Journal of the American Dental Association最新文献

{"title":"Guideline for the use of vital pulp therapy in permanent teeth.","authors":"James A Coll, Vineet Dhar, Noel K Childers","doi":"10.1016/j.adaj.2026.03.020","DOIUrl":"https://doi.org/10.1016/j.adaj.2026.03.020","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare diseases: Challenges for optimal oral health.","authors":"Davis C Thomas, J Tim Wright","doi":"10.1016/j.adaj.2026.03.023","DOIUrl":"https://doi.org/10.1016/j.adaj.2026.03.023","url":null,"abstract":"<p><strong>Background: </strong>It is estimated that 30 million people in the United States have a rare disease, and few of these conditions have available cures. The diversity of rare disease etiologies and phenotypes has hindered both diagnostics and treatment approaches. Many rare diseases are caused by pathogenic genetic variations and involve the craniofacial structures and function. Dental care providers are called on to serve the population with rare diseases and support their desire for optimal health. To address these oral health care challenges, JADA is presenting a special issue on rare diseases through a series of articles. These reviews will address some of the more common rare diseases and those that share features such as involvement of the dentition, skeleton, immune system, skin, or facial clefts.</p><p><strong>Types of studies reviewed: </strong>The authors searched the 5 major databases, including PubMed, Google Scholar, Web of Science, Embase, and Ovid MEDLINE, for articles pertaining to rare diseases and disorders affecting oral health and oral health care. The authors conducted an exhaustive search of the literature from 1990 through March 30, 2026, for articles on rare diseases, with a specific focus on oral health care.</p><p><strong>Results: </strong>There is no existing reliable classification that groups all of these complex syndromes into clinically identifiable clusters. This special issue may be the first of its kind in which the authors attempt to format a meaningful classification to group these entities of similar etiopathogenesis and phenotype.</p><p><strong>Conclusions and practical implications: </strong>The medical and dental management of rare disorders often requires teams of specialists and advocates to address the developmental, structural, functional, psychosocial, and economic aspects that can confront affected patients.</p>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare diseases and your patients.","authors":"Davis C Thomas, J Tim Wright","doi":"10.1016/j.adaj.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.adaj.2026.04.001","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual gingival lesion","authors":"Josefina Martínez-Ramírez DDS, MSc,&nbsp;Marina Silva DDS, MSc,&nbsp;Alan Roger Santos-Silva DDS, MSc, PhD,&nbsp;Pablo Agustin Vargas DDS, MSc, PhD,&nbsp;Márcio Ajudarte Lopes DDS, MSc, PhD","doi":"10.1016/j.adaj.2025.07.016","DOIUrl":"10.1016/j.adaj.2025.07.016","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Pages 539-543"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncommunicable Diseases Recognized","authors":"Mebin George Mathew BDS, MDS, PhD,&nbsp;Nirmal Kurian BDS, MDS","doi":"10.1016/j.adaj.2026.02.017","DOIUrl":"10.1016/j.adaj.2026.02.017","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Page 446"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary oral rinse offers a noninvasive method to detect oral human papillomavirus infections on the GeneXpert system","authors":"Xiaomin Huang PhD ,&nbsp;Jaikrishna Balakittnen PhD ,&nbsp;Chameera Ekanayake Weeramange PhD ,&nbsp;Sarju Vasani MB BChir, MA (Med) ,&nbsp;Akila Wijesekera MD ,&nbsp;Lizbeth Kenny MBBS ,&nbsp;Rahul Ladwa MPhil MedOnc ,&nbsp;Brett G.M. Hughes MBBS (Hons) ,&nbsp;Chamindie Punyadeera MPhil, PhD","doi":"10.1016/j.adaj.2026.02.013","DOIUrl":"10.1016/j.adaj.2026.02.013","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing, and human papillomavirus (HPV)-associated OPSCC is contributing substantially to this trend. Salivary HPV testing enables early detection of HPV-driven OPSCC. The GeneXpert system (Cepheid) is an automated polymerase chain reaction (PCR)-based diagnostic platform designed primarily for cervical cancer screening using vaginal swabs. Our goal was to adapt this platform for HPV testing using salivary oral rinse (SOR) samples to enable early detection of HPV-driven OPSCC.</div></div><div><h3>Methods</h3><div>Patients suspected of having any type of head and neck cancers and people at higher risk of acquiring HPV infections were recruited (n = 67). A volume of 5 to 10 mL of SOR samples was tested using the GeneXpert system. Genomic DNA was extracted from the same SOR samples and analyzed using quantitative real-time PCR for human papillomavirus type 16 (HPV-16). The detection status of HPV-16 was used to evaluate the efficiency of HPV detection using the GeneXpert system.</div></div><div><h3>Results</h3><div>The GeneXpert system had excellent specificity of 100% and sensitivity of 72.09%. There was strong agreement with quantitative real-time PCR results (κ = .649). This confirms the suitability of SOR as a sample medium on the GeneXpert system to detect oral HPV with minimal bias.</div></div><div><h3>Conclusions</h3><div>The GeneXpert system can effectively detect HPV in SOR samples. It offers rapid HPV detection, helps identify people at high risk of developing HPV-associated OPSCC, thereby holding promise for the early detection of HPV-driven OPSCC.</div></div><div><h3>Practical Implications</h3><div>The results of this study showed the feasibility of using SOR samples on the GeneXpert platform as a scalable, noninvasive screening approach for the early detection of patients at higher risk of developing HPV-associated OPSCC.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Pages 448-458.e4"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of living evidence-informed guidelines, part 3","authors":"Olivia Urquhart MPH,&nbsp;Francisca Verdugo-Paiva DDS, MSc,&nbsp;Carolina Martins-Pfeifer DDS, MSc, PhD,&nbsp;Ankita Shashikant Bhosale BDS, MPH,&nbsp;Michael Glick DMD,&nbsp;Alonso Carrasco-Labra DDS, MSc, PhD","doi":"10.1016/j.adaj.2025.09.010","DOIUrl":"10.1016/j.adaj.2025.09.010","url":null,"abstract":"<div><h3>Background</h3><div>Evidence-informed guidelines provide a basis for optimal clinical and public health decisions. Rigorous methodological standards have been developed for producing guidelines, and the purpose of this article is to consolidate and elaborate on these methods.</div></div><div><h3>Types of Studies Reviewed</h3><div>The body of evidence addressing methodological aspects for developing the first version of a guideline in the context of living evidence-informed clinical and public health guidelines was included. The latest version of methodological handbooks and articles presenting guideline methodology were selected.</div></div><div><h3>Results</h3><div>Guideline panels develop guideline questions and prioritize outcomes for decision making. Evidence syntheses provide summaries of the best available evidence to answer these questions. This evidence includes the benefits and harms of interventions, the certainty in this evidence, and people's values and preferences, among others. The guideline panel assesses this evidence and makes judgments when formulating recommendations. Guideline recommendations are disseminated and repackaged into implementation tools for the target users.</div></div><div><h3>Conclusions and Practical Implications</h3><div>Guideline recommendations developed following the rigorous and transparent methods outlined here equip clinicians and other target users with trustworthy information that can support better decision making and improve patient outcomes.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Pages 487-493"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral findings in patients with sexually transmitted infections","authors":"Alicia González-Romero DDS,&nbsp;Miguel Ramón Pecci-Lloret DDS, PhD,&nbsp;Julia Guerrero-Gironés DDS, PhD","doi":"10.1016/j.adaj.2025.11.011","DOIUrl":"10.1016/j.adaj.2025.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Oral findings may serve as early indicators of sexually transmitted infections (STIs), yet evidence of their diagnostic relevance remains limited. In this systematic review, the authors aimed to identify and synthesize the most frequent oral manifestations and associated conditions observed in patients with STIs, emphasizing their clinical diagnostic value.</div></div><div><h3>Types of Studies Reviewed</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search was conducted in MEDLINE, Web of Science, Scopus, Cochrane Library, and Scientific Electronic Library Online databases for observational studies published from 2015 through 2024. The population, exposure, comparator, and outcomes framework guided study selection, and quality was assessed using the Joanna Briggs Institute checklist. Seventeen studies met inclusion criteria.</div></div><div><h3>Results</h3><div>Of the 17 studies included, 7 had low risk of bias and 10 had moderate risk of bias. Reported oral findings included ulcers, plaques, papules, and papillomatous lesions directly linked to STIs. Associated conditions, such as periodontal disease, oral cancer, candidiasis, and temporomandibular disorders, were also described. The most frequently affected oral sites were the tongue, commissures, and palate. Variability among studies was due mainly to differences in population characteristics, diagnostic approaches, and sample size.</div></div><div><h3>Practical Implications</h3><div>Interdisciplinary collaboration between dental care professionals and health care professionals is crucial for prevention, early diagnosis, and comprehensive management of STIs. Dentists play a key role in identifying oral manifestations and distinguishing between direct lesions and associated conditions, facilitating prompt referral and treatment. This systematic review was registered at PROSPERO. The registration number is CRD42025640143.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Pages 521-531.e5"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awakening to opportunity","authors":"Aaron Glick DDS ,&nbsp;Harmeet K. Chiang DDS, MS ,&nbsp;Nelly Huynh PhD ,&nbsp;Mitchell Levine DMD, MS","doi":"10.1016/j.adaj.2025.12.020","DOIUrl":"10.1016/j.adaj.2025.12.020","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA) is the most common sleep disorder among adults and poses substantial public health and economic challenges. Amidst a shortage of sleep medicine specialists and the growing demand for OSA care, properly educated dentists are positioned to help bridge critical gaps in diagnosis and management.</div></div><div><h3>Types of Studies Reviewed</h3><div>The authors reviewed original data from studies, comparative analyses, and review articles describing the nature of OSA, its implications on systemic health, and assorted therapeutics in disease management.</div></div><div><h3>Results</h3><div>The studies reviewed support an important role for oral appliances in the management of OSA. In particular, mandibular advancement devices appear to have similar beneficence as positive airway pressure and are comparatively more likely to be tolerated by adults.</div></div><div><h3>Conclusions and Practical Implications</h3><div>The evolving integration of dental care professionals into OSA care is vital for meeting the growing demand for comprehensive management of this complex disorder. Strengthening collaboration between dentists and physicians alongside advancing sleep medicine education within dentistry can reduce underdiagnosis and elevate the quality of care.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Pages 459-470"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Directory","authors":"","doi":"10.1016/S0002-8177(26)00195-9","DOIUrl":"10.1016/S0002-8177(26)00195-9","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"157 5","pages":"Page A12"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}