile). Treatments at diagnosis included topical minoxidil in 76.5% and systemic minoxidil in 2.9%, spironolactone in 5.7% of females, and 5-alpha reductase inhibitors in 1.7% of males. Side effects were rare.</p><p><strong>Limitations: </strong>Data was limited to recorded information.</p><p><strong>Conclusion: </strong>AGA can occur in prepubertal patients. Potential risk factors for pediatric AGA include obesity and family history. Minoxidil has clinical benefit and is well tolerated in this population. Further prospective studies are recommended to confirm these findings and gather more evidence for treatments.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"'Plumage Sign' helps clinician easily identify pigmented squamous cell carcinoma in situ."
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jaad.2025.02.003
Erin Hurd
{"title":"\"'Plumage Sign' helps clinician easily identify pigmented squamous cell carcinoma in situ.\"","authors":"Erin Hurd","doi":"10.1016/j.jaad.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.003","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usefulness of rituximab for the treatment of systemic sclerosis-associated interstitial lung disease: further analysis of the DESIRES trial.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jaad.2025.02.006
Ai Kuzumi, Satoshi Ebata, Murray Baron, Shinichi Sato, Ayumi Yoshizaki
{"title":"Usefulness of rituximab for the treatment of systemic sclerosis-associated interstitial lung disease: further analysis of the DESIRES trial.","authors":"Ai Kuzumi, Satoshi Ebata, Murray Baron, Shinichi Sato, Ayumi Yoshizaki","doi":"10.1016/j.jaad.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.02.006","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Pemphigoid: A practical approach to diagnosis and management in the modern era.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jaad.2025.01.086
Camille M Powers, Sach Thakker, Nicholas Gulati, Jordan Talia, Danielle Dubin, John Zone, Donna A Culton, Zachary Hopkins, Jonas A Adalsteinsson
{"title":"Bullous Pemphigoid: A practical approach to diagnosis and management in the modern era.","authors":"Camille M Powers, Sach Thakker, Nicholas Gulati, Jordan Talia, Danielle Dubin, John Zone, Donna A Culton, Zachary Hopkins, Jonas A Adalsteinsson","doi":"10.1016/j.jaad.2025.01.086","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.01.086","url":null,"abstract":"<p><p>Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disorder, primarily presenting with tense bullae and severe pruritus. Diagnosing and treating BP can be challenging due to its variable clinical presentations. We will briefly discuss these phenotypes, highlight diagnostic basics, and briefly summarize recent laboratory advancements that have improved diagnostic sensitivity and accuracy. The treatment landscape for BP has evolved significantly. Newer therapies, including biologics such as rituximab, omalizumab, dupilumab and Janus kinase inhibitors target the immunopathogenesis of BP and can reduce the adverse effects associated with cumulative corticosteroid exposure and conventional immunosuppressants. This article provides a comprehensive overview of BP's clinical features, diagnostic approaches, and emerging therapeutic options, emphasizing personalized medicine and improved patient outcomes.</p>","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and tolerability of ritlecitinib in children with alopecia areata: A case series.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jaad.2025.01.090
Jundong Huang, Jia Jian, Min Li, Ruxin Ji, Ji Li, Wei Shi
{"title":"Effectiveness and tolerability of ritlecitinib in children with alopecia areata: A case series.","authors":"Jundong Huang, Jia Jian, Min Li, Ruxin Ji, Ji Li, Wei Shi","doi":"10.1016/j.jaad.2025.01.090","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.01.090","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics and Outcomes of Genital Pyoderma Gangrenosum - a Systematic Review.
IF 12.8 1区 医学
Journal of the American Academy of Dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jaad.2025.01.084
Rachel R Lin, Narges Maskan Bermudez, Olivia Burke, Robert S Kirsner
{"title":"Clinical Characteristics and Outcomes of Genital Pyoderma Gangrenosum - a Systematic Review.","authors":"Rachel R Lin, Narges Maskan Bermudez, Olivia Burke, Robert S Kirsner","doi":"10.1016/j.jaad.2025.01.084","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.01.084","url":null,"abstract":"","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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