Journal of the American Dental Association最新文献

{"title":"Oral manifestations of Crohn disease managed with ustekinumab","authors":"Patrick Ruck DDS,&nbsp;Elizabeth S. Gosnell DMD, MS,&nbsp;James R. Rick MD","doi":"10.1016/j.adaj.2024.11.006","DOIUrl":"10.1016/j.adaj.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>The authors reviewed a case involving the orofacial manifestations of Crohn disease (CD) in an adolescent whose treatment was ultimately managed with a newer class of biologic drug agent, ustekinumab (Stelara, Janssen Biotech). CD is a chronic inflammatory condition affecting the gastrointestinal tract that often causes extraintestinal complications. The underlying etiology of CD involves genetic, environmental, and local factors. Orofacial manifestations of CD include gingivitis, mucosal tags, aphthous ulcerations, labial swellings, cobblestoning, and linear ulcers of the oral vestibules.</div></div><div><h3>Case Description</h3><div>A previously healthy 12-year-old boy presented with painful, constant, diffuse oral ulcerations. His diagnostic and laboratory testing supported a diagnosis of CD. The patient was then treated with budesonide (Entocort, Perrigo Company), prednisone (Deltasone, Pfizer Inc), and infliximab infusions (Remicade, Janssen Biotech). Later, he had high levels of anti-infliximab antibodies and inadequate control of his orofacial lesions. He then began taking a different class of biologic medication, ustekinumab. After initiation of ustekinumab, both his oral and intestinal manifestations markedly improved.</div></div><div><h3>Practical Implications</h3><div>Collaboration between the treating dentist and treating gastroenterologist is recommended for management of the orofacial manifestations of CD. This may lead to an improvement in the patient’s prognosis and quality of life. Ustekinumab is an anti-p40 antibody that inhibits interleukins 12 and 23. It is a newer biologic medication, and its use has been increasing in the pediatric population with CD. Its use is typical after failure of an antitumor necrosis factor drug, like infliximab.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 2","pages":"Pages 160-165"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining success","authors":"Abdullah Alalyani MSc,&nbsp;Olivia Urquhart MPH,&nbsp;Ankita Shashikant Bhosale BDS, MPH,&nbsp;Michael Glick DMD","doi":"10.1016/j.adaj.2024.12.002","DOIUrl":"10.1016/j.adaj.2024.12.002","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 2","pages":"Pages 172-174"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymptomatic unilateral gingival swelling.","authors":"Kiranmeet Kaur, Amit Sethi, Devaki Sundararajan, Deeba Kashtwari","doi":"10.1016/j.adaj.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.adaj.2024.12.005","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT’s risk of misinformation in dentistry","authors":"Arman Danesh,&nbsp;Farzad Danesh DDS, MSC,&nbsp;Arsalan Danesh DDS","doi":"10.1016/j.adaj.2024.05.003","DOIUrl":"10.1016/j.adaj.2024.05.003","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Pages 3-5"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different daily times for at-home bleaching with 10% carbamide peroxide","authors":"Renata Maria Oleniki Terra DDS, MS, PhD,&nbsp;Elisama Sutil DDS, MS, PhD,&nbsp;Deisy Cristina Ferreira Cordeiro DDS, MS,&nbsp;Michael Willian Favoreto DDS, MS, PhD,&nbsp;André Faria-e-Silva DDS, MS, PhD,&nbsp;Al M. Best PhD,&nbsp;Alessandro D. Loguercio DDS, MS, PhD,&nbsp;Alessandra Reis DDS, PhD","doi":"10.1016/j.adaj.2024.10.010","DOIUrl":"10.1016/j.adaj.2024.10.010","url":null,"abstract":"<div><h3>Background</h3><div>This single-blind, noninferiority trial evaluated whether 10% carbamide peroxide (CP) applied for 2 or 4 hours daily is noninferior to 8 hours.</div></div><div><h3>Methods</h3><div>A total of 120 healthy adults, with teeth shade A2 or darker, were randomly allocated to 3 groups (n = 40). All participants used 10% CP gel in a bleaching tray for 2, 4, and 8 hours daily for 14 days, with the option to extend treatment if they were dissatisfied. Color change was measured using a spectrophotometer and shade guides at baseline, every 5 days, and 1 month posttreatment. Risk and intensity of tooth sensitivity (TS) were assessed daily using a 0 through 10 visual analog scale. Satisfaction was recorded via a Likert scale wherein 1 corresponded to very dissatisfied and 7 corresponded to very satisfied and the Orofacial Esthetic Scale. Noninferiority was tested for color change using the 1976 formula (ΔEab) at 1 month postbleaching (primary outcome), color change using the 2000 formula (ΔE00), Whiteness Index, and shade guide units, whereas TS and satisfaction were analyzed with χ², analysis of variance, Kruskal-Wallis, and Friedman tests.</div></div><div><h3>Results</h3><div>Color change in ΔEab (2 vs 8 h: mean difference, −0.6; 90% CI, −2.1 to 1.0, 4 vs 8 h: mean difference, 0.0; 90% CI, −1.6 to 1.6) and ΔE00 values for shorter durations were noninferior to 8 hours at 1 month. Whiteness Index results were inconclusive. TS risk and intensity were similar (<em>P</em> &gt; .05), and patient satisfaction improved across all groups similarly (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>Shorter 2- and 4-hour daily bleaching with 10% CP is noninferior to the 8-hour protocol.</div></div><div><h3>Practical Implications</h3><div>Shorter periods of at-home bleaching (2 and 4 h) can be prescribed depending on the patient's availability or preferences without jeopardizing the bleaching efficacy. This clinical trial was registered at Registro Brasileiro de Ensaios Clínicos (RBR-10vvfpcm).</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Pages 57-67.e5"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Response","authors":"Meredith A. Bailey DMD, MBA","doi":"10.1016/j.adaj.2024.11.008","DOIUrl":"10.1016/j.adaj.2024.11.008","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Page 7"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We are in the midst of a major generational transition in dentistry","authors":"Marko Vujicic PhD,&nbsp;Brittany Flynn MA,&nbsp;Bradley Munson BA","doi":"10.1016/j.adaj.2024.10.011","DOIUrl":"10.1016/j.adaj.2024.10.011","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Pages 85-86"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequent recreational cannabis use and its association with caries and severe tooth loss","authors":"Ellyce Clonan DDS, MPH, MA,&nbsp;Parth Shah DDS, MPH,&nbsp;Megan Cloidt DDS, MPH,&nbsp;Nadia Laniado DDS, MPH, MS","doi":"10.1016/j.adaj.2024.10.005","DOIUrl":"10.1016/j.adaj.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to examine the association of frequent recreational cannabis (FRC) use with untreated coronal caries, untreated root surface caries, and severe tooth loss.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed data obtained from 5,656 people, aged 18 through 59 years, who participated in the National Health and Nutrition Examination Survey from 2015 through 2018. FRC use was defined as self-reported use of marijuana or hashish at least once per month for the past 12 months. Log-binomial and logistic regression analyses were conducted before and after controlling for sociodemographic and behavioral factors to examine the association between FRC use and untreated coronal caries, root surface caries, and severe tooth loss.</div></div><div><h3>Results</h3><div>Compared with non–FRC users, people reporting FRC use had 17% higher probabilities of having untreated coronal caries (95% CI, 1.02 to 1.35), 55% higher odds of having untreated root surface caries (95% CI, 1.21 to 1.99), and 41% higher odds of having severe tooth loss (95% CI, 1.00 to 1.99) after controlling for age, sex, race or ethnicity, nativity, education, family income to poverty ratio, and alcohol consumption.</div></div><div><h3>Conclusions</h3><div>This study suggests that FRC use is associated with increased coronal caries, root surface caries, and severe tooth loss in the US adult population. Further longitudinal studies are warranted to assess the impact of varying frequencies, quantities, and forms of cannabis use.</div></div><div><h3>Practical Implications</h3><div>Dental care professionals should be aware that FRC use may be associated with caries and tooth loss.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Pages 9-16.e1"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Directory","authors":"","doi":"10.1016/S0002-8177(24)00664-0","DOIUrl":"10.1016/S0002-8177(24)00664-0","url":null,"abstract":"","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Page A12"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of self-reported flossing behavior on cardiovascular disease events and mortality","authors":"Nebu Philip MDS, PhD,&nbsp;Faleh Tamimi PhD,&nbsp;Abdulla Al-Sheebani,&nbsp;Abdulrahman Almuzafar,&nbsp;Zumin Shi MPhil, PhD","doi":"10.1016/j.adaj.2024.09.017","DOIUrl":"10.1016/j.adaj.2024.09.017","url":null,"abstract":"<div><h3>Background</h3><div>There is increasing evidence suggesting that daily oral hygiene self-care measures may alleviate cardiovascular disease (CVD) risk. The authors aimed to determine the influence of self-reported dental flossing behavior on the prevalence of CVD events, CVD-linked mortality, and a CVD risk marker of inflammation (ie, C-reactive protein [CRP]).</div></div><div><h3>Methods</h3><div>Data from 18,801 adult participants of the 2009-2016 National Health and Nutrition Examination Surveys were analyzed with regard to flossing behavior, prevalence of CVD events, mortality cause data, and CRP levels. Information on mortality was obtained from the US mortality registry, updated to 2019. Participants who answered the flossing question were divided into 4 groups according to their frequency of flossing: not flossing (0 d/wk); occasional flossing (1-3 d/wk); frequent flossing (4-6 d/wk); and daily flossing (7 d/wk). Multiple logistic regression and Cox proportional hazard regression were used for analysis.</div></div><div><h3>Results</h3><div>Daily flossing was associated with lower prevalence of CVD events after adjusting for age, sex, sociodemographic factors, and lifestyle habits (model 2); the odds ratio was 0.71 (95% CI, 0.59 to 0.85) for CVD prevalence in the daily flossing group compared with the not flossing group. The odds ratio for CVD prevalence for each additional day of flossing was 0.95 (95% CI, 0.93 to 0.98; <em>P</em> for linear trend &lt; .001) in model 2, and remained statistically significant after model 2 was further adjusted for metabolic syndrome. Daily flossing compared with not flossing was associated with lower risk of experiencing CVD mortality (hazard ratio, 0.64; 95% CI, 0.49 to 0.84) in model 2. The hazard ratio of CVD mortality for each additional day of flossing was 0.94 (95% CI, 0.90 to 0.98; <em>P</em> for linear trend = .002) in model 2. Participants in the not flossing group had significantly elevated CRP levels, even after multivariable adjustments.</div></div><div><h3>Conclusions</h3><div>Poor flossing behavior is associated with higher prevalence of cardiovascular events, increased risk of experiencing CVD mortality, and elevated CRP levels.</div></div><div><h3>Practical Implications</h3><div>Improvement in flossing behavior can have an additional benefit in the prevention of CVD events. Cardiologists need to advise patients to improve their personal oral hygiene practices, in addition to the standard diet and exercise advice.</div></div>","PeriodicalId":17197,"journal":{"name":"Journal of the American Dental Association","volume":"156 1","pages":"Pages 17-27.e3"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}