Journal of the American Academy of Dermatology最新文献_第3页

Ethical considerations of unsolicited advice in the management of traction alopecia 牵引性脱发治疗中主动咨询的伦理考虑

IF 13.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-18 DOI: 10.1016/j.jaad.2025.07.034

Aarushi K. Parikh MA, Noelle Desir BA, Susan C. Taylor MD, Shari R. Lipner MD PhD

引用次数: 0

MS.NO.JAAD-D-25-00096R2. New-onset psychiatric diagnoses, including suicidal ideation and suicide attempts, are more common among hidradenitis suppurativa patients compared to the general population: A propensity score-matched retrospective cohort-study of 43,707 patients utilizing the TriNetX Research Network. ms.no.jaad - d - 25 - 00096 - r2。新发精神病诊断，包括自杀意念和自杀企图，在化脓性汗腺炎患者中比一般人群更常见：利用TriNetX研究网络对43707例患者进行了倾向评分匹配的回顾性队列研究。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.025

Chunghwan Ro, Waleed Adawi, Ana Ormaza Vera, Clinton W Enos

引用次数: 0

Understanding JAK Inhibitor Toxicity: Is the Off-Target Kinome a Missing Piece of the Puzzle? 了解JAK抑制剂的毒性：脱靶Kinome是缺失的一块拼图吗？

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.024

Athira Sivadas, Kevin W Byram, Manuel Valdebran, Tyler Beck

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IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/S0190-9622(25)02313-8

引用次数: 0

Radiotherapy Versus Imiquimod for Complex Lentigo Maligna: a Phase 3 Randomized Clinical Trial. 放疗与咪喹莫特治疗复杂恶性Lentigo：一项3期随机临床试验

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.028

Angela M Hong, Serigne N Lo, Gerald B Fogarty, Jonathan Stretch, Wei Wang, Pablo Fernandez-Penas, Richard Cw Martin, Matthew Foote, H Peter Soyer, Jeremy Ruben, Victoria Mar, Lilian Rocha, Cyro Festa-Neto, Chris Wratten, Sam Hogarth, Helena Collgros, Amanda Glanz, Bruna Melhoranse Gouveia, Richard A Scolyer, Madeleine T King, Pascale Guitera

{"title":"Radiotherapy Versus Imiquimod for Complex Lentigo Maligna: a Phase 3 Randomized Clinical Trial.","authors":"Angela M Hong, Serigne N Lo, Gerald B Fogarty, Jonathan Stretch, Wei Wang, Pablo Fernandez-Penas, Richard Cw Martin, Matthew Foote, H Peter Soyer, Jeremy Ruben, Victoria Mar, Lilian Rocha, Cyro Festa-Neto, Chris Wratten, Sam Hogarth, Helena Collgros, Amanda Glanz, Bruna Melhoranse Gouveia, Richard A Scolyer, Madeleine T King, Pascale Guitera","doi":"10.1016/j.jaad.2025.07.028","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.028","url":null,"abstract":"Background: For patients with lentigo maligna who are not suitable for surgery, radiotherapy or topical imiquimod are alternative non-surgical treatments.Objective: This trial aimed to assess the efficacy, safety and patient-reported health-related quality of life (HRQL).Methods: A multi-institutional, phase 3 randomized trial conducted between August 2015 and November 2021. Patients were randomized to radiotherapy or imiquimod. Primary endpoint was treatment failure at 24 months. Secondary endpoints included response at 6 months, development of invasive disease, toxicity and HRQL.Results: Between August 2015 and November 2021, 126 patients were randomized. The response rate was 95% at 6 months in both groups. The treatment failure rates were low with 12 failures in the radiotherapy group and six in the imiquimod group at 24 months (OR 2.35, 95% CI 0.82-6.75, p=0.11). Both were well tolerated with mainly grade 1 and 2 acute skin toxicity with no significant differences between groups in skin symptoms or HRQL at long-term. Patients had significantly better emotional scores after treatment than at baseline in both groups. The trial is underpowered due to early cessation of recruitment.Conclusions: Both radiotherapy and imiquimod are efficient and well-tolerated treatments for LM. Neither have negative impacts on HRQL at 24 months.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Answers to CME examination CME考试答案

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2024.08.025

引用次数: 0

Patient-reported Economic Burden of Alopecia Areata in China: A Multicenter Cross-Sectional Study. 中国斑秃患者报告的经济负担：一项多中心横断面研究。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.023

Xiangqian Li, Xufeng Du, Hengguang Zhao, Yanyun Wang, Longquan Pi, Ying Luo, Chiachia Hsu, Yijie Sun, Huixin Liu, Jianzhong Zhang, Hongxia Li, Cheng Zhou

引用次数: 0

Satellitosis/in-transit metastasis in cutaneous squamous cell carcinoma: Risk factors and the prognostic significance. 皮肤鳞状细胞癌的伴星/转移：危险因素及预后意义。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.029

Vartan Pahalyants, Neil K Jairath, Derek E Maas, Shayan Cheraghlou, Soutrik Mandal, Steven Friedman, Maressa C Criscito, Nayoung Lee, Nicole A Doudican, Emily S Ruiz, Nina Ran, Emily E Granger, Shlomo Koyfman, Alison Vidimos, Ashley Wysong, David R Carr, Kathryn T Shahwan, Kelsey E Hirotsu, Joi B Carter, Javier Cañueto, Fabio Muradás Girardi, Aaron R Mangold, Divya Srivastava, David G Brodland, John A Zitelli, Tyler J Willenbrink, John A Carucci

{"title":"Satellitosis/in-transit metastasis in cutaneous squamous cell carcinoma: Risk factors and the prognostic significance.","authors":"Vartan Pahalyants, Neil K Jairath, Derek E Maas, Shayan Cheraghlou, Soutrik Mandal, Steven Friedman, Maressa C Criscito, Nayoung Lee, Nicole A Doudican, Emily S Ruiz, Nina Ran, Emily E Granger, Shlomo Koyfman, Alison Vidimos, Ashley Wysong, David R Carr, Kathryn T Shahwan, Kelsey E Hirotsu, Joi B Carter, Javier Cañueto, Fabio Muradás Girardi, Aaron R Mangold, Divya Srivastava, David G Brodland, John A Zitelli, Tyler J Willenbrink, John A Carucci","doi":"10.1016/j.jaad.2025.07.029","DOIUrl":"https://doi.org/10.1016/j.jaad.2025.07.029","url":null,"abstract":"Background: Satellitosis or in-transit metastasis (S-ITM) from cutaneous squamous cell carcinoma (cSCC) is associated with poor outcomes but is not included in current staging guidelines.Objective: To determine risk factors and prognostic significance of S-ITM.Methods: This cohort study included 8,901 patients with cSCC from 12 institutions (1998-2023). Risk factors for S-ITM were calculated using logistic regression. Outcomes were compared with 1:2 propensity score matched controls using a Fine-Gray subdistribution hazard model.Results: Seventy-seven patients developed S-ITM. Increased patient age (OR 1.03, 95% CI 1.01-1.05, p<0.01), history of immunosuppression (OR 4.31, 95% CI 2.59-7.10, p<0.001), higher BWH stage (T2a OR 4.14, 95% CI 2.05-8.41; T2b OR 15.96, 95% CI 8.58-31.19; T3 OR 30.27, 95% CI 10.70-79.04, all p<0.001) and LVI (OR 4.57, 95% CI 1.80-10.38, p=0.001) were independent risk factors for S-ITM. S-ITM was associated with LR (SHR 2.40, 95% CI 1.43-4.04, p<0.001), NM (SHR 1.89 (95% CI .02-3.49, p=0.04), DM (SHR 4.41, 95% CI 1.45-13.27, p=0.01), and DSD (SHR 4.48, 95% CI 2.34-8.58, p<0.001).Limitations: Retrospective cohort study. The rarity of S-ITM may limit statistical power.Conclusion: Patients with cSCC and S-ITM are at higher risk for poor outcomes independent of patient, tumor, and treatment characteristics.","PeriodicalId":17198,"journal":{"name":"Journal of the American Academy of Dermatology","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower Oncogenic Risk with Dermatologic Use of Mycophenolate Mofetil Compared to Transplant Prophylaxis: A Retrospective Study. 与移植预防相比，皮肤科使用霉酚酸酯的致癌风险更低：一项回顾性研究。

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2025.07.031

Robin C Yi, Ainsley J Ruley, Aishwarya Sharma, Matthew L Hrin, Steven R Feldman, Lindsay C Strowd

引用次数: 0

Answers to CME examination CME考试答案

IF 12.8 1区医学

Journal of the American Academy of Dermatology Pub Date : 2025-07-17 DOI: 10.1016/j.jaad.2024.08.023

引用次数: 0