Journal of the American College of Cardiology最新文献

{"title":"Audio Summary","authors":"","doi":"10.1016/s0735-1097(24)09993-5","DOIUrl":"https://doi.org/10.1016/s0735-1097(24)09993-5","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"16 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Conduction Mapping to Reduce Postoperative Atrioventricular Block in Complex Congenital Heart Disease","authors":"Edward T. O’Leary, Eric N. Feins, Jocelyn Davee, Christopher W. Baird, Rebecca Beroukhim, Pedro J. del Nido, Audrey Dionne, Kimberlee Gauvreau, David M. Hoganson, John K. Triedman, Edward P. Walsh, Meena Nathan, Sitaram M. Emani, Elizabeth S. DeWitt","doi":"10.1016/j.jacc.2024.07.054","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.07.054","url":null,"abstract":"<h3>Background</h3>Postoperative atrioventricular block requiring pacemaker (AVB/PM) complicates 14% to 25% of biventricular repair operations for complex congenital heart disease (CHD) and in those with heterotaxy syndrome.<h3>Objectives</h3>This study aimed to evaluate if intraoperative His bundle (HB) mapping during complex biventricular CHD repair can be performed safely and reduce postoperative AVB/PM.<h3>Methods</h3>HB mapping was performed using a commercially available multielectrode grid catheter in patients with complex CHD undergoing biventricular repair between 2019 and 2022 compared with an unmapped cohort. The primary outcome was postoperative AVB/PM.<h3>Results</h3>One hundred forty-nine patients underwent HB mapping compared to 201 unmapped controls. The median age of mapped patients was 1.9 years (Q1-Q3: 0.9-3.9 years). Heterotaxy syndrome was present in 31% (n = 46 of 149), ventricular septal defect in 95% (n = 142 of 149), and prior single ventricle palliation in 68% (n = 89 of 149). The HB was identified in 97% (n = 144 of 149) of cases. The median mapping time was 6 minutes. No episodes of intraoperative systemic air embolism occurred. Postoperative AVB/PM frequency was significantly reduced in mapped patients with heterotaxy (2% [n = 1 of 46] vs 16% [n = 11 of 67]; <em>P</em> = 0.026) and in patients without L-malposed great arteries (3% [n = 3 of 88] vs 11% [n = 15 of 134]; <em>P</em> = 0.045).<h3>Conclusions</h3>Intraoperative HB mapping can be performed safely and is associated with significantly reduced postoperative AVB/PM in select populations undergoing complex biventricular repair, including heterotaxy syndrome and non–L-malposed great arteries. Nonetheless, certain subgroups remain at risk for AVB/PM, showing the need for further improvements to current intraoperative HB mapping technology and techniques.","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"45 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten Years of Leadless Cardiac Pacing","authors":"Karel T.N. Breeman, Fleur V.Y. Tjong, Marc A. Miller, Petr Neuzil, Srinivas Dukkipati, Reinoud E. Knops, Vivek Y. Reddy","doi":"10.1016/j.jacc.2024.08.077","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.08.077","url":null,"abstract":"Leadless pacemakers (LPs) are self-contained pacemakers implanted inside the heart, providing a clinical strategy of pacing without pacemaker leads or a subcutaneous pocket. From an experimental therapy first used clinically in 2012, a decade later this technology is an established treatment option. Because of technologic advances and growing evidence, LPs are increasingly being used. Herein, the experience gained from a decade of leadless pacing is reviewed. We cover the safety and efficacy of single-chamber LPs, including comparisons with transvenous pacemakers and various models, and the initial clinical results of the first dual-chamber LP system. Furthermore, evidence and considerations regarding the optimal replacement strategy will be covered. Finally, we discuss future device developments that may broaden indications, such as LPs communicating with subcutaneous implantable cardiac defibrillators and energy-harvesting LPs.","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"2 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Guide to Implementation Science for Phase 3 Clinical Trialists","authors":"Harriette G.C. Van Spall MD ,&nbsp;Laura Desveaux PhD ,&nbsp;Tracy Finch PhD ,&nbsp;Cara C. Lewis PhD ,&nbsp;George A. Mensah MD ,&nbsp;Yves Rosenberg MD ,&nbsp;Kavita Singh PhD ,&nbsp;Francois Venter PhD ,&nbsp;Bryan J. Weiner PhD ,&nbsp;Faiez Zannad MD","doi":"10.1016/j.jacc.2024.08.068","DOIUrl":"10.1016/j.jacc.2024.08.068","url":null,"abstract":"<div><div>The delayed and modest uptake of evidence-based treatments following cardiovascular clinical trials highlights the need for greater attention to implementation early in the development and testing of treatments. However, implementation science is not well understood and is often an afterthought following phase 3 trials. In this review, we describe the goals, frameworks, and methods of implementation science, along with common multilevel barriers and facilitators of implementation. We propose that some of the approaches used for implementation well after a trial has ended can be incorporated into the design of phase 3 trials to foster early post-trial implementation. Approaches include, but are not limited to, engaging broad stakeholders including patients, clinicians, and decision-makers in trial advisory boards; using less restrictive eligibility criteria that ensure both internal validity and generalizability; having trial protocols reviewed by regulators; integrating trial execution with the health care system; evaluating and addressing barriers and facilitators to deployment of the intervention; and undertaking cost-effectiveness and cost utility analyses across jurisdictions. We provide case examples to highlight concepts and to guide end-of-trial implementation.</div></div>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Pages 2063-2072"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities in Cardiovascular Literature","authors":"Ruirui Hou MD,&nbsp;Jian Ren MD","doi":"10.1016/j.jacc.2024.07.053","DOIUrl":"10.1016/j.jacc.2024.07.053","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Page e279"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let Us Focus on Angina Mechanisms in Many, Not Just Typical Symptoms in a Few","authors":"Christiaan J.M. Vrints MD, PhD","doi":"10.1016/j.jacc.2024.05.085","DOIUrl":"10.1016/j.jacc.2024.05.085","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Page e275"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Socioeconomic Status and Diagnostic Timeline on Clinical Outcomes in ATTR Cardiomyopathy","authors":"Kuan-Yu Chi MD ,&nbsp;Cesia Gallegos-Kattán MD, MHS ,&nbsp;Nikhil V. Sikand MD ,&nbsp;Marc D. Samsky MD ,&nbsp;Michael G. Nanna MD, MHS","doi":"10.1016/j.jacc.2024.07.050","DOIUrl":"10.1016/j.jacc.2024.07.050","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Pages e289-e290"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vive la Différence","authors":"Xuan Jiang MD, PhD,&nbsp;Tianxiang Gu MD, PhD","doi":"10.1016/j.jacc.2024.07.047","DOIUrl":"10.1016/j.jacc.2024.07.047","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Pages e293-e294"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Women's CABG Outcomes","authors":"Yuli Guo MD ,&nbsp;Ruirui Hou MD","doi":"10.1016/j.jacc.2024.07.052","DOIUrl":"10.1016/j.jacc.2024.07.052","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Page e295"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audio Summary","authors":"","doi":"10.1016/S0735-1097(24)09923-6","DOIUrl":"10.1016/S0735-1097(24)09923-6","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 20","pages":"Page e267"},"PeriodicalIF":21.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}