Journal of the American Dental Association最新文献

{"title":"Operationalizing space dentistry","authors":"Lakshman Samaranayake DSc, DDS, FRCPath, Yiu Yan Leung BDS, MDS, PhD, Nozimjon Tuygunov BDS, MDSc, Thanaphum Osathanon DDS, PhD","doi":"10.1016/j.adaj.2026.06.010","DOIUrl":"10.1016/j.adaj.2026.06.010","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1230-1233"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral virome in health and disease","authors":"Yvonne L. Hernandez-Kapila DDS, PhD,&nbsp;Rachel Y. Kim MS,&nbsp;Sanika S. Gokhale BDS, MS,&nbsp;Yi-Ling Lin DDS, DMSC,&nbsp;Henrik Dommisch Dr Med Dent,&nbsp;Jørgen Slots DDS, MS, PhD, DMD, MBA,&nbsp;Daniel J. Weisenberger PhD","doi":"10.1016/j.adaj.2026.01.019","DOIUrl":"10.1016/j.adaj.2026.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Despite estimates suggesting more than 380 trillion viruses reside within the body, an order of magnitude greater than the number of bacteria, the human virome remains largely unexplored. Pandemics and worldwide threats over the past century have highlighted our limited knowledge of viral pathogens in the body. Moreover, knowledge of what constitutes a healthy human virome is lacking, representing a considerable knowledge gap. The National Institutes of Health Human Virome Program aims to fill this gap by means of defining all facets of the human virome across the life and health spans in diverse populations.</div></div><div><h3>Types of Studies Reviewed</h3><div>The authors summarized the known information and challenges related to interrogating the human virome across the oral-gut-brain axis and its implications for oral health and clinical dental practice.</div></div><div><h3>Results</h3><div>Viruses are the most abundant and diverse biological entities on the planet, and distinct viral communities inhabit human body sites. Most researchers have focused on viruses linked to systemic disease; however, commensal viruses have the potential for conferring health and therapeutic benefits. The aim of the Human Virome Program was to characterize commensal viruses in the human body across the lifespan.</div></div><div><h3>Conclusions and Practical Implications</h3><div>Human virome characterization will advance our understanding of healthy viromes, promote advances in biomedical research, enable identification of disease-associated disruptions, and improve our capacity to detect, diagnose, and discover viruses that may pose threats to human health. For the dental community, an understanding of the oral virome will be essential for correlating viral signatures with patient health, treatment response, and predicting future oral health risks.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1092-1104"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiology Consultation","authors":"Timothy G. Donley DDS, MDS","doi":"10.1016/j.adaj.2026.07.034","DOIUrl":"10.1016/j.adaj.2026.07.034","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Page 1090"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention Timing","authors":"Dehan Jin BDS,&nbsp;Xiangxue Yu MSc","doi":"10.1016/j.adaj.2026.06.019","DOIUrl":"10.1016/j.adaj.2026.06.019","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1084-1085"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tooth autotransplantation cost model for pediatric through young adult patients","authors":"Caitlin Miller DMD, MS,&nbsp;Jessica Lee DDS, MPH, PhD,&nbsp;Glenn Reside DMD, MS,&nbsp;Antonio Moretti DDS, MS,&nbsp;Gustavo Oliveira DDS, MS,&nbsp;Dick Barendregt DDS, PhD,&nbsp;John Christensen DDS, MS","doi":"10.1016/j.adaj.2026.03.011","DOIUrl":"10.1016/j.adaj.2026.03.011","url":null,"abstract":"<div><h3>Background</h3><div>Tooth autotransplantation (TA) is a proven and effective treatment option for children with missing teeth; however, it is seldom performed in the United States due in part to the lack of knowledge about its practicality and costs. In this study the authors sought to analyze and compare costs of TA with the most common tooth replacement options being used.</div></div><div><h3>Types of Studies Reviewed</h3><div>A comprehensive literature review and expert panel were used to establish treatment clinical pathways. Procedural costs were calculated using the <em>CDT 2024: Current Dental Terminology</em> codes, and their corresponding fees from FAIR Health data and the American Dental Association Survey of Dental Fees. Time costs, which were defined as work time lost per appointment for families, were calculated using the US Bureau of Labor Statistics hourly wage data and number of visits.</div></div><div><h3>Results</h3><div>A cost model was constructed comparing the cost of maxillary anterior TA in patients aged 8 through 25 years with the associated costs of implant-supported prosthesis, resin-bonded fixed partial denture, and orthodontic space closure. Implant-supported prosthesis without or with orthodontics was more costly (procedural costs: $9,186-$15,279) than TA with limited or comprehensive orthodontics (procedural costs: $6,134-$10,355). Resin-bonded fixed partial denture without orthodontic treatment was the least costly (procedural costs: $4,455; time costs: $437). Orthodontic space closure (procedural costs: $9,295; time costs: $2,187) was found to be more costly than TA with limited orthodontics but less costly than TA with comprehensive orthodontics.</div></div><div><h3>Conclusions and Practical Implications</h3><div>TA is a practical tooth replacement option for families, and dental care professionals should consider TA for pediatric patients who require tooth replacement in the maxillary anterior region.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1202-1212.e4"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid prescribing for tooth extraction in the United States, 2021 through 2023","authors":"Kao-Ping Chua MD, PhD,&nbsp;Hsou-Mei Hu PhD,&nbsp;Chad M. Brummett MD,&nbsp;Romesh P. Nalliah DDS, MHCM","doi":"10.1016/j.adaj.2026.03.003","DOIUrl":"10.1016/j.adaj.2026.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Compared with opioids, ibuprofen and acetaminophen are safer and equally effective options for analgesia after tooth extraction. Despite this, researchers found that tooth extraction accounted for 65% of opioid prescriptions dispensed after dental procedures from 2013 through 2018. It is unclear whether this proportion has since changed. In addition, the factors associated with opioid dispensing after tooth extraction are unclear.</div></div><div><h3>Methods</h3><div>The authors conducted a cross-sectional analysis of the Merative MarketScan Dental, Commercial and Multi-State Medicaid Databases, which include dental and pharmacy claims from privately and publicly insured patients. Analyses included dental procedures for patients aged 13 through 64 years from 2021 through 2023. The authors counted the number of opioid prescriptions dispensed within 3 days of these procedures and calculated the proportion of these dispensed opioid prescriptions accounted for by tooth extraction. Among patients undergoing tooth extraction, the authors used linear regression to identify patient and procedure factors associated with having a dispensed opioid prescription.</div></div><div><h3>Results</h3><div>The 3,643,224 procedures in the sample were associated with 569,729 dispensed opioid prescriptions, of which tooth extraction accounted for 76.2%. Among 1,290,061 tooth extractions, the opioid dispensing rate was 33.7%. For surgical and nonsurgical extractions, the rates were 45.7% and 19.0%, respectively. Factors positively associated with opioid dispensing included residence in the South, undergoing the procedure on a Friday, and having a mental health disorder.</div></div><div><h3>Conclusions</h3><div>Tooth extraction remains the dominant indication for dental opioid prescribing.</div></div><div><h3>Practical Implications</h3><div>Dental opioid stewardship initiatives may be most efficient if they focus on reducing opioid prescribing after tooth extraction.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1135-1150.e8"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of tooth resorption in patients receiving denosumab therapy","authors":"Emily Y. Chu DDS, PhD,&nbsp;Eswar Kandaswamy BDS, MS,&nbsp;Vinayak Joshi BDS, MS, PhD,&nbsp;Janina Golob Deeb DDS, MS,&nbsp;Mauricio Ronderos DDS, MS, MPH,&nbsp;Stephen P. Russo DMD,&nbsp;Golnar Jahanmir DDS,&nbsp;Vardit Kram PhD,&nbsp;Alison Boyce MD,&nbsp;Martha Somerman DDS, PhD,&nbsp;Vivek Thumbigere-Math BDS, PhD","doi":"10.1016/j.adaj.2026.01.007","DOIUrl":"10.1016/j.adaj.2026.01.007","url":null,"abstract":"<div><h3>Background</h3><div>Multiple external cervical root resorption (MECRR) is a rare, aggressive form of root resorption affecting multiple permanent teeth at the cementoenamel junction. A possible association between denosumab (DMAb), a receptor activator of nuclear factor-κB ligand (RANKL)-inhibiting antiresorptive medication, and MECRR has been proposed, although evidence remains limited.</div></div><div><h3>Case Description</h3><div>Two retrospective cases of MECRR were identified, including a 72-year-old woman receiving DMAb for osteoporosis and a 65-year-old man receiving high-dose DMAb for metastatic prostate cancer. In both cases, MECRR was first detected approximately 5 years after beginning DMAb therapy, without known predisposing factors. Lesions progressed despite professional intervention and rapidly worsened after DMAb cessation. Histology revealed multinucleated clastic cells with external resorption of cementum and dentin. One hypothesis is that localized, RANKL-independent osteoclastogenesis may potentially contribute to MECRR during DMAb treatment, subsequently exacerbated by rebound osteoclast activity on drug withdrawal.</div></div><div><h3>Practical Implications</h3><div>These cases illustrate a temporal association between DMAb therapy and MECRR but do not establish causality. Early recognition in patients receiving DMAb is important given the irreversible nature of MECRR. Interdisciplinary communication is important, and prospective and mechanistic studies are needed to clarify risk factors and develop preventive strategies.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1213-1222"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors’ Response","authors":"Shaiba Sandhu DDS, MS,&nbsp;Lisa Newsome MD,&nbsp;Muhammad Ali Shazib DMD","doi":"10.1016/j.adaj.2026.08.002","DOIUrl":"10.1016/j.adaj.2026.08.002","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 10","pages":"Pages 1090-1091"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandatory reporting of patients who are victims of abuse, neglect, violence, and human trafficking: Ten practical insights for dentists.","authors":"Peter E Murray, Franklin Garcia-Godoy","doi":"10.1016/j.adaj.2026.07.027","DOIUrl":"https://doi.org/10.1016/j.adaj.2026.07.027","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy and concomitant antibiotic treatment: A cautionary case report of a potential oral adverse event.","authors":"Quinton Steere, Sonal S Shah","doi":"10.1016/j.adaj.2026.06.012","DOIUrl":"https://doi.org/10.1016/j.adaj.2026.06.012","url":null,"abstract":"<p><strong>Background: </strong>Erythematous oral lesions have a broad differential diagnosis, including trauma, vascular lesions, precancer and cancer, and opportunistic infections. The authors present a case of erythematous palatal lesions in a male patient undergoing concurrent immunotherapy and antibiotic therapy.</p><p><strong>Case description: </strong>A 38-year-old man with ankylosing spondylitis undergoing long-term adalimumab (Humira; AbbVie) therapy sought treatment for asymptomatic erythematous palatal lesions after amoxicillin use. Clinical examination revealed multiple well-defined flat red lesions involving the hard and soft palate. Although the manifestation was atypical, a clinical diagnosis of erythematous candidiasis was made. Nystatin mouthrinse was prescribed and resulted in complete resolution of the lesions, supporting the clinical diagnosis. No recurrence was observed at 6-month follow-up.</p><p><strong>Practical implications: </strong>With immunotherapy use becoming more common, dental care professionals should recognize the increased risk of developing opportunistic infections that may manifest atypically in these patients. A thorough medical history is essential.</p>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}